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41. 发明授权

US11491109B2 Pharmaceutical compositions for basic or neutral, low molecular weight compounds 有权
公开(公告)号：US11491109B2
公开(公告)日：2022-11-08
申请号：US16791230
申请日：2020-02-14
申请人： Hoffmann-La Roche Inc.
发明人： Jochem Alsenz , Martin Kuentz , Alfred Ross , Wiebke Svea Saal , Nicole Wyttenbach
IPC分类号： A61K9/08 , A61K47/59 , A61K9/00
摘要： The present invention provides novel, solid or liquid pharmaceutical preparations comprising a basic or neutral, low molecular weight active pharmaceutical ingredient and the polymer Eudragit® EPO, optionally together with additional pharmaceutically acceptable excipients. The present preparations are for oral or topical administration.

42. 发明申请

US20220351864A1 MEANS AND METHODS FOR ASSESSING HUNTINGTON'S DISEASE (HD) 有权
公开(公告)号：US20220351864A1
公开(公告)日：2022-11-03
申请号：US17764763
申请日：2020-09-29
申请人： Hoffmann-La Roche Inc.
发明人： Michael LINDEMANN , Florian LIPSMEIER , Cedric André Marie Vincent Geoffrey SIMILLION
IPC分类号： G16H50/30 , G16H40/63
摘要： The present invention relates to the field of disease tracking and potentially even diagnostics. Specifically, it relates to a method for predicting the total motor score (TMS) in a subject suffering from Huntington's Disease (HD) comprising the steps of determining at least one performance parameter from a dataset of measurements of central motor function capabilities from said subject, comparing the determined at least one performance parameter to a reference obtained from a computer-implemented regression model generated on training data, in an embodiment using partial least-squares (PLS) analysis, with the at least one performance parameters, and predicting the TMS of the subject based on said comparison. The present invention also relates to a mobile device comprising a processor, at least one sensor and a database as well as software which is tangibly embedded to said device and, when running on said device, carries out the method of the invention as well as a system comprising a mobile device comprising at least one sensor and a remote device comprising a processor and a database as well as software which is tangibly embedded to said device and, when miming on said device, carries out the method of the invention, wherein said mobile device and said remote device are operatively linked to each other. Furthermore, the invention contemplates the use of the aforementioned mobile device or system for predicting the TMS in a subject suffering from HD using at least one performance parameter from a dataset of measurements of central motor function capabilities from said subject.

43. 发明授权

US11482320B2 Transformation of digital pathology images 有权
公开(公告)号：US11482320B2
公开(公告)日：2022-10-25
申请号：US16944922
申请日：2020-07-31
申请人： HOFFMANN-LA ROCHE INC.
发明人： Eldad Klaiman
IPC分类号： G16H30/40 , G06T7/00
摘要： The invention relates to a method of identifying a biomarker in a tissue sample. The method comprises receiving an acquired image depicting a tissue sample, the pixel intensity values of the acquired image correlating with an autofluorescence signal or of an X-ray induced signal or a signal of a non-biomarker specific stain or a signal of a first biomarker specific stain adapted to selectively stain a first biomarker. The acquired image is input into a trained machine learning logic—MLL which automatically transforms the acquired image into an output image highlighting tissue regions predicted to comprise a second biomarker.

44. 发明申请

US20220325223A1 IDENTIFICATION OF CALIBRATION DEVIATIONS OF pH-MEASURING DEVICES 有权
公开(公告)号：US20220325223A1
公开(公告)日：2022-10-13
申请号：US17575008
申请日：2022-01-13
申请人： Hoffmann-La Roche, Inc.
发明人： Detlef Eisenkraetzer , Christian Klinger , Katrin Greppmair
IPC分类号： C12M1/34 , G01N27/416 , G01D18/00 , G05D21/02
摘要： The invention relates to a comparison unit (130) configured for determining if a first pH measuring device of a first tank (104; 106) is affected by a pH-measuring problem, the comparison unit being configured for: receiving a first CO2 concentration and a first pH value, the first CO2 concentration being a CO2 concentration of a first gas volume above a medium in a first tank, the first CO2 concentration and the first pH value being measured at a first time when the medium in the first tank is in pH-CO2 equilibrium state with the first gas volume and before said equilibrium state is modified by the metabolism of a cell culture in the first tank, the first pH value being a measured value provided by a first pH measuring device operatively coupled to the first tank (102); receiving a second CO2 concentration and a second pH value, the second CO2 concentration being a CO2 concentration of a second gas volume above a medium in a second tank, the second CO2 concentration and the second pH value being measured at a second time when the medium in the second tank is in pH-CO2 equilibrium state with the second gas volume and before said equilibrium state is modified by the metabolism of a cell culture, the second pH value being a measured value provided by a second pH measuring device; comparing the first and second pH values and CO2 concentrations for determining if comparing (206), by the comparison unit, the first and second pH values and comparing the first and second CO2 concentrations for determining if the first pH measuring device is affected by the pH-measuring problem.

45. 外观设计

USD966323S1 Portion of a display screen with a graphical user interface 有权
公开(公告)号：USD966323S1
公开(公告)日：2022-10-11
申请号：US29830107
申请日：2022-03-10
申请人： Hoffmann-La Roche Inc.
设计人： Cassie Catherine Morrison

46. 外观设计

USD966294S1 Portion of a display screen with a graphical user interface 有权
公开(公告)号：USD966294S1
公开(公告)日：2022-10-11
申请号：US29830108
申请日：2022-03-10
申请人： Hoffmann-La Roche Inc.
设计人： Cassie Catherine Morrison

47. 发明申请

US20220315588A1 ALTERNATIVE PROCESS FOR THE PREPARATION OF 4-PHENYL-5-ALKOXYCARBONYL-2-THIAZOL-2-YL-1,4-DIHYDROPYRIMIDIN-6-YL]METHYL]-3-OXO-5,6,8,8A-TETRAHYDRO-1H-IMIDAZO[1,5-A]PYRAZIN-2-YL]-CARBOXYLIC ACID 有权
公开(公告)号：US20220315588A1
公开(公告)日：2022-10-06
申请号：US17616930
申请日：2020-06-04
申请人： Hoffmann-La Roche Inc.
发明人： Daniel Vincent FISHLOCK , Jianshu LIU , Paul SPURR , Georg WUITSCHIK , Zhixiang XU , Fugui ZHANG
IPC分类号： C07D487/04
摘要： The present invention relates to an alternative process for synthesizing a compound of formula (I), R1 is phenyl, which is unsubstituted or substituted with one, two or three substituents independently selected from halogen and C1-6alkyl; R2 is C1-6alkyl; R3 is —CxH2—; x is 1, 2, 3, 4, 5, 6 or 7; or pharmaceutically acceptable salt or diastereomer thereof, which is useful for prophylaxis and treatment of a viral disease in a patient relating to hepatitis B infection or a disease caused by hepatitis B infection.

48. 发明申请

US20220306761A1 BISPECIFIC ANTI-HUMAN CD20/HUMAN TRANSFERRIN RECEPTOR ANTIBODIES AND METHODS OF USE 有权
公开(公告)号：US20220306761A1
公开(公告)日：2022-09-29
申请号：US17664609
申请日：2022-05-23
申请人： Hoffmann-La Roche Inc.
发明人： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
IPC分类号： C07K16/28 , A61P25/00
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.

49. 发明申请

US20220306607A1 ALKYNYL-(HETEROARYL)-CARBOXAMIDE HCN1 INHIBITORS 有权
公开(公告)号：US20220306607A1
公开(公告)日：2022-09-29
申请号：US17830215
申请日：2022-06-01
申请人： Hoffmann-La Roche Inc.
发明人： Bjoern Bartels , Amanda Lee Dupont , Benjamin J. Hall , Jean-Yves Wach , Christian Schnider , Patrick Schnider , Michael Reutllinger , Eoin O'Connor , Eva Katrin Harde , Michael Weber
IPC分类号： C07D401/14 , C07D409/14 , C07D401/04 , C07D405/14 , C07D233/90 , C07D401/06
摘要： The present invention provides compounds of formula I wherein R1, R2 or R3 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula I, pharmaceutical compositions comprising them and their use as medicaments.

50. 发明申请

US20220298490A1 METHOD TO GENERATE MONOCYTIC PROGENITOR CELLS 有权
公开(公告)号：US20220298490A1
公开(公告)日：2022-09-22
申请号：US17520267
申请日：2021-11-05
申请人： Hoffmann-La Roche Inc.
发明人： Nadine DAHM , Simon GUTBIER , Christoph PATSCH
IPC分类号： C12N5/074 , C12N5/0735
摘要： This application relates to methods for generating monocytic progenitor cells and their differentiation into macrophages and microglia as well as to large scale cell cultures for producing monocytic progenitor cells.

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