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41. 发明申请

US20140356961A1 USE OF PHASED SMALL RNAS FOR SUPPRESSION OF PLANT DEFENSE AND OTHER PLANT GENES 审中-公开
标题翻译：使用相同的小RNA来抑制植物防御和其他植物基因
公开(公告)号：US20140356961A1
公开(公告)日：2014-12-04
申请号：US14234174
申请日：2012-07-20
申请人： Blake Meyers , Jixian Zhai , Janine Sherrier
发明人： Blake Meyers , Jixian Zhai , Janine Sherrier
IPC分类号： C12N15/82
CPC分类号： C12N15/8218 , C12N15/8279
摘要： A method for generating a phased siRNA (phasiRNA) in a plant cell comprises introducing into the plant cell an effective amount of a microRNA (miRNA). A transcript of a NB-LRR encoding gene may be cleaved in the plant cell. Resistance of the plant to a microbe may be reduced. The plant may enter a symbiotic interaction with a microbe. Nodulation in the plant may be improved. Related compositions are provided.
摘要翻译：用于在植物细胞中产生相序siRNA（phasiRNA）的方法包括向植物细胞中引入有效量的微小RNA（miRNA）。 NB-LRR编码基因的转录物可能在植物细胞中裂解。植物对微生物的抗性可能会降低。植物可能与微生物共生相互作用。植物中的结瘤可能得到改善。提供相关的组合物。

42. 发明授权

US08903204B2 Optical interconnect systems and methods 有权
标题翻译：光互连系统和方法
公开(公告)号：US08903204B2
公开(公告)日：2014-12-02
申请号：US13082547
申请日：2011-04-08
申请人： Rohit Nair , Tian Gu , Michael W. Haney
发明人： Rohit Nair , Tian Gu , Michael W. Haney
IPC分类号： G02B6/00 , G02F1/035 , G02B6/43 , G02B6/12 , G02B6/42
CPC分类号： G02B6/43 , G02B6/4214 , G02B2006/12173
摘要： Optical interconnect systems and methods are disclosed. An optical interconnect system includes a substrate, an optical waveguide, and first and second modulators. The optical waveguide has a first waveguide portion extending to a first coupling structure, a second waveguide portion extending from the first coupling structure to a second coupling structure, and a third waveguide portion extending from the second coupling structure. The first modulator is positioned adjacent the first coupling structure, and the second modulator is positioned adjacent the second coupling structure. The optical interconnect method includes modulating light with a first modulator to produce one-time modulated light, and modulating the one-time modulated light with a second modulator to produce two-time modulated light.
摘要翻译：公开了光互连系统和方法。光学互连系统包括基板，光波导以及第一和第二调制器。光波导具有延伸到第一耦合结构的第一波导部分，从第一耦合结构延伸到第二耦合结构的第二波导部分和从第二耦合结构延伸的第三波导部分。第一调制器位于第一耦合结构附近，并且第二调制器位于第二耦合结构附近。光学互连方法包括用第一调制器调制光以产生一次调制光，并用第二调制器调制一次调制光以产生两次调制光。

43. 发明申请

US20140315715A1 COMPOSITIONS AND METHODS FOR INCREASING BIOMASS, IRON CONCENTRATION, AND TOLERANCE TO PATHOGENS IN PLANTS 审中-公开
标题翻译：增加生物量，铁浓度和耐受植物病原体的组合物和方法
公开(公告)号：US20140315715A1
公开(公告)日：2014-10-23
申请号：US14252346
申请日：2014-04-14
申请人： UNIVERSITY OF DELAWARE
发明人： Harsh Bais , Darla Janine Sherrier , Venkatachalam Lakshmanan
IPC分类号： A01N63/02
CPC分类号： A01N63/02 , A01N63/00 , A01N25/00 , A01N2300/00
摘要： Methods for producing greater biomass in a plant, increasing the drought tolerance of a plant, producing a decreased lignin concentration in a plant, producing a greater iron concentration in a plant, or inhibiting fungal infection in a plant comprise administering Bacillus subtilis FB17 to the plant, the seed of the plant, or soil surrounding the plant or the seed in an amount effective to produce greater biomass, increase the drought tolerance, produce a decreased lignin concentration, produce a greater iron concentration, or inhibit fungal infection in the plant compared to an untreated plant, respectively. Agricultural carriers and seed coatings comprising Bacillus subtilis FB17 are provided. The biomass of a plant which has been administered Bacillus subtilis FB17 can be converted to a biofuel or can be used as a food crop or in other uses.
摘要翻译：在植物中产生更大生物量的方法，增加植物的耐旱性，在植物中产生木质素浓度降低，在植物中产生更大的铁浓度或抑制植物中的真菌感染，包括向植物施用枯草芽孢杆菌FB17 植物种子或植物周围的土壤或有效产生更大生物量的量的种子可增加干旱耐受性，产生较低的木质素浓度，产生较高的铁浓度或抑制植物中的真菌感染，与一个未经处理的植物。提供包含枯草芽孢杆菌FB17的农业载体和种子包衣。已经施用枯草芽孢杆菌FB17的植物的生物量可以转化为生物燃料，或者可以用作食物作物或其他用途。

44. 发明授权

US08834926B2 Macromolecular diffusion and release from self-assembled β-hairpin peptide hydrogels 有权
标题翻译：大分子扩散和释放自组装和毛发肽水凝胶
公开(公告)号：US08834926B2
公开(公告)日：2014-09-16
申请号：US12533708
申请日：2009-07-31
申请人： Joel P. Schneidér , Monica C. Branco , Darrin J. Pochan , Norman J. Wagner
发明人： Joel P. Schneidér , Monica C. Branco , Darrin J. Pochan , Norman J. Wagner
IPC分类号： A61K9/06 , A61K38/10 , A61K38/16 , A61K9/00 , A61K47/36
CPC分类号： A61K9/06 , A61K9/0019 , A61K38/10 , A61K38/16 , A61K47/36
摘要： A hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 through SEQ ID NO:33 in an aqueous medium at a pH of 7.4; wherein the anionic macromolecule has an isoelectric point of at most 6.8; and wherein the hydrogel is capable of retaining at least 25% of the anionic macromolecule after 28-day extraction at 37° C. with a pH=7.4 BTP buffer containing 150 mM NaCl.
摘要翻译：一种用于延迟释放阴离子大分子的水凝胶，其中所述水凝胶包含阴离子大分子，150mM NaCl和选自SEQ ID NO：1至SEQ ID NO：33的肽，在水性介质中的pH为 7.4; 其中所述阴离子大分子的等电点至多为6.8; 并且其中所述水凝胶在37℃下用含有150mM NaCl的pH = 7.4BTP缓冲液在28天提取后能够保留至少25％的阴离子大分子。

45. 发明授权

US08760970B2 Method for detection of a plume of a first fluid within a second fluid 有权
标题翻译：用于检测第二流体内的第一流体羽流的方法
公开(公告)号：US08760970B2
公开(公告)日：2014-06-24
申请号：US13273852
申请日：2011-10-14
申请人： Mohsen Badiey , Boris G. Katsnelson , James F. Lynch
发明人： Mohsen Badiey , Boris G. Katsnelson , James F. Lynch
IPC分类号： G01S15/06
CPC分类号： G01S15/003 , G01N29/032 , G01N2291/0222 , G01N2291/103 , G01S15/58
摘要： Methods and systems for detecting a plume of a first fluid in a second fluid using an acoustic wave are provided, where the first fluid has a different acoustic index of refraction than the second fluid. A horizontal array having a plurality of receiving elements receives an acoustic signal propagated through the second fluid and at least one refracted signal refracted by the first fluid. The acoustic signal and the at least one refracted signal form a received signal. An interference pattern is detected from the received signal over the plurality of receiving elements. The interference pattern is due to interference between the acoustic signal and the at least one refracted signal. A horizontal angle of refraction is determined between the acoustic signal and the at least one refracted signal from the interference pattern. The horizontal angle of refraction is indicative of a physical characteristic of the first fluid.
摘要翻译：提供了使用声波来检测第二流体中的第一流体的羽流的方法和系统，其中第一流体具有与第二流体不同的声学折射率。具有多个接收元件的水平阵列接收通过第二流体传播的声信号和由第一流体折射的至少一个折射信号。声信号和至少一个折射信号形成接收信号。从多个接收元件的接收信号中检测出干扰图案。干涉图案是由于声信号和至少一个折射信号之间的干扰。在声学信号和来自干涉图案的至少一个折射信号之间确定水平折射角。水平折射角表示第一流体的物理特性。

46. 发明申请

US20140098841A2 UNDERWATER ACOUSTIC MULTIPLE-INPUT/MULTIPLE-OUTPUT (MIMO) COMMUNICATION SYSTEMS AND METHODS 审中-公开
标题翻译：水下多声道多输入/多输出（MIMO）通信系统和方法
公开(公告)号：US20140098841A2
公开(公告)日：2014-04-10
申请号：US13642704
申请日：2011-06-07
申请人： Aijun Song , Mohsen Badiey
发明人： Aijun Song , Mohsen Badiey
IPC分类号： H04B15/00 , H04B13/02
CPC分类号： H04B15/00 , H04B11/00 , H04B13/02
摘要： Methods and systems for acoustic multiple-input/multiple-output (MIMO) communication in an underwater environment. The method includes: a) receiving signals at multiple receivers representing transmitted signals from multiple transmitters, b) estimating channel responses between the multiple receivers and the multiple transmitters, c) performing an initial demodulation process on the received signals using the estimated channel responses to remove inter-symbol interference (ISI), and d) performing at least one subsequent demodulation process on the received signals. The subsequent demodulation process: i) removes co-channel interference (CoI) using the estimated channel responses and demodulated signals from an immediately preceding demodulation process to form interference cancelled signals and ii) removes ISI from the interference cancelled signals. In the initial and subsequent demodulation processes, ISI removal includes a time reversal combining process followed by a single-channel decision feedback equalization (DFE) process.
摘要翻译：在水下环境下进行声学多输入/多输出（MIMO）通信的方法和系统。该方法包括：a）在多个接收机处接收表示来自多个发射机的发射信号的信号，b）估计多个接收机与多个发射机之间的信道响应，c）使用所估计的信道响应来对接收到的信号执行初始解调处理以去除符号间干扰（ISI），以及d）对所接收的信号执行至少一个后续解调处理。随后的解调过程：i）使用估计的信道响应和来自紧接在前的解调过程的解调信号去除同信道干扰（CoI），以形成干扰消除信号，以及ii）从干扰消除信号中去除ISI。在初始和随后的解调过程中，ISI去除包括后续单信道判决反馈均衡（DFE）过程的时间反转组合过程。

47. 发明申请

US20140067107A1 Process and System for Generating a Specification for a Customized Device, and Device Made Thereby 有权
标题翻译：用于生成定制设备的规范的过程和系统，以及由此制造的设备
公开(公告)号：US20140067107A1
公开(公告)日：2014-03-06
申请号：US14012620
申请日：2013-08-28
申请人： Steven J. Stanhope , Elisa Schrank
发明人： Steven J. Stanhope , Elisa Schrank
IPC分类号： G06F17/50
CPC分类号： G06F17/50 , B33Y50/00 , G01B5/008 , G06T19/00 , G06T2210/41
摘要： A process and system for generating a specification for customized devices, such as rehabilitation or assistive devices, including prostheses and orthoses, or sports padding or equipment. A digital model, which is fully parameterized at least for characterizing clinical shape characteristics and functional characteristics of the device, is populated with a plurality of design parameter values and 3-dimensional coordinates of captured and calculated virtual landmarks to construct a customized model corresponding to the specification. The customized device may be manufactured based upon the specification. A system connected to a computer aided manufacturing system may generate instructions for automatically fabricating the device. In embodiments with standardized design parameter values, the customized model may be constructed without involving a human operator.
摘要翻译：用于生成定制设备的规范的过程和系统，例如康复或辅助设备，包括假体和矫形器，或运动衬垫或设备。至少用于表征装置的临床形状特征和功能特征的完全参数化的数字模型被填充有捕获和计算的虚拟地标的多个设计参数值和3维坐标，以构建对应于规范。可以基于规格制造定制装置。连接到计算机辅助制造系统的系统可以产生用于自动制造装置的指令。在具有标准化设计参数值的实施例中，可以构造定制模型而不涉及人类操作者。

48. 发明申请

US20140005763A1 REGENERATIVE PERIPHERAL NERVE INTERFACE 有权
标题翻译：再生外周神经界面
公开(公告)号：US20140005763A1
公开(公告)日：2014-01-02
申请号：US13979507
申请日：2012-01-13
申请人： Paul S. Cederna , Melanie G. Urbanchek , David C. Martin
发明人： Paul S. Cederna , Melanie G. Urbanchek , David C. Martin
IPC分类号： A61F2/72
CPC分类号： A61N1/0551 , A61F2/0811 , A61F2/72 , A61L27/34 , A61L2430/32 , G06F19/00 , C08L89/00
摘要： The present disclosure provides a regenerative peripheral nerve interface (RPNI) for a subject comprising an insulating substrate, at least one metallic electrode deposited onto the insulating substrate forming a thin-film array; a portion of the at least one metallic electrode surface having a layer of a first conductive polymer and a layer of decellularized small intestinal submucosa (SIS) coating a portion of the electrode, wherein a second conductive polymer is electrochemically polymerized through the SIS to form the regenerative peripheral nerve interface. The present disclosure also provides that a layer of muscle tissue contacts the regenerative peripheral nerve interface.
摘要翻译：本公开提供了一种用于受试者的再生周围神经接口（RPNI），其包括绝缘基底，沉积到形成薄膜阵列的绝缘基底上的至少一个金属电极; 所述至少一个金属电极表面的一部分具有第一导电聚合物层和涂覆所述电极的一部分的脱细胞化小肠粘膜下层（SIS）层，其中第二导电聚合物通过SIS进行电化学聚合以形成再生周围神经界面。本公开还提供了一层肌肉组织接触再生的周围神经接口。

49. 发明申请

US20140004403A1 MULTIPLE-MEMBRANE MULTIPLE-ELECTROLYTE REDOX FLOW BATTERY DESIGN 有权
标题翻译：多层膜多电极氧化还原电池电池设计
公开(公告)号：US20140004403A1
公开(公告)日：2014-01-02
申请号：US13918452
申请日：2013-06-14
申请人： University of Delaware
发明人： Yushan YAN , Shuang GU , Ke GONG
IPC分类号： H01M8/20
CPC分类号： H01M8/20 , H01M2/00 , H01M2/40 , H01M8/04 , H01M8/04186 , H01M8/18 , H01M8/188 , H01M10/4242 , H01M2300/0082 , Y02E60/528 , Y10T29/49108
摘要： A redox flow battery is provided. The redox flow battery involves multiple-membrane (at least one cation exchange membrane and at least one anion exchange membrane), multiple-electrolyte (one electrolyte in contact with the negative electrode, one electrolyte in contact with the positive electrode, and at least one electrolyte disposed between the two membranes) as the basic characteristic, such as a double-membrane, triple electrolyte (DMTE) configuration or a triple-membrane, quadruple electrolyte (TMQE) configuration. The cation exchange membrane is used to separate the negative or positive electrolyte and the middle electrolyte, and the anion exchange membrane is used to separate the middle electrolyte and the positive or negative electrolyte.
摘要翻译：提供氧化还原液流电池。氧化还原液流电池包括多膜（至少一个阳离子交换膜和至少一个阴离子交换膜），多电解质（与负极接触的一个电解质，与正电极接触的一个电解质，以及至少一个配置在两个膜之间的电解质）作为基本特征，例如双膜，三重电解质（DMTE）构型或三重膜，四重电解质（TMQE）构型。阳离子交换膜用于分离阴性或正电解质和中间电解质，阴离子交换膜用于分离中间电解质和正电解质或负电解质。

50. 发明申请

US20130244975A1 CHEMICAL CONJUGATES FOR TARGETED DEGRADATION UNDER REDUCING CONDITIONS 有权
标题翻译：化学结合在减少条件下进行有针对性的降解
公开(公告)号：US20130244975A1
公开(公告)日：2013-09-19
申请号：US13605297
申请日：2012-09-06
申请人： Aaron Baldwin , Kristi Lynn Kiick
发明人： Aaron Baldwin , Kristi Lynn Kiick
IPC分类号： A61K47/48
CPC分类号： A61K47/48215 , A61K47/48784 , A61K47/60 , A61K47/6903
摘要： The present invention is related to compositions which can undergo targeted degradation under certain physiological reducing conditions. The compositions may, for example, be hydrogels in which maleimide-functionalized low molecular weight heparin is cross-linked with various thiol-functionalized polyethylene glycol multi-arm star polymers. Both the gelation and degradation of the hydrogels can be modified by careful selection of the thiol. For example, hydrogels prepared from aryl thiol-maleimide adducts can undergo a retro Michael addition-type reaction, leading to degradation of the composition and release of the bioactive molecule.
摘要翻译：本发明涉及可在某些生理降解条件下经历目标降解的组合物。组合物可以是例如水凝胶，其中马来酰亚胺官能化的低分子量肝素与各种硫醇官能化的聚乙二醇多臂星形聚合物交联。可以通过仔细选择硫醇来改变水凝胶的凝胶化和降解。例如，由芳基硫醇 - 马来酰亚胺加合物制备的水凝胶可以进行复合迈克尔加成型反应，导致组合物的降解和生物活性分子的释放。

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