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41. 发明授权

US10420840B2 Anticancer therapeutic agents 有权
公开(公告)号：US10420840B2
公开(公告)日：2019-09-24
申请号：US14684259
申请日：2015-04-10
申请人： RLL, LLC
发明人： Robert J. Hickey , Linda H. Malkas
IPC分类号： A61K45/06 , A61K31/167 , A61P35/00
摘要： The invention described herein pertains to anticancer therapeutic agents that exhibit preferential cytotoxicity to malignant cells that express a cancer specific isoform of proliferating cell nuclear antigen (caPCNA) compared to cytotoxicity to comparable non-malignant cells, pharmaceutical compositions comprising the agents, and their use in cancer therapy.

42. 发明授权

US10413655B2 Artificial lung system and its methods of use 有权
公开(公告)号：US10413655B2
公开(公告)日：2019-09-17
申请号：US15598947
申请日：2017-05-18
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC.
发明人： Zhongjun Wu , Bartley Griffith , David N. Wells
IPC分类号： A61M1/36 , A61M1/16
摘要： An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line operational mode where the oxygen supply unit is being powered by battery only, a larger flow of recycled gas from the blood oxygenator is passed through the carbon dioxide scrubber and combined with a lesser amount of oxygen-rich gas from the oxygen concentrator. The oxygen supply unit may be used in combination with a blood pump and oxygenator to provide ambulatory blood oxygenation to patients with compromised lung function.

43. 发明授权

US10225129B2 Method and apparatus for the extrication of quadrature pairs of amplitude modulated signals from intermingled extraneous signals 有权
公开(公告)号：US10225129B2
公开(公告)日：2019-03-05
申请号：US15474329
申请日：2017-03-30
申请人： Edward P. Callaghan
发明人： Edward P. Callaghan
IPC分类号： H04L27/38 , H04L27/26 , H04L27/34
摘要： Signal extrication of a pair of quadrature amplitude modulated signals of a particular carrier frequency and phase constant by equally splitting all input signals into two independent circuit paths that contain identical components but one independent circuit path performs a complementary signal processing function with respect to the other resulting in a counterbalance between the two paths, canceling all output signals with the exception of said pair of quadrature amplitude modulated signals which are not canceled because of the singular signal nullification property of a product detector circuit that is a component in each of said independent circuit paths.

44. 发明授权

US10188902B2 Signal analysis and recharging system 有权
公开(公告)号：US10188902B2
公开(公告)日：2019-01-29
申请号：US14530851
申请日：2014-11-03
申请人： Roger Davenport
发明人： Roger Davenport
IPC分类号： A63B57/00 , A63B53/00 , A63B24/00 , A63B53/04 , A63B60/42 , A63B69/36 , G06F1/26 , G09B19/00 , A61B5/11
摘要： A measurement device may include one or more piezoelectric elements that output power signals. The device may split each power signal, analyzing a first portion of the signal while supplying a second portion to an energy storage assembly. A processor may dynamically adjust the first and second portions of each power signal to change how much of each power signal is used for signal processing versus energy storage, and may make the adjustments based on detected activities and/or pre-programmed timelines. The device may be used in or on sports equipment, such as a golf club.

45. 发明授权

US10173058B2 Functional electrical stimulation ergometer including automatic spasm control 有权
公开(公告)号：US10173058B2
公开(公告)日：2019-01-08
申请号：US15804441
申请日：2017-11-06
申请人： Restorative Therapies
发明人： Michael Duncan
IPC分类号： A61N1/36 , A61B5/11 , A61N1/372
摘要： This invention controls stimulation levels and cycling cadence on an FES ergometer to minimize or prevent the occurrence of spasm in spinal cord injured or other neurologically impaired patients.

46. 发明授权

US10160373B2 Utility truck bed 有权
公开(公告)号：US10160373B2
公开(公告)日：2018-12-25
申请号：US15173755
申请日：2016-06-06
申请人： Edward J. Tovornik
发明人： Edward J. Tovornik
IPC分类号： B60P3/14
摘要： Disclosed is a utility truck bed comprising one or more of the following elements: (i) two worker stations located behind the cabin of the truck, each of which comprises a passenger well with a floor that is horizontally positioned below the bottom plane of the rest of the bed; (ii) a safety gate on the outside of the bed that slides horizontally to provide access to the well; (iii) a safety harness for connecting the worker to a fixed portion of the assembly; (iv) a sliding safety gate adjacent the passenger well on the inside of the bed; and (v) storage compartments positioned on the back of the truck bed, each extending longitudinally away from each worker station and positioned to provide sufficient space between each compartment to place working materials that do not fit in the storage compartments. Each storage compartment may include a closed box portion, an open box portion with guide rails to accommodate materials but allow the worker to have full view of the road behind the truck, and a safety guard to keep materials secured within the open box.

47. 发明授权

US10151709B2 Device and method for evaluation of a material 有权
公开(公告)号：US10151709B2
公开(公告)日：2018-12-11
申请号：US14732831
申请日：2015-06-08
申请人： PaneraTech, Inc.
发明人： Yakup Bayram , Alexander Ruege , Eric Walton , Peter Hagan
IPC分类号： G01N22/02 , G01M3/16 , G01M3/40
摘要： Disclosed is an improved device and method to evaluate the status of a material by scanning an area that overlaps a region of the material under evaluation. The device and method are operative to identify a leakage of a first material into a second material, such as a molten material surrounded by a refractory material, to measure the thickness of the second material, using electromagnetic waves, and to generate images. The device is designed to reduce a plurality of reflections associated with the propagation of electromagnetic waves launched into the material under evaluation, by a sufficient extent so as to enable detection of electromagnetic waves of interest reflected from remote discontinuities present in between the device and the enclosed material. Furthermore, the device can be configured to scan areas of interest in either a portable or fixed configuration, manually in a standalone mode or as part of an automated system.

48. 发明授权

US09968839B2 Golf swing measurement and analysis system 有权
公开(公告)号：US09968839B2
公开(公告)日：2018-05-15
申请号：US15299356
申请日：2016-10-20
申请人： Golf Impact LLC
发明人： Roger Davenport
IPC分类号： A63B69/36 , A63B24/00 , A63B53/04 , A63B71/06
CPC分类号： A63B69/3614 , A63B24/0006 , A63B53/0466 , A63B60/46 , A63B69/36 , A63B69/3632 , A63B2071/0625 , A63B2071/063 , A63B2220/00 , A63B2220/40 , A63B2220/53 , A63B2220/56 , A63B2225/50 , Y10T29/49002
摘要： A golf club head includes a club face with at least one impact sensor, where the sensor has a passive piezoelectric element that is integrated into the club face, the passive piezoelectric element being able to generate a signal when an impact force is applied to the club face. An energy storage assembly includes a battery, a capacitor, or both. An energy harvesting assembly includes a signal divider with at least one input and at least two outputs, the at least two outputs providing a known ratio of a given input signal, wherein the at least one input of the signal divider is electrically coupled to one or more of the piezoelectric elements and a first of the at least two signal divider outputs is electrically coupled to the energy storage assembly.

49. 发明授权

US09630079B2 Golf swing measurement and analysis system 有权
公开(公告)号：US09630079B2
公开(公告)日：2017-04-25
申请号：US13687682
申请日：2012-11-28
申请人： Golf Impact LLC
发明人： Roger Davenport
IPC分类号： A63B57/00 , A63B69/36 , A63B24/00 , A63B53/04 , A63B71/06
CPC分类号： A63B69/3614 , A63B24/0006 , A63B53/0466 , A63B60/46 , A63B69/36 , A63B69/3632 , A63B2071/0625 , A63B2071/063 , A63B2220/00 , A63B2220/40 , A63B2220/53 , A63B2220/56 , A63B2225/50 , Y10T29/49002
摘要： A golf club assembly includes at least one sensor assembly, the sensor assembly being operable to sense at least motion and impact of a golf club head and a processor communicatively coupled to the sensor assembly, the processor being operable to sample data from the sensor assembly at a first rate, receive a signal indicating motion of the golf club head, and sample data from the sensor assembly at a second rate different from the first rate upon receiving the signal indicating motion of the golf club head.

50. 发明授权

US09540687B2 DNA fragment detection method, DNA fragment detection kit and the use thereof 有权
标题翻译： DNA片段检测方法，DNA片段检测试剂盒及其用途
公开(公告)号：US09540687B2
公开(公告)日：2017-01-10
申请号：US14347113
申请日：2012-07-11
申请人： Jianguang Zhang , Zhongchun Zhou , Daixing Zhou , Genming Xu , Yang Gao , Feng Tian
发明人： Jianguang Zhang , Zhongchun Zhou , Daixing Zhou , Genming Xu , Yang Gao , Feng Tian
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2521/501 , C12Q2525/307
摘要： The disclosure claims a cleaved Deoxyribonucleic acid (DNA) detection method, a DNA fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the DNA fragment; cyclizing the DNA fragment to obtain acyclized DNA; implementing Polymerase Chain Reaction (PCR) amplification for the cyclized DNA by using the primers; and detecting the PCR amplification product. In the disclosure, by cyclizing the DNA fragment, the amplification can be implemented even if only one PCR primer can match with a template, thus, the adaption range and effective template amount of the primer amplification can be greatly increased, and the detection sensitivity of the DNA fragment can be greatly improved.
摘要翻译：本公开要求切割的脱氧核糖核酸（DNA）检测方法，DNA片段检测试剂盒及其用途。其中该方法包括以下步骤：根据DNA片段的测试位点或测试区设计引物; 使DNA片段环化以获得非环化DNA; 通过使用引物对环化DNA进行聚合酶链反应（PCR）扩增; 并检测PCR扩增产物。在本公开中，通过使DNA片段环化，即使只有一个PCR引物可以与模板匹配，也可以实现扩增，因此可以大大增加引物扩增的适应范围和有效模板量，并且检测灵敏度 DNA片段可以大大提高。

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