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41. 发明申请

US20080103543A1 Implantable medical device with titanium alloy housing 审中-公开
标题翻译：带钛合金外壳的植入式医疗器械
公开(公告)号：US20080103543A1
公开(公告)日：2008-05-01
申请号：US11590678
申请日：2006-10-31
申请人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh , John E. Kast , Keith A. Miesel , Darren A. Janzig , Gerald G. Lindner
发明人： Bernard Q. Li , John J. Grevious , Timothy J. Davis , Leroy Perz , Chris J. Paidosh , John E. Kast , Keith A. Miesel , Darren A. Janzig , Gerald G. Lindner
IPC分类号： A61N1/375
CPC分类号： C22C14/00 , A61L31/022 , A61N1/375
摘要： An implantable medical device includes a housing comprising a titanium alloy selected from the group consisting of Ti-4.5Al-3V-2Fe-2Mo-0.15O, Ti-4Al-2.5V-1.5Fe-0.25O, Ti-6Al-2Sn-4Zr-2Mo, Ti-3Al-2.5V, and combinations thereof
摘要翻译：一种可植入医疗装置，包括：外壳，其包含选自Ti-4.5Al-3V-2Fe-2Mo-0.15O，Ti-4Al-2.5V-1.5Fe-0.25O，Ti-6Al-2Sn- 4Zr-2Mo，Ti-3Al-2.5V及其组合

42. 发明授权

US07366572B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US07366572B2
公开(公告)日：2008-04-29
申请号：US10825953
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61B5/02 , A61B5/04 , A61B5/4815 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量度量值来控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

43. 发明授权

US07313440B2 Collecting posture and activity information to evaluate therapy 有权
标题翻译：收集姿势和活动信息以评估治疗
公开(公告)号：US07313440B2
公开(公告)日：2007-12-25
申请号：US11106051
申请日：2005-04-14
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61B5/0205 , A61B5/1116 , A61B5/6823 , A61B5/6825 , A61B5/686 , A61N1/36082 , A61N1/36585
摘要： A medical device, programmer, or other computing device may determine values of one or more activity and, in some embodiments, posture metrics for each therapy parameter set used by the medical device to deliver therapy. The metric values for a parameter set are determined based on signals generated by the sensors when that therapy parameter set was in use. Activity metric values may be associated with a postural category in addition to a therapy parameter set, and may indicate the duration and intensity of activity within one or more postural categories resulting from delivery of therapy according to a therapy parameter set. A posture metric for a therapy parameter set may indicate the fraction of time spent by the patient in various postures when the medical device used a therapy parameter set. The metric values may be used to evaluate the efficacy of the therapy parameter sets.
摘要翻译：医疗设备，程序员或其他计算设备可以确定一个或多个活动的值，并且在一些实施例中，确定由医疗设备用于递送治疗的每个治疗参数集的姿势度量。当参数组被使用时，基于由传感器产生的信号来确定参数集的度量值。除了治疗参数集之外，活动度量值可以与姿势类别相关联，并且可以指示根据治疗参数集合递送治疗产生的一个或多个姿势类别内的活动的持续时间和强度。用于治疗参数组的姿势度量可以指示当医疗装置使用治疗参数集时患者在各种姿势中花费的时间的分数。度量值可用于评估治疗参数组的功效。

44. 发明授权

US07167743B2 Collecting activity information to evaluate therapy 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US07167743B2
公开(公告)日：2007-01-23
申请号：US11081785
申请日：2005-03-16
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/04 , A61N1/18
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device or another device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗装置或其他装置可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

45. 发明授权

US06248080B1 Intracranial monitoring and therapy delivery control device, system and method 有权
标题翻译：颅内监测和治疗传递控制装置，系统和方法
公开(公告)号：US06248080B1
公开(公告)日：2001-06-19
申请号：US09299774
申请日：1999-04-26
申请人： Keith A. Miesel , Lee Stylos
发明人： Keith A. Miesel , Lee Stylos
IPC分类号： A61B503
CPC分类号： A61N1/36557 , A61B5/0031 , A61B5/0215 , A61B5/02154 , A61B5/031 , A61B5/076 , A61B5/14539 , A61B5/1459 , A61B5/6864 , A61N1/05 , A61N1/056 , A61N1/36585 , Y10S977/90
摘要： An implantable medical device having an hermetically sealed enclosure housing electrical and electronic circuitry and a battery for powering such circuitry is connected to an intracranial lead or pigtail which measures or senses intracranial physiologic signals such as intracranial fluid pressure and/or temperature. The implantable medical device is preferably implanted subcutaneously beneath a patient's skin and telemeters stored data or real-time-sensed data to an external device which may be configured to combine barometric pressure data with intracranial pressure data to derive intracranial gage pressure. The implantable medical device and its associated lead reduce the risk of intracranial infections.
摘要翻译：具有容纳电气和电子电路的气密密封的壳体和用于为这种电路供电的电池的可植入医疗装置连接到测量或感测颅内生理信号如颅内流体压力和/或温度的颅内引线或尾纤。优选将植入式医疗装置皮下植入患者皮肤下方，并将电能存储数据或实时检测数据传输到外部装置，外部装置可被配置为将大气压力数据与颅内压数据组合以导出颅内计量压力。可植入医疗器械及其相关的导线可降低颅内感染的风险。

46. 发明授权

US06198952B1 Multiple lens oxygen sensor for medical electrical lead 有权
标题翻译：多透镜氧传感器，用于医用电子铅
公开(公告)号：US06198952B1
公开(公告)日：2001-03-06
申请号：US09182971
申请日：1998-10-30
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61B50205
CPC分类号： A61B5/1459 , A61B5/14539 , A61N1/056 , A61N1/36557
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译：公开了一种用于可植入医疗装置的植入式传感器组件。传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。

47. 发明授权

US6106477A Chronically implantable blood vessel cuff with sensor 有权
标题翻译：长期可植入血管袖带与传感器
公开(公告)号：US6106477A
公开(公告)日：2000-08-22
申请号：US221059
申请日：1998-12-28
申请人： Keith A. Miesel , Lee Stylos
发明人： Keith A. Miesel , Lee Stylos
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/08
CPC分类号： A61B5/6876 , A61B5/0215 , A61B5/6884 , A61B5/0031 , A61B5/1459 , A61B5/418
摘要： A system for chronically measuring a physiologic parameter by an implantable device which has several forms is described. At its core a fixture for holding on to a blood vessel and forcing a sensor against a surface of the vessel is taught. Numerous adaptations and uses with various sensors are described.
摘要翻译：描述了通过具有多种形式的可植入装置长期测量生理参数的系统。在其核心处，教导了用于保持血管并迫使传感器抵靠血管表面的夹具。描述了各种传感器的许多适应和使用。

48. 发明授权

US6024704A Implantable medical device for sensing absolute blood pressure and barometric pressure 失效
标题翻译：用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US6024704A
公开(公告)日：2000-02-15
申请号：US70310
申请日：1998-04-30
申请人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
发明人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
IPC分类号： A61B5/0215 , A61B5/03 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译：与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室压力传感器。大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

49. 发明授权

US09155885B2 Incontinence therapy 有权
标题翻译：失禁治疗
公开(公告)号：US09155885B2
公开(公告)日：2015-10-13
申请号：US13265702
申请日：2010-04-09
申请人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
发明人： Xuan K. Wei , Eric H. Bonde , Keith A. Miesel , Mark S. Lent , Gregory F. Molnar
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36007 , A61N1/0514 , A61N1/0551 , A61N1/36128 , A61N1/36135 , A61N1/37235 , A61N1/37252
摘要： Techniques for managing urinary or fecal incontinence include delivering a first type of therapy to generate a first physiological response and, upon detecting a trigger event, delivering a second type of therapy to generate a second physiological response. The first type of therapy can be delivered on a substantially regular basis, while the second type of therapy is delivered as needed to provide an additional boost of therapy. The trigger event for activating the delivery of the second type of therapy may include input from a sensor that indicates a bladder condition, patient activity level or patient posture, or patient input. In some examples, the therapy is stimulation therapy.
摘要翻译：用于管理尿失禁或大便失禁的技术包括递送第一类型的治疗以产生第一生理反应，并且在检测到触发事件时，递送第二类型的治疗以产生第二生理反应。第一种类型的治疗可以基本上定期地递送，而第二种类型的治疗根据需要被递送以提供额外的治疗效果。用于激活第二类治疗的递送的触发事件可以包括来自传感器的输入，其指示膀胱状况，患者活动水平或患者姿势或患者输入。在一些例子中，治疗是刺激疗法。

50. 发明授权

US09033920B2 Determining catheter status 有权
标题翻译：确定导管状态
公开(公告)号：US09033920B2
公开(公告)日：2015-05-19
申请号：US12721647
申请日：2010-03-11
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61M5/00 , A61M5/142 , A61M5/168 , A61M27/00 , A61M5/172
CPC分类号： A61M5/14276 , A61M5/16859 , A61M27/006 , A61M2005/1726 , A61M2202/0464
摘要： A method for monitoring the status of an implanted catheter includes monitoring changes in pressure within a lumen of a catheter associated with physiological parameters (“physiological pressure”) and changes in pressure within the lumen of the catheter associated with bolus infusion of fluid into the catheter or bolus withdrawal of infusion from the catheter (“bolus pressure”). Methods that employ monitoring both physiological pressure and bolus pressure can provide information that cannot be obtained from monitoring physiological pressure or bolus pressure alone.
摘要翻译：用于监测植入导管的状态的方法包括监测与生理参数（“生理压力”）相关联的导管的内腔内的压力变化以及与将液体推入导管相关联的导管内腔内的压力变化或推注从导管中取出输注（“推注压力”）。采用监测生理压力和推注压力的方法可以提供单独监测生理压力或推注压力不能获得的信息。

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