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1. 发明授权

US08712539B2 Rule-based stimulation program search 有权
标题翻译：基于规则的刺激程序搜索
公开(公告)号：US08712539B2
公开(公告)日：2014-04-29
申请号：US11402657
申请日：2006-04-12
申请人： Steven M. Goetz , Donald R. Johnson , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Kenneth T. Heruth , Gary W. King , Roy L. Testerman
发明人： Steven M. Goetz , Donald R. Johnson , Andrew H. Houchins , Jeffrey T. Keacher , Theodore J. Stone , Kenneth T. Heruth , Gary W. King , Roy L. Testerman
IPC分类号： A61N1/372
CPC分类号： A61N1/37264 , A61N1/36071 , A61N1/36132 , A61N1/36185 , A61N1/37247 , G06F19/00 , G16H40/63 , G16H50/20
摘要： Techniques that involve application of one or more rules to a “parent” program to generate a plurality of different “child” programs are described. Each of the rules may define a respective electrode configuration modification, and each child program may be a variation of the parent based on a modification of the electrode configuration of the parent according to one of the rules. The systems or devices may generate further generations of child programs from a previous generation child program using the same one or more rules. The child programs may be provided to a user, so that the user may test the efficacy of the new programs, assisting the user in identifying desirable programs. The child programs may be relatively minor variations of the parent program, and the user may “fine tune” a generally desirable parent program by testing the child programs.
摘要翻译：描述涉及将一个或多个规则应用于“父”程序以生成多个不同的“子”程序的技术。每个规则可以限定相应的电极配置修改，并且每个子程序可以是基于根据规则之一的父母的电极配置的修改的父母的变体。系统或设备可以使用相同的一个或多个规则从上一代子程序生成更多代的子程序。子程序可以被提供给用户，使得用户可以测试新程序的功效，帮助用户识别期望的程序。子程序可能是父程序的相对小的变化，并且用户可以通过测试子程序来“微调”通常期望的父程序。

2. 发明授权

US08688221B2 Collecting posture and activity information to evaluate therapy 有权
标题翻译：收集姿势和活动信息以评估治疗
公开(公告)号：US08688221B2
公开(公告)日：2014-04-01
申请号：US13401348
申请日：2012-02-21
申请人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
发明人： Keith A. Miesel , Kenneth T. Heruth , Gregory F. Molnar
IPC分类号： A61N1/36
CPC分类号： A61B5/103 , A61B5/0205 , A61B5/1116 , A61B5/4082 , A61B5/4094 , A61B5/6804 , A61B5/6825 , A61B5/686 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36585 , A61N1/37235 , G06F19/00
摘要： A medical device, programmer, or other computing device may determine values of one or more activity and, in some embodiments, posture metrics for each therapy parameter set used by the medical device to deliver therapy. The metric values for a parameter set are determined based on signals generated by the sensors when that therapy parameter set was in use. Activity metric values may be associated with a postural category in addition to a therapy parameter set, and may indicate the duration and intensity of activity within one or more postural categories resulting from delivery of therapy according to a therapy parameter set. A posture metric for a therapy parameter set may indicate the fraction of time spent by the patient in various postures when the medical device used a therapy parameter set. The metric values may be used to evaluate the efficacy of the therapy parameter sets.
摘要翻译：医疗设备，程序员或其他计算设备可以确定一个或多个活动的值，并且在一些实施例中，确定由医疗设备用于递送治疗的每个治疗参数集的姿势度量。当参数组被使用时，基于由传感器产生的信号来确定参数集的度量值。除了治疗参数集之外，活动度量值可以与姿势类别相关联，并且可以指示根据治疗参数集合递送治疗产生的一个或多个姿势类别内的活动的持续时间和强度。用于治疗参数组的姿势度量可以指示当医疗装置使用治疗参数集时患者在各种姿势中花费的时间的分数。度量值可用于评估治疗参数组的功效。

3. 发明授权

US08337431B2 Collecting activity and sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集活动和睡眠质量信息
公开(公告)号：US08337431B2
公开(公告)日：2012-12-25
申请号：US12351414
申请日：2009-01-09
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/103 , A61B5/117
CPC分类号： A61B5/1116 , A61B5/1118 , A61B5/4519 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61N1/36135 , A61N1/36542
摘要： A device, such as an implantable medical device (IMD) or a programming device, determines when a patient is attempting to sleep. When the device determines that the patient is attempting to sleep, the device determines values for one or more metrics that indicate the quality of a patient's sleep based on at least one physiological parameter of the patient. When the device determines that the patient is not attempting to sleep, the device periodically determines activity levels of the patient. Activity metric values may be determined based on the determined activity levels. A clinician may use sleep quality information and patient activity information presented by a programming device to, for example, evaluate the effectiveness of therapy delivered to the patient by the medical device.
摘要翻译：诸如可植入医疗装置（IMD）或编程装置之类的装置确定患者何时试图睡觉。当设备确定患者正在尝试睡眠时，设备基于患者的至少一个生理参数来确定指示患者睡眠质量的一个或多个度量的值。当设备确定患者没有尝试睡眠时，设备周期性地确定患者的活动水平。活动度量值可以基于确定的活动水平来确定。临床医生可以使用由编程设备呈现的睡眠质量信息和患者活动信息，以例如评估由医疗设备递送给患者的治疗的有效性。

4. 发明授权

US08335568B2 Controlling therapy based on sleep quality 有权
标题翻译：基于睡眠质量控制治疗
公开(公告)号：US08335568B2
公开(公告)日：2012-12-18
申请号：US12544727
申请日：2009-08-20
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61B5/02 , A61B5/04 , A61B5/4815 , A61M5/1723 , A61M2230/06 , A61M2230/63 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.
摘要翻译：诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

5. 发明授权

US08137334B2 Reduction of inflammatory mass with spinal catheters 有权
标题翻译：减少脊髓导管的炎症质量
公开(公告)号：US08137334B2
公开(公告)日：2012-03-20
申请号：US10745897
申请日：2003-12-23
申请人： Kenneth T. Heruth , Mark S. Lent
发明人： Kenneth T. Heruth , Mark S. Lent
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/16827 , A61M25/007 , A61M2025/0007 , A61M2025/0057 , A61M2025/0073 , A61M2202/0464 , A61M2205/0244 , A61M2205/123 , A61M2205/128 , A61M2205/3331 , A61M2205/3523 , A61M2205/50 , A61M2210/0693 , A61M2210/1003
摘要： Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes that develop significant back pressure to enhance uniform delivery of the drug over an infusion section; catheters that have two or more infusion sections spaced apart along the length of the same catheter, catheters that include two or more infusion sections serviced by independent lumens (such that, e.g., different drug solutions can be delivered to the different infusion sections); implantable drug delivery systems with pumps and multiple reservoirs from which drugs can be delivered; systems that are capable of delivering drug solutions with selected densities; etc. Methods for treating diseases, including pain and spasticity are also discussed, as well as methods for screening patients and optimizing therapies. In addition, methods for delivering a drug to a brain through a spinal canal are described.
摘要翻译：公开了用于将一种或多种药物递送到一个或多个内部身体位置（例如脑脊液）的装置，系统和方法。在各个方面，系统和方法可以包括具有渗透膜的输注部分的导管，其具有显着的背压以增强药物在输注部分上的均匀递送; 具有沿相同导管的长度间隔开的两个或更多个输注部分的导管，包括由独立管腔服务的两个或更多个输注部分的导管（使得例如不同的药物溶液可以被递送到不同的输注部分）; 具有泵和多个储存器的可植入药物递送系统，药物可以从其中递送; 能够递送选定密度的药物溶液的系统; 还讨论了治疗疾病，包括疼痛和痉挛症的方法，以及筛选患者和优化疗法的方法。另外，描述了通过椎管将药物递送到脑的方法。

6. 发明申请

US20110167630A1 Field Steerable Electrical Stimulation Paddle, Lead System, and Medical Device Incorporating the Same 有权
标题翻译：现场可转向电刺激桨，引导系统和医疗器械
公开(公告)号：US20110167630A1
公开(公告)日：2011-07-14
申请号：US13053786
申请日：2011-03-22
申请人： Kenneth T. Heruth , Mark Holle , James Skakoon
发明人： Kenneth T. Heruth , Mark Holle , James Skakoon
IPC分类号： H01R43/16
CPC分类号： A61N1/0553 , A61N1/36071 , Y10T29/49204
摘要： An implantable electrode paddle is adapted to receive an electrical signal from a medical device and generate an electrical field to stimulate selected body tissue. The paddle includes a housing including walls that define an interior space and a plurality of windows formed through at least a first one of the walls for transmitting the electrical field to the body tissue, an electrode array including a plurality of electrode groups, each electrode group including at least two electrodes individually secured in a respective window and spaced between about 0.1 mm and about 10 mm apart, and a plurality of wires, each of the wires being coupled to a respective electrode and routed within the interior space to receive the electrical signal. A lead assembly and an implantable medical device can include the paddle.
摘要翻译：可植入电极桨适于接收来自医疗装置的电信号并产生电场以刺激所选择的身体组织。桨包括壳体，其包括限定内部空间的壁和通过用于将电场传递到身体组织的至少第一壁形成的多个窗口，包括多个电极组的电极阵列，每个电极组包括至少两个电极分别固定在相应窗口中并且间隔开约0.1mm至约10mm之间，以及多根导线，每条导线连接到相应的电极并在内部空间内布线以接收电信号。引线组件和可植入医疗装置可包括桨叶。

7. 发明授权

US07974703B2 Shifting between electrode combinations in electrical stimulation device 有权
标题翻译：在电刺激装置中的电极组合之间移动
公开(公告)号：US07974703B2
公开(公告)日：2011-07-05
申请号：US12406607
申请日：2009-03-18
申请人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
发明人： Steven M. Goetz , Andrew H. Houchins , Jeffrey T. Keacher , Gary W. King , Kenneth T. Heruth , Roy L. Testerman , Michael T. Lee , Nathan A. Torgerson , Joseph J. Nolan
IPC分类号： A61N1/18
CPC分类号： A61N1/37247 , A61N1/36071 , A61N1/36185 , A61N1/37252
摘要： Techniques for shifting between two electrode combinations. An amplitude of a first electrode combination is incrementally decreased while an amplitude of a second, or subsequent, electrode combination is concurrently incrementally increased. Alternatively, an amplitude of the first electrode combination is maintained at a target amplitude level while the amplitude of the second electrode combination is incrementally increased. The stimulation pulses of the electrode combinations are delivered to the patient interleaved in time. In this manner, the invention provides for a smooth, gradual shift from a first electrode combination to a second electrode combination, allowing the patient to maintain a continual perception of stimulation. The shifting techniques described herein may be used during programming to shift between different electrode combinations to find an efficacious electrode combination. Additionally, the techniques may be used for shifting between different electrode combinations associated with different stimulation programs or program sets.
摘要翻译：用于在两个电极组合之间切换的技术。第一电极组合的振幅逐渐减小，而第二或随后的电极组合的振幅同时递增地增加。或者，第一电极组合的振幅保持在目标振幅水平，而第二电极组合的振幅逐渐增加。电极组合的刺激脉冲在时间上交付给患者。以这种方式，本发明提供从第一电极组合到第二电极组合的平滑，逐渐的移动，允许患者保持连续的刺激感知。本文描述的移位技术可以在编程期间用于在不同电极组合之间移动以找到有效的电极组合。另外，这些技术可用于在与不同刺激程序或程序集相关联的不同电极组合之间进行移位。

8. 发明授权

US07930037B2 Field steerable electrical stimulation paddle, lead system, and medical device incorporating the same 有权
标题翻译：现场可控电刺激桨，引导系统和包含其的医疗装置
公开(公告)号：US07930037B2
公开(公告)日：2011-04-19
申请号：US10846329
申请日：2004-05-14
申请人： Kenneth T. Heruth , Mark Holle , James Skakoon
发明人： Kenneth T. Heruth , Mark Holle , James Skakoon
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/36071 , Y10T29/49204
摘要： An implantable electrode paddle is adapted to receive an electrical signal from a medical device and generate an electrical field to stimulate selected body tissue. The paddle includes a housing including walls that define an interior space and a plurality of windows formed through at least a first one of the walls for transmitting the electrical field to the body tissue, an electrode array including a plurality of electrode groups, each electrode group including at least two electrodes individually secured in a respective window and spaced between about 0.1 mm and about 10 mm apart, and a plurality of wires, each of the wires being coupled to a respective electrode and routed within the interior space to receive the electrical signal. A lead assembly and an implantable medical device can include the paddle.
摘要翻译：可植入电极桨适于接收来自医疗装置的电信号并产生电场以刺激所选择的身体组织。桨包括壳体，其包括限定内部空间的壁和通过用于将电场传递到身体组织的至少第一壁形成的多个窗口，包括多个电极组的电极阵列，每个电极组包括至少两个电极分别固定在相应窗口中并且间隔开约0.1mm至约10mm之间，以及多根导线，每条导线连接到相应的电极并在内部空间内布线以接收电信号。引线组件和可植入医疗装置可包括桨叶。

9. 发明授权

US07792583B2 Collecting posture information to evaluate therapy 有权
标题翻译：收集姿势信息以评估治疗
公开(公告)号：US07792583B2
公开(公告)日：2010-09-07
申请号：US11691391
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/36
CPC分类号： A61B5/4848 , A61B5/103 , A61B5/1116 , A61B5/4082 , A61B5/6825 , A61B5/686 , A61M5/14276 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/37235
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。识别姿势事件，例如，周期性地确定患者的姿势和/或患者的姿势转换，并且每个确定的姿势事件与当前治疗参数组相关联。基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。

10. 发明授权

US07717848B2 Collecting sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集睡眠质量信息
公开(公告)号：US07717848B2
公开(公告)日：2010-05-18
申请号：US10826925
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/00 , A61B5/02 , A61B5/08 , A61N1/00
CPC分类号： A61N1/36139 , A61B3/113 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/1116 , A61B5/1118 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61M5/14276 , A61M5/1723 , A61N1/36071 , A61N1/36078 , A61N1/36135 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/3702 , A61N1/37247
摘要： At least one of a medical device, such as an implantable medical device, and a programming device determines values for one or more metrics that indicate the quality of a patient's sleep. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. In some embodiments, determined sleep quality metric values are associated with a current therapy parameter set. In some embodiments, a programming device presents sleep quality information to a user based on determined sleep quality metric values values. A clinician, for example, may use the sleep quality information presented by the programming device to evaluate the effectiveness of therapy delivered to the patient by the medical device, to adjust the therapy delivered by the medical device, or to prescribe a therapy not delivered by the medical device in order to improve the quality of the patient's sleep.
摘要翻译：诸如可植入医疗设备的医疗设备和编程设备中的至少一个确定了指示患者睡眠质量的一个或多个度量的值。睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。在一些实施例中，确定的睡眠质量度量值与当前治疗参数组相关联。在一些实施例中，编程设备基于确定的睡眠质量度量值值向用户呈现睡眠质量信息。例如，临床医生可以使用编程设备呈现的睡眠质量信息来评估由医疗设备递送给患者的治疗的有效性，以调整由医疗设备递送的治疗，或者开出不由医疗器械为了提高病人的睡眠质量。

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