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    • 41. 发明申请
    • Asulfonate Discrete PEG Based Dyes
    • 磺酸盐离散PEG基染料
    • US20160222212A1
    • 2016-08-04
    • US15088404
    • 2016-04-01
    • EquIP, LLC
    • Paul D. Davis
    • C09B67/00G01N33/58
    • C09B68/444C07D209/58C07D403/12C09B69/00G01N33/533G01N33/582
    • Disclosed are discrete PEGylated dyes, that is, dyes, generally ones that are fluorescent, but could also include chemiluminescent or electrochemiluminescent and related dye or dye precursors, that have discrete PEG constructs chemically attached in various configurations on the dye, and in the entire range of constructs, discrete PEG compounds (polyethylene glycol oligomers that are made synthetically according to methods disclosed in U.S. Pat. No. 7,888,536 and US Pub. No. 2013/0052130). The dyes are modified in a range of ways to control or optimize the properties of water solubility, non-specific binding (in vitro), biodistribution (in vivo), cell internalization (non-cell or cell based assays in vitro, and in vivo diagnostics and therapy), as well as aggregation. The modified dyes do not contain sulfonate groups and, thus, are asulfonate modified dyes.
    • 公开了分散的聚乙二醇化染料,即染料,通常是荧光的染料,但也可以包括化学发光或电化学发光和相关的染料或染料前体,其具有化学连接在染料上的各种构型,并且在整个范围内 的构建体,离散PEG化合物(根据美国专利号7,888,536和美国公开号2013/0052130中公开的方法合成制备的聚乙二醇低聚物)。 染色在一系列方法中进行修饰,以控制或优化水溶性,非特异性结合(体外),生物分布(体内),细胞内化(体外和体内非细胞或细胞测定)的性质 诊断和治疗),以及聚合。 改性染料不含有磺酸盐基团,因此是磺酸盐改性染料。