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51. 发明申请

US20100061506A1 RADIATION-AND-DETECTION SYSTEM 审中-公开
标题翻译：辐射与检测系统
公开(公告)号：US20100061506A1
公开(公告)日：2010-03-11
申请号：US12516356
申请日：2007-11-21
申请人： Thomas Koehler
发明人： Thomas Koehler
IPC分类号： G01D18/00 , A61B6/03
CPC分类号： A61B6/022 , A61B6/027 , A61B6/032 , A61B6/4028
摘要： The invention relates to radiation-and-detection system comprising a radiation unit (2) for alternately illuminating a detection unit (6) with radiation of a first emanating region (15) at first time intervals and with radiation of a second emanating region (16) at second time intervals, wherein first detection values are detected at the first time intervals and second detection values are detected at the second time intervals. The radiation-and-detection system is calibrated with respect to the influence of the radiation of the second emanating region (16) to the first detection values and with respect to the influence of the radiation of the first emanating region (15) to the second detection values.
摘要翻译：本发明涉及辐射和检测系统，其包括用于以第一时间间隔和第二发射区域（16）的辐射交替地照射具有第一发射区域（15）的辐射的检测单元（6）的辐射单元（2）），其中在第一时间间隔检测第一检测值，并且以第二时间间隔检测第二检测值。相对于第二发射区域（16）的辐射对第一检测值的影响并且关于第一发射区域（15）的辐射对第二发射区域（15）的影响的辐射和检测系统的校准检测值。

52. 发明授权

US07672424B2 Image reconstruction with voxel dependent interpolation 有权
标题翻译：用体素依赖插值进行图像重建
公开(公告)号：US07672424B2
公开(公告)日：2010-03-02
申请号：US11575902
申请日：2005-09-22
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
IPC分类号： A61B6/00
CPC分类号： G06T11/006
摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.
摘要翻译：放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹（12）。基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

53. 发明申请

US20100030084A1 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
公开(公告)号：US20100030084A1
公开(公告)日：2010-02-04
申请号：US12514589
申请日：2007-11-12
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

54. 发明授权

US07596203B2 Computer tomography method 失效
标题翻译：计算机断层扫描法
公开(公告)号：US07596203B2
公开(公告)日：2009-09-29
申请号：US11575716
申请日：2005-10-06
申请人： Thomas Koehler , Andy Ziegler
发明人： Thomas Koehler , Andy Ziegler
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B6/027
摘要： The invention relates to a computer tomography method with a circular relative movement between the beam source and an iterative reconstruction method suitable therefor. The reconstruction method is substantially improved by deriving the first approximation image from a CT image, which is obtained from a prior acquisition during helical relative movement.
摘要翻译：本发明涉及一种计算机断层摄影方法，其具有在光束源之间的圆周相对运动和适合于其的迭代重建方法。通过从螺旋相对运动期间的先前获取获得的CT图像导出第一近似图像，实质上改进了重建方法。

55. 发明申请

US20090113212A1 Multiprocessor electronic circuit including a plurality of processors and electronic data processing system 有权
标题翻译：多处理器电子电路包括多个处理器和电子数据处理系统
公开(公告)号：US20090113212A1
公开(公告)日：2009-04-30
申请号：US12248549
申请日：2008-10-09
申请人： Thomas Koehler , Thomas Fuchs , Ulrich Mayer , Chung-Lung Kevin Shum , Scott Barnett Swaney
发明人： Thomas Koehler , Thomas Fuchs , Ulrich Mayer , Chung-Lung Kevin Shum , Scott Barnett Swaney
IPC分类号： G06F21/00
CPC分类号： G06F21/72
摘要： A multiprocessor electronic circuit and an electronic data processing system comprising such circuit are disclosed for reducing the power consumption and the chip area consumption of a multiprocessor system having cryptographic functionality. In one embodiment, the multiprocessor electronic circuit comprises a plurality of processors, a single cryptographic processing unit that comprises a plurality of input/output buffer pairs and two cryptographic engines, a cipher engine and a hash engine, and associated control logic.
摘要翻译：公开了一种包括这种电路的多处理器电子电路和电子数据处理系统，用于降低具有加密功能的多处理器系统的功耗和芯片面积消耗。在一个实施例中，多处理器电子电路包括多个处理器，包括多个输入/输出缓冲器对和两个加密引擎，密码引擎和哈希引擎以及相关控制逻辑的单个密码处理单元。

56. 发明申请

US20090060124A1 ENERGY RESOLVED COMPUTER TOMOGRAPHY 审中-公开
标题翻译：能量分析计算机图形学
公开(公告)号：US20090060124A1
公开(公告)日：2009-03-05
申请号：US11718718
申请日：2005-11-02
申请人： Michael Grass , Thomas Koehler
发明人： Michael Grass , Thomas Koehler
IPC分类号： H05G1/08
CPC分类号： G01T1/2985 , A61B6/032 , A61B6/4241 , A61B6/482 , A61B6/483
摘要： Interpolation of the momentum transfer prior to the filtered backprojection reconstruction in computer tomography baggage inspection or medical applications may not result in best image quality or minimal computational cost. According to an exemplary embodiment of the invention, a non-linear energy binning of an energy-resolved single-row detector is provided, which automatically leads to a Cartesian q-sampling on a parallel rebinned detector. This may avoid the q interpolation prior to the filtered back projection reconstruction, resulting in improved spatial resolution, reduction of computational effort and improved image quality.
摘要翻译：在计算机断层摄影行李检查或医疗应用中的滤波反投影重建之前的动量传递的插值可能不会导致最佳图像质量或最小的计算成本。根据本发明的示例性实施例，提供了能量分辨的单行检测器的非线性能量合并，其自动地在并行重新组合的检测器上导致笛卡尔q取样。这可以避免在滤波反投影重建之前的q内插，导致改善的空间分辨率，减少计算量和改善图像质量。

57. 发明申请

US20080267344A1 Signal Processing Unit for Producing Images 审中-公开
标题翻译：用于制作图像的信号处理单元
公开(公告)号：US20080267344A1
公开(公告)日：2008-10-30
申请号：US12093181
申请日：2006-11-06
申请人： Thomas Koehler , Michael Grass
发明人： Thomas Koehler , Michael Grass
IPC分类号： A61B6/03
CPC分类号： A61B6/032 , A61B5/7289 , A61B6/5264
摘要： An exemplary embodiment of the invention provides a signal processing unit for producing images of an object under examination based on data signals of a tomography system, the signal processing unit comprising a processor and an input interface, wherein the input interface is adapted to receive measured data signals. Furthermore, the processor is adapted to generate a pulmonary gating signal based on said measured data signals and is further adapted to generate an image based on said measured data signals by using the pulmonary gating signal.
摘要翻译：本发明的示例性实施例提供了一种信号处理单元，用于基于断层摄影系统的数据信号产生被检查对象的图像，信号处理单元包括处理器和输入接口，其中输入接口适于接收测量数据信号。此外，处理器适于基于所述测量的数据信号产生肺门控信号，并且还适于通过使用肺门控信号基于所述测量的数据信号生成图像。

58. 发明申请

US20080095305A1 Computer Tomography Apparatus And Method For Examining An Object Of Interest 失效
标题翻译：计算机断层扫描仪和方法，用于检查感兴趣的对象
公开(公告)号：US20080095305A1
公开(公告)日：2008-04-24
申请号：US11718724
申请日：2005-11-02
申请人： Andy Ziegler , Thomas Koehler , Michael Grass
发明人： Andy Ziegler , Thomas Koehler , Michael Grass
IPC分类号： A61B6/03
CPC分类号： G01T1/2985 , A61B6/027 , A61B6/032 , A61B6/4241 , A61B6/482 , A61B6/483 , G01V5/0025 , G01V5/005 , G06T11/006 , G06T2211/424
摘要： A computer tomography apparatus (100) for examination of an object of interest (107), the computer tomography apparatus (100) comprising detecting elements (123) adapted to detect electromagnetic radiation coherently scattered from an object of interest (107) in an energy-resolving manner, and a determination unit (118) adapted to determine structural information concerning the object of interest (107) based on a statistical analysis of detecting signals received from the detecting elements (123).
摘要翻译：一种用于检查感兴趣对象（107）的计算机断层摄影装置（100），所述计算机断层摄影装置（100）包括检测元件（123），所述检测元件适于检测能量相关物体（107）相干散射的电磁辐射，以及确定单元（118），其适于基于从所述检测元件（123）接收的检测信号的统计分析来确定关于感兴趣对象的结构信息（107）。

59. 发明申请

US20070026423A1 Method and test kit for the detection of target nucleic acids 审中-公开
标题翻译：用于检测靶核酸的方法和检测试剂盒
公开(公告)号：US20070026423A1
公开(公告)日：2007-02-01
申请号：US11393912
申请日：2006-03-16
申请人： Thomas Koehler , Anne-Katrin Rost
发明人： Thomas Koehler , Anne-Katrin Rost
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/706 , C12Q2565/1015 , C12Q2565/525 , C12Q2561/113 , C12Q2565/101
摘要： This invention concerns a method for the detection of target nucleic acids or analoga to nucleic acids (targets), wherein at least one pair of labeled oligonucleotides or analoga to oligonucleotides (probes) are used, characterised in that the upstream probe proportionally hybridises to the target with its 5′ end and proportionally hybridises to the 5′ end of the downstream probe with its 3′ end, as well as the 3′ end of the downstream probe proportionally hybridises to the target again, this resulting in a triplex structure built up between the target nucleic acid and the probe pair. This invention moreover relates to a test kit required to carry out the method.
摘要翻译：本发明涉及用于检测靶核酸或类似物至核酸（靶）的方法，其中使用至少一对标记的寡核苷酸或类似物（寡核苷酸（探针）），其特征在于上游探针与目标物成比例地杂交其5'端与其3'末端的下游探针的5'末端成比例地杂交，并且下游探针的3'端再次成比例地与目标杂交，导致三重结构靶核酸和探针对。本发明还涉及实施该方法所需的检测试剂盒。

60. 发明授权

US06984734B2 Cyclo[n]pyrroles and methods thereto 有权
公开(公告)号：US06984734B2
公开(公告)日：2006-01-10
申请号：US10373949
申请日：2003-02-26
申请人： Jonathan L. Sessler , Daniel Seidel , Frederic R. Bolze , Thomas Koehler
发明人： Jonathan L. Sessler , Daniel Seidel , Frederic R. Bolze , Thomas Koehler
IPC分类号： C07D245/00 , G02F1/035 , G11B7/24 , B32B3/26
CPC分类号： C07D487/22 , Y10T428/249953
摘要： The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.

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