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51. 发明申请

US20050084862A1 Sample preparation for the detection of infectious agents 审中-公开
标题翻译：用于检测感染剂的样品制备
公开(公告)号：US20050084862A1
公开(公告)日：2005-04-21
申请号：US10500167
申请日：2002-12-24
申请人： Helen Lee , Ling Huang , Elpidio Casar , Nigel Buttress
发明人： Helen Lee , Ling Huang , Elpidio Casar , Nigel Buttress
IPC分类号： G01N33/569 , C12Q1/68
CPC分类号： G01N33/56927 , G01N2333/295 , G01N2333/922
摘要： Methods for improving the quality of sub-optimal patient samples for detection of infectious agents are described. In particular, endocervical fluid samples or vaginal fluid samples are treated with DNase to improve the reliability of detection of infectious agents. Kits for carrying out the methods are also described.
摘要翻译：描述了用于提高用于检测感染因子的次优患者样品质量的方法。特别地，用DNase处理子宫颈内液体样品或阴道液样品以提高感染剂检测的可靠性。还描述了用于执行方法的套件。

52. 外观设计

USD950667S1 Inflatable pool toy 有权
公开(公告)号：USD950667S1
公开(公告)日：2022-05-03
申请号：US29826193
申请日：2022-02-10
申请人： Ling Huang
设计人： Ling Huang

53. 外观设计

USD908703S1 Active stylus 有权
公开(公告)号：USD908703S1
公开(公告)日：2021-01-26
申请号：US29696185
申请日：2019-06-26
申请人： Ling Huang
设计人： Ling Huang

54. 发明申请

US20140230046A1 TURING TEST BASED USER AUTHENTICATION AND USER PRESENCE VERIFICATION SYSTEM, DEVICE, AND METHOD 有权
标题翻译：基于测试的用户认证和用户存在的验证系统，设备和方法
公开(公告)号：US20140230046A1
公开(公告)日：2014-08-14
申请号：US13976918
申请日：2011-12-27
申请人： Prashant Dewan , David M. Durham , Ling Huang , Karanvir S. Grewal , Xiaozhu Kang
发明人： Prashant Dewan , David M. Durham , Ling Huang , Karanvir S. Grewal , Xiaozhu Kang
IPC分类号： G06F21/32
CPC分类号： G06F21/32 , G06K9/00288 , G06K9/00899
摘要： A password-less method for authenticating a user includes capturing one or more images of a face of the user and comparing the one or more images with a previously collected face template. Randomly selected colored light and randomized blinking patterns are used to capture the images of the user. Such captured images are compared to previously collected face templates, thereby thwarting spoof attacks. A secret image, known only to the user and the device, is moved from one area of the display to another randomly selected area, using the movements of the user's head or face, thereby providing a Turing based challenge. Protected audio video path (PAVP) enabled devices and components are used to protect the challenge from malware attacks.
摘要翻译：用于认证用户的无密码方法包括捕获用户的脸部的一个或多个图像并将一个或多个图像与先前收集的面部模板进行比较。随机选择的彩色光和随机闪烁图案用于捕获用户的图像。将这样的拍摄图像与先前收集的面部模板进行比较，从而阻止欺骗攻击。使用用户和设备已知的秘密图像使用用户头部或脸部的移动从显示器的一个区域移动到另一个随机选择的区域，从而提供基于图灵的挑战。受保护的音频视频路径（PAVP）启用的设备和组件用于保护挑战免受恶意软件攻击。

55. 发明申请

US20120094272A1 SIGNAL ENHANCEMENT SYSTEM WITH MULTIPLE LABELED-MOIETIES 审中-公开
标题翻译：具有多个标签的信号增强系统
公开(公告)号：US20120094272A1
公开(公告)日：2012-04-19
申请号：US13165624
申请日：2011-06-21
申请人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
发明人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
IPC分类号： G01N33/53 , G01N33/577 , C12Q1/70 , C07K16/46 , C07K1/107
CPC分类号： G01N33/558 , Y10S435/81 , Y10S436/807 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918
摘要： Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labelled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labelled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.
摘要翻译：描述了用于检测分析物的浸渍试验。在优选的实施方案中，能够结合分析物的多重生物素化抗体与由胶体金标记的抗生物素抗体结合，并且将被认为含有分析物的测试溶液弄脏。分析物，生物素化抗分析物抗体和胶体金标记的抗生物素抗体之间形成的复合物在量油尺的捕获区捕获。在捕获区存在胶体金标记表示测试溶液中存在分析物。使用这种方法的分析物检测的灵敏度比在第一步中将测得的与分析物结合的生物素化的抗分析物抗体被弄脏的可比较方法高一个数量级，并且胶体金标记的抗生物素抗体被恶化量油尺在一个单独的步骤。还描述了用于执行本发明的测试的套件。

56. 发明申请

US20090143246A1 Patterning with compositions comprising lipid 有权
标题翻译：用包含脂质的组合物进行图案化
公开(公告)号：US20090143246A1
公开(公告)日：2009-06-04
申请号：US12213301
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Rafael A. Vega , Steven Lenhert
发明人： Chad A. Mirkin , Ling Huang , Rafael A. Vega , Steven Lenhert
IPC分类号： C40B40/06 , B05D5/00 , C40B40/10 , C40B40/04
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译：更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。脂质可以是磷脂如DOPC。图案化物质可以是寡核苷酸或蛋白质。可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。脂质可以激活图案化或增加图案化速率。可以实现简化的尖端准备。可以使用纳米镜，SPM和AFM提示。

57. 发明申请

US20080206853A1 SIGNAL ENHANCEMENT SYSTEM WITH MULTIPLE LABELED-MOIETIES 有权
标题翻译：具有多个标签的信号增强系统
公开(公告)号：US20080206853A1
公开(公告)日：2008-08-28
申请号：US12042762
申请日：2008-03-05
申请人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
发明人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
IPC分类号： C12M1/00 , B01J19/00
CPC分类号： G01N33/558 , Y10S435/81 , Y10S436/807 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918
摘要： Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labeled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labeled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labeled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.
摘要翻译：描述了用于检测分析物的浸渍试验。在优选的实施方案中，能够结合分析物的多重生物素化抗体与由胶体金标记的抗生物素抗体结合，并且将被认为含有分析物的测试溶液弄脏。分析物，生物素化抗分析物抗体和胶体金标记的抗生物素抗体之间形成的复合物在量油尺的捕获区捕获。在捕获区存在胶体金标记表示测试溶液中存在分析物。使用这种方法的分析物检测的灵敏度比在第一步中将测得的与分析物结合的生物素化的抗分析物抗体被弄脏的可比较方法高一个数量级，并且胶体金标记的抗生物素抗体被恶化量油尺在一个单独的步骤。还描述了用于执行本发明的测试的套件。

58. 发明申请

US20050037000A1 Identification and engineering of antibodies with variant Fc regions and methods of using same 有权
标题翻译：具有变体Fc区的抗体的鉴定和工程及其使用方法
公开(公告)号：US20050037000A1
公开(公告)日：2005-02-17
申请号：US10754922
申请日：2004-01-09
申请人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
发明人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
IPC分类号： C07K16/00 , A61K39/395 , C07K16/44
CPC分类号： C07K14/70535 , C07K14/36 , C07K14/405 , C07K16/005 , C07K16/283 , C07K16/2887 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/70 , G01N33/6857 , G01N2333/70535
摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
摘要翻译：本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区相对于包含野生型Fc区的可比分子，以更高的亲和力结合FcγRIIA和/或FcγRIIA。本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。本发明的分子特别可用于治疗或预防需要通过FcγAMR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效的治疗性抗体，其作用由ADCC介导。

59. 外观设计

USD944799S1 Stylus 有权
公开(公告)号：USD944799S1
公开(公告)日：2022-03-01
申请号：US29758852
申请日：2020-11-19
申请人： Ling Huang
设计人： Ling Huang

60. 外观设计

USD936653S1 Stylus 有权
公开(公告)号：USD936653S1
公开(公告)日：2021-11-23
申请号：US29758859
申请日：2020-11-19
申请人： Ling Huang
设计人： Ling Huang

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