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51. 发明申请

US20060166248A1 Fluorescent N2, N3-etheno-purine (2'deoxy) riboside derivatives and uses thereof 失效
标题翻译：荧光素N2，N3-乙烯嘌呤（2脱氧）核苷衍生物及其用途
公开(公告)号：US20060166248A1
公开(公告)日：2006-07-27
申请号：US11337438
申请日：2006-01-24
申请人： Bilha Fischer , Einat Sharon
发明人： Bilha Fischer , Einat Sharon
IPC分类号： C12Q1/68 , C07H21/02 , C07H19/22
CPC分类号： C07H21/02 , C07H19/22
摘要： The invention relates to fluorescent N2,N3-etheno-purine (2′-deoxy) riboside derivatives and fluorescent oligonucleotide probes comprising one or more moieties thereof, their preparation and uses thereof for staining DNA/RNA and for detection and quantitation of genetic material.
摘要翻译：本发明涉及荧光N 2，N 3 - 乙烯 - 嘌呤（2'-脱氧）核苷衍生物和包含其一个或多个部分的荧光寡核苷酸探针，其制备及其用于染色DNA / RNA的用途和用于检测和定量遗传物质。

52. 发明授权

US06040342A Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases 失效
标题翻译：可用于治疗癌症和其他增殖性疾病的视黄醇氧基（烷基取代的）甲基丁酸盐
公开(公告)号：US06040342A
公开(公告)日：2000-03-21
申请号：US674481
申请日：1996-07-02
申请人： Ada Rephaeli , Abraham Nudelman
发明人： Ada Rephaeli , Abraham Nudelman
IPC分类号： A61K31/225 , A61K31/23 , A61K31/232 , A61K31/44 , C07C403/10 , C07C403/12 , C07D213/30
CPC分类号： C07D213/30 , A61K31/232 , C07C403/20 , C07B2200/09 , C07C2101/16
摘要： This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically-acceptable salts and prodrugs thereof. ##STR1## The compounds of the invention are also useful in methods of ameliorating wrinkles, inducing wound healing, treating cutaneous ulcers and treating gastrointestinal disorders.
摘要翻译：本发明涉及式（I）的新化合物和含有该化合物的药物组合物，涉及在需要这种治疗的受试者中治疗，预防或改善癌症和其他增殖性疾病的方法，包括给予式（I）化合物和药学上可接受的盐可接受的盐和前药。本发明的化合物还可用于改善皱纹，诱导伤口愈合，治疗皮肤溃疡和治疗胃肠道疾病的方法。

53. 发明授权

US5569675A Methods of using carboxylic acid esters to increase fetal-hemoglobin levels 失效
标题翻译：使用羧酸酯增加胎儿血红蛋白水平的方法
公开(公告)号：US5569675A
公开(公告)日：1996-10-29
申请号：US206690
申请日：1994-03-07
申请人： Ada Rephaeli , Abraham Nudelman , Matityahu Shaklai
发明人： Ada Rephaeli , Abraham Nudelman , Matityahu Shaklai
IPC分类号： G01N33/72 , A61K31/215 , A61K31/22 , A61K31/23 , A61K31/265 , A61K31/335 , A61K31/355 , A61K31/365 , A61K49/00 , A61P7/00 , A61P7/06 , A61P43/00 , C07D311/76 , A61K31/225
CPC分类号： A61K31/355 , A61K31/22 , A61K31/23 , A61K31/265 , A61K31/335 , A61K31/365 , Y10S514/815 , Y10S514/895
摘要： This invention relates to novel methods of increasing the level of fetal hemoglobin (HbF) in a subject and methods of treating, preventing or ameliorating .beta.-globin or other HbF-related disorders by increasing the level of HbF in a subject in need of such treatment comprising administering one or more compounds of the Formulae (I), (II), or (III):(I) XCH.sub.2 --CHX--CHX--C(.dbd.O)--O--Z(II) CH.sub.3 --CO--CH.sub.2 --C(.dbd.O)--O--Z(III) CH.sub.3 --CH.sub.2 --CO--C(.dbd.O)--O--Zwherein:X is H, or one of X only may be OH;Z is --CHR--O--C(.dbd.O)R', --CHR--O--C(.dbd.O)--O--R', or ##STR1## R is H, alkyl, aryl, arylalkyl; and R' is alkyl, aminoalkyl, aralkyl, aryl, alkoxy, aralkoxy and aryloxy, in which aryl by itself, and aryl in aralkyl, aralkoxy and aryloxy are each selected from the group consisting of phenyl, naphthyl, furyl, or thienyl, each of which is unsubstituted or substituted by at least one substituent selected from the group consisting of alkyl, alkoxy, or halogen; and pharmaceutically acceptable salts and prodrugs thereof.
摘要翻译：本发明涉及增加受试者胎儿血红蛋白（HbF）水平的新方法和通过增加需要这种治疗的受试者中HbF水平来治疗，预防或改善β-珠蛋白或其他HbF相关疾病的方法包括施用一种或多种式（I），（II）或（III）的化合物：（I）XCH 2 -CHX-CHX-C（= O）-OZ（II）CH 3 -CO-CH 2 -C O）-OZ（III）CH 3 -CH 2 -CO-C（= O）-OZ其中：X是H，或者X中的一个可以是OH; Z是-CHR-O-C（= O）R'，-CHR-O-C（= O）-O-R'，或者R是H，烷基，芳基，芳基烷基; 和R'是烷基，氨基烷基，芳烷基，芳基，烷氧基，芳烷氧基和芳氧基，其中芳基本身和芳烷基，芳烷氧基和芳氧基中的芳基各自选自苯基，萘基，呋喃基或噻吩基，各自其中未取代或被至少一个选自烷基，烷氧基或卤素的取代基取代; 及其药学上可接受的盐和前药。

54. 发明授权

US5416114A Physiologically active and nutritional composition 失效
标题翻译：生理活性和营养成分
公开(公告)号：US5416114A
公开(公告)日：1995-05-16
申请号：US94769
申请日：1993-07-20
申请人： Shlomo Yehuda
发明人： Shlomo Yehuda
IPC分类号： A23K1/00 , A23L1/20 , A23L1/30 , A61K31/19 , A61K31/20 , A61K31/23 , C07C57/02 , A61K31/07 , A61K31/12 , A61K31/34 , A61K31/355 , A61K31/415 , A61K31/44 , A61K31/51 , A61K31/525 , A61K31/595 , A61K31/70 , A61K33/24 , A61K33/32 , A61K33/34 , A61K33/42
CPC分类号： A61K31/23 , A23L33/12 , A61K31/20
摘要： A composition of matter which consists of (a) from about 13.0 to about 27.5% by weight of at least one compound selected from the group consisting of linolenic acid and derivatives thereof, calculated as the free acid, said derivatives or linolenic acid being both physiologically hydrolyzable and pharmacologically acceptable, and (b) about 87.0 to about 72.5% by weight of at least one compound selected from the group consisting of linoleic acid and derivatives thereof, calculated as the free acid, said derivatives of linoleic acid being both physiologically hydrolyzable and pharmacologically acceptable, is utilized e.g. as a pharmaceutical formulation or nutritional composition, in absence of an oily carrier or diluent which comprises at least one member of the group consisting of C.sub.8-18 saturated fatty acids, oleic acid and derivatives of these acids, in order to induce in a mammal (including humans) at least one physiological effect selected from memory enhancement, analgesia, sleep regulation and inhibition of the symptoms of senility, and in order to treat Alzheimer's disease and related dementia, and epilspsy.
摘要翻译：由（a）约13.0-约27.5重量％的至少一种选自亚麻酸及其衍生物的化合物（以游离酸计算）的组合物，所述衍生物或亚麻酸均为生理学上可水解和药理学上可接受的，和（b）约87.0至约72.5重量％的至少一种选自亚油酸及其衍生物的化合物，其计算为游离酸，所述亚油酸衍生物既生理上可水解，又药理学上可接受的，例如作为药物制剂或营养组合物，在没有油性载体或稀释剂的情况下，其包含至少一种由C8-18饱和脂肪酸，油酸和这些酸的衍生物组成的组，以诱导哺乳动物（包括人）至少一种选自记忆增强，止痛，睡眠调节和抑制衰老症状的生理效应，以及治疗阿尔茨海默病和相关痴呆以及癫痫。

55. 发明授权

US5024528A Alignment apparatus employing a laser light scatterer 失效
标题翻译：采用激光散射体的对准装置
公开(公告)号：US5024528A
公开(公告)日：1991-06-18
申请号：US435019
申请日：1989-11-13
申请人： Isaac Freund , Michael Rosenbluh
发明人： Isaac Freund , Michael Rosenbluh
IPC分类号： G01S17/06
CPC分类号： G01S17/06
摘要： Alignment apparatus including a source of coherent radiation mounted in a reference location and arranged to provide an output beam extending along a reference axis, a laser light reflector mounted at a location sought to be aligned with respect to the reference location and/or the reference axis, a laser light scatterer arranged to receive reflected laser light from the reflector and to produce a speckle pattern and a detector arranged to sense the speckle pattern produced by the laser light scatterer in response to incident reflected laser light, whereby variations in the speckle pattern indicate changes in relative orientation between the reference location and the laser light reflector.
摘要翻译：对准设备包括安装在参考位置并被设置成提供沿着参考轴线延伸的输出光束的相干辐射源，激光反射器安装在寻求相对于参考位置对准的位置和/或参考轴线激光散射体，被布置成从所述反射器接收反射的激光并产生散斑图案和布置成响应于入射的反射激光感测由所述激光散射体产生的散斑图案的检测器，由此斑纹图案的变化表示在参考位置和激光反射器之间的相对定向的变化。

56. 发明授权

US4772540A Manufacture of microsieves and the resulting microsieves 失效
标题翻译：制造微型和微型产品
公开(公告)号：US4772540A
公开(公告)日：1988-09-20
申请号：US771315
申请日：1985-08-30
申请人： Mordechai Deutsch , Tamar Landau , Richard E. Gordon
发明人： Mordechai Deutsch , Tamar Landau , Richard E. Gordon
IPC分类号： B01D39/20 , C25D1/08 , G03C5/00
CPC分类号： C25D1/08
摘要： An ordinarily delicate microsieve is provided with greater resistance to mechanical distortion by being formed integrally with a rigid frame or by having its thickness built up to an extent where it is significantly more capable of withstanding flex.
摘要翻译：通常通过与刚性框架一体形成或通过将其厚度建立在显着更能承受弯曲的程度上，通常具有较好的抗机械变形性的微型筛。

57. 发明授权

US4034226A Method of and means for producing radiation in the X-ray region 失效
标题翻译：用于在X射线区域产生辐射的方法和装置
公开(公告)号：US4034226A
公开(公告)日：1977-07-05
申请号：US474329
申请日：1974-05-29
申请人： Isaac Freund
发明人： Isaac Freund
IPC分类号： H01S4/00
CPC分类号： H01S4/00
摘要： A method for producing stimulated emission of radiation in the X-ray region comprising the steps of: selecting as an active medium a system having the following properties; two energy levels separated by an energy difference .DELTA.E corresponding to radiation of frequency .omega..sub.t in the X-ray region such that a transition from the upper to the lower of the two levels by one-photon emission is weakly allowed or strictly forbidden, one of the two levels having a nearly degenerate partner level optically coupled thereto such that a transistion therebetween by one-photon emission has a high probability; providing a resonator containing such an active medium; subjecting the active medium in the resonator to stimulating radiation at a frequency .omega..sub.1 that is preferably, substantially equal to the frequency of the optical coupling between the nearly degenerate levels but much smaller than the frequency .omega..sub.t ; arranging for the polarization of the stimulating radiation to be parallel to the polarization of the output of the resonator; and turning the resonator to the frequency .omega..sub.2 = .omega..sub.t .+-. .omega..sub.1.
摘要翻译：一种用于在X射线区域产生受辐射辐射的方法，包括以下步骤：选择具有以下特性的系统作为活性介质; 两个能级与能量差DELTA E相分离，对应于X射线区域的频率ωt的辐射，使得弱光被允许或严格禁止从两个电平的上部到下部的单光子发射的转变，一个两个级别具有与其光学耦合的几乎退化的伙伴级别，使得其间通过单光子发射的转移具有很高的概率; 提供包含这种活性介质的谐振器; 对共振器中的活性介质进行激励，其频率ω1优选地基本上等于近似退化水平之间的光耦合的频率，但远小于频率ωt; 将激励辐射的极化设置成与谐振器的输出的极化平行; 并将谐振器转换为频率ω2 =ω+ t +/-ω1。

58. 发明授权

US2200852A Thermostatic switch 失效
公开(公告)号：US2200852A
公开(公告)日：1940-05-14
申请号：US19639038
申请日：1938-03-17
申请人： HONEYWELL REGULATOR CO
发明人： POND BERTRAM P
IPC分类号： H01H37/04
CPC分类号： H01H37/04

59. 发明授权

US11599681B2 Bit decomposition secure computation apparatus, bit combining secure computation apparatus, method and program 有权
公开(公告)号：US11599681B2
公开(公告)日：2023-03-07
申请号：US16614259
申请日：2017-05-18
申请人： NEC CORPORATION , BAR-ILAN UNIVERSITY
发明人： Toshinori Araki , Kazuma Ohara , Jun Furukawa , Lindell Yehuda , Nof Ariel
IPC分类号： G06F21/78 , G06F7/501 , G06F21/82 , H04L9/08 , G06F7/72 , H04L9/00 , H04L9/30
摘要： The present invention provides a bit decomposition secure computation system comprising: a share value storage apparatus to store share values obtained by applying (2, 3) type RSS using modulo of power of 2 arithmetic; a decomposed share value storage apparatus to store a sequence of share values obtained by applying (2, 3) type RSS using modulo 2 arithmetic; and a bit decomposition secure computation apparatus that, with respect to sharing of a value w, r1, r2, and r3 satisfying w=r1+r2+r3 mod 2{circumflex over ( )}n, where {circumflex over ( )} is a power operator and n is a preset positive integer, being used as share information by the (2, 3) type RSS stored in the share value storage apparatus, includes: an addition sharing unit that sums two values out of r1, r2 and r3 by modulo 2{circumflex over ( )}n, generates and distributes a share value of the (2, 3) type RSS with respect to the sum; and a full adder secure computation unit that executes addition processing of the value generated by the addition sharing unit and a value not used by the addition sharing unit, for each digit, by using secure computation of a full adder, and stores the result in the decomposed share value storage apparatus.

60. 发明申请

US20230002906A1 CONTINUOUS-FEED CHEMICAL VAPOR DEPOSITION SYSTEM 有权
公开(公告)号：US20230002906A1
公开(公告)日：2023-01-05
申请号：US17305203
申请日：2021-07-01
申请人： MELLANOX TECHNOLOGIES, LTD. , BAR-ILAN UNIVERSITY , RAMOT AT TEL- AVIV UNIVERSITY LTD. , SIMTAL NANO-COATINGS LTD
发明人： Elad MENTOVICH , Yaniv ROTEM , Yaakov GRIDISH , Doron NAVEH , Chen STERN , Yosi BEN-NAIM , Ariel ISMACH , Eran BAR-RABI , Tal KAUFMAN
IPC分类号： C23C16/54 , C23C16/46 , C23C16/52
摘要： A continuous-feed chemical vapor deposition system and an associated method are provided. An example of the continuous-feed chemical vapor deposition system includes a first chamber configured to receive a substrate. The continuous-feed chemical vapor deposition system includes a second chamber downstream from the first chamber and configured to receive the substrate from the first chamber. The second chamber is configured to perform a chemical vapor deposition process on the substrate. The continuous-feed chemical vapor deposition system includes a third chamber downstream from the second chamber that is configured to receive the substrate from the second chamber upon completion of the chemical vapor deposition process. The second chamber can be environmentally isolated from the first chamber and the third chamber. The first chamber is further configured to receive a subsequent substrate when the chemical vapor deposition process is occurring in the second chamber.

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