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51. 发明申请

US20140264009A1 DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF 有权
标题翻译：差分移动光谱仪及其方法
公开(公告)号：US20140264009A1
公开(公告)日：2014-09-18
申请号：US14361378
申请日：2012-11-21
申请人： DH Technologies Development Pte. Ltd.
发明人： John Lawrence Campbell , Yves LeBlanc
IPC分类号： G01N27/62
CPC分类号： G01N27/624 , G01N27/622 , G01N33/6848 , H01J49/0072
摘要： An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译：提供了用于分析分子样品的装置和方法。该装置包括质量分析系统，其包括差动迁移谱仪，其包括限定两个离子流动路径的至少三个过滤器电极，其中过滤电极基于样品离子的迁移率特性产生用于穿过样本离子的选定部分的电场。差动迁移谱仪还包括电压源，其向至少一个滤波电极提供DC和RF电压以产生电场;接收样品离子的第一和第二离子入口;以及输出所选部分的离子出口的样品离子。质谱仪接收样品离子的部分或全部选定部分。

52. 发明授权

US08785845B2 Method and system for operating a time of flight mass spectrometer detection system 有权
标题翻译：操作飞行时间质谱仪检测系统的方法和系统
公开(公告)号：US08785845B2
公开(公告)日：2014-07-22
申请号：US13017709
申请日：2011-01-31
申请人： Alexandre Loboda
发明人： Alexandre Loboda
IPC分类号： H01J49/02 , H01J49/40 , G01T1/17
CPC分类号： H01J49/025 , G01T1/17 , H01J49/0027 , H01J49/40
摘要： Dual TDC-ADC detection systems for time of flight mass spectrometry are disclosed herein. Detection systems based upon TDC generally provide higher timing resolution as opposed to detection systems based upon ADC. However, ADC generally provides increased dynamic range over TDC. By combining TDC and ADC into a tandem detector, and adjusting performance parameters of the respective converter types, the dynamic range of the dual TDC-ADC detection can be extended beyond what either detector type could have achieved individually. Composite time of flight mass spectra can be generated by aggregating individual mass spectra acquired from multiple time-of-flight extractions, and selecting the number of time-of-flight extractions to ensure overlap between the ADC and TDC dynamic ranges in the dual TDC-ADC detector system.
摘要翻译：本文公开了用于飞行时间质谱的双TDC-ADC检测系统。与基于ADC的检测系统相反，基于TDC的检测系统通常提供更高的定时分辨率。然而，ADC通常提供比TDC更大的动态范围。通过将TDC和ADC组合成串联检测器，并调整各种转换器类型的性能参数，双TDC-ADC检测的动态范围可以扩展到单独检测器类型之外。复合飞行时间质谱可以通过聚合从多次飞行时间提取获得的单个质谱，并选择飞行时间提取次数，以确保双TDC中ADC和TDC动态范围之间的重叠， ADC检测器系统。

53. 发明授权

US08712695B2 Method, system, and computer program product for scoring theoretical peptides 有权
标题翻译：方法，系统和计算机程序产品，用于评分理论肽
公开(公告)号：US08712695B2
公开(公告)日：2014-04-29
申请号：US11246722
申请日：2005-10-06
申请人： Ignat V. Shilov , Sean L. Seymour , Ron Bonner , Alpesh A. Patel
发明人： Ignat V. Shilov , Sean L. Seymour , Ron Bonner , Alpesh A. Patel
IPC分类号： G01N33/48 , G06F19/00 , C12N15/87
CPC分类号： G06F19/00 , C12N15/87 , G01N33/6842 , G01N33/6848 , G06F19/22 , G06F19/28
摘要： The present teachings provide for identification of peptides using small sequence tags to focus computational resources on searching regions of a protein database that are the most likely to yield correct identifications. They allow for the incorporation of modifications and in doing so focuses the search to peptides with a precursor mass match. Additionally, probability or relevance factors can be used to determine peptide hypotheses. Various embodiments are presented that search for peptides when a single precursor is selected or when multiple precursors are simultaneously fragmented.
摘要翻译：本教导提供使用小序列标签鉴定肽，以将计算资源集中在最有可能产生正确鉴定的蛋白质数据库的搜索区域上。它们允许引入修饰，这样做可以将搜索重点放在具有前体大量匹配的肽上。此外，概率或相关因素可用于确定肽假说。呈现了当选择单一前体时或当多个前体同时分裂时搜索肽的各种实施方案。

54. 发明授权

US08679773B2 Kits pertaining to analyte determination 有权
标题翻译：与分析物测定有关的试剂盒
公开(公告)号：US08679773B2
公开(公告)日：2014-03-25
申请号：US11623510
申请日：2007-01-16
申请人： Darryl J. C. Pappin , Michael Bartlett-Jones
发明人： Darryl J. C. Pappin , Michael Bartlett-Jones
IPC分类号： C12Q1/34 , C12N9/48 , C07D211/32 , C07D401/06 , C07D211/06 , C07D241/06 , C07D403/06 , C07D413/06 , C07D295/18
CPC分类号： G01N33/6848 , A61K51/04 , C07D207/46 , C07D401/12 , G01N33/532 , G01N33/6842 , G01N2458/15 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/24
摘要： This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
摘要翻译：本发明涉及通过使用独特的标记试剂或独特标记试剂组的质量分析来测定分析物的方法，试剂盒和/或组合物。标记试剂可以是异构体或同量异构体，并且可用于产生适于多重分析标记分析物的混合物。

55. 发明授权

US08633031B2 Expression quantification using mass spectrometry 有权
标题翻译：使用质谱法进行表达量化
公开(公告)号：US08633031B2
公开(公告)日：2014-01-21
申请号：US12571005
申请日：2009-09-30
申请人： Christine L. Hunter
发明人： Christine L. Hunter
IPC分类号： G01N33/00 , B01D59/44
CPC分类号： G01N33/68 , G01N33/6848 , G01N33/6851 , G01N2333/90209
摘要： In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present teachings provide methods of determining the absolute concentration of one or more isoforms of a protein using standard samples of signature protein fragments and parent-daughter ion transition monitoring (PDITM). In various embodiments, the absolute concentration of multiple isoforms of a biomolecule in a sample, multiple proteins in a biological process, a combination of multiple samples, or combinations thereof, can be determined in a multiplex fashion using the present teachings. In various aspects, provided are methods of assessing the response of a biological system to a chemical agent.
摘要翻译：在各个方面，本教导提供用于蛋白质表达的绝对定量的系统，方法，测定和试剂盒。在各个方面，本教导提供了确定感兴趣的一种或多种感兴趣的一种或多种感兴趣的蛋白质的浓度的方法。在各个方面，本教导提供使用标记蛋白片段和父 - 子离子转移监测（PDITM）的标准样品测定蛋白质的一种或多种同种型的绝对浓度的方法。在各种实施方案中，可以使用本教导以多种方式确定样品中生物分子的多种同种型，生物过程中的多种蛋白，多种样品的组合或其组合的绝对浓度。在各个方面，提供了评估生物系统对化学试剂的响应的方法。

56. 发明申请

US20130240723A1 Systems and Methods for Rapidly Screening Samples by Mass Spectrometry 有权
标题翻译：通过质谱快速筛选样品的系统和方法
公开(公告)号：US20130240723A1
公开(公告)日：2013-09-19
申请号：US13876349
申请日：2011-11-02
申请人： Ronald F. Bonner , Stephen A. Tate
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/04
CPC分类号： H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/04
摘要： Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.
摘要翻译：系统和方法用于快速筛选样品。指示非色谱的快速样品引入装置使用处理器将多个样品的每个样品提供给串联质谱仪。快速样品引入装置可以包括流动注射分析装置，离子迁移率分析装置或快速样品清除装置。指示串联质谱仪在使用处理器的多个采样的质量范围的两个或更多个质量选择窗口上进行碎片扫描。跨质量范围的两个或多个质量选择窗口可以具有固定或可变窗口宽度。在指示串联质谱仪进行碎片扫描之前，可以指示串联质谱仪获得质量范围的质谱。

57. 发明申请

US20130211734A1 Systems and Methods for Calculating Protein Confidence Values 审中-公开
标题翻译：用于计算蛋白质置信度的系统和方法
公开(公告)号：US20130211734A1
公开(公告)日：2013-08-15
申请号：US13697707
申请日：2011-05-12
申请人： Ignat V. Shilov
发明人： Ignat V. Shilov
IPC分类号： G06F19/00
CPC分类号： G16C20/20 , G16B40/10
摘要： Protein confidence values are calculated in proteomic analysis. A protein database is searched for proteins matching peptides found from mass spectrometry of a sample producing a set of proteins and a corresponding set of peptides. Peptide confidence values for the set of peptides are determined. Protein confidence values are calculated for the set of proteins based on the peptide confidence values. A protein is selected from the set of proteins with a largest protein confidence value, the largest protein confidence value is saved for the protein, the protein is removed from the set of proteins, and one or more peptides corresponding to the protein are removed from the set of peptides. Protein confidence values are recalculated for the set of proteins based on the peptide confidence values and an effect of removing the one or more peptides from the set of peptides.
摘要翻译：在蛋白质组学分析中计算蛋白质置信度值。搜索蛋白质数据库，从匹配产生一组蛋白质和相应肽组的样品的质谱的质谱图匹配的蛋白质。确定该组肽的肽置信度值。基于肽置信度值为蛋白质组计算蛋白质置信度值。蛋白质选自具有最大蛋白质置信度值的一组蛋白质，为蛋白质节省了最大的蛋白质置信度值，蛋白质从该组蛋白质中除去，并且从蛋白质相应的一个或多个肽从一套肽。基于肽置信度值和从该组肽中除去一种或多种肽的效果，对蛋白质组重新计算蛋白质置信度值。

58. 发明授权

US08501498B2 Mass tags for quantitative analyses 有权
标题翻译：用于定量分析的质量标签
公开(公告)号：US08501498B2
公开(公告)日：2013-08-06
申请号：US12618452
申请日：2009-11-13
申请人： Xiongwei Yan , Pau-Miau Yuan , Sylvia W. Yuen , Kuo-Liang Hsi , Joe Y. Lam , Krishna G. Upadhya , Subhakar Dey , Darryl J. C. Pappin , Sasi Pillai , Helena Huang , Subhasish Purkayastha
发明人： Xiongwei Yan , Pau-Miau Yuan , Sylvia W. Yuen , Kuo-Liang Hsi , Joe Y. Lam , Krishna G. Upadhya , Subhakar Dey , Darryl J. C. Pappin , Sasi Pillai , Helena Huang , Subhasish Purkayastha
IPC分类号： G01N33/532 , G01N33/534 , G01N33/533 , G01N24/00
CPC分类号： C07D295/185 , C07B2200/05 , C07D239/54 , C07D239/553 , C07K5/0806 , C07K5/1013 , C07K7/06 , C07K7/08 , G01N33/6848 , G01N2458/15 , Y10T436/143333 , Y10T436/24
摘要： This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.
摘要翻译：本发明涉及通过使用独特标记试剂或独特标记试剂组的质量分析来测定分析物的方法，混合物，试剂盒和/或组合物。标记试剂可以是异构体或同量异构体，并且可用于产生适于多重分析标记分析物的混合物。

59. 发明授权

US08389934B2 Heated time of flight source 有权
标题翻译：加热时间的飞行来源
公开(公告)号：US08389934B2
公开(公告)日：2013-03-05
申请号：US12732426
申请日：2010-03-26
申请人： Mihajlo Dzepina , William Loyd , Gregor Sprah
发明人： Mihajlo Dzepina , William Loyd , Gregor Sprah
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/067
摘要： A lens assembly for use in mass spectrometry and a method for reducing contaminant build up on ion optic components in a lens assembly for use in a mass spectrometer are disclosed herein. In various embodiments of applicant's teachings, the lens assembly comprises a plurality of ion optic components assembled to form an ion lens and a heater. The plurality of ion optic components has a generally similar expansion coefficient. The heater is operatively coupled to the ion optic components. The heater heats the ion optic components to reduce the accumulation of debris on the ion optic components. In various embodiments, the method includes receiving, in a lens assembly, ions from an ion source. The lens assembly includes a plurality of ion optic components assembled to form an ion lens, the plurality of ion optic components having a generally similar expansion coefficient. The method also comprises heating the ion optic components to a first temperature.
摘要翻译：本文公开了一种用于质谱的透镜组件和用于减少用于质谱仪的透镜组件中的离子光学部件上积聚的污染物的方法。在申请人的教导的各种实施例中，透镜组件包括组装成离子透镜和加热器的多个离子光学元件。多个离子光学元件具有大致相似的膨胀系数。加热器可操作地耦合到离子光学部件。加热器加热离子光学部件以减少离子光学部件上的碎屑积聚。在各种实施例中，该方法包括在透镜组件中接收离子源的离子。透镜组件包括组装成离子透镜的多个离子光学元件，该多个离子光学部件具有大致相似的膨胀系数。该方法还包括将离子光学元件加热至第一温度。

60. 发明授权

US08384024B2 Tandem differential mobility spectrometers and mass spectrometer for enhanced analysis 有权
标题翻译：串联差示迁移率光谱仪和质谱仪用于增强分析
公开(公告)号：US08384024B2
公开(公告)日：2013-02-26
申请号：US12873493
申请日：2010-09-01
申请人： Raanan A. Miller , Erkinjon G. Nazarov , Paul Vouros
发明人： Raanan A. Miller , Erkinjon G. Nazarov , Paul Vouros
IPC分类号： H01J49/04
CPC分类号： G01N27/624
摘要： The invention relates generally to systems, methods and devices for analyzing samples and, more particularly, to systems using a differential mobility spectrometer in combination with a mass analyzer to enhance the analysis process of constituents of a sample.
摘要翻译：本发明一般涉及用于分析样品的系统，方法和装置，更具体地，涉及使用差示迁移率光谱仪与质量分析器组合以增强样品组分的分析过程的系统。

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