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61. 发明申请

US20130040995A1 NOVEL COMPOUNDS 有权
标题翻译：新型化合物
公开(公告)号：US20130040995A1
公开(公告)日：2013-02-14
申请号：US13639887
申请日：2011-04-08
申请人： John King-Underwood , Kazuhiro Ito , Peter Strong , William Garth Rapeport , Catherine Elisabeth Charron , Peter John Murray , Jonathan Gareth Williams , Stuart Thomas Onions
发明人： John King-Underwood , Kazuhiro Ito , Peter Strong , William Garth Rapeport , Catherine Elisabeth Charron , Peter John Murray , Jonathan Gareth Williams , Stuart Thomas Onions
IPC分类号： C07D401/12 , A61P11/00 , A61P11/06 , A61P17/00 , A61P35/00 , A61P1/04 , A61P19/02 , A61P1/18 , A61P35/04 , A61K31/4439 , A61P17/06
CPC分类号： C07D401/12
摘要： There is provided inter alia a compound of formula (I): wherein R1, J, Ar, L, X, R3 and R4 are as defined in the specification, for use in the treatment of inflammatory disorders.
摘要翻译：尤其提供式（I）化合物：其中R 1，J，Ar，L，X，R 3和R 4如说明书中所定义，用于治疗炎症性疾病。

62. 发明授权

US08299074B2 P38 MAP kinase inhibitors 有权
标题翻译： P38 MAP激酶抑制剂
公开(公告)号：US08299074B2
公开(公告)日：2012-10-30
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/5377 , A61K31/505 , A61K31/445 , A61K31/4427 , C07D413/14 , C07D403/02 , C07D213/02 , C07D211/06
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译：本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中的炎性疾病，包括肺的炎性疾病，如COPD。

63. 发明授权

US08299073B2 P38 MAP kinase inhibitors 有权
标题翻译： P38 MAP激酶抑制剂
公开(公告)号：US08299073B2
公开(公告)日：2012-10-30
申请号：US13133998
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Simon Christopher Hirst , David Michel Adrien Taddei , Catherine Elisabeth Charron
IPC分类号： A61K31/5377 , A61K31/505 , A61K31/445 , A61K31/4427 , A61K31/496 , C07D413/14 , C07D403/02 , C07D213/02 , C07D211/06 , C07D401/02 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其包括其所有的立体异构体，互变异构体和同位素衍生物，其是p38丝裂原活化蛋白激酶的抑制剂（本文称为p38 MAP激酶抑制剂），特别是其α和γ激酶亚型，以及它们在治疗中的用途，包括药物组合，特别是治疗炎症性疾病，包括肺炎性疾病如COPD。

64. 发明授权

US08164519B1 Fast acquisition engine 有权
标题翻译：快速采集引擎
公开(公告)号：US08164519B1
公开(公告)日：2012-04-24
申请号：US12468242
申请日：2009-05-19
申请人： Mario A. Bedoya Martinez , Gareth Williams , David P. Tester
发明人： Mario A. Bedoya Martinez , Gareth Williams , David P. Tester
IPC分类号： G01S19/30 , G01S19/31
CPC分类号： G01S19/34 , G01S19/24
摘要： A method of fast acquisition of a location of a device is disclosed. The method generally includes the steps of (A) repeatedly powering up automatically (i) a radio receiver and (ii) a given subset of a plurality of correlators in some of a plurality of search engines in the device, (B) buffering first data of a plurality of position signals received through the radio receiver over a first period, each of the position signals comprising a respective one of a plurality of code sequences, (C) searching through the first data with the correlators to find at least one of the code sequences, each of the correlators using a search window comprising a fraction of a code length of the code sequences and (D) generating an output signal carrying a location of the device based on the position signals corresponding to the code sequences that were found.
摘要翻译：公开了一种快速获取设备位置的方法。该方法通常包括以下步骤：（A）自动地重新上电（i）无线电接收机和（ii）设备中的多个搜索引擎中的一些中的多个相关器的给定子集，（B）缓冲第一数据通过第一周期通过无线电接收器接收的多个位置信号中的每个位置信号包括多个码序列中的相应一个，（C）通过第一数据与相关器搜索以找到至少一个代码序列，每个相关器使用包括代码序列的代码长度的一部分的搜索窗口，以及（D）基于与所找到的代码序列对应的位置信号来生成携带设备的位置的输出信号。

65. 发明申请

US20110312963A1 P38 MAP KINASE INHIBITORS 有权
标题翻译： P38 MAP激酶抑制剂
公开(公告)号：US20110312963A1
公开(公告)日：2011-12-22
申请号：US13139010
申请日：2009-12-11
申请人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
发明人： Kazuhiro Ito , Peter Strong , William Garth Rapeport , Peter John Murray , John King-Underwood , Jonathan Gareth Williams , Stuart Thomas Onions , Kevin Joly , Catherine Elisabeth Charron
IPC分类号： A61K31/4439 , C07D405/14 , C07D413/14 , C07D401/14 , C07D403/12 , A61K31/5377 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/506 , A61P11/00 , A61P11/06 , A61P17/00 , A61P37/08 , A61P11/02 , A61P27/02 , A61P27/14 , A61P17/06 , A61P1/04 , A61P29/00 , A61P19/02 , A61P1/18 , A61P3/00 , A61P35/00 , A61P35/04 , C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present disclosure relates to compounds of formula (I): which are inhibitors of p38 mitogen-activated protein kinase enzymes, particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD
摘要翻译：本公开涉及式（I）化合物：其是p38丝裂原活化蛋白激酶的抑制剂，特别是其α和γ激酶亚型的抑制剂及其在治疗中的用途，包括在药物组合中，特别是在治疗中的炎性疾病，包括肺的炎性疾病，如COPD

66. 发明授权

US08026342B2 Compositions and methods for binding sphingosine-1-phosphate 有权
标题翻译：用于结合鞘氨醇-1-磷酸的组合物和方法
公开(公告)号：US08026342B2
公开(公告)日：2011-09-27
申请号：US12258383
申请日：2008-10-24
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译：本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。

67. 发明申请

US20100286088A1 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d][1,2,3,5-Tetrazine-8-Carboxylic Acid Amides and Their Use 有权
标题翻译： 3-取代-4-氧代-3,4-二氢咪唑并[5,1-d] [1,2,3,5-四嗪-8-羧酸酰胺及其用途
公开(公告)号：US20100286088A1
公开(公告)日：2010-11-11
申请号：US12808604
申请日：2008-12-16
申请人： Malcolm Francis Graham Stevens , David Cousin , Sharon Jennings , Andrew James McCarroll , John Gareth Williams , Marc Geoffery Hummersone , Jihong Zhang
发明人： Malcolm Francis Graham Stevens , David Cousin , Sharon Jennings , Andrew James McCarroll , John Gareth Williams , Marc Geoffery Hummersone , Jihong Zhang
IPC分类号： A61K31/4188 , C07D487/04 , A61K31/4545 , A61K31/5377 , C07F7/10 , A61K31/695 , A61K31/4245 , A61K31/4192 , C07F9/40 , A61K31/683 , A61P35/00
CPC分类号： C07D487/04 , C07D519/00 , C07F7/10 , C07F7/1804 , C07F9/6561
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及某些3-取代-4-氧代-3,4-二氢 - 咪唑并[5,1-d] [1,2,3,5]四嗪 - 8-羧酸酰胺（本文统称为3TM化合物）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内都用于抑制细胞增殖以及治疗增殖性疾病例如癌症等的用途，以及制备此类化合物。

68. 发明授权

US07829674B2 Compositions and methods for binding sphingosine-1-phosphate 有权
标题翻译：用于结合鞘氨醇-1-磷酸的组合物和方法
公开(公告)号：US07829674B2
公开(公告)日：2010-11-09
申请号：US11924890
申请日：2007-10-26
申请人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
发明人： Roger A. Sabbadini , William A. Garland , Genevieve Hansen , Steven Tarran Jones , David Gareth Williams
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to anti-S1P agents, for example, humanized monoclonal antibodies, and their uses for detection of S1P or for treatment of diseases and conditions associated with S1P.
摘要翻译：本发明涉及抗S1P剂，例如人源化单克隆抗体及其用于检测S1P或用于治疗与S1P相关的疾病和病症的用途。

69. 发明申请

US20100069473A1 Inhibitors Of IKK-Beta Serine-Threonine Protein Kinase 失效
标题翻译： IKK-β丝氨酸 - 苏氨酸蛋白激酶抑制剂
公开(公告)号：US20100069473A1
公开(公告)日：2010-03-18
申请号：US12447271
申请日：2007-10-29
申请人： David Festus Charles Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathon Gareth Williams
发明人： David Festus Charles Moffat , Stephen John Davies , Michael Hugh Charlton , Simon Christopher Hirst , Stuart Thomas Onions , Jonathon Gareth Williams
IPC分类号： A61K31/381 , C07D333/36 , C12N9/99 , A61P35/00 , A61P37/00 , A61P29/00 , A61P11/00 , A61P17/00 , A61P3/10
CPC分类号： C07D333/38
摘要： Compounds of formula (IA) or (IB) are inhibitors of IkB kinase (IKK) activity, and are useful in the treatment of autoimmune and inflammatory diseases: wherein R7 is hydrogen or optionally substituted (C1-C6)alkyl; ring A is an optionally substituted aryl or heteroaryl ring of 5-13 ring atoms; Z is a radical of formula R-L1-Y1—(CH2)z—, wherein: z is 0 or 1; R is a radical of formula (X) or (Y) R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; R6 is hydrogen, or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl or heteroaryl or —(C═O)R3, —(C═O)OR3, or —(C═O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl; Y1 is a bond, —(C═O)—, —S(O2)—, —C(═O)O—, —OC(═O)—, —(C═O)NR3—, —NR3(C═O)—, —S(O2)NR3—, —NR3S(O2)—, or —NR3(C═O)NR4—, wherein R3 and R4 are independently hydrogen or optionally substituted (C1-C6)alkyl, L1 is a divalent linker radical of formula -(Alk1)m(Q)n(Alk2)p- wherein m, n, p, Q, Alk1 and Alk2 are as defined in the claims.
摘要翻译：式（IA）或（IB）的化合物是IkB激酶（IKK）活性的抑制剂，可用于治疗自身免疫性和炎性疾病：其中R 7为氢或任选取代的（C 1 -C 6）烷基; 环A是任选取代的5-13个环原子的芳基或杂芳基环; Z是式R-L1-Y1-（CH2）z-的基团，其中：z是0或1; R是式（X）或（Y）的基团，R 1是羧酸基团（-COOH）或可被一个或多个细胞内酯酶水解成羧酸基团的酯基; R 6是氢或任选取代的C 1 -C 6烷基，C 3 -C 7环烷基，芳基或杂芳基或 - （C = O）R 3， - （C = O）OR 3或 - （C = O）NR 3，其中R 3是氢或任选取代的（C 1 -C 6）烷基; Y1是一个键， - （C = O） - ， - S（O 2） - ， - C（= O）O-，-OC（= O） - ， - （C = O）NR 3 - ， - NR 3 （O） - ， - S（O 2）NR 3 - ， - NR 3 S（O 2） - 或-NR 3（C = O）NR 4 - ，其中R 3和R 4独立地是氢或任选取代的（C 1 -C 6）式 - （Alk1）m（Q）n（Alk2）p的二价连接基团其中m，n，p，Q，Alk1和Alk2如权利要求中所定义。

70. 发明申请

US20080081093A1 COHESIVE NON-FREE FLOWING SWEETENER COMPOSITIONS CONTAINING A GLUING AGENT 审中-公开
标题翻译：含有GLUENT代理的非自由流动SWEETENER组合物
公开(公告)号：US20080081093A1
公开(公告)日：2008-04-03
申请号：US11532667
申请日：2006-09-18
申请人： Renny Ison , Melanie Loades , Gareth Williams
发明人： Renny Ison , Melanie Loades , Gareth Williams
IPC分类号： A23L1/236
CPC分类号： A23L2/60 , A23L27/30 , A23L27/37 , A23P10/28 , A23P30/10
摘要： Cohesive non-free flowing sweetener compositions for adding sweetness to liquid foodstuffs, for example, beverages, having a reduced caloric burden as compared to a conventional sucrose cubes, are provided. More particularly, a cohesive non-free flowing compositions containing a high intensity sweetener, a bulking agent, and a gluing agent in a sufficient quantity to maintain the structural integrity of the sweetener cube, wherein the cohesive non-free flowing compositions has lower caloric burden and an equivalent sweetness to a sucrose cube of the same dimensions and the bulking agent and gluing agent are different substances. Also provided are cohesive non-free flowing sweetener compositions containing sucralose, polydextrose, erythritol, lactose, and trehalose, wherein the cohesive non-free flowing sweetener compositions have a caloric burden of 2, 3, or 4 kilocalories per cube and a sweetness equivalent to about one teaspoon of sucrose. Methods of making such low-calorie cohesive non-free flowing sweetener compositions are also provided.
摘要翻译：提供了与传统蔗糖立方体相比具有降低热量负担的液体食品例如饮料的甜味的粘性非自由流动甜味剂组合物。更具体地，含有足够量的高强度甜味剂，填充剂和胶合剂的粘性非自由流动组合物以保持甜味剂立方体的结构完整性，其中内聚非自由流动组合物具有较低的热量负担并且具有相同尺寸的蔗糖立方体的相当甜度，并且填充剂和胶合剂是不同的物质。还提供了含有三氯半乳蔗糖，聚右旋糖，赤藓糖醇，乳糖和海藻糖的内聚非自由流动甜味剂组合物，其中粘性非自由流动甜味剂组合物具有每立方体2,3或4千卡的热量负担和相当于约一茶匙蔗糖。还提供了制备这种低热量内聚非自由流动甜味剂组合物的方法。

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