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71. 发明授权

US08853428B2 Method for preparing an amino acid from 2 aminobutyrolactone 有权
标题翻译：从2氨基丁内酯制备氨基酸的方法
公开(公告)号：US08853428B2
公开(公告)日：2014-10-07
申请号：US13821318
申请日：2011-10-04
申请人： Robert Huet , Jean-Michel Joerger , Vivien Henryon
发明人： Robert Huet , Jean-Michel Joerger , Vivien Henryon
IPC分类号： C07D307/00
CPC分类号： C07C391/00 , C07C253/16 , C07C319/02 , C07C319/14 , C07C319/24 , C07D307/33 , C07C323/58 , C07C255/28
摘要： The invention relates to a method for preparing an amino acid, or its salts, from 2-aminobutyrolactone (2ABL), said amino acid fitting the formula I, XCH2CH2CHNH2COOH, wherein X is such that X− represents a nucleophilic ion, according to which N-carboxylation of 2-aminobutyrolactone (2ABL) is achieved with carbon dioxide, and the thereby obtained 2ABL carbamate is reactive with an XH reagent or its salts.
摘要翻译：本发明涉及一种由2-氨基丁内酯（2ABL）制备氨基酸或其盐的方法，所述氨基酸适合式I，XCH2CH2CHNH2COOH，其中X表示X-表示亲核离子，根据该方法，N 用二氧化碳实现2-氨基丁内酯（2ABL）的羧化，由此得到的2ABL氨基甲酸酯与XH试剂或其盐反应。

72. 发明授权

US08822706B2 Method for preparing 2-hydroxybutyrolactone 有权
公开(公告)号：US08822706B2
公开(公告)日：2014-09-02
申请号：US13879442
申请日：2011-10-17
申请人： Vivien Henryon , Jerome Monbrun
发明人： Vivien Henryon , Jerome Monbrun
IPC分类号： C07D307/33 , C07C29/09
CPC分类号： C07D307/33 , C07C51/41 , C07C381/12 , C07C59/10
摘要： The invention relates to a method for preparing 2-hydroxybutyrolactone (2HBL) from a compound or its salt or its oligomers, said compound fitting formula (I) CH3—S—CH2CH2CR1R2R3 Wherein R1 represents H R2 represents a group selected from OH; OR4 and OCOR4 wherein R4 represents a group selected from linear, cyclic, alicyclic or branches alkyl groups having from 1 to 10 carbon atoms, and aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, halogens and hydroxyl, amino, nitro and alkoxy groups having from 1 to 10 carbon atoms; and OSiRR′R″ wherein R, R′ and R″ are selected independently of each other from linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, or R1 and R2 represent together ═O, R3 represents COOH or a COOR5 group wherein R5 represents a group selected from linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, benzyl groups and benzyl groups substituted with one or two substituents selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, halogens and hydroxyl, amino, nitro and alkoxy groups having from 1 to 10 carbon atoms, or R3 represents a cyano group, method according to which a sulfonium of said compound is obtained, said sulfonium fitting the formula (II) [CH3][CH2CH2CR1R2CR3][CR6R7R8]S+X− wherein R1, R2 and R3 have the above definition, and R6 and R7 are selected independently of each other from H, linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, and aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, halides and hydroxyl, amino, nitro and alkoxy groups having from 1 to 10 carbon atoms; R8 is selected from H, linear, cyclic, alicyclic or branched alkyl groups having from 1 to 10 carbon atoms, aryl groups having from 6 to 10 carbon atoms, optionally substituted with substituent(s) selected from linear or branched alkyl groups having from 1 to 10 carbon atoms, and attractor groups notably those comprising a function selected from acid, ester, cyano functions and X represents a counter-ion, and the thereby obtained sulfonium is hydrolyzed and 2,4-dihydroxybutyric acid or its salt is cyclized into 2-hydroxybutyrolactone.

73. 发明授权

US08765798B2 Peptide derivatives with therapeutic activity 失效
标题翻译：具有治疗活性的肽衍生物
公开(公告)号：US08765798B2
公开(公告)日：2014-07-01
申请号：US12306259
申请日：2007-06-15
申请人： Gianpaolo Negrisoli , Renato Canevotti
发明人： Gianpaolo Negrisoli , Renato Canevotti
IPC分类号： A61K31/4172 , C07D233/64
CPC分类号： A61K31/4172 , A61K38/00 , C07D233/64 , C07K5/06 , C07K5/06026 , C07K5/06078
摘要： Dipeptide compounds containing a histidine residue proved to have interesting blocking activity on secondary products from lipid oxidative stress, in particular on unsaturated aldehydes such as malondialdehyde and hydroxynonenal, which are known to contribute to the inset of quite a number of chronic pathologies such as neurodegenerative, inflammatory chronic, cardiovascular diseases, diabetes complications and cataract.
摘要翻译：含有组氨酸残基的二肽化合物被证明对来自脂质氧化应激的次生产物具有有趣的阻断活性，特别是对不饱和醛如丙二醛和羟基壬烯醛，这已知有助于插入相当多的慢性病理如神经变性，炎性慢性，心血管疾病，糖尿病并发症和白内障。

74. 发明授权

US08703061B2 Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette 有权
标题翻译：集成模块化单元，包括连接到盒式磁带的分析物浓缩器 - 微反应器装置
公开(公告)号：US08703061B2
公开(公告)日：2014-04-22
申请号：US13487451
申请日：2012-06-04
申请人： Norberto A. Guzman
发明人： Norberto A. Guzman
IPC分类号： G01N27/00 , B01L3/00 , B01L9/00 , G01N33/53 , G01N33/543
CPC分类号： G01N1/405 , B01L3/502715 , B01L3/502753 , B01L9/527 , B01L2200/02 , B01L2200/026 , B01L2200/027 , B01L2200/028 , B01L2200/0631 , B01L2200/10 , B01L2300/021 , B01L2300/0636 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , G01N27/44743 , G01N33/53 , G01N33/5302 , G01N33/543 , G01N33/54313 , G01N33/54353
摘要： The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.
摘要翻译：本发明涉及用于捕获以简单或复杂基质中高或低浓度存在的一种或多种分析物的免疫亲和装置。该设备被设计为集成的模块化单元，并连接到毛细管电泳或液相色谱，用于分离，富集，分离和鉴定聚合物大分子，主要是蛋白质生物标志物。集成模块化单元包括连接到改进的盒式磁带的分析物 - 浓缩器 - 微反应装置。

75. 发明授权

US08652559B2 Method for preparing aseptic packaged instant wet scorched rice 有权
标题翻译：无菌包装即食湿焦米制备方法
公开(公告)号：US08652559B2
公开(公告)日：2014-02-18
申请号：US13132936
申请日：2009-12-02
申请人： Jong-Wook Kim , Chang-Yong Lee
发明人： Jong-Wook Kim , Chang-Yong Lee
IPC分类号： A23L1/40
CPC分类号： A23L7/1965
摘要： The present invention relates to a method for preparing aseptic packaged instant wet scorched rice, which mixes roasted rice, polished rice, and dried scorched rice, sterilizes the mixture, and adds a concentrate extracted from roasted rice, a polygonatum concentrate, and rice cooking water with a rice starch to the mixture to produce wet scorched rice. Subsequently, the thus-produced wet scorched rice is sealed in an aseptic condition, steamed, and cooled to produce aseptic packaged instant wet scorched rice. As the aseptic packaged instant wet scorched rice prepared according to the method of the present invention is sterilized, the rice can be preserved over 6 months or longer at room temperature. Further, the flavor of the roasted rice and the scorched rice is diffused to maximize the unique flavor of the scorched rice. The starch of the scorched rice is eluted to the rice cooking water to provide a predetermined turbidity and to enrich the flavor of the scorched rice. The scorched rice of the present invention is well softened, and has the unique texture of scorched rice. Therefore, the scorched rice of the present invention has a superior quality rivaling that of homemade scorched rice, and can be preserved over a long period of time.
摘要翻译：本发明涉及一种制备无菌包装即食湿焦米的方法，将炒米，抛光米和干烧焦米混合，对混合物进行灭菌，并加入从烤米，多孔浓缩物和米饭烹调水中提取的浓缩物用大米淀粉混合，制成湿焦糯米。随后，将如此生产的湿焦烧米在无菌条件下密封，蒸干，冷却，生成无菌包装的即时湿焦米。由于将根据本发明的方法制备的无菌包装的即时湿焦煲灭菌，所以可以在室温下保存6个月或更长时间。此外，烤米饭和烧焦米饭的味道被扩散以使烧焦米的独特风味最大化。烧焦的米饭的淀粉被洗脱到米饭烹饪水以提供预定的浊度并且丰富烧焦米饭的风味。本发明的烧焦米很好地软化，具有独特的烧焦米的质地。因此，本发明的烧焦米具有与自制烧焦米相当的优良品质，可以长时间保存。

76. 发明授权

US08617618B2 Topical compositions containing magaldrate 有权
标题翻译：含有镁盐的局部组合物
公开(公告)号：US08617618B2
公开(公告)日：2013-12-31
申请号：US12593299
申请日：2008-03-28
申请人： Pier Luigi Guasti
发明人： Pier Luigi Guasti
IPC分类号： A61K33/38 , A61K33/06 , A61K33/30 , A61K33/08
CPC分类号： A61K9/0034 , A61K9/0031 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/12 , A61K9/1652 , A61K31/00 , A61K31/355 , A61K31/375 , A61K33/08 , A61K33/30 , A61K45/06 , A61K47/02 , A61K47/36 , A61K47/42 , A61K2300/00
摘要： Disclosed are topical compositions containing the active ingredient magaldrate mixed with suitable vehicles and excipients.
摘要翻译：公开了含有与合适的载体和赋形剂混合的活性成分镁盐的局部组合物。

77. 发明授权

US08611647B2 Method for generating background image and system for generating background image 有权
标题翻译：用于生成背景图像的方法和用于生成背景图像的系统
公开(公告)号：US08611647B2
公开(公告)日：2013-12-17
申请号：US12374498
申请日：2008-08-11
申请人： Kouji Kataoka
发明人： Kouji Kataoka
IPC分类号： G06K9/00
CPC分类号： H04N5/262 , G06K9/00744 , G06T11/001 , H04N9/76
摘要： An unprocessed image is prepared which is shot against an arbitrary background, including materials to be trimmed. Color values are collected from a plurality of frames of this unprocessed image in a collection point including one or more pixels, whereby a color information set is obtained. From the color information set, it is judged which color shows the background and which color shows the materials to be trimmed, thereby determining an optimum background-side color value. This process is applied to an area where to extract the background from, thereby obtaining a background image into which the background is extracted. This makes it possible to obtain background images from unprocessed images that are shot in busy locations, without traffic controls or dedicated studios.
摘要翻译：准备了一个未经处理的图像，它是针对任意背景拍摄的，包括要修剪的材料。在包括一个或多个像素的收集点中从该未处理图像的多个帧中收集颜色值，由此获得颜色信息集。从颜色信息集合中，判断哪种颜色显示背景，哪种颜色显示要修剪的材料，从而确定最佳的背景侧颜色值。将该处理应用于从中提取背景的区域，从而获得提取背景的背景图像。这使得可以在没有流量控制或专用工作室的情况下从繁忙地点拍摄的未处理图像获得背景图像。

78. 外观设计

USD694566S1 Coffee machine 有权
公开(公告)号：USD694566S1
公开(公告)日：2013-12-03
申请号：US29417682
申请日：2012-04-06
申请人： Jeroen Harthoorn , Maximiliaan Noordanus
设计人： Jeroen Harthoorn , Maximiliaan Noordanus

79. 外观设计

USD693523S1 Medical pet shirt 有权
公开(公告)号：USD693523S1
公开(公告)日：2013-11-12
申请号：US29432088
申请日：2012-09-13
申请人： Nicole Kok-Duson
设计人： Nicole Kok-Duson

80. 发明授权

US08582415B2 Multilayer optical recording medium 有权
标题翻译：多层光记录介质
公开(公告)号：US08582415B2
公开(公告)日：2013-11-12
申请号：US13368573
申请日：2012-02-08
申请人： Atsuko Kosuda , Takashi Kikukawa , Tomoki Ushida , Motohiro Inoue
发明人： Atsuko Kosuda , Takashi Kikukawa , Tomoki Ushida , Motohiro Inoue
IPC分类号： G11B7/24
CPC分类号： G11B7/24038 , G11B2007/24312 , G11B2007/24314 , G11B2007/2432 , G11B2007/25706 , G11B2007/25715
摘要： An object of the present invention is to increase the number of stacked layers in a multilayer optical recording medium while simplifying the design of the multilayer optical recording medium is provided a multilayer optical recording medium including at least four recording and reading layers from which information can be reproduced by light irradiation, the layers stacked through intermediate layers. The multilayer optical recording medium includes a plurality of recording and reading layers that are continuous in order of stacking and includes at least one recording and reading layer group in which reflectance in a stacked state decreases from a near side of a light incident surface to a far side. A single-layer reflectance of the nearest recording and reading layer is set to 0.2% or more and less than 2.0%, and a light transmittance improvement process is applied to the light incident surface.
摘要翻译：本发明的一个目的是增加多层光学记录介质中堆叠层的数量，同时简化多层光学记录介质的设计提供了一种多层光学记录介质，其包括至少四个记录层和读取层，信息可以从该层通过光照射再现，层通过中间层堆叠。多层光学记录介质包括多个按堆叠顺序连续的记录和读取层，并且包括至少一个记录和读取层组，其中堆叠状态的反射率从光入射表面的近侧减小到远侧。最近的记录和读取层的单层反射率设定为0.2％以上且小于2.0％，对光入射面施加透光率提高处理。

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