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71. 发明申请

US20050064514A1 Identification and engineering of antibodies with variant Fc regions and methods of using same 有权
标题翻译：具有变体Fc区的抗体的鉴定和工程及其使用方法
公开(公告)号：US20050064514A1
公开(公告)日：2005-03-24
申请号：US10902588
申请日：2004-07-28
申请人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
发明人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
IPC分类号： C07K16/00 , G01N33/53 , C07H21/04 , C07K16/44 , C12N5/06 , C12P21/04
CPC分类号： A61K39/39558 , A61K2039/505 , C07K16/00 , C07K16/005 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
摘要翻译：本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区相对于包含野生型Fc区的可比较分子，以更大的亲和力结合FcγRIIIA和/或FcγRIIA。本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。本发明的分子特别可用于治疗或预防需要通过FcγAMR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效的治疗性抗体，其作用由ADCC介导。

72. 外观设计

USD963096S1 Inflatable toy 有权
公开(公告)号：USD963096S1
公开(公告)日：2022-09-06
申请号：US29783203
申请日：2021-05-12
申请人： Ling Huang
设计人： Ling Huang

73. 外观设计

USD909378S1 Active stylus 有权
公开(公告)号：USD909378S1
公开(公告)日：2021-02-02
申请号：US29697424
申请日：2019-07-08
申请人： Ling Huang
设计人： Ling Huang

74. 发明授权

US09028815B2 Identification and engineering of antibodies with variant FC regions and methods of using same 有权
标题翻译：用变体FC区鉴定和设计抗体及其使用方法
公开(公告)号：US09028815B2
公开(公告)日：2015-05-12
申请号：US13182209
申请日：2011-07-13
申请人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
发明人： Jeffrey Stavenhagen , Sujata Vijh , Christopher Rankin , Sergey Gorlatov , Ling Huang
IPC分类号： A61K39/395 , A61K39/40 , C07K16/28 , C07K16/32 , C07K16/44 , C07K16/00
CPC分类号： C07K14/70535 , C07K14/36 , C07K14/405 , C07K16/005 , C07K16/283 , C07K16/2887 , C07K16/32 , C07K16/44 , C07K2317/24 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/70 , G01N33/6857 , G01N2333/70535
摘要： The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.
摘要翻译：本发明涉及包括变体Fc区的分子，特别是多肽，更特别是免疫球蛋白（例如，抗体），其中所述变体Fc区相对于野生型Fc区包含至少一个氨基酸修饰，所述变体Fc区相对于包含野生型Fc区的可比分子，以更高的亲和力结合FcγRIIIA和/或FcγRIIA。本发明的分子特别可用于预防，治疗或改善与疾病，病症或感染相关的一种或多种症状。本发明的分子特别可用于治疗或预防需要由FcγR介导的效应细胞功能增强的功效（例如ADCC）的疾病或病症，例如癌症，感染性疾病和增强治疗功效的治疗性抗体，其作用由ADCC介导。

75. 发明授权

US08669349B2 BCR-complex-specific antibodies and methods of using same 有权
标题翻译： BCR-复合物特异性抗体及其使用方法
公开(公告)号：US08669349B2
公开(公告)日：2014-03-11
申请号：US12933882
申请日：2009-03-25
申请人： Leslie Johnson , Ling Huang
发明人： Leslie Johnson , Ling Huang
IPC分类号： C07K16/46 , A61K39/395 , C07H21/04
CPC分类号： C07K16/28 , C07K16/2803 , C07K2317/24 , C07K2317/56
摘要： This invention relates to chimeric and humanized antibodies that specifically bind the BCR complex, and particularly chimeric and humanized antibodies to the BCR complex. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.
摘要翻译：本发明涉及特异性结合BCR复合物的嵌合和人源化抗体，特别是涉及BCR复合物的嵌合和人源化抗体。本发明还涉及将抗体及其组合物用于诊断，预后和治疗诸如癌症，自身免疫性疾病，炎症性疾病和感染性疾病的疾病的方法。

76. 发明申请

US20130293859A1 LARGE FIELD PROJECTION OBJECTIVE FOR LITHOGRAPHY 审中-公开
标题翻译：大图现场投影目标
公开(公告)号：US20130293859A1
公开(公告)日：2013-11-07
申请号：US13976353
申请日：2011-12-07
申请人： Heng Wu , Ling Huang , Guogan Liu
发明人： Heng Wu , Ling Huang , Guogan Liu
IPC分类号： G03F7/20
CPC分类号： G03F7/7015 , G02B13/14 , G03F7/70241
摘要： A lithography projection objective (30) for focusing and imaging a pattern of a reticle onto a wafer including, from the reticle and along an optical axis: a first lens group G31 having a positive refractive power; a second lens group G32 having a positive refractive power; a third lens group G33 having a positive refractive power; and a fourth lens group G34 having a positive refractive power. These four lens groups form a 2× magnification design which has a partial field of view of not smaller than 100 mm; a wavelength band of I-line±5 nm can ensure a sufficient exposure light intensity. Moreover, the present invention also achieves, with a relatively simple structure, the demanded millimeter-level resolution as well as the correction of distortions, field curvatures, astigmatisms and chromatic aberrations in a large field.
摘要翻译：一种用于将掩模版图案聚焦并成像到晶片上的光刻投影物镜（30），包括从光掩模和沿着光轴：具有正折光力的第一透镜组G31; 具有正折射光焦度的第二透镜组G32; 具有正折射光焦度的第三透镜组G33; 以及具有正折光力的第四透镜组G34。这四个透镜组形成2×放大倍率设计，其部分视场不小于100mm; I线±5nm的波长带可以确保足够的曝光光强度。此外，本发明还通过相对简单的结构实现了所需的毫米级分辨率以及在大场中校正失真，场曲率，像散和色差。

77. 发明授权

US08318508B2 Patterning with compositions comprising lipid 有权
标题翻译：用包含脂质的组合物进行图案化
公开(公告)号：US08318508B2
公开(公告)日：2012-11-27
申请号：US12213301
申请日：2008-06-17
申请人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
发明人： Chad A. Mirkin , Ling Huang , Rafael Vega , Steven Lenhert
IPC分类号： G01N1/00
CPC分类号： C09D11/03 , B01J19/0046 , B01J2219/00382 , B01J2219/00387 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00648 , B01J2219/00653 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , B01J2219/00734 , B82Y30/00 , C09D11/30 , C40B50/14 , Y10T428/24802 , Y10T436/143333 , Y10T436/25 , Y10T436/2575
摘要： Better patterning methods, including for better methods for forming biomolecular arrays, including a method comprising: providing a tip and a substrate surface, disposing a patterning composition at the end of the tip, depositing at least some of the patterning composition from the tip to the substrate surface to form a deposit disposed on the substrate surface, wherein the patterning composition comprises at least one lipid, optionally at least one solvent, and at least one patterning species different from the lipid and the optional solvent. The lipid can be a phospholipid such as DOPC. The patterning species can be an oligonucleotide or a protein. Microarrays and nanoarrays can be prepared including nanoscale resolution of deposits. The lipid can activate patterning or increase the rate of patterning. Simplified tip preparation can be achieved. Nanoscopic, SPM, and AFM tips can be used.
摘要翻译：更好的图案化方法，包括用于形成生物分子阵列的更好的方法，包括一种方法，包括：提供尖端和基底表面，在尖端的末端设置图案化组合物，将至少一些图案化组合物从尖端沉积到衬底表面以形成设置在衬底表面上的沉积物，其中所述图案化组合物包含至少一种脂质，任选的至少一种溶剂和至少一种不同于脂质和任选溶剂的图案化物种。脂质可以是磷脂如DOPC。图案化物质可以是寡核苷酸或蛋白质。可以制备微阵列和纳米阵列，包括沉积物的纳米级分辨率。脂质可以激活图案化或增加图案化速率。可以实现简化的尖端准备。可以使用纳米镜，SPM和AFM提示。

78. 发明申请

US20120141731A1 FABRICATION OF MICROSTRUCTURES AND NANOSTRUCTURES USING ETCHING RESIST 审中-公开
标题翻译：使用蚀刻电阻制造微结构和纳米结构
公开(公告)号：US20120141731A1
公开(公告)日：2012-06-07
申请号：US11958350
申请日：2007-12-17
申请人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
发明人： Chad A. Mirkin , Ling Huang , Raymond Sanedrin
IPC分类号： B32B3/00 , H01L21/306 , B44C1/22 , C23F1/00 , B82Y40/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y30/00 , B82Y40/00 , C23F1/02 , C23F1/14 , Y10T428/24355
摘要： Nanostructures and microstructures are formed by patterning methods such as Dip Pen Nanolithography (DPN) or microcontact printing of organic molecules functioning as a resist on a substrate followed by an etching step. The etch resist is a patterning composition and can contain on a substrate including polyethylene glycol (PEG). Positive and negative etch methods can be used.
摘要翻译：纳米结构和微结构通过诸如Dip Pen Nanoithography（DPN）的图案化方法或用作基底上的抗蚀剂的有机分子的微接触印刷形成，然后进行蚀刻步骤。抗蚀剂是图案化组合物，并且可以包含在包含聚乙二醇（PEG）的基材上。可以使用正和负蚀刻方法。

79. 发明授权

US07746571B2 Large-field unit-magnification projection optical system 有权
标题翻译：大场单位放大投影光学系统
公开(公告)号：US07746571B2
公开(公告)日：2010-06-29
申请号：US12302824
申请日：2006-12-04
申请人： Tiejun Li , Ling Huang , Jun Wei
发明人： Tiejun Li , Ling Huang , Jun Wei
IPC分类号： G02B9/60 , G02B17/00
CPC分类号： G02B17/08 , G02B13/26 , G03F7/70225 , G03F7/70791
摘要： The present invention discloses a large-field unit-magnification projection optical system. The optical system includes an optical axis, a spherical concave reflection mirror; a lens group with positive refracting power arranged adjacent the mirror with an air space therebetween. The lens group includes a first plano-convex lens, a negative meniscus lens adjacent the plano-convex lens, a positive lens adjacent the negative meniscus lens, a negative double-convex lens spaced apart far from the positive lens, and a second plano-convex lens. The optical system further includes a pair of prisms each having respective first and second surface. The second surfaces are arranged adjacent the flat surface of the plano-convex lens element on opposite sides of the optical axis and the first surfaces are arranged adjacent object planes and image planes, respectively. Each lens in the lens group and the pair of prisms provide chromatic aberration correction in a spectral region that contains at least g, h and i-line wavelengths. In this projection optical system, the object plane is parallel to the image plane.
摘要翻译：本发明公开了一种大视场单位放大投影光学系统。光学系统包括光轴，球面凹面反射镜; 具有正反射功率的透镜组，其布置在反射镜附近，其间具有空气空间。透镜组包括第一平凸透镜，与平凸透镜相邻的负弯月透镜，邻近负弯月透镜的正透镜，与正透镜间隔开的负双凸透镜，以及第二平凸透镜，凸透镜光学系统还包括一对棱镜，每个棱镜具有相应的第一和第二表面。第二面与光轴的相对侧的平凸透镜元件的平面相邻配置，第一面与物平面和像面分别配置。透镜组中的每个透镜和一对棱镜在包含至少g，h和i线波长的光谱区域中提供色差校正。在该投影光学系统中，物平面与图像平面平行。

80. 发明授权

US07466406B2 Analyte detection using nanowires produced by on-wire lithography 有权
标题翻译：使用在线光刻产生的纳米线的分析物检测
公开(公告)号：US07466406B2
公开(公告)日：2008-12-16
申请号：US11372583
申请日：2006-03-10
申请人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
发明人： Chad A. Mirkin , Lidong Qin , Can Xue , Sungho Park , Ling Huang
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , B82Y15/00 , G01N21/658 , Y10S977/762
摘要： The present invention relates to methods of detecting analytes using nanowires having nanodisk arrays. In particular, the present invention discloses methods of detecting analytes via surface enhanced Raman scattering (SERS) and employing nanowires prepared using on-wire lithography (OWL).
摘要翻译：本发明涉及使用具有纳米盘阵列的纳米线检测分析物的方法。特别地，本发明公开了通过表面增强拉曼散射（SERS）检测分析物并使用在线光刻（OWL）制备的纳米线的方法。

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