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71. 发明授权

US10153147B2 Method of compressing an ion beam 有权
公开(公告)号：US10153147B2
公开(公告)日：2018-12-11
申请号：US15316025
申请日：2015-06-09
申请人： Micromass UK Limited
发明人： Kevin Giles , Jason Lee Wildgoose
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42 , G01N27/62
摘要： A method of mass or ion mobility spectrometry is disclosed comprising: releasing ions from an ion trapping volume into an ion separation region; separating the ions along a longitudinal direction according to a physicochemical property; and compressing the ion beam in a direction orthogonal to the longitudinal axis. The method enables the ions to be focussed without increasing the charge density and hence space-charge effects to undesirable levels.

72. 发明授权

US10128097B2 Low cross-talk fast sample delivery system based upon acoustic droplet ejection 有权
公开(公告)号：US10128097B2
公开(公告)日：2018-11-13
申请号：US15606318
申请日：2017-05-26
申请人： Micromass UK Limited
发明人： Michael Raymond Morris , Steven Derek Pringle , Keith Richardson , Ian Sinclair
IPC分类号： H01J49/10 , H01J49/04 , G01N29/02 , H01J49/00
摘要： An ion source for a mass spectrometer is disclosed comprising an ultrasonic transducer which focuses ultrasonic energy onto a surface of a sample fluid without directly contacting the sample fluid.

73. 发明授权

US10128092B2 Compact mass spectrometer 有权
公开(公告)号：US10128092B2
公开(公告)日：2018-11-13
申请号：US14892374
申请日：2014-05-29
申请人： Micromass UK Limited
发明人： David Gordon , Daniel James Kenny
IPC分类号： H01J49/00 , H01J49/06 , H01J49/24 , H01J49/16
摘要： A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. A first vacuum pump is arranged and adapted to pump the first vacuum chamber, wherein the first vacuum pump is arranged and adapted to maintain the first vacuum chamber at a pressure

74. 发明授权

US10109472B2 Tool free gas cone retaining device for mass spectrometer ion block assembly 有权
公开(公告)号：US10109472B2
公开(公告)日：2018-10-23
申请号：US15022994
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： Steve O'Brien , Ian Trivett
IPC分类号： H01J49/04 , H01J49/24 , H01J49/16 , H01J49/26
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising an ion block or sub-assembly having an internal passage. The atmospheric pressure interface further comprises either an inner sampling cone, a capillary interface or other gas limiting interface. The mass spectrometer comprises a clamp formed from a thermally insulating material and a removable outer gas cone which is slidably inserted into or onto the clamp so that the outer gas cone is retained by the clamp in use. The clamp is arranged and adapted to be pushed by a user into engagement with the ion block or sub-assembly so as to position the outer gas cone adjacent the inner sampling cone, capillary interface or other gas limiting interface so as to secure the outer gas cone to the ion block or sub-assembly and to form a gas tight seal with the ion block or sub-assembly without use of mechanical fasteners.

75. 发明授权

US10109470B2 Time of flight detection system 有权
公开(公告)号：US10109470B2
公开(公告)日：2018-10-23
申请号：US15317326
申请日：2015-06-11
申请人： Micromass UK Limited
发明人： John Brian Hoyes
IPC分类号： H01J49/02 , H01J49/40
摘要： A ion detector system for a mass spectrometer is disclosed comprising a detector comprising an array of sensor pixels, wherein a dimension of the sensor pixels is

76. 发明授权

US10090138B2 Compact mass spectrometer 有权
公开(公告)号：US10090138B2
公开(公告)日：2018-10-02
申请号：US14892406
申请日：2014-05-29
申请人： Micromass UK Limited
发明人： David Gordon , Daniel James Kenny
IPC分类号： H01J49/00 , H01J49/06 , H01J49/24 , H01J49/10
摘要： A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionisation source, a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

77. 发明授权

US10083824B2 Ion mobility spectrometry data directed acquisition 有权
公开(公告)号：US10083824B2
公开(公告)日：2018-09-25
申请号：US15317045
申请日：2015-06-11
申请人： Micromass UK Limited
发明人： Kevin Giles , Martin Raymond Green , Steven Derek Pringle , Keith Richardson , Jason Lee Wildgoose
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0045
摘要： A method of analyzing ions, comprising performing an initial multidimensional survey scan comprising separating parent ions according to a first physico-chemical property and separating said parent ions according to a second physico-chemical property, producing a two-dimensional data set comprising data corresponding to said first physico-chemical property and data corresponding to said second physico-chemical property, identifying one or more target ion species of interest and determining a mode of operation of a mass spectrometer for said target ion species of interest using data relating to said target ion species of interest in said two-dimensional data set, wherein said mode of operation comprises the location of fragmentation of said target ions of interest.

78. 发明授权

US10049866B2 In-source chemical modification of non polar analytes using atmospheric pressure chemical ionisation source 有权
公开(公告)号：US10049866B2
公开(公告)日：2018-08-14
申请号：US15487537
申请日：2017-04-14
申请人： Micromass UK Limited
发明人： David Douce , Gareth R. Jones
IPC分类号： H01J49/14 , H01J49/00 , G01N27/62 , G01N30/72
摘要： A method for analyzing an aliphatic compound by mass spectrometry which comprises: (i) ionizing an aliphatic compound in the presence of a heterocyclic modifier; and (ii) mass analyzing the resulting ions to obtain mass spectrometric data.

79. 发明授权

US09995712B2 Segmented linear ion mobility spectrometer driver 有权
公开(公告)号：US09995712B2
公开(公告)日：2018-06-12
申请号：US15315587
申请日：2015-06-10
申请人： Micromass UK Limited
发明人： Richard Barrington Moulds
IPC分类号： G01N27/62 , H01J49/24 , H01J49/00
CPC分类号： G01N27/622 , H01J49/0031
摘要： An ion mobility spectrometer or separator is disclosed comprises plural groups of electrodes, each group of electrodes comprising: (i) a first electrode connected to a first independently controllable voltage supply; (ii) one or more intermediate electrodes; and (iii) a second electrode connected to a second independently controllable voltage supply, wherein the first electrode, the one or more intermediate electrodes and the second electrode are interconnected by a series of resistors or other components so as to form a resistive divider so that the potential of the one or more intermediate electrodes is determined by the voltages supplied by the first and second voltage supplies and the resistance of the resistors; a drift region; a first device arranged and adapted to pulse a packet of ions into the drift region so that the ions are caused to separate temporally and assume one or more ion distributions; and a control system arranged and adapted: (i) to cause at least some of the independently controllable voltage supplies to supply voltages to at least two adjacent groups of electrodes so as to substantially continuously subject at least part or substantially the whole of the one or more ion distributions to a first non-zero voltage gradient or a first non-zero constant or linear electric field as the one or more ion distributions progress along the drift region; and (ii) to cause at least some of the independently controllable voltage supplies to supply voltages to groups of electrodes other than the at least two adjacent groups of electrodes to create, maintain or apply a second different voltage gradient or a second different electric field across one or more portions of the drift region which are distal from the one or more ion distributions.

80. 发明授权

US09953819B2 Impactor spray atmospheric pressure ion source with target paddle 有权
公开(公告)号：US09953819B2
公开(公告)日：2018-04-24
申请号：US15121508
申请日：2015-02-26
申请人： Micromass UK Limited
发明人： Stevan Bajic
IPC分类号： H01J49/04 , H01J49/14 , H01J49/00 , H01J49/16
CPC分类号： H01J49/045 , H01J49/0031 , H01J49/0445 , H01J49/142 , H01J49/16
摘要： An ion source is provided comprising one or more nebulizers and one or more targets, wherein the one or more nebulizers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more targets and to ionise the droplets to form a plurality of ions. The ion source further comprises one or more electrodes arranged adjacent to and/or attached to the one or more targets wherein the one or more electrodes comprise one or more apertures, notches or cut-outs wherein at least some of the plurality of ions pass, in use, through the one or more apertures, notches or cut-outs.

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