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71. 发明申请

US20140275399A1 PREPARATION OF NOVEL FLUOROCOMPOUNDS, METHODS OF PREPARATION AND COMPOSITIONS MADE THEREFROM 审中-公开
标题翻译：新型荧光素的制备，制备方法和组合物的制备
公开(公告)号：US20140275399A1
公开(公告)日：2014-09-18
申请号：US14245015
申请日：2014-04-04
申请人： Henkel US IP LLC
发明人： Tianzhi Zhang , Matthew P. Burdzy , Dingsong Feng , Yonghui Zhang
IPC分类号： C07C265/08 , C07C271/14 , C08G18/02 , C08F120/24 , C09D133/16 , C08G77/24 , C07F7/02 , C08F126/02
CPC分类号： C08F220/18 , C07C265/08 , C07C271/12 , C07C271/14 , C07C271/20 , C07F7/025 , C07F7/0836 , C07F7/1804 , C08F120/24 , C08F126/02 , C08G18/02 , C08G77/24 , C09D133/16
摘要： Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed.
摘要翻译：公开了新的氟化化合物及其制备和使用方法，以及将新的和旧的含氟化合物引入受控的自由基聚合方法中以有效地制备具有独特和增强的性能的聚合物组合物。公开了各种固化机理和最终用途的类型。

72. 发明授权

US08802152B2 Microporous zirconium silicate for the treatment of hyperkalemia 有权
公开(公告)号：US08802152B2
公开(公告)日：2014-08-12
申请号：US13371080
申请日：2012-02-10
申请人： Donald Jeffrey Keyser , Alvaro F. Guillem
发明人： Donald Jeffrey Keyser , Alvaro F. Guillem
IPC分类号： C07F7/02 , A61K33/24 , A61K9/20 , A61K9/48 , B01J19/18 , B01J39/14 , B01J39/02 , C01B39/00 , B01J19/00 , A61K9/14 , A61K45/06 , A61K33/00
CPC分类号： A61K33/24 , A61K9/14 , A61K9/143 , A61K33/00 , A61K45/06 , B01J19/0013 , B01J19/006 , B01J19/0066 , B01J19/18 , B01J39/02 , B01J39/14 , B01J2219/00063 , B01J2219/00094 , B01J2219/00768 , C01B33/20 , C01B39/00 , C01B39/02 , C01B39/46 , C01P2002/72 , C01P2002/82 , C01P2004/52 , C01P2004/61 , C07F7/025 , Y10T428/2982 , A61K2300/00
摘要： The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of UZSi-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.

73. 发明授权

US08680304B1 Polyglycerol silicone polyesters 有权
标题翻译：聚甘油硅酮聚酯
公开(公告)号：US08680304B1
公开(公告)日：2014-03-25
申请号：US13986024
申请日：2013-03-25
申请人： Thomas George O'Lenick
发明人： Thomas George O'Lenick
IPC分类号： C07F7/02 , C07F7/18
CPC分类号： A61K8/89 , A61Q17/04 , A61Q19/00 , C08G77/14 , C08G77/38
摘要： The present invention is directed toward a series of polyglycerol silicone polyesters with tunable ascetics and performance in cosmetic formulation. These novel polyglycerol silicone polyesters are designed to be high definition polymers. High Definition Polymers is meant that the polymer contains a variety of groups containing different chemical and physical properties that can be controlled by the polymerization process. High definition polymers are polymers are synthesized to have each portion of the polymer to achieve a desired aesthetics. These high definition polymers physical properties can be tuned quickly and easily but the polymerization conditions. The physical properties of the current invention can be tuned rapidly by controlling the ratio of fatty groups, as well as the cross-linker used. The resulting polyglycerol silicone polyesters have outstanding aesthetics, unique solubility and physical properties.
摘要翻译：本发明涉及一系列具有可调节抑制作用和在化妆品制剂中的性能的聚甘油硅氧烷聚酯。这些新型聚甘油硅氧烷聚酯被设计成高分子聚合物。高分子聚合物是指聚合物含有可通过聚合过程控制的不同化学和物理性质的各种基团。高分辨聚合物是合成聚合物以具有聚合物的每一部分以达到期望的美观性。这些高分子聚合物的物理性质可以快速而容易地调整，但聚合条件。通过控制脂肪基团的比例以及所使用的交联剂可以快速调节本发明的物理性质。所得聚甘油硅氧烷聚酯具有出色的美观性，独特的溶解性和物理性能。

74. 发明申请

US20130319290A1 ORGANOAMINODISILANE PRECURSORS AND METHODS FOR DEPOSITING FILMS COMPRISING SAME 有权
标题翻译：有机阴离子表面活性剂和沉积膜的方法
公开(公告)号：US20130319290A1
公开(公告)日：2013-12-05
申请号：US13902375
申请日：2013-05-24
申请人： AIR PRODUCTS AND CHEMICALS, INC.
发明人： Manchao Xiao , Xinjian Lei , Daniel P. Spence , Haripin Chandra , Mark Leonard O'Neill
IPC分类号： C07F7/02 , H01L21/02
CPC分类号： H01L21/02211 , C07F7/025 , C07F7/10 , C23C16/345 , C23C16/402 , C23C16/45542 , C23C16/45553
摘要： Described herein are precursors and methods for forming silicon-containing films. In one aspect, there is a precursor of following Formula I: wherein R1 and R3 are independently selected from linear or branched C3 to C10 alkyl group, a linear or branched C3 to C10 alkenyl group, a linear or branched C3 to C10 alkynyl group, a C1 to C6 dialkylamino group, an electron withdrawing and a C6 to C10 aryl group; R2 and R4 are independently selected from hydrogen, a linear or branched C3 to C10 alkyl group, a linear or branched C3 to C10 alkenyl group, a linear or branched C3 to C10 alkynyl group, a C1 to C6 dialkylamino group, an electron withdrawing, and a C6 to C10 aryl group; and wherein any one, all, or none of R1 and R2, R3 and R4, R1 and R3, or R2 and R4 are linked to form a ring.
摘要翻译：这里描述的是用于形成含硅膜的前体和方法。在一方面，存在下式I的前体：其中R 1和R 3独立地选自直链或支链C 3至C 10烷基，直链或支链C 3至C 10烯基，直链或支链C 3至C 10炔基， C1至C6二烷基氨基，吸电子和C6至C10芳基; R 2和R 4独立地选自氢，直链或支链C 3至C 10烷基，直链或支链C 3至C 10烯基，直链或支链C 3至C 10炔基，C 1至C 6二烷基氨基，和C 6至C 10芳基; 并且其中R 1和R 2，R 3和R 4，R 1和R 3，或R 2和R 4中的任何一个，全部或没有一个连接形成环。

75. 发明授权

US08580992B1 Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis 有权
标题翻译：化学合成中芳基甲基化（苄基化）作为醇基保护的化合物和方法
公开(公告)号：US08580992B1
公开(公告)日：2013-11-12
申请号：US13690423
申请日：2012-11-30
申请人： Florida State University Research Foundation, Inc.
发明人： Gregory Dudley
IPC分类号： C07F7/02
CPC分类号： C07F7/083 , C07C41/14 , C07C67/31 , C07C2601/14 , C07C2603/74 , C07D213/64 , C07C43/164 , C07C43/205 , C07C43/1783 , C07C43/188 , C07C43/166 , C07C69/734
摘要： A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
摘要翻译：苄醇化醇的方法包括在具有预定沸点的芳烃溶剂中混合2-苄氧基-1-甲基吡啶鎓三氟甲磺酸酯; 向混合物中加入酸清除剂; 将待苄化的醇与混合物结合; 通过加热高于环境温度使醇与2-苄氧基-1-甲基吡啶鎓三氟甲磺酸酯反应，生成苄醇; 并从混合物中分离苄化醇。

76. 发明授权

US08512878B2 Diaminopyrene derivative and organic EL device using the same 有权
标题翻译：二氨基芘衍生物和使用其的有机EL器件
公开(公告)号：US08512878B2
公开(公告)日：2013-08-20
申请号：US12599274
申请日：2008-05-07
申请人： Masakazu Funahashi
发明人： Masakazu Funahashi
IPC分类号： H01L51/54 , C07C211/57 , C07D401/10 , C07F7/02 , C07F7/30
CPC分类号： H01L51/0058 , C07C211/61 , C07C2601/14 , C07C2603/50 , C07D213/74 , C07D215/24 , C07D215/38 , C07D401/12 , C07D471/04 , C07F5/027 , C07F7/081 , C07F7/0812 , C07F7/30 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , H01L51/0054 , H01L51/006 , H01L51/0067 , H01L51/5012
摘要： An organic EL device is provided that includes an emitting layer provided between an anode and a cathode. The emitting layer contains a diaminopyrene derivative represented by the following formula (1) as an emitting material for the organic EL device. The diaminopyrene derivative emits light with electrical energy.
摘要翻译：提供一种包括设置在阳极和阴极之间的发光层的有机EL器件。发光层含有作为有机EL元件的发光材料的下述式（1）表示的二氨基芘衍生物。二氨基芘衍生物用电能发光。

77. 发明申请

US20130203940A1 PREPARATION OF STYRENE BUTADIENE RUBBER MASTERBATCH USING POLYAMIDE AND AN EPOXIDIZED SILICA 审中-公开
标题翻译：使用聚酰胺和环氧化二氧化硅制备苯乙烯丁二烯橡胶主板
公开(公告)号：US20130203940A1
公开(公告)日：2013-08-08
申请号：US13594645
申请日：2012-08-24
申请人： Jorge Soto
发明人： Jorge Soto
IPC分类号： C08L9/08 , C07F7/10 , C07F7/02
CPC分类号： C08J3/22 , B60C1/00 , C08J2309/06 , C08J2321/02 , C08J2475/04 , C08J2477/02 , C08K9/06 , C08L9/06 , C08L75/04 , C08L77/02
摘要： A functionalized silica for incorporation into natural and synthetic polymers in latex form using precipitated or fumed silica with at least two organosilicon coupling compounds in an aqueous suspension to allow polyamide to load into the polymer latex or to allow polyurethane to load into the polymer latex without disturbing silica-polymer bonds. Polymer-silica reinforced masterbatches are prepared by addition of the functionalized silica slurry using the formed functionalized silica having two different silanes, one for coupling to polyamide or polyurethane and the polymer, the other for connecting directly to the polymer.
摘要翻译：一种官能化二氧化硅，用于在水性悬浮液中使用具有至少两种有机硅偶联化合物的沉淀或热解法二氧化硅并入胶体形式的天然和合成聚合物，以使聚酰胺负载到聚合物胶乳中或允许聚氨酯加载到聚合物胶乳中而不受干扰二氧化硅 - 聚合物键。通过使用具有两种不同硅烷的形成的官能化二氧化硅，一种用于偶联到聚酰胺或聚氨酯和聚合物，另一种用于直接连接到聚合物上，通过加入官能化的二氧化硅浆料来制备聚合物 - 二氧化硅增强的母料。

78. 发明授权

US08455477B2 Therapeutic compounds 失效
标题翻译：治疗化合物
公开(公告)号：US08455477B2
公开(公告)日：2013-06-04
申请号：US13057325
申请日：2009-07-27
申请人： Jason Katz , James Jewell , Joon Jung , Solomon Kattar , Yongquan Hou , Rachel MacCoss , Satoru Ito
发明人： Jason Katz , James Jewell , Joon Jung , Solomon Kattar , Yongquan Hou , Rachel MacCoss , Satoru Ito
IPC分类号： A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/5377 , A61K31/397 , A61K31/505 , A61K31/495 , A61K31/496 , A61K31/50 , C07F7/02 , C07D487/02 , C07D413/14 , C07D401/02 , C07D401/14 , C07D221/20
CPC分类号： A61K45/06 , A61K31/535 , C07D471/04 , C07D519/00 , A61K2300/00
摘要： The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.
摘要翻译：本发明涉及作为激酶PDK1的抑制剂的吡唑并吡啶和咪唑并吡啶，因此可用于治疗骨髓增生性疾病或癌症。该化合物也可用作其它激酶如FGFR3，NTRK3，RP-S6K和WEE1的抑制剂。此外，本发明化合物还选择性地抑制微管亲和调节激酶（MARK），因此可用于治疗或预防阿尔茨海默氏病。

79. 发明申请

US20130078392A1 HALOGENATED ORGANOAMINOSILANE PRECURSORS AND METHODS FOR DEPOSITING FILMS COMPRISING SAME 有权
标题翻译：用于沉积包含其的膜的前体和前体的方法
公开(公告)号：US20130078392A1
公开(公告)日：2013-03-28
申请号：US13622117
申请日：2012-09-18
申请人： Manchao Xiao , Xinjian Lei , Mark Leonard O'Neill , Bing Han , Ronald Martin Pearlstein , Haripin Chandra , Heather Regina Bowen , Agnes Derecskei-Kovacs
发明人： Manchao Xiao , Xinjian Lei , Mark Leonard O'Neill , Bing Han , Ronald Martin Pearlstein , Haripin Chandra , Heather Regina Bowen , Agnes Derecskei-Kovacs
IPC分类号： C07F7/02
CPC分类号： C07F7/025 , C07F7/12 , C23C16/402 , C23C16/45536 , C23C16/45553 , H01L21/02126 , H01L21/02164 , H01L21/02219 , H01L21/0228 , H01L21/02532 , H01L21/0262
摘要： Described herein are precursors and methods of forming films. In one aspect, there is provided a precursor having Formula I: XmR1nHpSi(NR2R3)4-m-n-p I wherein X is selected from Cl, Br, I; R1 is selected from linear or branched C1-C10 alkyl group, a C2-C12 alkenyl group, a C2-C12 alkynyl group, a C4-C10 cyclic alkyl, and a C6-C10 aryl group; R2 is selected from a linear or branched C1-C10 alkyl, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; R3 is selected from a branched C3-C10 alkyl group, a C3-C12 alkenyl group, a C3-C12 alkynyl group, a C4-C10 cyclic alkyl group, and a C6-C10 aryl group; m is 1 or 2; n is 0, 1, or 2; p is 0, 1 or 2; and m+n+p is less than 4, wherein R2 and R3 are linked or not linked to form a ring.
摘要翻译：这里描述的是形成膜的前体和方法。一方面，提供了具有式I的前体：XmR1nHpSi（NR2R3）4-m-n-p1其中X选自Cl，Br，I; R 1选自直链或支链C 1 -C 10烷基，C 2 -C 12烯基，C 2 -C 12炔基，C 4 -C 10环烷基和C 6 -C 10芳基; R2选自直链或支链C1-C10烷基，C3-C12烯基，C3-C12炔基，C4-C10环烷基和C6-C10芳基; R3选自支链C 3 -C 10烷基，C 3 -C 12烯基，C 3 -C 12炔基，C 4 -C 10环烷基和C 6 -C 10芳基; m为1或2; n为0,1或2; p为0,1或2; 并且m + n + p小于4，其中R2和R3连接或未连接形成环。

80. 发明申请

US20130060026A1 PROCESSES AND INTERMEDIATES FOR MAKING A JAK INHIBITOR 有权
公开(公告)号：US20130060026A1
公开(公告)日：2013-03-07
申请号：US13605331
申请日：2012-09-06
申请人： Jiacheng Zhou , Yongzhong Wu , Pingli Liu , Ganfeng Cao
发明人： Jiacheng Zhou , Yongzhong Wu , Pingli Liu , Ganfeng Cao
IPC分类号： C07D487/04 , C07D491/113 , C07D401/06 , C07F7/02
CPC分类号： C07D491/113 , C07D401/06 , C07D487/04 , C07D491/10
摘要： This invention relates to processes and intermediates for making {1-{1-[3-fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, useful in the treatment of diseases related to the activity of Janus kinases (JAK) including inflammatory disorders, autoimmune disorders, cancer, and other diseases.

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