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81. 发明申请

US20210325304A1 Resonator Networks for Improved Label Detection, Computation, Analyte Sensing, and Tunable Random Number Generation 有权
公开(公告)号：US20210325304A1
公开(公告)日：2021-10-21
申请号：US17363842
申请日：2021-06-30
申请人： Duke University
发明人： Alvin R. Lebeck , Chris Dwyer , Craig Laboda
IPC分类号： G01N21/64
摘要： The present disclosure provides resonator networks adapted to a variety of applications. The networks include fluorophores, quantum dots, dyes, plasmonic nanorods, or other optical resonators maintained in position relative to each other by a backbone (e.g., a backbone composed of DNA). The networks may exhibit optical absorption and re-emission according to specified temporal decay profiles, e.g., to provide temporally-multiplexed labels for imaging or flow cytometry. The networks can include resonators that exhibit a dark state, such that the behavior of the network can be modified by inducing the dark state in one or more resonators. Such networks could be configured as logic gates or other logical elements, e.g., to provide multiplexed detection of analytes by a single network, to permit the temporal decay profile of the network to be adjusted (e.g., to use the networks as a controllable random number generator), or to provide other benefits.

82. 发明申请

US20210322355A1 MODULATORS OF PROSTATE-SPECIFIC G-PROTEIN RECEPTOR (PSGR/OR51E2) AND METHODS OF USING SAME 有权
公开(公告)号：US20210322355A1
公开(公告)日：2021-10-21
申请号：US17355898
申请日：2021-06-23
申请人： Duke University
发明人： Tatjana Abaffy , Hiro Matsunami
IPC分类号： A61K31/203 , A61K47/06 , A61K31/352 , A61K31/7016 , A61K31/19 , A61K31/568 , A61K31/565
摘要： The present disclosure provides, in part, modulators of prostate-specific G-protein receptor (OR51E2/PSGR) and methods of treating, preventing, and diagnosing prostate cancer using the same.

83. 发明申请

US20210318335A1 BIOMARKERS, COMPOSITIONS, AND METHODS FOR DIAGNOSING AND TREATING SUBJECTS EXPOSED TO PROTEIN/HEPARIN COMPLEXES 有权
公开(公告)号：US20210318335A1
公开(公告)日：2021-10-14
申请号：US17271841
申请日：2019-08-28
申请人： DUKE UNIVERSITY
发明人： Sanjay Khandelwal , Gowthami Arepally
IPC分类号： G01N33/68 , C07K16/18 , A61K31/713
摘要： The present disclosure provides methods of determining the presence of the risk of developing complement activation by protein/heparin binding complexes in a subject, methods of determining the presence of complement activation by protein/heparin binding complexes in a subject, and methods of treating diseases including heparin-induced thrombocytopenia (HIT) in a subject by administering a compound capable of blocking the classical pathway of complement activation.

84. 发明申请

US20210309711A1 ANTI-LYPD3 CAR T-CELL THERAPY FOR THE TREATMENT OF CANCER 有权
公开(公告)号：US20210309711A1
公开(公告)日：2021-10-07
申请号：US17261488
申请日：2019-07-19
申请人： DUKE UNIVERSITY
发明人： Qi-Jing Li , Xiao-Fan Wang , Mengyang Chong , Rui Chen
IPC分类号： C07K14/725 , A61K35/17 , C07K16/30 , A61K45/06 , A61P35/00 , C07K14/705
摘要： The present disclosure relates to a chimeric antigen receptor (CAR) molecule that specifically binds LYPD3, and also provides compositions comprising CAR T-cell-derived effector cells specific for LYPD3 and methods of making and using same.

85. 发明授权

US11123333B2 Inhibitors of intracellular invasion 有权
公开(公告)号：US11123333B2
公开(公告)日：2021-09-21
申请号：US16278126
申请日：2019-02-17
申请人： Meharry Medical College , Duke University
发明人： Hua Xie , Chin-Ho Chen
IPC分类号： A61K31/439 , A61K31/166 , A61P31/04 , C12Q1/18 , A61P1/02 , A61K31/4748 , A61K8/02 , A61K8/04 , A61K8/42 , A61K8/49 , A61Q11/00 , G01N33/50
摘要： The disclosure provides compounds that inhibit the invasion of host cells by intracellular parasites. These find use, for example, in treating and preventing periodontitis or a periodontitis-related condition or symptom.

86. 发明申请

US20210278419A1 Compositions and Methods for Identifying and Modulating Metabolic Health 有权
公开(公告)号：US20210278419A1
公开(公告)日：2021-09-09
申请号：US17200886
申请日：2021-03-14
申请人： Duke University
发明人： John F. Rawls , James E.N. Minchin
IPC分类号： G01N33/68 , A61K38/26 , A61K38/28 , A61K39/395 , A61K45/06
摘要： This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for metabolic dysfunction.

87. 发明申请

US20210275149A1 SYSTEMS AND METHODS FOR INTRA-BEAM COMPOUNDING FOR ULTRASOUND IMAGING 有权
公开(公告)号：US20210275149A1
公开(公告)日：2021-09-09
申请号：US16621785
申请日：2018-06-28
申请人： Duke University
发明人： Nicholas Bottenus , Gregg Trahey
IPC分类号： A61B8/00
摘要： A method for ultrasound imaging a target region with an ultrasound system having an ultrasound transducer array with a plurality of ultrasound elements thereon includes: (a) transmitting an ultrasound tracking beam from at least a subset of the plurality of elements of the array to the target region, each of the subset of the plurality of elements emitting a signal of the tracking beam with a respective transmission time shift; (b) receiving a plurality of echo signals at at least of the subset of the plurality of elements of the array, each echo signal being responsive to the tracking pulse; (c) applying the transmission time shift to at at least some of the subset of the respective plurality of elements to the plurality of echo signals received at corresponding ones of the plurality of elements; (d) modifying the transmission time shift and repeating steps (a)-(c) to provide an ultrasound dataset representing a recovered source element domain of the ultrasound dataset; (e) focusing and beamforming the ultrasound dataset to map time signals of the ultrasound dataset and combine channel signals to provide spatial pixel data; and (f) forming an ultrasound image from the spatial pixel data.

88. 发明申请

US20210268066A1 METHODS AND KITS FOR TREATING PAIN 有权
公开(公告)号：US20210268066A1
公开(公告)日：2021-09-02
申请号：US17317333
申请日：2021-05-11
申请人： Duke University
发明人： Ru-Rong Ji , Gang Chen , Zilong Wang , Changyu Jiang , Kaiyuan Wang
IPC分类号： A61K38/17 , A61P25/04 , A61B5/00 , A61K31/485 , C07K16/28
摘要： The present disclosure provides methods and kits for treating pain. More particularly, the present disclosure relates to methods of using PD-L1/PD-1-associated compounds to treat pain and/or bone destruction from bone cancer, and associated kits. The present disclosure also provides methods to assess the efficacy of compounds to suppress PD-1-associated nociceptive neuron activity.

89. 发明申请

US20210260184A1 MULTIVALENT CMV VACCINE AND USES THEREOF 有权
公开(公告)号：US20210260184A1
公开(公告)日：2021-08-26
申请号：US17261554
申请日：2019-07-19
申请人： Duke University
发明人： Sallie PERMAR , Cody NELSON , Jennifer JENKS
IPC分类号： A61K39/295 , A61P31/22 , A61K39/245
摘要： The invention is directed to multivalent HCMV immunogenic compositions and their use.

90. 发明授权

US11099176B2 Lactate biosensors and uses thereof 有权
公开(公告)号：US11099176B2
公开(公告)日：2021-08-24
申请号：US15777061
申请日：2016-11-19
申请人： Duke University
发明人： Homme W. Hellinga , Malin J. Allert
IPC分类号： G01N33/53 , G01N33/542 , G01N21/64 , C07K14/00 , G01N33/566
摘要： The present subject matter provides lactate biosensors as well as compositions, devices, and methods comprising such biosensors.

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