专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明申请

US20100082095A1 Coatings Including Dexamethasone Derivatives And Analogs And Olimus Drugs 有权
标题翻译：包括地塞米松衍生物和类似物和奥林匹克药物的涂料
公开(公告)号：US20100082095A1
公开(公告)日：2010-04-01
申请号：US12240917
申请日：2008-09-29
申请人： Stephen D. Pacetti , John L. Toner , Keith R. Cromack
发明人： Stephen D. Pacetti , John L. Toner , Keith R. Cromack
IPC分类号： A61F2/82 , A61M25/10
CPC分类号： A61L29/16 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/45 , A61L2300/606 , C08L27/16
摘要： The present invention encompasses a coating on the surface of a substrate and the coated substrates. The coating includes a polymer, an olimus drug (sirolimus, everolimus, zotarolimus, etc.), and a dexamethasone derivative. The polymer may be a hydrophobic polymer, preferably a fluoropolymer, and more preferably a fluoropolymer with at least 25% vinylidene fluoride by weight.
摘要翻译：本发明包括在基底表面上的涂层和涂覆的基底。涂层包括聚合物，奥林匹克药物（西罗莫司，依维莫司，佐他莫司等）和地塞米松衍生物。聚合物可以是疏水性聚合物，优选含氟聚合物，更优选具有至少25重量％偏二氟乙烯的含氟聚合物。

82. 发明申请

US20090319031A1 Bioabsorbable Polymeric Stent With Improved Structural And Molecular Weight Integrity 审中-公开
标题翻译：具有改善结构和分子量完整性的生物可吸收聚合物支架
公开(公告)号：US20090319031A1
公开(公告)日：2009-12-24
申请号：US12142281
申请日：2008-06-19
申请人： Yunbing Wang , Stephen D. Pacetti , Carina V. Harold
发明人： Yunbing Wang , Stephen D. Pacetti , Carina V. Harold
IPC分类号： A61F2/82 , H01J37/30
CPC分类号： A61L31/143 , A61L31/148 , B23K26/0624 , B23K2103/42 , B23K2103/50
摘要： Various embodiments of the present invention include implantable medical devices such as stents manufactured from polymers, and more particularly, biodegradable polymers including biodegradable polyesters. Other embodiments include methods of fabricating implantable medical devices from polymers. The devices and methods utilize one or more stabilizers, where each stabilizer may be chosen from the following categories: free radical scavengers, peroxide decomposers, catalyst deactivators, water scavengers, and metal scavengers.
摘要翻译：本发明的各种实施例包括诸如由聚合物制成的支架的可植入医疗装置，更具体地，包括可生物降解的聚酯的可生物降解聚合物。其他实施例包括从聚合物制造可植入医疗装置的方法。装置和方法利用一种或多种稳定剂，其中每种稳定剂可以选自以下类别：自由基清除剂，过氧化物分解剂，催化剂失活剂，除水剂和金属清除剂。

83. 发明申请

US20090297583A1 POLY(ESTER AMIDES) FOR THE CONTROL OF AGENT-RELEASE FROM POLYMERIC COMPOSITIONS 有权
标题翻译： POLY（ESTER AMIDES）用于控制聚合物组合物的发行
公开(公告)号：US20090297583A1
公开(公告)日：2009-12-03
申请号：US12478693
申请日：2009-06-04
申请人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
发明人： JESSICA R. DesNoyer , Stephen D. Pacetti , Lothar W. Kleiner , Syed F.A. Hossainy , Yung-Ming Chen , Gordon Stewart , Gina Zhang
IPC分类号： A61K9/00 , A61K31/765 , A61P9/10
CPC分类号： A61L31/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/16 , A61L2300/416 , A61L2300/604 , C08L77/12
摘要： The present invention generally encompasses a medical article, such as a medical device or coating comprising an agent or combination of agents, wherein the agent is distributed throughout a polymeric matrix. The polymeric matrix comprises an agent and a poly(ester amide) having a design that was preselected to provide a predetermined release rate of the combination of agents from the medical article.
摘要翻译：本发明通常包括医疗制品，例如包含试剂或试剂组合的医疗装置或涂层，其中所述试剂分布在整个聚合物基质中。聚合物基质包含试剂和聚（酯酰胺），该聚（酯酰胺）具有预设以提供来自医药制品的试剂组合的预定释放速率的设计。

84. 发明申请

US20090291111A1 COATING COMPRISING AN AMORPHOUS PRIMER LAYER AND A SEMI-CRYSTALLINE RESERVOIR LAYER 有权
标题翻译：包含不规则前置层和半结晶储层的涂层
公开(公告)号：US20090291111A1
公开(公告)日：2009-11-26
申请号：US12124991
申请日：2008-05-21
申请人： Florencia Lim , Mikael Trollsas , Syed F.A. Hossainy , Stephen D. Pacetti
发明人： Florencia Lim , Mikael Trollsas , Syed F.A. Hossainy , Stephen D. Pacetti
IPC分类号： A61K9/00 , B05D3/06 , A61P9/10 , A61F2/00
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译：本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。

85. 发明申请

US20090252780A1 COATINGS FOR IMPLANTABLE MEDICAL DEVICES 失效
公开(公告)号：US20090252780A1
公开(公告)日：2009-10-08
申请号：US12484045
申请日：2009-06-12
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61K9/00 , A61P43/00
CPC分类号： A61L31/10 , A61N1/0565
摘要： Coatings for implantable medical devices comprising non-fouling moieties or polymers chemically bonded to the surface of the device via chelating structures, and methods of fabricating the coatings are disclosed.

86. 发明申请

US20090148591A1 Methods to improve adhesion of polymer coatings over stents 有权
标题翻译：改善聚合物涂层在支架上的附着力的方法
公开(公告)号：US20090148591A1
公开(公告)日：2009-06-11
申请号：US11953657
申请日：2007-12-10
申请人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
发明人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
IPC分类号： A61L33/00
CPC分类号： A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
摘要： Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.
摘要翻译：公开了改进聚合物涂层在支架聚合物表面上的附着力的方法，包括等离子体处理，施加粘合促进层，用溶剂进行表面处理和机械粗糙化技术。

87. 发明授权

US07507211B2 Guide wire and method of making same 失效
标题翻译：导丝及其制作方法
公开(公告)号：US07507211B2
公开(公告)日：2009-03-24
申请号：US10990654
申请日：2004-11-17
申请人： Stephen D. Pacetti , Douglas H. Gesswein , Emmanuel C. Biagtan
发明人： Stephen D. Pacetti , Douglas H. Gesswein , Emmanuel C. Biagtan
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09083 , A61M2025/09166 , Y10T29/49826
摘要： An improved intracorporeal device such as a guide wire or other guiding member for use within a patient's body that is at least in part visible under magnetic resonance imaging (MRI) but is not detrimentally affected by the imaging is disclosed. The intracorporeal device has a non-conductive proximal core section, an essentially non-magnetic metallic distal core section that is preferably more flexible than the proximal core section, and that has an MRI visible member or coil in the distal section.
摘要翻译：公开了一种改进的体内器件，例如在病人体内使用的引导线或其它引导部件，其在磁共振成像（MRI）下至少部分可见，但不受成像的不利影响。体内装置具有不导电的近端芯部分，基本上非磁性的金属远侧芯部分优选地比近侧芯部更柔性，并且在远侧部分中具有MRI可见部件或线圈。

88. 发明申请

US20090053391A1 Method Of Coating A Drug-Releasing Layer Onto A Substrate 审中-公开
标题翻译：将药物释放层涂覆在基材上的方法
公开(公告)号：US20090053391A1
公开(公告)日：2009-02-26
申请号：US12239328
申请日：2008-09-26
申请人： Florian N. Ludwig , Stephen D. Pacetti
发明人： Florian N. Ludwig , Stephen D. Pacetti
IPC分类号： B05D3/00
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/61 , B05D7/56
摘要： This invention relates to processes for coating a substrate with a drug-containing layer in which the microstructure of the resulting dry drug reservoir layer is not a function of solvent removal.
摘要翻译：本发明涉及用药物含有层涂覆基质的方法，其中所得干药物储存层的微结构不是溶剂去除的函数。

89. 发明申请

US20090012259A1 BIOBENEFICIAL POLYAMIDE/POLYETHYLENE GLYCOL POLYMERS FOR USE WITH DRUG ELUTING STENTS 失效
标题翻译：生物聚酰胺/聚乙烯甘油聚合物与药物治疗
公开(公告)号：US20090012259A1
公开(公告)日：2009-01-08
申请号：US12207416
申请日：2008-09-09
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： C08G73/10 , C08G69/08
CPC分类号： C08G69/44 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/606 , Y10T428/31551 , Y10T428/31725
摘要： Provided herein is a coating comprising a polymer. The polymer comprises at least two different blocks, at least one L1 block with the formula and at least one L2 block with the formula
摘要翻译：本文提供的是包含聚合物的涂层。聚合物包含至少两个不同的嵌段，至少一个具有下式的L1嵌段和至少一个具有下式的L2嵌段

90. 发明申请

US20080262606A1 POLYMERS CONTAINING SILOXANE MONOMERS 有权
标题翻译：含硅氧烷单体的聚合物
公开(公告)号：US20080262606A1
公开(公告)日：2008-10-23
申请号：US12135921
申请日：2008-06-09
申请人： Ni Ding , Stephen D. Pacetti
发明人： Ni Ding , Stephen D. Pacetti
IPC分类号： A61F2/82 , C08G77/04 , A61F2/00
CPC分类号： C08G77/442 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L83/04
摘要： A polymer of siloxanes as flexibility monomers and strength monomers is provided. It is also provided a polymer blend that contains a polymer formed of siloxane monomers and strength monomers and another biocompatible polymer. The biocompatible polymer or polymer blend described herein and optionally a bioactive agent can form a coating on an implantable device such as a drug-delivery stent. The implantable device can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供了作为柔性单体和强度单体的硅氧烷的聚合物。还提供了一种聚合物共混物，其包含由硅氧烷单体和强度单体形成的聚合物和另一种生物相容性聚合物。本文所述的生物相容性聚合物或聚合物共混物和任选的生物活性剂可以在可植入装置如药物递送支架上形成涂层。可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式