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1. 发明授权

US09339592B2 Polymers of fluorinated monomers and hydrocarbon monomers 有权
标题翻译：氟化单体和烃单体的聚合物
公开(公告)号：US09339592B2
公开(公告)日：2016-05-17
申请号：US11784997
申请日：2007-04-09
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： C08L27/12 , C08L23/04 , A61L31/04 , A61L31/10 , A61L31/16 , C08F214/18 , C08F295/00 , C09D127/16 , A61K31/436
CPC分类号： A61L31/048 , A61K31/436 , A61L31/10 , A61L31/16 , A61L2300/416 , C08F214/18 , C08F295/00 , C09D127/16 , C08L27/12 , A61K31/10
摘要： A polymer of fluorinated monomers and hydrocarbon monomers is provided. It is also provided a polymer blend that contains a polymer-formed of fluorinated monomers and hydrocarbon monomers and another biocompatible polymer. The polymer or polymer blend described herein and optionally a bioactive agent can form an implantable device such as a stent or a coating on an implantable device such as a drug-delivery stent, which can be used for treating or preventing a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供氟化单体和烃单体的聚合物。还提供了一种聚合物共混物，其包含由氟化单体和烃单体和另一种生物相容性聚合物形成的聚合物。本文所述的聚合物或聚合物共混物和任选的生物活性剂可以在诸如药物递送支架的可植入装置上形成可植入装置，例如支架或涂层，其可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖，胆管阻塞，输尿管梗阻，肿瘤阻塞或其组合。

2. 发明授权

US09254212B2 Segmented scaffolds and delivery thereof for peripheral applications 有权
标题翻译：分段支架及其周边应用的交付
公开(公告)号：US09254212B2
公开(公告)日：2016-02-09
申请号：US13441756
申请日：2012-04-06
申请人： John E. Papp , Hung T. Nguyen , Justin K. Elerath , Dion I. Herabadi , Michael T. Martins , Kirsten S. King , Scott H. Mueller , Coeta K. Peloquin , Stephen D. Pacetti
发明人： John E. Papp , Hung T. Nguyen , Justin K. Elerath , Dion I. Herabadi , Michael T. Martins , Kirsten S. King , Scott H. Mueller , Coeta K. Peloquin , Stephen D. Pacetti
IPC分类号： A61F2/06 , A61F2/958 , A61F2/966 , A61F2/82
CPC分类号： A61F2/958 , A61F2/844 , A61F2/91 , A61F2/915 , A61F2/966 , A61F2002/826 , A61F2002/9583 , A61F2210/0076 , A61F2250/0019 , A61F2250/0039
摘要： Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps. When the balloon is inflated the gaps between the disconnected scaffold segments stays constant Pillowed or banded balloons are used to deliver the segments.
摘要翻译：由断开的支架段组成的分段支架被输送到输送球囊上的植入部位。这些片段被卷曲到球囊并且通过间隙彼此分离。当气球膨胀时，断开的支架段之间的间隙保持不变。使用枕形或带状气球来递送段。

3. 发明授权

US09061091B2 Methods to improve adhesion of polymer coatings over stents 有权
公开(公告)号：US09061091B2
公开(公告)日：2015-06-23
申请号：US13175684
申请日：2011-07-01
申请人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
发明人： Yunbing Wang , Daniel A. Castro , Stephen D. Pacetti
IPC分类号： A61L33/00 , A61L31/14 , A61L31/10 , B32B27/38 , A61F2/06 , B32B17/06 , A61M29/00
CPC分类号： A61F2/82 , A61F2/06 , A61F2210/0004 , A61F2210/0076 , A61F2250/0067 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61L33/00 , A61L2420/08 , A61M29/00 , B32B17/06 , B32B27/38 , Y10T428/31511 , C08L67/04
摘要： Methods are disclosed to improved adhesion of polymer coatings over polymer surfaces of stents which include plasma treatment, applying an adhesion promoting layer, surface treatments with solvents, and mechanical roughening techniques.

4. 发明授权

US08883244B2 Method for electrostatic coating of a medical device balloon 有权
标题翻译：医疗器械气囊的静电涂覆方法
公开(公告)号：US08883244B2
公开(公告)日：2014-11-11
申请号：US13600038
申请日：2012-08-30
申请人： Cameron K. Kerrigan , Stephen D. Pacetti
发明人： Cameron K. Kerrigan , Stephen D. Pacetti
IPC分类号： B05D3/00 , A61L31/14 , A61L31/16
CPC分类号： A61L31/08 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2420/02 , B05D1/007
摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.
摘要翻译：描述了诸如支架和气囊的医疗装置的静电涂覆方法。该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。聚合物组分可以是球囊壁。然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

5. 发明授权

US08828069B2 Coating construct containing poly(vinyl alcohol) 有权
标题翻译：包含聚（乙烯醇）
公开(公告)号：US08828069B2
公开(公告)日：2014-09-09
申请号：US12546534
申请日：2009-08-24
申请人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar W. Kleiner , Jessica Reneé´ DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/06 , A61L31/16 , A61L31/10
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
摘要： A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
摘要翻译：提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。

6. 发明授权

US08778375B2 Amorphous poly(D,L-lactide) coating 有权
标题翻译：无定形聚（D，L-丙交酯）涂层
公开(公告)号：US08778375B2
公开(公告)日：2014-07-15
申请号：US11117813
申请日：2005-04-29
申请人： Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy , David C. Gale
发明人： Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy , David C. Gale
IPC分类号： A61F2/00 , A61F2/82
CPC分类号： A61L31/10 , A61L31/06 , A61L31/148 , A61L31/16 , C08L101/00 , C09D167/04 , C08L67/04 , C08L2666/02
摘要： Implantable devices formed of or coated with a material that includes an amorphous poly(D,L-lactide) formed of a starting material such as meso-D,L-lactide are provided. The implantable device can be used for the treatment, mitigation, prevention, or inhibition of a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, patent foramen ovale, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.
摘要翻译：提供由包含由诸如内消旋-D，L-丙交酯的原料形成的无定形聚（D，L-丙交酯）的材料形成或涂覆的可植入装置。可植入装置可用于治疗，缓解，预防或抑制动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，卵圆孔未闭，跛行，静脉和人造移植物的吻合增殖，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

7. 发明授权

US08685431B2 Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same 有权
标题翻译：基于具有酯键的共聚物的可植入装置的生物可吸收涂层及其制造方法
公开(公告)号：US08685431B2
公开(公告)日：2014-04-01
申请号：US10805036
申请日：2004-03-16
申请人： Stephen D. Pacetti
发明人： Stephen D. Pacetti
IPC分类号： A61F2/00 , C08G69/26
CPC分类号： A61L31/10 , A61L31/06 , Y10T428/31725 , C08L77/12
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, and the coatings comprise biologically absorbable poly(ester amides).
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，并且涂层包括生物可吸收的聚（酯酰胺）。

8. 发明授权

US08661630B2 Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer 有权
标题翻译：包含非晶底漆层和半结晶储层的涂层
公开(公告)号：US08661630B2
公开(公告)日：2014-03-04
申请号：US12124991
申请日：2008-05-21
申请人： Florencia Lim , Mikael Trollsas , Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Florencia Lim , Mikael Trollsas , Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： A61L27/54 , A61L27/58 , A61P9/00 , A61P9/10
CPC分类号： A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604 , A61L2300/606 , Y10T24/258 , C08L67/04
摘要： The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.
摘要翻译：本发明提供一种包含储存层的涂层，其包含半结晶聚合物和在可植入装置上包含无定形聚合物的底漆层及其制备和使用该涂层的方法。

9. 发明授权

US08658194B2 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 有权
标题翻译：包含亲水物质的可植入医疗装置用涂料及其制造方法
公开(公告)号：US08658194B2
公开(公告)日：2014-02-25
申请号：US12909668
申请日：2010-10-21
申请人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
发明人： Thierry Glauser , Connie S. Kwok , Charles D. Claude , Eugene T. Michal , Yiwen Tang , Irina Astafieva , John Whatley , Stephen D. Pacetti , Ashok Shah
IPC分类号： A61F13/00
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/10 , A61L2300/252 , A61L2300/606 , C08L75/04
摘要： A segmented polyurethane and an amphiphilic random or block copolymer are disclosed. The segmented polyurethane and the amphiphilic random or block copolymer can be used for fabricating a coating for an implantable medical device such as a stent.
摘要翻译：公开了一种分段聚氨酯和两亲无规或嵌段共聚物。分段聚氨酯和两亲无规或嵌段共聚物可用于制造可植入医疗装置例如支架的涂层。

10. 发明授权

US08632845B2 Method of drying bioabsorbable coating over stents 有权
标题翻译：在支架上干燥生物可吸收涂层的方法
公开(公告)号：US08632845B2
公开(公告)日：2014-01-21
申请号：US12766758
申请日：2010-04-23
申请人： Yung-Ming Chen , Jason Van Sciver , Syed F. A. Hossainy , Stephen D. Pacetti
发明人： Yung-Ming Chen , Jason Van Sciver , Syed F. A. Hossainy , Stephen D. Pacetti
IPC分类号： B05D3/04 , A61F2/06
CPC分类号： B29C65/76 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2210/0004 , A61F2210/0076 , A61F2240/001 , A61F2250/0067 , A61F2310/00389 , A61L31/14 , A61L31/148 , A61L2420/02 , B05D1/38 , B05D3/0254 , B05D3/0473 , B29C65/10 , B29K2067/046 , B29K2105/258 , B29L2031/7534
摘要： Various embodiments of methods for coating stents are described herein. Applying a composition including polymer component and solvent to a stent substrate followed by exposing the polymer component to a temperature equal to or greater than a Tg of the polymer component is disclosed. Repeating the applying and exposing one or more times to form a coating with the result that the solvent content of the coating after the final exposing step is at a level suitable for a finished stent is further disclosed.
摘要翻译：本文描述了用于涂覆支架的方法的各种实施例。公开了将包含聚合物组分和溶剂的组合物施用到支架基底，然后将聚合物组分暴露于等于或大于聚合物组分的Tg的温度。重复施加和暴露一次或多次以形成涂层，结果是在最终曝光步骤之后涂层的溶剂含量处于适合成品支架的水平。

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