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1. 发明授权

US11524092B2 Particle suitable for the manufacture of an implantable soft tissue engineering material 有权
公开(公告)号：US11524092B2
公开(公告)日：2022-12-13
申请号：US16650555
申请日：2018-10-04
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： Amélie Béduer , Thomas Braschler , Philippe Renaud
IPC分类号： A61L27/20 , A61F2/00 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/52 , A61L27/54 , A61L27/36 , A61L27/56 , A61F2/12 , A61L24/00 , A61K9/14
摘要： The particle (1) is suitable for the manufacture of an implantable soft tissue engineering material and comprises: a three-dimensionally warped and branched sheet (2) where (i) the three-dimensionally warped and branched sheet (2) is made from a biocompatible material having a Young's modulus of 1 kPa to 1 GPa; (ii) the three-dimensionally warped and branched sheet (2) has an irregular shape which is encompassed in a virtual three-dimensional envelope (3) having a volume VE; (iii) the three-dimensionally warped and branched sheet (2) has a mean sheet thickness T; iv) the three-dimensionally warped and branched sheet (2) has a volume VS; (v) the particle (1) has a Young's modulus of 100 Pa to 15 kPa; and (vi) the particle (1) further comprises a number of protrusions where the three-dimensionally warped and branched sheet (2) reaches the envelope (3); (vii) the particle (1) has a number of interconnected channel-type conduits (5) defined by the branching of the sheet (2) and/or by voids in the sheet (2); and (viii) where the conduits (5) have (a) a mean diameter DC; and (b) an anisotropicity index of 1.01 to 5.00.

2. 发明申请

US20220031909A1 Cross-Linkable Polymer, Hydrogel, and Method of Preparation Thereof 有权
公开(公告)号：US20220031909A1
公开(公告)日：2022-02-03
申请号：US17282154
申请日：2019-10-04
申请人： ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
发明人： Peyman Karami , Dominique Pioletti , Céline Samira Wyss , Pierre-Etienne Bourban , Christophe Moser
IPC分类号： A61L27/20 , C08B37/08 , C08J3/075 , A61L27/52
摘要： The invention relates to a cross-linkable polymer including a base polymer including functional groups at least some of which have been reacted with a first organic molecule including a cross-linkable unit and with a second organic molecule capable of bonding to organic and/or inorganic substrates. The invention further relates to a hydrogel including the cross-linkable polymer that includes cross-linkable polymer strands, wherein at least some of the cross-linkable units of different cross-linkable polymer strands have reacted to form a covalent bond thereby forming a covalently linked network. The invention further relates to a method for the preparation of the hydrogel and to the use of the hydrogel.

3. 发明授权

US10732405B2 Refractive surface 有权
$Refractive surface$
公开(公告)号：US10732405B2
公开(公告)日：2020-08-04
申请号：US15323645
申请日：2015-06-11
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： Mark Pauly , Romain P. Testuz , Yuliy Schwartzburg
IPC分类号： G02B27/00 , G02B27/09 , G02B3/00 , G06F30/17 , G01N21/41
摘要： Method of designing a refractive surface, comprising providing a refractive object having a refractive surface with an initial geometry, determining a refraction of incident illumination through the refractive surface with the initial geometry to create a source irradiance ES distribution on a receiver; and determining a shape of the refractive surface of the refractive object such that a resulting irradiance distribution on the receiver matches a desired target irradiance ET provided by a user.

4. 发明申请

US20150368209A1 4-Pyrimidinylamino-benzenesulfonamide derivatives and their use for the inhibition of polo-like kinase 1 (PLK1) for the treatment of cancer and their use for the treatment of bacterial infections 审中-公开
标题翻译： 4-嘧啶基氨基 - 苯磺酰胺衍生物及其用于抑制球状激酶1（PLK1）用于治疗癌症及其用于治疗细菌感染的用途
公开(公告)号：US20150368209A1
公开(公告)日：2015-12-24
申请号：US14759247
申请日：2014-01-07
申请人： VICHEM CHEMIE KUTATÓ KFT. , ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)
发明人： Zoltán GREFF , Zoltán VARGA , György KÉRI , László ÕRFI , János PATÓ , Péter BÁNHEGYI , Csaba SZÁNTAI-KIS , Stewart COLE , Ruben HARTKOORN , Rita Edina SZÉKELY
IPC分类号： C07D239/42 , C07D413/14 , C07D417/12 , C07D413/12
CPC分类号： C07D239/42 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present invention relates to 4-pyrimidinylamino-benzenesulfonamide derivatives of general formula (I) and pharmaceutically acceptable salts, solvates, hydrates, regioisomeric and polymorphic forms thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the inhibition of polo-like kinases (PLKs) and the treatment of cancer. Said 4-pyrimidinylamino-benzenesulfonamide compounds have been also identified as new drug candidates for the prevention and/or treatment of infectious diseases like bacterial diseases e.g. tuberculosis, including the currently multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) as well as for preventing tuberculosis.
摘要翻译：本发明涉及通式（I）的4-嘧啶基氨基 - 苯磺酰胺衍生物及其药学上可接受的盐，溶剂化物，水合物，区域异构体和多晶型物，它们的制备方法，它们的用途以及含有其中至少一种作为药物活性剂以及药学上可接受的载体，赋形剂和/或稀释剂，特别是抑制polo样激酶（PLK）和癌症治疗。所述4-嘧啶基氨基 - 苯磺酰胺化合物也被鉴定为用于预防和/或治疗感染性疾病如细菌性疾病的新候选药物。结核病，包括目前多药耐药结核病（耐多药结核病），广泛耐药结核病（XDR-TB）以及预防结核病。

5. 发明授权

US08863096B1 Parallel symbolic execution on cluster of commodity hardware 有权
标题翻译：商品硬件集群上的并行符号执行
公开(公告)号：US08863096B1
公开(公告)日：2014-10-14
申请号：US13345585
申请日：2012-01-06
申请人： Stefan Bucur , Cristian Zamfir , George Candea
发明人： Stefan Bucur , Cristian Zamfir , George Candea
IPC分类号： G06F9/44 , G06F9/45 , G06F9/46
CPC分类号： G06F11/3604 , G06F9/5088
摘要： A symbolic execution task is dynamically divided among multiple computing nodes. Each of the multiple computing nodes explores a different portion of a same symbolic execution tree independently of other computing nodes. Workload status updates are received from the multiple computing nodes. A workload status update includes a length of a job queue of a computing node. A list of the multiple computing nodes ordered based on the computing nodes' job queue lengths is generated. A determination is made regarding whether a first computing node in the list is underloaded. A determination is made regarding whether a last computing node in the list is overloaded. Responsive to the first computing node being underloaded and the last computing node being overloaded, a job transfer request is generated that instructs the last computing node to transfer a set of one or more jobs to the first computing node.
摘要翻译：符号执行任务在多个计算节点之间动态划分。多个计算节点中的每一个独立于其他计算节点探索相同符号执行树的不同部分。从多个计算节点接收工作负载状态更新。工作负载状态更新包括计算节点的作业队列的长度。生成基于计算节点的作业队列长度排列的多个计算节点的列表。确定列表中的第一计算节点是否欠载。确定列表中的最后一个计算节点是否过载。响应于第一计算节点被负载并且最后的计算节点被重载，生成作业传送请求，其指示最后的计算节点将一组一个或多个作业传送到第一计算节点。

6. 发明申请

US20140016724A1 Power and Pin Efficient Chip-to-Chip Communications with Common-Mode Rejection and SSO Resilience 有权
标题翻译：具有共模抑制和SSO弹性的功率和引脚高效的芯片到芯片通信
公开(公告)号：US20140016724A1
公开(公告)日：2014-01-16
申请号：US14028240
申请日：2013-09-16
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： Harm Cronie , Amin Shokrollahi
IPC分类号： H04L1/00
CPC分类号： H04L1/0041 , H03M5/04 , H03M5/16 , H03M13/31 , H04L1/0057 , H04L2001/0094
摘要： In bus communications methods and apparatus, a first set of physical signals representing the information to be conveyed over the bus is provided, and mapped to a codeword of a spherical code, wherein a codeword is representable as a vector of a plurality of components and the bus uses at least as many signal lines as components of the vector that are used, mapping the codeword to a second set of physical signals, wherein components of the second set of physical signals can have values from a set of component values having at least three distinct values for at least one component, and providing the second set of physical signals for transmission over the data bus in a physical form.
摘要翻译：在总线通信方法和装置中，提供表示要通过总线传送的信息的第一组物理信号，并将其映射到球码的码字，其中码字可表示为多个分量的向量，并且总线使用至少与所使用的向量的分量相同的信号线，将码字映射到第二组物理信号，其中第二组物理信号的分量可以具有来自具有至少三个的组分值的集合的值提供用于至少一个组件的不同值，以及提供第二组物理信号，以便以物理形式在数据总线上传输。

7. 发明授权

US11577005B2 Composition for bone regeneration 有权
公开(公告)号：US11577005B2
公开(公告)日：2023-02-14
申请号：US15757207
申请日：2015-09-14
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： Ulrike Kettenberger , Dominique Pioletti
IPC分类号： A61L27/52 , A61C17/02 , A61L27/46 , A61L27/54 , A61L27/58 , A61C8/00 , A61C19/06 , A61M5/32 , A61B17/16 , A61C17/022 , A61C17/20
摘要： The composition for bone regeneration, comprises a) a first phase (3) comprising a plurality of cross-linked hydrogel chunks (1) having a mean diameter of less than 1000 μm and incorporating an amount of mineral particles (2); and b) a second phase (4) comprising a physiologically-compatible aqueous liquid acting as a carrier for the chunks; the chunks being embedded in the second phase (4). The mineral particles (2) have a mean diameter of less than 10 μm and the amount of the mineral particles (2) is less than 20 weight-% of the first phase.

8. 发明授权

US11219703B2 Shapeable scaffold material and uses thereof 有权
公开(公告)号：US11219703B2
公开(公告)日：2022-01-11
申请号：US15752752
申请日：2016-08-18
申请人： École Polytechnique Fédérale de Lausanne (EPFL)
发明人： Amélie Barbara Hildegarde Béduer , Thomas Braschler , Philippe Renaud , Giorgio Pietramaggiori , Saja Scherer
IPC分类号： A61L27/56 , A61L24/04 , A61L27/34 , A61L15/42 , A61L15/28 , A61L27/50 , A61L27/20 , A61L27/36 , A61L27/52 , A61L27/38 , A61L27/22
摘要： The invention relates to a scaffold material comprising a plurality of particles of a highly porous polymeric material, characterized in that said scaffold material becomes a shapeable paste once hydrated. The specific features of the particle material impart a special behavior to the scaffold, which can be easily shaped and even highly reversibly compressed, so that in certain aspects it can, if needed, be injected, said capacity to be shaped being maintained over a high range of hydration conditions. A particular aspect of the invention relates, therefore, to the use of such scaffold material for the manufacturing of shapeable body implants, such as breast implants, to the shapeable body implants themselves as well as to non-invasive methods for using thereof in creating or reconstructing a three-dimensional volume in a subject's body part.

9. 发明授权

US10787576B2 Method for the preparation of a coating comprising oligomeric alkynes 有权
公开(公告)号：US10787576B2
公开(公告)日：2020-09-29
申请号：US15570538
申请日：2016-05-02
申请人： ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) EPFL-TTO
发明人： Holger Frauenrath , Stephen Schrettl , Bjoern Schulte , Yves Leterrier
IPC分类号： C09D4/00 , G03F7/025 , C09D5/00 , C09D149/00 , C08F38/00 , G03F7/16
摘要： The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N)x-(L)m-(C═C)n-(L′)o-(N′)y—R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C)n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C1-C25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis of the monomers according to the invention.

10. 发明授权

US10509945B2 Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof 有权
公开(公告)号：US10509945B2
公开(公告)日：2019-12-17
申请号：US16075998
申请日：2017-02-08
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)
发明人： Diego Gabriel Dupouy , Ata Tuna Ciftlik , Deborah Heintze , Martin Gijs
IPC分类号： G06K9/00 , G01N33/574 , G06T7/00
摘要： The invention relates to a method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof. In particular, the invention relates to a method which is a useful tool for use in the field of diagnosis, prevention and/or treatment of disease or disorders, in particular in the field of cancer management and therapy.

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