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1. 发明授权

US07738946B2 System, method and apparatus for the detection of patient-borne fluorescing materials 有权
标题翻译：用于检测病人携带的荧光材料的系统，方法和装置
公开(公告)号：US07738946B2
公开(公告)日：2010-06-15
申请号：US11906706
申请日：2007-10-03
申请人： Marlin O. Thurston , Helen Thurston, legal representative , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

2. 发明申请

US20100092392A1 Pet Scanning Determination of Lymph Nodes Enriched in 124 I Labeled Antibodies for Cancer Patient Prognostication 有权
标题翻译：宠物扫描测定在124 I标记抗体癌症患者预后中丰富的淋巴结
公开(公告)号：US20100092392A1
公开(公告)日：2010-04-15
申请号：US12248074
申请日：2008-10-09
申请人： Marlin O. Thurston
发明人： Marlin O. Thurston
IPC分类号： A61K49/04
CPC分类号： A61K51/1045
摘要： A method for detecting antigen associated with adenocarcinoma commences by forming a 124I conjugate of a preferential locator, such as an antibody, and introducing the conjugate into a patient suspected of having adenocarcinoma. Positron emission tomography (PET) scanning of the patient reveals sites of accumulated conjugate, such sites including lymph nodes. The course of treatment of the patient then is determined by the amount of revealed lymph nodes.
摘要翻译：用于检测与腺癌相关的抗原的方法通过形成优先定位剂例如抗体的124I缀合物，并将该缀合物引入疑似患有腺癌的患者中。患者的正电子发射断层扫描（PET）扫描显示累积结合物的位点，包括淋巴结的位点。然后患者的治疗过程由显露淋巴结的数量决定。

3. 发明授权

US07689269B2 System, method and apparatus for the detection of patient-borne fluorescing nanocrystals 失效
标题翻译：用于检测病人携带的荧光纳米晶体的系统，方法和装置
公开(公告)号：US07689269B2
公开(公告)日：2010-03-30
申请号：US11801549
申请日：2007-05-10
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： G01J3/4406 , A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/027 , G01J3/28 , G01J3/2889 , G01N21/6408 , G01N21/6428
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

4. 发明申请

US20080281172A1 System, method and apparatus for the detection of patient-borne fluorescing nanocrystals 失效
标题翻译：用于检测病人携带的荧光纳米晶体的系统，方法和装置
公开(公告)号：US20080281172A1
公开(公告)日：2008-11-13
申请号：US11801549
申请日：2007-05-10
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： G01J5/28 , A61B6/00
CPC分类号： G01J3/4406 , A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/027 , G01J3/28 , G01J3/2889 , G01N21/6408 , G01N21/6428
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

5. 发明申请

US20110233421A1 Universal Intraoperative Radiation Detection Probe 审中-公开
标题翻译：通用术中放射检测探头
公开(公告)号：US20110233421A1
公开(公告)日：2011-09-29
申请号：US13076495
申请日：2011-03-31
申请人： Marlin O. Thurston , Richard B. Thurston
发明人： Marlin O. Thurston , Richard B. Thurston
IPC分类号： G01T1/161
CPC分类号： G01T1/161 , A61B6/4258
摘要： A radiation-detecting probe instrument has a forward working portion housing a radiation detector and a rearward user directed portion, and is in communication with a control assembly for processing and outputting signals received from the radiation detector correlative to a located radionuclide source emitting energy above 88 KeV (for Pb). The disclosed probe instrument forward portion has an annular housing having a radiation transparent tip. The radiation detector is disposed behind the radiation transparent tip. A characteristic x-ray radiation emitting wafer (e.g., Pb) is disposed either between or behind the radiation transparent tip and the radiation detector. A radiation resistant (e.g., W) shield is disposed between the annular housing and the radiation detector and the characteristic x-ray emission wafer. Radiation emitted from the radionuclide source strikes the wafer causing the wafer to emit the characteristic x-ray radiation of the wafer material, which strikes the radiation detector for generating signals for communication to the said control assembly.
摘要翻译：放射线检测探头仪器具有容纳放射线检测器和向后用户指向部分的前向工作部分，并且与控制组件通信，用于处理和输出从辐射检测器接收的信号，该辐射检测器与放射性核素源相关，发射能量高于88 KeV（Pb）。所公开的探针仪器前部具有具有辐射透明尖端的环形壳体。辐射检测器设置在辐射透明尖端的后面。特征X射线辐射发射晶片（例如，Pb）设置在辐射透明尖端和辐射检测器之间或之后。防辐射（例如，W）屏蔽设置在环形壳体和辐射检测器和特征X射线发射晶片之间。从放射性核素源发射的辐射撞击晶片，导致晶片发射晶片材料的特征X射线辐射，其撞击辐射检测器以产生用于与所述控制组件通信的信号。

6. 发明申请

US20100249583A1 Universal Intraoperative Radiation Detection Probe 审中-公开
标题翻译：通用术中放射检测探头
公开(公告)号：US20100249583A1
公开(公告)日：2010-09-30
申请号：US12730324
申请日：2010-03-24
申请人： Marlin O. Thurston , Richard B. Thurston
发明人： Marlin O. Thurston , Richard B. Thurston
IPC分类号： A61B6/00 , G01T1/161 , G01T1/166 , G01T1/202 , G01T1/24 , G01T7/00
CPC分类号： G01T1/161 , A61B6/4258
摘要： A radiation-detecting probe instrument has a forward working portion housing a radiation detector and a rearward user directed portion, and is in communication with a control assembly for processing and outputting signals received from the radiation detector correlative to a located radionuclide source emitting energy above about 80 KeV. The disclosed probe instrument forward portion has an annular housing having a radiation transparent tip. The radiation detector is disposed behind the radiation transparent tip. A K alpha radiation emitting wafer (e.g., Pb) wafer is disposed between the radiation transparent tip and the radiation detector. A radiation resistant (e.g., W) shield is disposed between the annular housing and the radiation detector and the Pb wafer. Radiation emitted from the radionuclide source strikes the Pb wafer causing the Pb wafer to emit K alpha radiation, which strikes the radiation detector for generating signals for communication the said control assembly.
摘要翻译：放射线检测探针仪器具有容纳放射线检测器和向后用户指向部分的前向工作部分，并且与控制组件通信，用于处理和输出从辐射检测器接收的信号，所述信号与放射性核素源相关，所述放射性核素源发射超过约 80 KeV。所公开的探针仪器前部具有具有辐射透明尖端的环形壳体。辐射检测器设置在辐射透明尖端的后面。 K辐射发射晶片（例如，Pb）晶片设置在辐射透射尖端和辐射检测器之间。防辐射（例如W）屏蔽设置在环形外壳和辐射检测器和Pb晶片之间。从放射性核素源发射的辐射撞击Pb晶片，导致Pb晶片发射Kα辐射，该辐射探测器用于产生用于通信所述控制组件的信号。

7. 发明授权

US08475763B2 Method of determining the course of treatment for a patient having adenocarcinoma 有权
标题翻译：确定患有腺癌的患者的治疗过程的方法
公开(公告)号：US08475763B2
公开(公告)日：2013-07-02
申请号：US12248074
申请日：2008-10-09
申请人： Marlin O. Thurston
发明人： Marlin O. Thurston
IPC分类号： A61K51/10 , A61K49/04
CPC分类号： A61K51/1045
摘要： A method for detecting antigen associated with adenocarcinoma commences by forming a 124I conjugate of a preferential locator, such as an antibody, and introducing the conjugate into a patient suspected of having adenocarcinoma. Positron emission tomography (PET) scanning of the patient reveals sites of accumulated conjugate, such sites including lymph nodes. The course of treatment of the patient then is determined by the amount of revealed lymph nodes.
摘要翻译：用于检测与腺癌相关的抗原的方法通过形成优先定位剂例如抗体的124I缀合物，并将该缀合物引入疑似患有腺癌的患者中。患者的正电子发射断层扫描（PET）扫描显示累积结合物的位点，包括淋巴结的位点。然后患者的治疗过程由显露淋巴结的数量决定。

8. 发明申请

US20090208417A1 Detection and Localized Imaging of Cancer Using X-Ray Fluorescent Nanoparticle/Preferential Locator Conjugates 审中-公开
标题翻译：使用X射线荧光纳米颗粒/优先定位器缀合物检测和定位癌症
公开(公告)号：US20090208417A1
公开(公告)日：2009-08-20
申请号：US12365939
申请日：2009-02-05
申请人： Marlin O. Thurston , Vishwanath V. Subramaniam
发明人： Marlin O. Thurston , Vishwanath V. Subramaniam
IPC分类号： A61K49/08
CPC分类号： A61K49/0428 , B82Y5/00
摘要： A method for detecting gold or other nanoparticles conjugated to preferential locators commences by contacting tissue suspected of being neoplastic with gold nanoparticle/preferential locator conjugates for a time adequate for the conjugates to bind with the tissue. A beam of gamma photons (such as from, 99mTc) is directed at the conjugate bound tissue to remove electrons from the K-shell or L-shell, for example, of the gold nanoparticles. The removed electrons can be detected for locating neoplastic tissue or X-ray fluorescence corresponding to an electron transitioning from one shell to another shell can be detected, or by detecting resulting X-ray fluorescence corresponding to an electron transitioning from one shell to another shell, such as X-ray fluorescence arising from K-alpha emission corresponding to an electron transitioning from the L shell to the K shell. Additional X-ray fluorescing detecting molecules include Ag, I, Fe, Tc, Zn, Mn, Cr (trivalent).
摘要翻译：用于检测与优先定位器缀合的金或其他纳米颗粒的方法是通过将疑似肿瘤的组织与金纳米颗粒/优先定位剂缀合物接触足以使结合物与组织结合的时间开始的。伽马光子束（例如，99mTc）被引导到缀合物结合的组织以从例如金纳米颗粒的K-壳或L-壳去除电子。可以检测去除的电子以定位肿瘤组织，或者可以检测对应于从一个壳向另一个壳转化的电子的X射线荧光，或通过检测对应于从一个壳转移到另一个壳的电子转移的所得X射线荧光，例如对应于从L壳向K壳转移的电子的K-α发射产生的X射线荧光。另外的X射线荧光检测分子包括Ag，I，Fe，Tc，Zn，Mn，Cr（三价）。

9. 发明申请

US20080281208A1 System, method and apparatus for the detection of patient-borne fluorescing materials 有权
标题翻译：用于检测病人携带的荧光材料的系统，方法和装置
公开(公告)号：US20080281208A1
公开(公告)日：2008-11-13
申请号：US11906706
申请日：2007-10-03
申请人： Marlin O. Thurston , Helen Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Helen Thurston , Karl W. Olson
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

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