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1. 发明授权

US5495111A Crystal array based localizer for tissue sampling 失效
标题翻译：用于组织采样的基于水晶阵列的定位器
公开(公告)号：US5495111A
公开(公告)日：1996-02-27
申请号：US329319
申请日：1994-10-26
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： G01T1/29 , G01T7/00 , G01T1/24
CPC分类号： G01T1/2942 , G01T7/00
摘要： Intended for use in a pathology laboratory, the apparatus includes a multi-segment crystal array over which is positioned a platform supported receiving region with a pattern carrying indicia emulating and in registry with the pattern of the crystal array segments. The tissue carrying a radiolabeled locator is positioned on the receiving region and the photon emission count values for each segment are compiled and displayed at a computer monitor or as a print-out in conjunction with crystal segment identification. Observation of the count values by a pathologist then shows the location over a segment of highest count value at which locator is more likely to be concentrated. Sectioning then is carried out at that location.
摘要翻译：旨在用于病理学实验室中，该装置包括多段晶体阵列，在其上定位有平台支撑的接收区域，其具有模拟模式并与晶体阵列段的图案对齐的模式。携带放射性标记的定位器的组织定位在接收区域上，并且每个段的光子发射计数值被编译并显示在计算机监视器处或作为结合晶片段识别的打印输出。然后由病理学家观察计数值，然后显示定位器更有可能集中在最高计数值的一段上的位置。然后在那个地方执行剖面。

2. 发明授权

US5441050A Radiation responsive surgical instrument 失效
标题翻译：辐射反应手术器械
公开(公告)号：US5441050A
公开(公告)日：1995-08-15
申请号：US992622
申请日：1992-12-18
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B6/00 , A61B17/00 , A61B19/00 , G01T1/161
CPC分类号： G01T1/161 , A61B17/00 , A61B6/4258 , A61B2017/00079 , A61B2017/00438 , A61B2090/3614
摘要： A crystal containing detector particularly suited for use in immunoguided surgery capable of detecting gamma emissions present at tumor sites. The instrument utilizes a cadmium-zinc-telluride detector crystal which may be retained within a finger mount positioned over the surgeon's finger. Within this mount there also is incorporated a first preamplification stage designed to accumulate charge signals from the detector as well as to drive a relatively short length of cable to a second preamplification stage located, for example, within a housing at the surgeon's upper arm. The small finger mounted probe may be moved between operative orientations at the underside of the tip of the finger to stand-by orientations at the top of the finger adjacent the knuckles. In an additional embodiment, the finger probe incorporates a sodium iodide crystal, the scintillations from which are transmitted via a short length of fiber optic cable to an upper arm mounted housing which contains a photomultiplier tube. Signals from the remote, arm-mounted housing then are transmitted via longer cabling or the like to a control console.
摘要翻译：一种含晶体检测器，特别适用于能够检测肿瘤部位存在的γ发射的免疫手术。仪器使用镉 - 锌 - 碲化物检测器晶体，其可以保留在位于外科医生手指上的手指支架内。在该安装件内还包括第一预放大级，其被设计为累积来自检测器的电荷信号，以及将较短长度的电缆驱动到位于外科医生的上臂处的壳体内的第二预扩增级。小手指安装的探针可以在手指尖端的下侧的操作方向之间移动，以在靠近指关节的手指的顶部处的待机取向。在另外的实施例中，手指探针结合了碘化钠晶体，其中的闪烁通过短长度的光纤电缆传输到包含光电倍增管的上臂安装的外壳。远程手臂式外壳的信号通过较长的布线等传输到控制台。

3. 发明授权

US4276029A Visual cue simulator 失效
标题翻译：视觉提示模拟器
公开(公告)号：US4276029A
公开(公告)日：1981-06-30
申请号：US40059
申请日：1979-05-17
申请人： Richard D. Gilson , Marlin O. Thurston , Karl W. Olson , Ronald W. Ventola
发明人： Richard D. Gilson , Marlin O. Thurston , Karl W. Olson , Ronald W. Ventola
IPC分类号： G09B9/30 , G09B9/08 , H04N7/18
CPC分类号： G09B9/302
摘要： A simulator arrangement wherein visual cues are generated by a video system at a display surface (18) spaced from an eye position (14). The image at the display surface is formed as longitudinal boundaries emanating from a vanishing point (VP) positioned a predetermined distance above a fixed horizon (30) image. Hue and texture visual information are developed between the longitudinal boundaries from a memory function (178). The slopes of the longitudinal boundaries are developed as the quotient of the value of the transverse displacement of a boundary from the corresponding position of the eye position divided by a value representing simulated height of the eye position. The arrangement finds particular utilization in conjunction with flight trainers.
摘要翻译：一种模拟器装置，其中在与眼睛位置（14）间隔开的显示表面（18）处由视频系统产生视觉提示。显示表面上的图像形成为从位于固定水平线（30）图像上方预定距离的消失点（VP）发出的纵向边界。在记忆功能（178）的纵向边界之间形成色相和纹理视觉信息。纵向边界的斜率作为从眼睛位置的相应位置除以表示眼睛位置的模拟高度的值的边界的横向位移值的值来展开。该安排与飞行训练员结合起来特别有用。

4. 发明授权

US07738946B2 System, method and apparatus for the detection of patient-borne fluorescing materials 有权
标题翻译：用于检测病人携带的荧光材料的系统，方法和装置
公开(公告)号：US07738946B2
公开(公告)日：2010-06-15
申请号：US11906706
申请日：2007-10-03
申请人： Marlin O. Thurston , Helen Thurston, legal representative , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

5. 发明授权

US5857463A Remotely controlled apparatus and system for tracking and locating a source of photoemissions 失效
标题翻译：遥控设备和系统，用于跟踪和定位光摄取源
公开(公告)号：US5857463A
公开(公告)日：1999-01-12
申请号：US543032
申请日：1995-10-13
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： G01T1/161 , G01T1/24 , A61B5/00
CPC分类号： G01T1/161 , A61B6/4258 , Y10S977/873
摘要： System and apparatus particularly suited for tracking a radiopharmaceutical present within a lymph duct and locating a sentinel node within which the radiopharmaceutical has concentrated. A smaller, straight, hand-held probe is employed carrying two hand actuable switches. For tracking procedures, the probe is moved in an undulatory manner wherein the location of the radiopharmaceutical containing duct is determined by observing a graphics readout developed preferably employing a circularly accessed data memory. When the region of the sentinel node is approached, a switch on the probe device is actuated by the surgeon to carry out a sequence of squelching operations until a small node locating region is defined. At that point in the procedure, the straight small probe will be pointed at and in adjacency with the radiopharmaceutical containing sentinel node. The probe-mounted switches are configured to apply preset current levels upon the probe pre-amplifier power supply. These levels are detected, identified by a discriminator and emulating signals are generated. A sterilizable remote switch provides a squelch threaded level trim function.
摘要翻译：特别适用于跟踪存在于淋巴管内的放射性药物并定位放射性药物集中在其中的前哨淋巴结的系统和装置。采用较小直的手持式探头承载双手可致动开关。对于跟踪程序，探针以波动方式移动，其中通过观察优选采用循环访问的数据存储器开发的图形读出来确定放射性药物容纳管道的位置。当前哨淋巴结的区域接近时，外科医生启动探针装置上的一个开关，以执行一系列压制操作，直到定义小节点定位区域。在该过程的那一点上，直接的小探针将被指向并且与包含前哨淋巴结的放射性药物相邻。探头安装的开关配置为在探头前置放大器电源上施加预设电流电平。通过鉴别器检测这些电平，并产生仿真信号。可灭菌的遥控开关提供静噪线程调整功能。

6. 发明授权

US07689269B2 System, method and apparatus for the detection of patient-borne fluorescing nanocrystals 失效
标题翻译：用于检测病人携带的荧光纳米晶体的系统，方法和装置
公开(公告)号：US07689269B2
公开(公告)日：2010-03-30
申请号：US11801549
申请日：2007-05-10
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B6/00 , A61B8/00
CPC分类号： G01J3/4406 , A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/027 , G01J3/28 , G01J3/2889 , G01N21/6408 , G01N21/6428
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

7. 发明申请

US20080281172A1 System, method and apparatus for the detection of patient-borne fluorescing nanocrystals 失效
标题翻译：用于检测病人携带的荧光纳米晶体的系统，方法和装置
公开(公告)号：US20080281172A1
公开(公告)日：2008-11-13
申请号：US11801549
申请日：2007-05-10
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： G01J5/28 , A61B6/00
CPC分类号： G01J3/4406 , A61B5/0059 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/027 , G01J3/28 , G01J3/2889 , G01N21/6408 , G01N21/6428
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing nanocrystal tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光纳米晶体示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

8. 发明授权

US5682888A Apparatus and system for detecting and locating photon emissions with remote switch control 失效
标题翻译：用于通过远程开关控制来检测和定位光子发射的装置和系统
公开(公告)号：US5682888A
公开(公告)日：1997-11-04
申请号：US662600
申请日：1996-06-13
申请人： Karl W. Olson , Marlin O. Thurston
发明人： Karl W. Olson , Marlin O. Thurston
IPC分类号： A61B17/00 , G01T1/161 , A61B5/00
CPC分类号： G01T1/161 , A61B6/4258 , A61B2017/00119
摘要： A probe instrument which is formed having a unitary housing with indented switch actuating surfaces intended for surgical procedures employs internally disposed piezoelectric switching components within an elongate internally disposed switch receiving channel. The forward end of the instrument supports a crystal containing detector assembly with a preamplifier and associated leads which extend within a detector signal channel spaced from the switch receiving channel and protected therefrom by a shield wall. The piezoelectric components are held in preloaded association adjacent outwardly disposed switch actuating surfaces by a dual wedge switch support assembly. An elongate cable is permanently attached to the rearward end of the housing component through the utilization of a medical grade silicone seal and relief component.
摘要翻译：形成有具有用于外科手术的凹入开关致动表面的单一壳体的探针仪器在内部设置的细长的开关接收通道内采用内部设置的压电开关部件。仪器的前端支撑含晶体的检测器组件，其具有前置放大器和相关联的引线，其在与开关接收通道间隔开的检测器信号通道内延伸并由屏蔽壁保护。压电部件通过双楔形开关支撑组件保持在预加载的关联中，邻近向外设置的开关致动表面。细长电缆通过使用医用级硅胶密封和浮雕部件而永久地附接到壳体部件的后端。

9. 发明申请

US20080281208A1 System, method and apparatus for the detection of patient-borne fluorescing materials 有权
标题翻译：用于检测病人携带的荧光材料的系统，方法和装置
公开(公告)号：US20080281208A1
公开(公告)日：2008-11-13
申请号：US11906706
申请日：2007-10-03
申请人： Marlin O. Thurston , Helen Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Helen Thurston , Karl W. Olson
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/418
摘要： System, method and apparatus wherein a probe employing non-imagining optics is utilized in conjunction with a fluorescing (e.g., nanocrystal) tracer at the body of a patient. Excitation components within the probe working end are utilized to excite the nanocrystals to fluoresce at wavelengths in the near infrared region, such fluorescent energy is homogenized by interacting with involved tissue to provide a uniform fluorescing intensity over the surface of a photo-detector. Initialization and background determination procedures are described along with a technique for determining statistically significant levels of fluorescing activity.
摘要翻译：系统，方法和装置，其中使用非想象光学元件的探针与患者体内的荧光（例如，纳米晶体）示踪剂结合使用。探针工作端内的激发元件用于激发纳米晶体以在近红外区域的波长发荧光，通过与所涉及的组织相互作用使荧光能量均匀化，以在光检测器的表面上提供均匀的荧光强度。描述初始化和背景确定程序以及用于确定统计学显着水平的荧光活性的技术。

10. 发明授权

US06222193B1 Radiation responsive surgical probe apparatus 有权
标题翻译：辐射反应手术探针装置
公开(公告)号：US06222193B1
公开(公告)日：2001-04-24
申请号：US09167704
申请日：1998-10-06
申请人： Marlin O. Thurston , Karl W. Olson
发明人： Marlin O. Thurston , Karl W. Olson
IPC分类号： A61B600
CPC分类号： G01T1/161 , A61B6/4258
摘要： A hand-held surgical probe is provided with a crystal detector mount architecture wherein a rigid mounting of key components is achieved. In one embodiment, the crystal detector mount is supported and suspended by a vibration damping suspension externally located with respect to the crystal detector mount. The crystal detector mount architecture and vibration damping suspension act to reduce a variety of noise phenomena.
摘要翻译：手持式手术探针具有晶体检测器安装架构，其中实现了关键部件的刚性安装。在一个实施例中，晶体检测器支架由相对于晶体检测器支架外部的振动阻尼悬架支撑和悬挂。晶体检测器安装架构和减震悬架可减少各种噪声现象。

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