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1. 发明申请

US20140038294A1 SYSTEMS AND METHODS FOR ENGINEERING NUCLEIC ACID CONSTRUCTS USING SCORING TECHNIQUES 审中-公开
标题翻译：使用分选技术工程化核酸结构的系统和方法
公开(公告)号：US20140038294A1
公开(公告)日：2014-02-06
申请号：US13650049
申请日：2012-10-11
申请人： Amryis Biotechnologies, Inc.
发明人： Darren M. Platt , Michael W. Bissell , Sunil S. Chandran , Brian L. Hawthorne , Erik Jedediah Dean , Christopher Dolan
IPC分类号： C40B30/02
CPC分类号： G16B35/00 , G16B30/00 , G16C20/60
摘要： Systems and methods are provided for defining a nucleic acid construct for integration at locus L of an organism. Nucleic acid requests are received, each such request specifying a genetic change to L. The request are expanded into component polynucleotides which are then arranged into {AR1, . . . , ARm} different arrangements, each ARi in {AR1, . . . , ARm} defining a different arrangement of the component polynucleotides. A score Si for each ARi in {AR1, . . . , ARm} is determined based on whether source constructs encoding a portion of ARi are physically present. An ARf in {AR1, . . . , ARm} is selected based on the score for ARf. Primer pairs are calculated to amplify the portions of ARf not represented in the source constructs. The portions of ARf amplified by the primer pairs and the portions of ARf in the source constructs, ordered by ARf, define the nucleic acid construct.
摘要翻译：提供了用于定义用于在生物体的基因座L处整合的核酸构建体的系统和方法。接收核酸请求，每个这样的请求指定对L的遗传变化。该请求被扩展成组分多核苷酸，然后将其排列成{AR1，...。。。，ARm}不同的安排，每个ARi在{AR1，。。。，ARm}定义组分多核苷酸的不同排列。每个ARi在{AR1，。。。 ARm}是基于编码ARi的一部分的源结构是否物理存在来确定。 {AR1，。。。，ARm}根据ARf的得分进行选择。计算引物对以扩增源结构中未表示的部分ARf。通过引物对扩增的ARf的部分和由ARf排序的源结构中的ARf的部分定义了核酸构建体。

2. 发明授权

US08332160B1 Systems and methods for engineering nucleic acid constructs using scoring techniques 有权
标题翻译：使用评分技术设计核酸构建体的系统和方法
公开(公告)号：US08332160B1
公开(公告)日：2012-12-11
申请号：US13442625
申请日：2012-04-09
申请人： Darren M. Platt , Michael W. Bissell , Sunil S. Chandran , Brian L. Hawthorne , Erik Jedediah Dean , Christopher Dolan
发明人： Darren M. Platt , Michael W. Bissell , Sunil S. Chandran , Brian L. Hawthorne , Erik Jedediah Dean , Christopher Dolan
IPC分类号： G06F19/00 , G06F15/00 , G11C17/00 , G01N33/48
CPC分类号： C40B30/02 , G06F19/22
摘要： Systems and methods are provided for defining a nucleic acid construct for integration at locus L of an organism. Nucleic acid requests are received, each such request specifying a genetic change to L. The request are expanded into component polynucleotides which are then arranged into {AR1, . . . , ARm} different arrangements, each ARi in {AR1, . . . , ARm} defining a different arrangement of the component polynucleotides. A score Si for each ARi in {AR1, . . . , ARm} is determined based on whether source constructs encoding a portion ofARi are physically present. An ARf in {AR1, . . . , ARm} is selected based on the score for ARf. Primer pairs are calculated to amplify the portions of ARf not represented in the source constructs. The portions of ARf amplified by the primer pairs and the portions of ARf in the source constructs, ordered by ARf, define the nucleic acid construct.
摘要翻译：提供了用于定义用于在生物体的基因座L处整合的核酸构建体的系统和方法。接收核酸请求，每个这样的请求指定对L的遗传变化。该请求被扩展成组分多核苷酸，然后将其排列成{AR1，...。。。，ARm}不同的安排，每个ARi在{AR1，。。。，ARm}定义组分多核苷酸的不同排列。每个ARi在{AR1，。。。 ARm}是基于是否存在编码一部分的ARi的源结构来确定的。 {AR1，。。。，ARm}根据ARf的得分进行选择。计算引物对以扩增源结构中未表示的部分ARf。通过引物对扩增的ARf的部分和由ARf排序的源结构中的ARf的部分定义了核酸构建体。

3. 发明授权

US07868115B1 Farnesene interpolymer 有权
标题翻译：法呢烯互聚物
公开(公告)号：US07868115B1
公开(公告)日：2011-01-11
申请号：US12825364
申请日：2010-06-29
申请人： Derek James McPhee
发明人： Derek James McPhee
IPC分类号： C08F236/22 , C08F36/00 , C08F36/22
CPC分类号： C08F36/22 , A61L15/58 , B32B7/12 , C08F290/06 , C08F297/02 , C08L47/00 , C08L51/003 , C08L53/005 , C08L2666/02 , C09J147/00 , C09J151/003 , C09J153/005 , Y10T428/28 , Y10T428/2852 , Y10T428/2878 , Y10T428/31899
摘要： Provided herein are farnesene interpolymers derived from a farnesene and at least one vinyl monomer. In certain embodiments, the farnesene is α-farnesene, β-farnesene or a combination thereof. In some embodiments, the at least one vinyl monomer is ethylene, an α-olefin such as styrene, or a substituted or unsubstituted vinyl halide, vinyl ether, acrylonitrile, acrylic ester, methacrylic ester, acrylamide or methacrylamide, or a combination thereof.
摘要翻译：本文提供的是法呢烯衍生自法呢烯和至少一种乙烯基单体的法呢烯互聚物。在某些实施方案中，法呢烯是α-法呢烯，法呢烯或其组合。在一些实施方案中，所述至少一种乙烯基单体是乙烯，α-烯烃如苯乙烯，或取代或未取代的乙烯基卤化物，乙烯基醚，丙烯腈，丙烯酸酯，甲基丙烯酸酯，丙烯酰胺或甲基丙烯酰胺或其组合。

4. 发明授权

US07854774B2 Fuel components, fuel compositions and methods of making and using same 有权
标题翻译：燃料组分，燃料组成及其制造和使用方法
公开(公告)号：US07854774B2
公开(公告)日：2010-12-21
申请号：US11753586
申请日：2007-05-25
申请人： Neil S. Renninger , Jack D. Newman , Keith Kinkead Reiling
发明人： Neil S. Renninger , Jack D. Newman , Keith Kinkead Reiling
IPC分类号： C10L1/18
CPC分类号： G06Q50/00 , C10L1/00 , C10L1/02 , C10L1/143 , C10L1/1852 , C10L1/19 , C10L1/2437 , C10L1/2641 , C12P7/04
摘要： A fuel composition comprises at least a C5 isoprenoid compound or its derivative and a conventional fuel additive. The C5 isoprenoid compound or its derivative can be used as a fuel component or as a fuel additive in the fuel composition. The fuel composition may further comprise a conventional fuel component selected from a diesel fuel, jet fuel, kerosene or gasoline. Methods of making and using the fuel composition are also disclosed.
摘要翻译：燃料组合物包含至少C5类异戊二烯化合物或其衍生物和常规燃料添加剂。 C5类异戊二烯化合物或其衍生物可用作燃料组分或燃料组合物中的燃料添加剂。燃料组合物还可包含选自柴油，喷气燃料，煤油或汽油的常规燃料成分。还公开了制备和使用燃料组合物的方法。

5. 发明申请

US20100178679A1 PRODUCTION OF ISOPRENOIDS 审中-公开
标题翻译：异丙酚的生产
公开(公告)号：US20100178679A1
公开(公告)日：2010-07-15
申请号：US12595600
申请日：2008-04-14
申请人： Larry Anthony , Jack Newman
发明人： Larry Anthony , Jack Newman
IPC分类号： C12P5/02 , C12N1/15 , C12N1/21
CPC分类号： C12N15/52 , C12P5/007 , C12P9/00 , C12P23/00
摘要： The present invention provides methods for a robust production of isoprenoids utilizing the DXP biosynthetic path-way. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods.
摘要翻译：本发明提供了使用DXP生物合成途径方式强力生产类异戊二烯的方法。本发明还提供用于实施本发明方法的核酸，酶，表达载体和遗传修饰的宿主细胞。

6. 发明授权

US07691792B1 Lubricant compositions 有权
标题翻译：润滑剂组合物
公开(公告)号：US07691792B1
公开(公告)日：2010-04-06
申请号：US12577093
申请日：2009-10-09
申请人： Karl Fisher , Frank X. Woolard
发明人： Karl Fisher , Frank X. Woolard
IPC分类号： C10M169/04 , C07C13/18
CPC分类号： C10M105/04 , C07C13/18 , C07C13/20 , C10M2203/0206 , C10M2203/022 , C10M2203/024 , C10M2203/04 , C10N2220/022 , C10N2220/023 , C10N2230/74 , C10N2240/04 , C10N2240/046 , C10N2240/08 , C10N2240/10 , C10N2240/12 , C10N2240/30 , C10N2240/40
摘要： Compositions comprising a farnesane dimer and/or a farnesene dimer and a compound selected from squalene, squalene and dehydrosqualene are described. The compositions provided comprise conventional additives. Methods of making and using the compounds and composition are also disclosed.
摘要翻译：描述了包含法呢基二聚体和/或法呢烯二聚物的组合物和选自角鲨烯，角鲨烯和脱氢山梨醇的化合物。提供的组合物包含常规的添加剂。还公开了制备和使用化合物和组合物的方法。

7. 发明申请

US20100056743A1 POLYFARNESENES 有权
标题翻译：聚合物
公开(公告)号：US20100056743A1
公开(公告)日：2010-03-04
申请号：US12552278
申请日：2009-09-01
申请人： Derek James MCPHEE
发明人： Derek James MCPHEE
IPC分类号： C08F12/08 , C08F10/14
CPC分类号： C08F293/00 , C08C19/02 , C08F8/04 , C08F36/22 , C08F210/02 , C08F290/06 , C08F297/02 , C08L23/02 , C08L47/00 , C08L51/003 , C08L53/005 , C08L71/12 , C08L75/04 , C08L77/00 , Y10T428/139 , C08L2666/02 , C08F236/20 , C08F2500/03
摘要： Provided herein are polyfarnesenes such as farnesene homopolymers derived from a farnesene and farnesene interpolymers derived from a farnesene and at least a vinyl monomer; and the processes of making and using the polyfarnesenes. The farnesene homopolymer can be prepared by polymerizing the farnesene in the presence of a catalyst. In some embodiments, the farnesene is prepared from a sugar by using a microorganism.
摘要翻译：本文提供的是聚法呢烯，例如衍生自法呢烯的法呢烯均聚物和衍生自法呢烯和至少乙烯基单体的法呢烯互聚物; 以及制造和使用聚法呢烯的方法。法呢烯均聚物可以通过在催化剂存在下聚合法呢烯来制备。在一些实施方案中，通过使用微生物从糖制备法呢烯。

8. 发明授权

US07671245B2 Jet fuel compositions and methods of making and using same 有权
标题翻译：喷气燃料组合物及其制造和使用方法
公开(公告)号：US07671245B2
公开(公告)日：2010-03-02
申请号：US12431769
申请日：2009-04-29
申请人： Jason A. Ryder
发明人： Jason A. Ryder
IPC分类号： C10L1/16
CPC分类号： C10L1/04 , C10L1/06 , C10L1/08 , C10L1/1608 , C10L1/1616 , Y10S208/95
摘要： Provided herein are, among other things, jet fuel compositions and methods of making and using the same. In some embodiments, the fuel compositions comprise at least a fuel component readily and efficiently produced, at least in part, from a microorganism. In certain embodiments, the fuel compositions provided herein comprise a high concentration of at least a bioengineered fuel component. In further embodiments, the fuel compositions provided herein comprise amorphane.
摘要翻译：喷雾燃料组合物及其制备和使用方法尤其如此。在一些实施方案中，燃料组合物至少部分地由微生物包含至少一种燃料成分，并且至少部分地有效地产生。在某些实施方案中，本文提供的燃料组合物包含高浓度的至少一种生物工程燃料组分。在另外的实施方案中，本文提供的燃料组合物包括不可见的。

9. 发明申请

US20090020089A1 FUEL COMPOSITIONS COMPRISING TETRAMETHYLCYCLOHEXANE 有权
标题翻译：包含四氢四氢呋喃的燃料组合物
公开(公告)号：US20090020089A1
公开(公告)日：2009-01-22
申请号：US12175465
申请日：2008-07-18
申请人： Jason A. Ryder , Karl Fisher
发明人： Jason A. Ryder , Karl Fisher
IPC分类号： F02B75/12 , C10L1/00 , B60K15/03
CPC分类号： C10L1/06 , C10L1/04 , Y02P30/20
摘要： A fuel composition comprises at least a tetramethylcyclohexane and a fuel component. The tetramethylcyclohexane can be used as a fuel component or as a fuel additive in the fuel composition. The fuel composition may further comprise a conventional fuel component selected from a petroleum-based fuel component such as diesel fuel, jet fuel, kerosene or gasoline; or a coal-based fuel component. Methods of making and using the fuel composition are also disclosed.
摘要翻译：燃料组合物至少包含四甲基环己烷和燃料组分。四甲基环己烷可以用作燃料组分或燃料组合物中的燃料添加剂。燃料组合物可以进一步包括选自石油基燃料组分如柴油，喷气燃料，煤油或汽油的常规燃料组分; 或煤基燃料组分。还公开了制备和使用燃料组合物的方法。

10. 发明授权

US07942940B2 Jet fuel compositions and methods of making and using same 有权
标题翻译：喷气燃料组合物及其制造和使用方法
公开(公告)号：US07942940B2
公开(公告)日：2011-05-17
申请号：US11986484
申请日：2007-11-20
申请人： Neil Stephen Renninger , Jason A. Ryder , Karl J. Fisher
发明人： Neil Stephen Renninger , Jason A. Ryder , Karl J. Fisher
IPC分类号： C10L1/10 , F02B47/00
CPC分类号： C10L1/1608 , C10L1/04 , C10L1/143 , C12P5/00 , C12P5/007
摘要： Provided herein are, among other things, jet fuel compositions and methods of making and using the same. In some embodiments, the fuel compositions comprise at least a fuel component readily and efficiently produced, at least in part, from a microorganism. In certain embodiments, the fuel compositions provided herein comprise a high concentration of at least a bioengineered fuel component. In further embodiments, the fuel compositions provided herein comprise a C10 bicyclic isoprenoid such as carane, pinane, sabinane or a combination thereof.
摘要翻译：喷雾燃料组合物及其制备和使用方法尤其如此。在一些实施方案中，燃料组合物至少部分地由微生物包含至少一种燃料成分，并且至少部分地有效地产生。在某些实施方案中，本文提供的燃料组合物包含高浓度的至少一种生物工程燃料组分。在另外的实施方案中，本文提供的燃料组合物包含C10双环类异戊二烯，例如癸烷，蒎烷，沙宾或其组合。

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