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1. 发明授权

US10350406B2 Implant tool and improved electrode design for minimally invasive procedure 有权
公开(公告)号：US10350406B2
公开(公告)日：2019-07-16
申请号：US15251239
申请日：2016-08-30
申请人： CVRx, Inc.
发明人： Adam Cates , Eric Lovett , Loren Murney , Kip Ludwig , Paul Pignato , Brian Soltis
IPC分类号： A61N1/05 , A61N1/36
摘要： Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.

2. 发明授权

US08583236B2 Devices and methods for cardiovascular reflex control 有权
标题翻译：用于心血管反射控制的装置和方法
公开(公告)号：US08583236B2
公开(公告)日：2013-11-12
申请号：US12719696
申请日：2010-03-08
申请人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
发明人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
IPC分类号： A61N1/04
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. An intravascularly implantable medical device may include a sleeve formed at least in part of an expandable member configured to be movably attachable about at least a portion of an outer surface of an expandable intravascular stent, and one or more electrodes disposed on the sleeve and coupled to a control system and configured to selectively activate baroreceptors within a wall of a vessel when the expandable intravascular stent is implanted within the vessel.
摘要翻译：公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。血管内可植入医疗装置可以包括至少部分可扩张构件形成的套筒，所述可扩张构件构造成围绕可膨胀血管内支架的外表面的至少一部分可移动地附接，以及一个或多个设置在套筒上并连接到控制系统，并且被配置为当可扩张血管内支架植入血管内时选择性地激活血管壁内的压力感受器。

3. 发明申请

US20130079617A1 MEASUREMENT OF PATIENT PHYSIOLOGICAL PARAMETERS 有权
公开(公告)号：US20130079617A1
公开(公告)日：2013-03-28
申请号：US13682317
申请日：2012-11-20
申请人： CVRx, Inc.
发明人： Russell Eugene Anderson , Nadim Yared , John Charles Stroebel , Robert S. Kieval , Steve Check , Eric Lovett
IPC分类号： A61B5/0215 , A61N1/36
CPC分类号： A61B5/0538 , A61B5/02007 , A61B5/0215 , A61B5/024 , A61B5/053 , A61B5/4035 , A61B5/6862 , A61B5/6876 , A61N1/3606 , A61N1/36117 , A61N1/36139
摘要： A method of determining one or more physiological parameter of a patient by providing a plurality of implantable electrodes proximate a blood vessel of the patient, applying a measurement signal through the plurality of electrodes, the measurement signal having a known parameter, obtaining a resultant signal through the plurality of electrodes, the resultant signal having a resultant parameter, calculating vascular impedance based on the measurement signal and the resultant signal, and calculating a physiological parameter based on the vascular impedance. In some embodiments, the physiological parameter is utilized to modify a therapy signal controlling therapy delivered to the patient.

4. 发明申请

US20130030309A1 DEVICES AND METHODS FOR TREATMENT OF HEART FAILURE AND ASSOCIATED CONDITIONS 有权
标题翻译：用于治疗心力衰竭和相关条件的装置和方法
公开(公告)号：US20130030309A1
公开(公告)日：2013-01-31
申请号：US13645122
申请日：2012-10-04
申请人： CVRx, Inc.
发明人： Nadim Yared , Dimitrios Georgakopoulos , Eric Grant Lovett
IPC分类号： A61N1/36 , A61B5/0215
CPC分类号： A61N1/36117 , A61B5/0031 , A61B5/02007 , A61B5/02108 , A61B5/0215 , A61B5/053 , A61N1/3962 , G06F19/00
摘要： Devices and methods of use for identification, treatment, and/or management of heart failure and/or associated conditions. Methods may include providing a baroreflex therapy system including a blood pressure sensor and a heart rate sensor, providing an implantable measurement device proximate a blood vessel of a patient, the implantable measurement device including an electrode, providing a control system coupled to the baroreflex therapy system and the implantable measurement device, the control system programmed to automatically determine an impedance of the blood vessel with the implantable measurement device over a time period of at least one cardiac cycle, determine arterial stiffness of the blood vessel based on the impedance, determine blood pressure and heart rate, and activate, deactivate or otherwise modulate the baroreflex therapy system to deliver a baroreflex therapy based on the blood pressure, heart rate and arterial stiffness.
摘要翻译：用于识别，治疗和/或管理心力衰竭和/或相关病症的装置和方法。方法可以包括提供包括血压传感器和心率传感器的压力反射治疗系统，在患者的血管附近提供可植入测量装置，所述可植入测量装置包括电极，提供耦合到所述压力反射治疗系统的控制系统以及所述可植入测量装置，所述控制系统被编程为在至少一个心动周期的时间段内自动确定所述血管与所述可植入测量装置的阻抗，基于所述阻抗来确定所述血管的动脉刚度，确定血压和心率，并激活，停用或以其他方式调节压力反射治疗系统，以基于血压，心率和动脉僵硬递送压力反射治疗。

5. 发明授权

US08290595B2 Method and apparatus for stimulation of baroreceptors in pulmonary artery 有权
标题翻译：用于刺激肺动脉压力感受器的方法和装置
公开(公告)号：US08290595B2
公开(公告)日：2012-10-16
申请号：US11482264
申请日：2006-07-07
申请人： Robert S. Kieval , Peter T. Keith , David J. Serdar , Bruce Persson
发明人： Robert S. Kieval , Peter T. Keith , David J. Serdar , Bruce Persson
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/08 , A61N1/36117
摘要： Devices and methods for controlling the low-pressure baroreflex system for the treatment and/or management of cardiovascular, renal, and neurological disorders.
摘要翻译：用于控制用于治疗和/或治疗心血管，肾脏和神经障碍的低压压力反射系统的装置和方法。

6. 发明授权

US08224437B2 Baroreflex activation for sedation and sleep 有权
标题翻译：巴罗反射激活镇静和睡眠
公开(公告)号：US08224437B2
公开(公告)日：2012-07-17
申请号：US12245636
申请日：2008-10-03
申请人： Robert S. Kieval , Martin A. Rossing
发明人： Robert S. Kieval , Martin A. Rossing
IPC分类号： A61M21/00 , A61N1/36
CPC分类号： A61N1/08 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
摘要翻译：系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活压力反射激活装置。在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

7. 发明授权

US08214050B2 Method for monitoring physiological cycles of a patient to optimize patient therapy 有权
标题翻译：监测患者生理周期以优化患者治疗的方法
公开(公告)号：US08214050B2
公开(公告)日：2012-07-03
申请号：US12347813
申请日：2008-12-31
申请人： Robert S. Kieval
发明人： Robert S. Kieval
IPC分类号： A61B5/04
CPC分类号： A61B5/042 , A61B5/0402 , A61B5/053 , A61B5/4035 , A61N1/36114 , A61N1/36117 , A61N1/36585 , A61N1/368 , A61N1/372
摘要： Improved methods for obtaining physiological parameters of a patient in accordance with various embodiments of the present invention can be used to monitor patient status and/or in conjunction with patient therapy. Physiological parameters can be monitored with an implantable device including a first lead and a second lead. Physiological parameters can be measured along at least three distinct vectors defined by the first lead and second lead, the first lead and an electrode located on the device body, and the second lead an the electrode. An output indicative of the physiological parameter can then be provided. Therapy, such as baroreflex therapy, can optionally be optimized based on the physiological measurements.
摘要翻译：根据本发明的各种实施方案，用于获得患者生理参数的改进方法可用于监测患者状况和/或与患者治疗相结合。可以用包括第一引线和第二引线的可植入装置监测生理参数。可以沿着由第一引线和第二引线，第一引线和位于器件主体上的电极限定的至少三个不同的向量来测量生理参数，而第二引线是电极。然后可以提供指示生理参数的输出。基于生理测量可以任选地优化治疗，例如压力反射治疗。

8. 发明授权

US08150521B2 Methods and devices for controlling battery life in an implantable pulse generator 有权
标题翻译：用于控制可植入式脉冲发生器的电池寿命的方法和装置
公开(公告)号：US08150521B2
公开(公告)日：2012-04-03
申请号：US12049956
申请日：2008-03-17
申请人： Thomas Patrick Crowley , Jeffrey J. Hagen
发明人： Thomas Patrick Crowley , Jeffrey J. Hagen
IPC分类号： A61N1/32
CPC分类号： A61N1/36114
摘要： Methods, devices, and systems for controlling an implantable pulse generator for activation of a nerve or receptor are provided. In particular, the method, devices, and systems embodying features of the present invention control the energy output of a battery in an implantable pulse generator for stimulation of the baroreflex system of the patient.
摘要翻译：提供了用于控制用于激活神经或受体的可植入脉冲发生器的方法，装置和系统。具体地，体现本发明特征的方法，装置和系统控制可植入脉冲发生器中的电池的能量输出，用于刺激患者的压力反射系统。

9. 发明申请

US20090132002A1 BAROREFLEX ACTIVATION THERAPY WITH CONDITIONAL SHUT OFF 审中-公开
标题翻译： BAROREFLEX激活治疗与条件关闭
公开(公告)号：US20090132002A1
公开(公告)日：2009-05-21
申请号：US12116435
申请日：2008-05-07
申请人： Robert S. Kieval
发明人： Robert S. Kieval
IPC分类号： A61N1/36
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/36117
摘要： An exemplary embodiment of the present invention provides systems, devices, and methods for using the same for activating (stimulating) the baroreflex system of a patient using a baroreflex activation system which may be automatically shut off or discontinue therapy by sensing/monitoring/interpreting sensed data which is indicative of a physiological condition of a patient.
摘要翻译：本发明的示例性实施例提供了使用其来激活（刺激）患者的压力反射系统的系统，装置和方法，所述压力反射激活系统可以通过感测/监测/解释所感测到的自动切断或停止治疗指示患者生理状况的数据。

10. 发明申请

US20090069738A1 Electrode Structures Having Anti-Inflammatory Properties And Methods Of Use 审中-公开
标题翻译：具有抗炎特性和使用方法的电极结构
公开(公告)号：US20090069738A1
公开(公告)日：2009-03-12
申请号：US12174428
申请日：2008-07-16
申请人： Martin A. Rossing , Robert S. Kieval , Mary L. Cole
发明人： Martin A. Rossing , Robert S. Kieval , Mary L. Cole
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/056 , A61N1/306
摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.
摘要翻译：用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。

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