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1. 发明授权

US08583236B2 Devices and methods for cardiovascular reflex control 有权
标题翻译：用于心血管反射控制的装置和方法
公开(公告)号：US08583236B2
公开(公告)日：2013-11-12
申请号：US12719696
申请日：2010-03-08
申请人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
发明人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
IPC分类号： A61N1/04
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. An intravascularly implantable medical device may include a sleeve formed at least in part of an expandable member configured to be movably attachable about at least a portion of an outer surface of an expandable intravascular stent, and one or more electrodes disposed on the sleeve and coupled to a control system and configured to selectively activate baroreceptors within a wall of a vessel when the expandable intravascular stent is implanted within the vessel.
摘要翻译：公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。血管内可植入医疗装置可以包括至少部分可扩张构件形成的套筒，所述可扩张构件构造成围绕可膨胀血管内支架的外表面的至少一部分可移动地附接，以及一个或多个设置在套筒上并连接到控制系统，并且被配置为当可扩张血管内支架植入血管内时选择性地激活血管壁内的压力感受器。

2. 发明授权

US08224437B2 Baroreflex activation for sedation and sleep 有权
标题翻译：巴罗反射激活镇静和睡眠
公开(公告)号：US08224437B2
公开(公告)日：2012-07-17
申请号：US12245636
申请日：2008-10-03
申请人： Robert S. Kieval , Martin A. Rossing
发明人： Robert S. Kieval , Martin A. Rossing
IPC分类号： A61M21/00 , A61N1/36
CPC分类号： A61N1/08 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
摘要翻译：系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活压力反射激活装置。在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

3. 发明申请

US20100222831A1 ELECTRODE STRUCTURES AND METHODS FOR THEIR USE IN CARDIOVASCULAR REFLEX CONTROL 有权
标题翻译：用于心脏反射控制的电极结构和方法
公开(公告)号：US20100222831A1
公开(公告)日：2010-09-02
申请号：US12762891
申请日：2010-04-19
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译：描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。控制系统可用于调节压力感受器激活装置。控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。压力感受器激活装置可以利用电极来激活压力感受器。电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

4. 发明申请

US20090198294A1 BAROREFLEX ACTIVATION FOR ARRHYTHMIA TREATMENT 审中-公开
标题翻译： BAROREFLEX激活ARRHYTHMIA治疗
公开(公告)号：US20090198294A1
公开(公告)日：2009-08-06
申请号：US12422147
申请日：2009-04-10
申请人： Martin A. Rossing , Robert S. Kieval , Roy C. Martin , Davdi S. Serdar , Eric D. Irwin
发明人： Martin A. Rossing , Robert S. Kieval , Roy C. Martin , Davdi S. Serdar , Eric D. Irwin
IPC分类号： A61N1/39 , A61N1/36 , A61N1/365
CPC分类号： A61N1/0556 , A61N1/36114
摘要： Devices, systems and methods provide baroreflex activation to prevent, or at least reduce the likelihood of occurrence of, cardiac arrhythmias. Various embodiments may additionally or alternatively promote recovery from arrhythmias. In one embodiment, a device for preventing or reducing the likelihood of occurrence of arrhythmias includes one or more baroreflex activation devices, one or more sensors coupled to the baroreflex activation device(s), and a processor for processing information from the sensor and activating and/or modulation the baroreflex activation device. Sensors, such as electrocardiogram devices, generally sense factors indicative of a potential, ensuing arrhythmia.
摘要翻译：装置，系统和方法提供压力反射激活以防止或至少降低发生心律失常的可能性。各种实施方案可以额外地或替代地促进从心律失常的恢复。在一个实施例中，用于防止或减少发生心律失常的可能性的装置包括一个或多个压力反射激活装置，耦合到压力反射激活装置的一个或多个传感器，以及用于处理来自传感器的信息的处理器， /或调制压力反射激活装置。传感器，例如心电图设备，通常感测指示潜在的随之而来的心律失常的因子。

5. 发明申请

US20090069738A1 Electrode Structures Having Anti-Inflammatory Properties And Methods Of Use 审中-公开
标题翻译：具有抗炎特性和使用方法的电极结构
公开(公告)号：US20090069738A1
公开(公告)日：2009-03-12
申请号：US12174428
申请日：2008-07-16
申请人： Martin A. Rossing , Robert S. Kieval , Mary L. Cole
发明人： Martin A. Rossing , Robert S. Kieval , Mary L. Cole
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/056 , A61N1/306
摘要： Electrode structures for implantation include an electrode, an elastic backing attached to the electrode, and a sequestered drug on the backing or the electrode which is released to control and/or limit the growth of scar tissue. The elastic backing includes a tissue contacting side which contacts a tissue structure, and an exposed side away from the tissue contacting side. The electrode structure can be used to activate baroreceptors, and the backing is elastic and can stretch and retract with the tissue structure, for example the carotid sinus. The electrode and the sequestered drug can be positioned on the tissue contacting side so the drug is released near the electrode. The backing can be made from an insulating material and limit diffusion of the drug toward the exposed side, permitting scar tissue to grow near the exposed side to maintain positioning of the electrode.
摘要翻译：用于植入的电极结构包括电极，附着到电极的弹性背衬和背衬或电极上的螯合药物，其被释放以控制和/或限制瘢痕组织的生长。弹性背衬包括接触组织结构的组织接触侧和远离组织接触侧的暴露侧。电极结构可用于激活压力感受器，并且背衬是弹性的并且可以与组织结构例如颈动脉窦一起伸展和缩回。电极和螯合药物可以定位在组织接触侧，因此药物在电极附近释放。背衬可以由绝缘材料制成并且限制药物朝向暴露侧的扩散，允许瘢痕组织在暴露侧附近生长以保持电极的定位。

6. 发明申请

US20080172101A1 NON-LINEAR ELECTRODE ARRAY 审中-公开
标题翻译：非线性电极阵列
公开(公告)号：US20080172101A1
公开(公告)日：2008-07-17
申请号：US11933283
申请日：2007-10-31
申请人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
发明人： Stephen L. Bolea , Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Eric D. Irwin , Martin A. Rossing
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/05 , A61N1/08 , A61N1/36117 , A61N1/36185
摘要： A system for stimulation, including an implantable pulse generator, a lead comprising an array body disposed at a distal end of the lead and a plurality of electrodes concentrically arranged on the array body, and a plurality of conductors, wherein one of the conductors is attached to each electrode and wherein the conductors are configured and arranged to couple the electrodes to the implantable pulse generator.
摘要翻译：一种用于刺激的系统，包括可植入脉冲发生器，包括设置在引线的远端的阵列体的引线和同心地布置在阵列体上的多个电极，以及多个导体，其中一个导体被附接并且其中所述导体被配置和布置成将所述电极耦合到所述可植入脉冲发生器。

7. 发明授权

US08606359B2 System and method for sustained baroreflex stimulation 有权
标题翻译：持续压力反射刺激的系统和方法
公开(公告)号：US08606359B2
公开(公告)日：2013-12-10
申请号：US11735303
申请日：2007-04-13
申请人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
发明人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
IPC分类号： A61N1/18 , A61N1/32
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： The present invention comprises a medical device having a baroreflex stimulator to generate a stimulation signal, the stimulation signal being adapted to stimulate a baroreflex, and a controller to communicate with the baroreflex stimulator and implement a baroreflex stimulus regimen to vary an intensity of the baroreflex stimulation provided by the stimulation signal to maintain stimulation efficacy.
摘要翻译：本发明包括具有压力反射刺激器以产生刺激信号的医疗装置，所述刺激信号适于刺激压力反射，以及控制器与压力反射刺激器通信并实施压力反射刺激方案以改变压力反射刺激的强度由刺激信号提供，以维持刺激功效。

8. 发明授权

US07801614B2 Stimulus regimens for cardiovascular reflex control 有权
标题翻译：用于心血管反射控制的刺激方案
公开(公告)号：US07801614B2
公开(公告)日：2010-09-21
申请号：US11552005
申请日：2006-10-23
申请人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
发明人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
IPC分类号： A61N1/18 , A61N1/32
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔（可能在数分钟到数小时，或者可能是不确定的持续时间），建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔（可能具有与心跳之间的间隔相当的持续时间），以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

9. 发明授权

US07623926B2 Stimulus regimens for cardiovascular reflex control 有权
标题翻译：用于心血管反射控制的刺激方案
公开(公告)号：US07623926B2
公开(公告)日：2009-11-24
申请号：US10818738
申请日：2004-04-05
申请人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
发明人： Martin A. Rossing , Robert S. Kieval , David J. Serdar , Bruce J. Persson
IPC分类号： A61N1/18 , A61N1/32
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔（可能在数分钟到数小时，或者可能是不确定的持续时间），建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔（可能具有与心跳之间的间隔相当的持续时间），以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

10. 发明授权

US07616997B2 Devices and methods for cardiovascular reflex control via coupled electrodes 有权
标题翻译：通过耦合电极进行心血管反射控制的装置和方法
公开(公告)号：US07616997B2
公开(公告)日：2009-11-10
申请号：US10402393
申请日：2003-03-27
申请人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
发明人： Robert S. Kieval , Bruce J. Persson , David J. Serdar , Peter T. Keith , Martin A. Rossing
IPC分类号： A61N1/18
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/37229
摘要： Devices, systems and methods are disclosed by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize RF-coupled or other electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译：公开了装置，系统和方法，通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。控制系统可用于调节压力感受器激活装置。控制系统可以利用定义促进长期疗效并降低功率需求/消耗的刺激方案的算法。压电感受器激活装置可以利用RF耦合或其它电极来激活压力感受器。电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

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