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1. 发明授权

US08450086B2 Bacterial membrane protein secretion 有权
标题翻译：细菌膜蛋白分泌
公开(公告)号：US08450086B2
公开(公告)日：2013-05-28
申请号：US13509287
申请日：2010-11-15
申请人： Chichi Huang , Lu Lu
发明人： Chichi Huang , Lu Lu
IPC分类号： A61K39/42 , C12P21/00
CPC分类号： C07K14/395 , C07K2319/03
摘要： Improved bacterial secretion signals derived from pelB and ompA are provided. The improved variants enhance bacterial membrane secretion are thus useful for production of proteins secreted from bacteria including proteins displayed on filamentous phage particles, and, in particular, proteins requiring oxidative formation of covalent bonds, such as disulfide bonds within or between polypeptide chains in order to form a correctly folded and functional protein structure. Described herein are methods for the multivalent display of complex dimeric proteins on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structures may also be displayed using the method of the invention.
摘要翻译：提供了从pelB和ompA得到的改善的细菌分泌信号。因此，改进的变体增强细菌膜分泌因此可用于产生从细菌分泌的蛋白质，包括显示在丝状噬菌体颗粒上的蛋白质，特别是需要氧化形成共价键的蛋白质，例如多肽链内或多肽链之间的二硫键，以便形成正确折叠和功能的蛋白质结构。本文描述的是在噬菌体颗粒的表面上复杂二聚体蛋白质的多价显示和显示为具有丝状噬菌体pIX外壳蛋白的融合多肽的蛋白质的组合合成文库的方法。也可以使用本发明的方法显示异二聚体或更复杂的链间结合结构。

2. 发明授权

US08399630B2 Engineered anti-IL-13 antibodies, compositions, methods and uses 有权
标题翻译：工程化的抗IL-13抗体，组合物，方法和用途
公开(公告)号：US08399630B2
公开(公告)日：2013-03-19
申请号：US13058453
申请日：2009-08-11
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiqing Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

3. 再颁专利

USRE43876E1 Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm 有权
标题翻译：表达多能性标记并表达定形内胚层特征的标志物的细胞
公开(公告)号：USRE43876E1
公开(公告)日：2012-12-25
申请号：US13372641
申请日：2012-02-14
申请人： Alireza Rezania
发明人： Alireza Rezania
IPC分类号： C12N5/02 , C12N5/04
CPC分类号： C12N5/0606 , C12N2500/02 , C12N2501/105 , C12N2501/16 , C12N2501/415 , C12N2501/70 , C12N2533/90
摘要： The present invention is directed to pluripotent cells that can be readily expanded in culture on tissue culture substrate that is not pre-treated with protein or an extracellular matrix, and do not require a feeder cell line. The present invention also provides methods to derive the pluripotent cell line from human embryonic stem cells.
摘要翻译：本发明涉及能够在不用蛋白质或细胞外基质预处理并且不需要饲养细胞系的组织培养基质上容易地在培养物中扩增的多能细胞。本发明还提供了从人胚胎干细胞衍生多能细胞系的方法。

4. 发明申请

US20110281355A1 Differentiation of Human Embryonic Stem Cells 有权
标题翻译：人类胚胎干细胞的分化
公开(公告)号：US20110281355A1
公开(公告)日：2011-11-17
申请号：US13105285
申请日：2011-05-11
申请人： JEAN XU
发明人： JEAN XU
IPC分类号： C12N5/02 , C12N5/00
CPC分类号： C12N5/0678 , A61K35/12 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/727 , C12N2501/998 , C12N2506/02
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
摘要翻译：本发明提供促进多能干细胞分化成胰岛素生成细胞的方法。特别地，本发明提供了一种产生表达胰腺内胚层谱系特征性标志物的细胞群的方法，其中大于50％的群体中的细胞共表达PDX1和NKX6.1。

5. 发明授权

US08017325B2 Selection of high-producing cell lines 有权
标题翻译：选择高产细胞系
公开(公告)号：US08017325B2
公开(公告)日：2011-09-13
申请号：US12021270
申请日：2008-01-28
申请人： Haimanti Dorai
发明人： Haimanti Dorai
IPC分类号： G01N33/53 , C12N5/06 , C12N15/63
CPC分类号： C07K16/00 , A01K2267/01
摘要： The invention describes a method for screening antibody producing cell lines for selection of high expressing clones.
摘要翻译：本发明描述了筛选抗体产生细胞系以选择高表达克隆的方法。

6. 发明授权

US07935344B2 Human anti-IL-23 antibodies, compositions, methods and uses 有权
标题翻译：人抗IL-23抗体，组合物，方法和用途
公开(公告)号：US07935344B2
公开(公告)日：2011-05-03
申请号：US11617503
申请日：2006-12-28
申请人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
发明人： Jacqueline Benson , Jill Carton , Mark Cunningham , Yevgeniya I. Orlovsky , Robert Rauchenberger , Raymond Sweet
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K9/0019 , A61K9/08 , A61K39/3955 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： A human anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
摘要翻译：人抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离的核酸，载体，宿主细胞及其制备和使用方法在诊断和/或治疗组合物，方法和装置中的应用。

7. 发明申请

US20100129318A1 CYNOMOLGUS IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES 有权
标题翻译： CYNOMOLGUS IL-13静脉蛋白，抗体，组合物，方法和用途
公开(公告)号：US20100129318A1
公开(公告)日：2010-05-27
申请号：US12443503
申请日：2007-10-12
申请人： Karyn O'Neil , Leslee Conrad , Dusti Fisher
发明人： Karyn O'Neil , Leslee Conrad , Dusti Fisher
IPC分类号： A61K38/20 , G01N33/53 , C12P21/06 , C12N5/10 , C12N5/02 , C12N15/63 , C07K14/54 , C07K16/24 , C07H21/04
CPC分类号： C07K14/5437 , A61K38/00 , G01N2333/5437
摘要： The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译：本发明涉及至少一种新颖的食蟹猴IL-13突变蛋白（Mut-IL-13）蛋白，抗体，包括编码至少一种Mut-IL-13蛋白或抗体的分离的核酸，Mut-IL-13载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。

8. 发明授权

US08618264B2 Anti-CD147 antibodies, methods and uses 失效
标题翻译：抗CD147抗体，方法和用途
公开(公告)号：US08618264B2
公开(公告)日：2013-12-31
申请号：US13062702
申请日：2009-08-19
申请人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
发明人： Mark Cunningham , Bethany Swencki-Underwood , Yi Tang , Li Yan
IPC分类号： C07K16/30
CPC分类号： C07K16/2803 , A61K2039/505 , A61K2039/507 , C07K14/70503 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32
摘要： The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
摘要翻译：本发明提供能够阻断与恶性疾病相关的CD147的生物活性的人CD147的抗体，例如肿瘤细胞刺激来自成纤维细胞的MMPs，VEGF的释放和促进血管发生。本发明的抗体可用于治疗恶性疾病和其中CD147活性发挥致病作用的疾病，例如眼睛，肺和心血管系统的疾病。

9. 发明授权

US08323646B2 Engineered anti-IL-13 antibodies, compositions, methods and uses 有权
标题翻译：工程化的抗IL-13抗体，组合物，方法和用途
公开(公告)号：US08323646B2
公开(公告)日：2012-12-04
申请号：US12539630
申请日：2009-08-12
申请人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
发明人： Ronald V. Swanson , Ellen Chi , Gopalan Raghunathan , Shanrong Zhao , Johan Fransson , Wendy Cordier , Hong Mimi Zhou , Juan C. Almagro , Linus Hyun , Jill Giles-Komar , Karyn T. O'Neil , Jill M. Carton , Alexey V. Teplyakov , Yiging Feng
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N15/63 , C12P21/06 , G01N33/53
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C07K2319/21 , G01N2333/5437
摘要： The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
摘要翻译：本发明涉及针对人白细胞介素-13（IL-13）蛋白或其片段免疫特异性的工程化抗体，以及其制备和使用方法，包括治疗适应症。

10. 发明授权

US08278419B2 Fibronectin type III domain based scaffold compositions, methods and uses 有权
标题翻译：纤连蛋白III型结构域的支架组合物，方法和用途
公开(公告)号：US08278419B2
公开(公告)日：2012-10-02
申请号：US12606382
申请日：2009-10-27
申请人： Steven Jacobs , Karyn O'Neil
发明人： Steven Jacobs , Karyn O'Neil
IPC分类号： C07K14/00 , C07K17/00
CPC分类号： C07K14/78 , C40B40/08 , C40B50/06
摘要： A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
摘要翻译：基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。

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