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1. 发明申请

US20210039105A1 SYSTEMS AND METHODS FOR MICROFLUIDIC PARTICLE SELECTION, ENCAPSULATION, AND INJECTION USING SURFACE ACOUSTIC WAVES 有权
公开(公告)号：US20210039105A1
公开(公告)日：2021-02-11
申请号：US16989570
申请日：2020-08-10
申请人： CYTONOME/ST, LLC
发明人： Kiryakos S. Mutafopulos , Johnathan Charles Sharpe
IPC分类号： B01L3/00 , G01N15/14
摘要： This relates to acoustic microfluidic systems that can generate emulsions/droplets or encapsulate particles of interest (including mammalian cells, bacteria cells, or other cells) into droplets upon detection of the particles of interest flowing in a stream of particles. The systems operate on the detect/decide/deflect principle wherein the deflection step, in a single operation, not only deflects particles of interest from a stream of particles but also encapsulates the particles of interest in an emulsion droplet. The microfluidic systems have an abrupt transition in the channel geometry from a shorter channel to a taller channel (i.e., in the shape of a ‘step’) to break the stream of the dispersed phase into a droplet upon acoustic actuation. When there is no acoustic wave present, no droplets/emulsions are generated and the stream of particles proceeds uninterrupted. The rapid actuation and post-actuation recovery employed by the microfluidic systems taught herein ensure that the vast majority of selected particles are properly deflected, that few or no empty droplets are produced, and that total throughput remains high.

2. 发明授权

US10543992B2 Multilayer hydrodynamic sheath flow structure 有权
公开(公告)号：US10543992B2
公开(公告)日：2020-01-28
申请号：US15797790
申请日：2017-10-30
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Manish Deshpande , Bernard Bunner
IPC分类号： B65G51/01 , B65G51/08 , B01L3/00 , G01N15/14 , B01F13/00 , B65G51/00
摘要： A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

3. 发明授权

US10274414B2 Particle processing systems and methods for normalization/calibration of same 有权
公开(公告)号：US10274414B2
公开(公告)日：2019-04-30
申请号：US14281353
申请日：2014-05-19
申请人： CYTONOME/ST, LLC
发明人： Johnathan Charles Sharpe , Emanuel Tito Mendes Machado , Rudolf Hulspas
IPC分类号： G01N15/14 , G01N15/10 , G01N21/53 , G01N21/64
摘要： Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.

4. 发明授权

US10029263B2 Method and apparatus for sorting particles 有权
公开(公告)号：US10029263B2
公开(公告)日：2018-07-24
申请号：US13849365
申请日：2013-03-22
申请人： CYTONOME/ST, LLC
发明人： Sebastian Böhm , John R. Gilbert , Manish Deshpande
IPC分类号： B07C5/34 , B03B5/00 , F15C5/00 , F16K99/00 , G01N15/14 , B01L3/00
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

5. 外观设计

USD791338S1 Droplet sorter 有权
公开(公告)号：USD791338S1
公开(公告)日：2017-07-04
申请号：US29491124
申请日：2014-05-16
申请人： CYTONOME/ST, LLC
设计人： Michael I. Morkos , Jeffrey T. Samson

6. 发明授权

US09011797B2 Microfluidic system including a bubble valve for regulating fluid flow through a microchannel 有权
公开(公告)号：US09011797B2
公开(公告)日：2015-04-21
申请号：US13527331
申请日：2012-06-19
申请人： John R. Gilbert , Sebastian Böhm , Manish Deshpande
发明人： John R. Gilbert , Sebastian Böhm , Manish Deshpande
IPC分类号： B81B3/00 , B01L3/00 , B07C5/34 , F16K99/00 , G01N15/14
CPC分类号： B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要： A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

7. 发明授权

US08964184B2 Optical detector for a particle sorting system 有权
公开(公告)号：US08964184B2
公开(公告)日：2015-02-24
申请号：US12966654
申请日：2010-12-13
申请人： John R. Gilbert , Edward Sinofsky , Manish Deshpande
发明人： John R. Gilbert , Edward Sinofsky , Manish Deshpande
IPC分类号： G01N21/00 , G01N21/64 , G01N15/14
CPC分类号： G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6452 , G01N2015/1081
摘要： An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be monitored, one or more lenses or optical fibers for capturing the light from the light source after interaction with the particles or chemicals in the microfluidic channels, and one or more detectors. The detectors, which may include light amplifying elements, detect each light signal and transducer the light signal into an electronic signal. The electronic signals, each representing the intensity of an optical signal, pass from each detector to an electronic data acquisition system for analysis. The light amplifying element or elements may comprise an array of phototubes, a multianode phototube, or a multichannel plate based image intensifier coupled to an array of photodiode detectors.

8. 发明申请

US20140170697A1 FLOW CELL 审中-公开
标题翻译：流通池
公开(公告)号：US20140170697A1
公开(公告)日：2014-06-19
申请号：US14030946
申请日：2013-09-18
申请人： CYTONOME/ST, LLC
发明人： Johnathan Charles Sharpe , Rudolf Hulspas , Kristopher Scott Buchanan
IPC分类号： G01N15/14
CPC分类号： G01N15/1436 , G01N15/1404 , G01N15/1459 , G01N2015/149 , Y10T436/25375
摘要： A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.
摘要翻译：用于颗粒处理的流动池例如颗粒分选可以可操作地接合到颗粒处理装置。流动池的流体接触表面可以是完全封闭的。此外，流动池可以将所有流体接触表面封装在颗粒处理装置中。流体接触表面的封闭或封装确保，改善或促进操作者隔离和/或产品隔离。流动池可以采用任何合适的处理颗粒的技术。流动池可以是一次性的并且适合用于液滴分选。流动池可以包括具有颗粒流聚焦区域，孔口，询问区域和分选区域的可操作地密封的分类室。

9. 发明申请

US20140170673A1 UNITARY CARTRIDGE FOR PARTICLE PROCESSING 有权
标题翻译：颗粒加工单位盒
公开(公告)号：US20140170673A1
公开(公告)日：2014-06-19
申请号：US14179760
申请日：2014-02-13
申请人： CYTONOME/ST, LLC
发明人： John R. Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： G01N33/577
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

10. 发明授权

US08681335B2 Fluid stream imaging apparatus 有权
标题翻译：流体流成像装置
公开(公告)号：US08681335B2
公开(公告)日：2014-03-25
申请号：US13366124
申请日：2012-02-03
申请人： Johnathan Charles Sharpe , Donald Francis Perrault, Jr. , Nemanya Sedoglavich
发明人： Johnathan Charles Sharpe , Donald Francis Perrault, Jr. , Nemanya Sedoglavich
IPC分类号： G01N21/59 , G06K9/00
CPC分类号： G01N15/14 , G01N1/08 , G01N15/1404 , G01N15/1434 , G01N2015/1406 , G01N2015/144 , G01N2015/149
摘要： A fluid stream imaging apparatus having either optics for manipulating the aspect ratio or sensing elements configured for manipulating the aspect ratio of an image of the fluid stream. This application may also relate to a system for acquiring images of a portion of a fluid stream at high speeds for image processing to measure and predict droplet delays for individual forming particles.
摘要翻译：流体流成像装置具有用于操纵纵横比的光学元件或被配置用于操纵流体流的图像的纵横比的感测元件。该应用还可以涉及用于以高速获取流体流的一部分图像以进行图像处理以测量和预测单个成形颗粒的液滴延迟的系统。

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