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1. 发明授权

US08679422B2 Unitary cartridge for particle processing 有权
标题翻译：用于颗粒处理的单一墨盒
公开(公告)号：US08679422B2
公开(公告)日：2014-03-25
申请号：US13240521
申请日：2011-09-22
申请人： John R. Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
发明人： John R. Gilbert , Hugh Lewis , Derek Beaupre , Jaishree Trikha , Manish Deshpande
IPC分类号： B01L3/00
CPC分类号： G01N33/577 , B01L3/502761 , B01L3/502776 , B01L5/00 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/082 , B01L2200/10 , B01L2300/0809 , B01L2300/0864 , B01L2400/0487 , C12M47/04 , G01N15/1056 , G01N15/1484 , G01N2015/1486 , G01N2015/149 , Y10T436/2575
摘要： A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
摘要翻译：用于在颗粒上进行过程的单个一次性盒，例如颗粒分选，将所有流体接触表面封装在盒中以用于微流体颗粒处理技术。墨盒与操作系统接口，用于进行颗粒处理。流体接触表面的封装确保，改善或促进操作者隔离和/或产品隔离。墨盒可以采用任何合适的处理颗粒的技术。

2. 发明授权

US08567608B2 Method and apparatus for sorting particles 有权
公开(公告)号：US08567608B2
公开(公告)日：2013-10-29
申请号：US12499254
申请日：2009-07-08
申请人： Manish Deshpande , John Gilbert
发明人： Manish Deshpande , John Gilbert
IPC分类号： B07C5/00
CPC分类号： B07C5/36 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0652 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2400/0487 , B07C5/02 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0019 , F16K99/0028 , F16K99/0046 , F16K99/0048 , G01N15/10 , G01N15/14 , G01N2015/1075 , G01N2015/1081 , G01N2015/1477 , G01N2015/149 , G01N2015/1497 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

3. 发明授权

US08408399B2 Method and apparatus for sorting particles 有权
公开(公告)号：US08408399B2
公开(公告)日：2013-04-02
申请号：US13158960
申请日：2011-06-13
申请人： Sebastian Böhm , John R. Gilbert , Manish Deshpande
发明人： Sebastian Böhm , John R. Gilbert , Manish Deshpande
IPC分类号： B07C5/00
CPC分类号： B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要： A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.

4. 发明申请

US20120302848A1 Inter Dialytic Monitoring Device 有权
标题翻译：相互透析监测装置
公开(公告)号：US20120302848A1
公开(公告)日：2012-11-29
申请号：US13113175
申请日：2011-05-23
申请人： Manish Deshpande
发明人： Manish Deshpande
IPC分类号： A61B5/145
CPC分类号： A61B5/1427 , A61B5/14528 , A61B5/15003 , A61B5/150229 , A61B5/150755 , A61B5/150992 , A61B5/155 , A61B5/157 , A61B5/6852 , A61B5/6866 , A61B2560/0443 , A61B2562/0295 , A61M1/3609 , A61M2230/20 , A61M2230/30
摘要： An inter dialytic monitoring device is disclosed which monitors in vivo preselected parameters of blood content during an inter dialytic period to monitor patient health. The monitoring device is configured to extend through and releasably engage a catheter which has been placed within a patient to monitor a patient's blood. A sensor is provided to detect the presence of selected analytes and to identify when preselected parameters have been reached.
摘要翻译：公开了一种透析前监测装置，其在体内透析期间监测血液内容物的预选参数以监测患者健康。监测装置构造成延伸通过并可释放地接合已经放置在患者体内以便监测患者血液的导管。提供了一个传感器来检测选定分析物的存在并识别何时达到了预先选择的参数。

5. 发明申请

US20120261013A1 MICROFLUIDIC SYSTEM INCLUDING A BUBBLE VALVE FOR REGULATING FLUID FLOW THROUGH A MICROCHANNEL 有权
公开(公告)号：US20120261013A1
公开(公告)日：2012-10-18
申请号：US13527331
申请日：2012-06-19
申请人： John Richard Gilbert , Sebastian Böhm , Manish Deshpande
发明人： John Richard Gilbert , Sebastian Böhm , Manish Deshpande
IPC分类号： B81B5/00 , B81C1/00 , C25B15/00 , F15C3/04 , F16K31/12
CPC分类号： B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要： A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.

6. 发明申请

US20120078145A1 COMPRESSION GARMENT APPARATUS HAVING SUPPORT BLADDER 有权
标题翻译：具有支撑叶片的压缩装置
公开(公告)号：US20120078145A1
公开(公告)日：2012-03-29
申请号：US12893683
申请日：2010-09-29
申请人： Arnaz S. Malhi , Manish Deshpande
发明人： Arnaz S. Malhi , Manish Deshpande
IPC分类号： A61H7/00
CPC分类号： A61H1/008 , A61F13/085 , A61H9/0092 , A61H2201/165 , A61H2201/5058 , A61H2201/5064 , A61H2201/5071 , A61H2201/5084 , A61H2205/06 , A61H2205/10 , A61H2230/625
摘要： A compression garment apparatus includes a compression garment and a pressurizer. The pressurizer intermittently pressurizes a therapeutic bladder on the compression garment and pressurizes a support bladder on the compression garment to enhance the fit of the compression garment and maintain the therapeutic bladder in position with respect to a target compression zone on a body part on which the garment is worn. The support bladder may be selectively pressurized when needed based at least in part on sensed physical characteristics.
摘要翻译：压缩服装设备包括压缩衣服和加压器。加压器间歇地对压缩衣服上的治疗膀胱加压并对压缩衣服上的支撑囊进行加压，以增强压缩服装的配合，并将治疗囊保持在相对于身体部位上的目标压缩区的适当位置，被磨损当需要时，至少部分地基于检测到的物理特性，可以选择性地加压支撑囊。

7. 发明授权

US08096964B1 Compression garment having grip 有权
标题翻译：压缩服装有抓地力
公开(公告)号：US08096964B1
公开(公告)日：2012-01-17
申请号：US12893694
申请日：2010-09-29
申请人： Michel Bruehwiler , Melissa Rosen , Manish Deshpande
发明人： Michel Bruehwiler , Melissa Rosen , Manish Deshpande
IPC分类号： A61F5/00
CPC分类号： A61F13/085
摘要： A compression garment adapted for placement in a self-retaining configuration on a body part for imparting compression therapy on the body part. The compression garment includes a flexible wrap and a bladder held in use by the wrap for compressing the body part. The wrap includes and inner flap and an outer flap. The outer flap overlaps the inner flap when the garment is in a self-retaining configuration on the body part. A fastener secures the wrap in the self-retaining configuration. When the outer flap overlaps the inner flap, at least a portion of the inner flap is exposed forming a grip for grasping the inner flap when tightening and fastening the garment in the self-retaining configuration.
摘要翻译：一种压缩衣服，其适于放置在身体部位上的自保持构造中，用于对身体部位进行压缩治疗。压缩衣服包括柔性包装和保持在使用中的用于压缩身体部分的包裹物的囊。包裹物和内皮瓣和外皮瓣。当衣服处于身体部位上的自保持构造时，外翼片与内折板重叠。紧固件将包裹件固定在自保持配置中。当外翼片与内翼片重叠时，当紧固并固定衣服处于自保持构造时，内翼片的至少一部分露出，形成用于抓握内翼片的把手。

8. 发明申请

US20110201981A1 COMPRESSION GARMENT ASSEMBLY 有权
标题翻译：压缩服装组装
公开(公告)号：US20110201981A1
公开(公告)日：2011-08-18
申请号：US12705290
申请日：2010-02-12
申请人： Manish Deshpande , Ross Kanter
发明人： Manish Deshpande , Ross Kanter
IPC分类号： A61H7/00
CPC分类号： A61H23/04 , A61H9/0078 , A61H2201/165 , A61H2201/50 , A61H2205/106
摘要： A compression garment assembly comprises a compression garment adapted for placement on a body part in a self-retaining configuration and for removal from the body part. The compression garment has at least one inflatable bladder for applying compression to the body part. A portable controller unit is adapted for fluid connection to the inflatable bladder and is configured for cyclically inflating the bladder. The compression garment and portable controller unit are configured so that the portable controller unit must be disconnected from the compression garment before the compression garment can be removed from the body part. Loss of the portable controller unit by, for example, accidental disposal with the compression garment is thus prevented.
摘要翻译：压缩衣服组件包括压缩衣服，其适于放置在自身保持构造的身体部分上并且用于从身体部分移除。压缩衣服具有至少一个用于对身体部位施加压力的可充气囊。便携式控制器单元适于流体连接到可膨胀气囊，并且被配置用于循环地使气囊膨胀。压缩衣物和便携式控制器单元构造成使得便携式控制器单元必须在压缩衣服可以从身体部位移除之前与压缩衣服断开连接。因此防止例如通过压缩服装意外处理便携式控制器单元的损失。

9. 发明授权

US07514000B2 Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system 有权
$Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system$
标题翻译：在微流体系统中实施微流体组分，包括分子分馏装置
公开(公告)号：US07514000B2
公开(公告)日：2009-04-07
申请号：US11479125
申请日：2006-06-30
申请人： John R. Gilbert , Manish Deshpande , Jaishree Trikha
发明人： John R. Gilbert , Manish Deshpande , Jaishree Trikha
IPC分类号： B01D15/00 , B01D61/00 , B01D63/00
CPC分类号： B01D63/087 , B01D63/088 , B01D67/0034 , B01D67/0062 , B01D2313/13 , B01D2313/40 , B01D2325/028 , B01D2325/12 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C02F2209/36 , C30B7/00 , C30B29/58 , G01N27/44743 , G01N27/44773 , Y10S977/786 , Y10T156/10
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. The microfluidic element may comprise a matrix having an affinity for selected molecules in a sample. The matrix binds, reacts with and/or retains the selected molecules without affecting other molecules in the sample.
摘要翻译：用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。封盖模块包括用于执行微流控功能的微流体元件。封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。微流体元件可以包含对样品中选定分子具有亲和性的基质。该基质与所选择的分子结合，反应和/或保留，而不影响样品中的其它分子。

10. 发明授权

US07455770B2 Implementation of microfluidic components in a microfluidic system 有权
标题翻译：在微流体系统中实现微流体组分
公开(公告)号：US07455770B2
公开(公告)日：2008-11-25
申请号：US10951473
申请日：2004-09-27
申请人： John R. Gilbert , Manish Deshpande
发明人： John R. Gilbert , Manish Deshpande
IPC分类号： B01D35/26 , B01D29/01 , B01D63/08 , G01N1/02 , B01D63/00
CPC分类号： C30B7/00 , B01L3/06 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C30B29/58 , F04B43/02 , F04B43/043 , Y10T137/0324 , Y10T436/2575
摘要： A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system. An infusion pump for delivering a fluid from a fluid source may be integrated in a microfluidic chip using a capping module having pumping components formed therein.
摘要翻译：用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。封盖模块包括用于执行微流控功能的微流体元件。封盖模块堆叠在具有微流管道的微流体衬底上，以将微流控功能结合到系统中。用于从流体源输送流体的输液泵可以使用其中形成有泵送部件的封盖模块集成在微流体芯片中。

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