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1. 外观设计

USD779670S1 Abrasion device with abrasive tip 有权
标题翻译：磨具磨具
公开(公告)号：USD779670S1
公开(公告)日：2017-02-21
申请号：US29530275
申请日：2015-06-15
申请人： Echo Therapeutics, Inc.
设计人： Keith E. Krystyniak , Stephen J. Perry

2. 发明授权

US09572527B2 Skin permeation device for analyte sensing or transdermal drug delivery 有权
标题翻译：用于分析物感测或透皮药物递送的皮肤渗透装置
公开(公告)号：US09572527B2
公开(公告)日：2017-02-21
申请号：US13746673
申请日：2013-01-22
申请人： Echo Therapeutics, Inc.
发明人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
IPC分类号： A61B5/05 , A61B5/00 , A61B5/053 , A61B17/54 , A61B18/20 , A61N1/04 , A61N1/32 , A61B17/00 , A61B17/32 , A61B18/00 , A61M37/00
CPC分类号： A61B18/14 , A61B5/0531 , A61B5/145 , A61B5/14532 , A61B5/14542 , A61B5/442 , A61B5/7239 , A61B17/54 , A61B18/20 , A61B18/203 , A61B2017/00761 , A61B2017/00765 , A61B2017/320004 , A61B2018/00452 , A61B2018/00642 , A61M2037/0007 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/327 , A61N1/328
摘要： Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
摘要翻译：本文描述了用于增加由测量的皮肤电参数控制的皮肤渗透性的装置，系统，试剂盒和方法。它们可用于透皮药物递送和/或分析物提取或测量。受控磨损装置包括（i）手件，（ii）研磨尖端，（iii）反馈控制机构，（iv）两个或更多个电极，和（v）电动机。反馈控制机构可以是内部反馈控制机构或外部反馈控制。该套件包含受控的磨损装置，一个或多个研磨尖端，任选地具有润湿流体。增加皮肤渗透性的方法需要将受控的磨损装置施用于皮肤表面的一部分短时间，直至达到所需的渗透性水平。然后去除磨损装置，并将药物递送组合物或装置或分析物传感器施加到处理部位。

3. 外观设计

USD719267S1 Analyte sensor 有权
标题翻译：分析物传感器
公开(公告)号：USD719267S1
公开(公告)日：2014-12-09
申请号：US29455630
申请日：2013-05-22
申请人： Echo Therapeutics, Inc.
设计人： Lorenzo C. Vaccarella

4. 发明授权

US08812071B2 Transdermal analyte monitoring systems and methods for analyte detection 有权
标题翻译：透皮分析物监测系统和分析物检测方法
公开(公告)号：US08812071B2
公开(公告)日：2014-08-19
申请号：US12043469
申请日：2008-03-06
申请人： Han Chuang , James P. Hurley , Joseph Kost
发明人： Han Chuang , James P. Hurley , Joseph Kost
IPC分类号： A61B5/05 , A61B5/00 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/6833
摘要： Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.
摘要翻译：本文描述了具有增加的寿命和改进的分析物检测的透皮分析物监测系统（TAMS）。还描述了与TAMS一起使用的试剂盒和使用TAMS和试剂盒的方法。在优选实施方案中，TAMS包括覆盖水凝胶表面的保护性半透膜。保护性半透膜与使用者的皮肤接触并防止水凝胶的污染或结垢。任选地，水凝胶包含一种或多种湿润剂和/或固定化酶。在另一个优选的实施方案中，TAMS含有至少一个通道或口袋，用于增加提供给水凝胶的氧气的量。在一个实施方案中，提供了一种通过TAMS改进分析物检测的方法。例如，在通过适当的预处理增加皮肤孔隙率之后，将皮肤制剂擦拭物施加到经处理的皮肤区域，然后将TAMS施加到处理区域。

5. 发明授权

US08386027B2 Skin permeation device for analyte sensing or transdermal drug delivery 有权
标题翻译：用于分析物感测或透皮药物递送的皮肤渗透装置
公开(公告)号：US08386027B2
公开(公告)日：2013-02-26
申请号：US12110034
申请日：2008-04-25
申请人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
发明人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
IPC分类号： A61B5/05 , A61B5/00 , A61B17/20 , A61N1/30 , A61N1/00
CPC分类号： A61B18/14 , A61B5/0531 , A61B5/145 , A61B5/14532 , A61B5/14542 , A61B5/442 , A61B5/7239 , A61B17/54 , A61B18/20 , A61B18/203 , A61B2017/00761 , A61B2017/00765 , A61B2017/320004 , A61B2018/00452 , A61B2018/00642 , A61M2037/0007 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/327 , A61N1/328
摘要： Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
摘要翻译：本文描述了用于增加由测量的皮肤电参数控制的皮肤渗透性的装置，系统，试剂盒和方法。它们可用于透皮药物递送和/或分析物提取或测量。受控磨损装置包括（i）手件，（ii）研磨尖端，（iii）反馈控制机构，（iv）两个或更多个电极，和（v）电动机。反馈控制机构可以是内部反馈控制机构或外部反馈控制。该套件包含受控的磨损装置，一个或多个研磨尖端，任选地具有润湿流体。增加皮肤渗透性的方法需要将受控的磨损装置施用于皮肤表面的一部分短时间，直至达到所需的渗透性水平。然后去除磨损装置，并将药物递送组合物或装置或分析物传感器施加到处理部位。

6. 发明授权

US08224414B2 System and method for analyte sampling and analysis with hydrogel 有权
标题翻译：用水凝胶分析物取样和分析的系统和方法
公开(公告)号：US08224414B2
公开(公告)日：2012-07-17
申请号：US11223971
申请日：2005-09-13
申请人： Scott C. Kellogg , Han Chuang
发明人： Scott C. Kellogg , Han Chuang
IPC分类号： A61B5/05 , A61B5/00 , C12Q1/54 , G01N33/50
CPC分类号： C08L33/26 , A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/681 , A61L31/048 , A61L31/145 , C08L33/24 , C08L2203/02 , G01N27/3273 , G01N27/4166 , Y10T436/144444
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

7. 发明授权

US08870810B2 Method and apparatus for enhancement of transdermal transport 有权
标题翻译：用于增强透皮运输的方法和装置
公开(公告)号：US08870810B2
公开(公告)日：2014-10-28
申请号：US13614032
申请日：2012-09-13
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F Warner , Tuan A Elstrom
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F Warner , Tuan A Elstrom
IPC分类号： A61B17/20 , A61M31/00
CPC分类号： A61K49/0004 , A61M37/0092
摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
摘要翻译：根据本发明，公开了一种增强透皮转运的方法。该方法包括通过透化装置增加膜的面积的渗透性的步骤。膜可以是生物皮肤或合成皮肤。渗透装置可以是超声产生装置。物质被运送进入膜并通过该区域。该物质可以是药物，疫苗或组织液的组分。

8. 发明授权

US08287483B2 Method and apparatus for enhancement of transdermal transport 有权
标题翻译：用于增强透皮运输的方法和装置
公开(公告)号：US08287483B2
公开(公告)日：2012-10-16
申请号：US10792862
申请日：2004-03-05
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
IPC分类号： A61B17/20 , A61M31/00
CPC分类号： A61B5/411 , A61B5/14532 , A61B5/415 , A61B5/418 , A61K49/0004 , A61M37/0092 , A61M2037/0007
摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
摘要翻译：根据本发明，公开了一种增强透皮转运的方法。该方法包括通过透化装置增加膜的面积的渗透性的步骤。膜可以是生物皮肤或合成皮肤。渗透装置可以是超声产生装置。物质被运送进入并通过膜的区域。该物质可以是药物，疫苗或组织液的组分。

9. 发明申请

US20110282327A1 SYSTEM AND METHOD FOR CONTINUOUS NON-INVASIVE GLUCOSE MONITORING 审中-公开
标题翻译：用于连续非侵入式葡萄糖监测的系统和方法
公开(公告)号：US20110282327A1
公开(公告)日：2011-11-17
申请号：US13085370
申请日：2011-04-12
申请人： Scott C. KELLOGG , Han Chuang , Shikha Barman , Nick Warner
发明人： Scott C. KELLOGG , Han Chuang , Shikha Barman , Nick Warner
IPC分类号： A61M5/00 , A61B5/1468
CPC分类号： A61B5/1486 , A61B5/0002
摘要： A system and method for continuous non-invasive glucose monitoring is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter; (2) extracting the at least one analyte through and out of the area of biological membrane and into the sensor; (3) generating an electrical signal representative of a level of the at least one analyte; (4) transmitting the electrical signal to a base device; (5) processing the electrical signal to determine the level of the at least one analyte; and (6) displaying the level of the at least one analyte in real time. The system includes a remote device that includes a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and a transmitter that transmits the electrical signal. The system further includes a base device that includes a receiver that receives the electrical signal; a processor that processes the electrical signal; and a display that displays the processed signal in real time.
摘要翻译：公开了一种用于连续非侵入性葡萄糖监测的系统和方法。根据本发明的一个实施例，该方法包括以下步骤：（1）使远程设备接触具有渗透性水平的生物膜的区域，所述远程设备包括传感器和发射器; （2）将至少一种分析物提取出生物膜的区域并进入传感器; （3）产生代表所述至少一种分析物的水平的电信号; （4）将电信号发送到基站装置; （5）处理所述电信号以确定所述至少一种分析物的水平; 和（6）实时显示至少一种分析物的水平。该系统包括远程设备，其包括产生代表至少一种分析物的浓度的电信号的传感器; 以及发送电信号的发送器。该系统还包括一个基本设备，其包括接收电信号的接收机; 处理器，用于处理电信号; 以及实时显示被处理信号的显示器。

10. 发明申请

US20080281178A1 TRANSDERMAL ANALYTE MONITORING SYSTEMS AND METHODS FOR ANALYTE DETECTION 有权
标题翻译：传感器分析监测系统和分析仪检测方法
公开(公告)号：US20080281178A1
公开(公告)日：2008-11-13
申请号：US12043469
申请日：2008-03-06
申请人： Han Chuang , James P. Hurley , Joseph Kost
发明人： Han Chuang , James P. Hurley , Joseph Kost
IPC分类号： A61B5/1486
CPC分类号： A61B5/0002 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/6833
摘要： Transdermal analyte monitoring systems (TAMS) having increased longevity and improved analyte detection are described herein. Kits for use with the TAMS and methods of using the TAMS and kits are also described. In a preferred embodiment, the TAMS includes a protective, semi-permeable membrane covering the surface of the hydrogel. The protective, semi-permeable membrane contacts with the skin of a user and prevents contamination or fouling of the hydrogel. Optionally, the hydrogel comprises one or more humectants and/or an immobilized enzyme. In another preferred embodiment, the TAMS contains at least one channel or pocket for increasing the amount of oxygen provided to the hydrogel. In one embodiment, a method for improving analyte detection by the TAMS is provided. For example, after the skin porosity is increased by an appropriate pretreatment, a skin preparation wipe is applied to the treated skin area and then the TAMS is applied to the treated area.
摘要翻译：本文描述了具有增加的寿命和改进的分析物检测的透皮分析物监测系统（TAMS）。还描述了与TAMS一起使用的试剂盒和使用TAMS和试剂盒的方法。在优选实施方案中，TAMS包括覆盖水凝胶表面的保护性半透膜。保护性半透膜与使用者的皮肤接触并防止水凝胶的污染或结垢。任选地，水凝胶包含一种或多种湿润剂和/或固定化酶。在另一个优选的实施方案中，TAMS含有至少一个通道或口袋，用于增加提供给水凝胶的氧气的量。在一个实施方案中，提供了一种通过TAMS改进分析物检测的方法。例如，在通过适当的预处理增加皮肤孔隙率之后，将皮肤制剂擦拭物施加到经处理的皮肤区域，然后将TAMS施加到处理区域。

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