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1. 发明申请

US20080275468A1 SKIN PERMEATION DEVICE FOR ANALYTE SENSING OR TRANSDERMAL DRUG DELIVERY 有权
标题翻译：用于分析仪感光或透皮药物输送的皮肤渗透装置
公开(公告)号：US20080275468A1
公开(公告)日：2008-11-06
申请号：US12110034
申请日：2008-04-25
申请人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
发明人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
IPC分类号： A61B17/00 , A61B5/053
CPC分类号： A61B18/14 , A61B5/0531 , A61B5/145 , A61B5/14532 , A61B5/14542 , A61B5/442 , A61B5/7239 , A61B17/54 , A61B18/20 , A61B18/203 , A61B2017/00761 , A61B2017/00765 , A61B2017/320004 , A61B2018/00452 , A61B2018/00642 , A61M2037/0007 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/327 , A61N1/328
摘要： Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
摘要翻译：本文描述了用于增加由测量的皮肤电参数控制的皮肤渗透性的装置，系统，试剂盒和方法。它们可用于透皮药物递送和/或分析物提取或测量。受控磨损装置包括（i）手件，（ii）研磨尖端，（iii）反馈控制机构，（iv）两个或更多个电极，和（v）电动机。反馈控制机构可以是内部反馈控制机构或外部反馈控制。该套件包含受控的磨损装置，一个或多个研磨尖端，任选地具有润湿流体。增加皮肤渗透性的方法需要将受控的磨损装置施用于皮肤表面的一部分短时间，直至达到所需的渗透性水平。然后去除磨损装置，并将药物递送组合物或装置或分析物传感器施加到处理部位。

2. 发明授权

US08386027B2 Skin permeation device for analyte sensing or transdermal drug delivery 有权
标题翻译：用于分析物感测或透皮药物递送的皮肤渗透装置
公开(公告)号：US08386027B2
公开(公告)日：2013-02-26
申请号：US12110034
申请日：2008-04-25
申请人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
发明人： Han Chuang , Juan P. Eslava , James P. Hurley , Debashis Ghosh , Keith Krystyniak , Scott C. Kellogg
IPC分类号： A61B5/05 , A61B5/00 , A61B17/20 , A61N1/30 , A61N1/00
CPC分类号： A61B18/14 , A61B5/0531 , A61B5/145 , A61B5/14532 , A61B5/14542 , A61B5/442 , A61B5/7239 , A61B17/54 , A61B18/20 , A61B18/203 , A61B2017/00761 , A61B2017/00765 , A61B2017/320004 , A61B2018/00452 , A61B2018/00642 , A61M2037/0007 , A61N1/042 , A61N1/0424 , A61N1/0436 , A61N1/044 , A61N1/30 , A61N1/327 , A61N1/328
摘要： Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.
摘要翻译：本文描述了用于增加由测量的皮肤电参数控制的皮肤渗透性的装置，系统，试剂盒和方法。它们可用于透皮药物递送和/或分析物提取或测量。受控磨损装置包括（i）手件，（ii）研磨尖端，（iii）反馈控制机构，（iv）两个或更多个电极，和（v）电动机。反馈控制机构可以是内部反馈控制机构或外部反馈控制。该套件包含受控的磨损装置，一个或多个研磨尖端，任选地具有润湿流体。增加皮肤渗透性的方法需要将受控的磨损装置施用于皮肤表面的一部分短时间，直至达到所需的渗透性水平。然后去除磨损装置，并将药物递送组合物或装置或分析物传感器施加到处理部位。

3. 发明授权

US08224414B2 System and method for analyte sampling and analysis with hydrogel 有权
标题翻译：用水凝胶分析物取样和分析的系统和方法
公开(公告)号：US08224414B2
公开(公告)日：2012-07-17
申请号：US11223971
申请日：2005-09-13
申请人： Scott C. Kellogg , Han Chuang
发明人： Scott C. Kellogg , Han Chuang
IPC分类号： A61B5/05 , A61B5/00 , C12Q1/54 , G01N33/50
CPC分类号： C08L33/26 , A61B5/14514 , A61B5/14532 , A61B5/1486 , A61B5/681 , A61L31/048 , A61L31/145 , C08L33/24 , C08L2203/02 , G01N27/3273 , G01N27/4166 , Y10T436/144444
摘要： The invention relates to a transdermal analyte monitoring system comprising a medium adapted to interface with a biological membrane and to receive an analyte from the biological membrane and an electrode assembly comprising a plurality of electrodes, wherein the medium is adapted to react continuously with the analyte, an electrical signal is detected by the electrode assembly, and the electrical signal correlates to an analyte value. The analyte value may be the flux of the analyte through the biological membrane or the concentration of the analyte in a body fluid of a subject. The medium may comprise a vinyl acetate based hydrogel, an agarose based hydrogel, or a polyethylene glycol diacrylate (PEG-DA) based hydrogel, for example. The surface region of the electrode may comprise pure platinum. The system may include an interference filter located between the biological membrane and the electrode assembly for reducing interference in the system. The system may comprise a processor programmed to implement an error correction method that corrects for sensor drift.
摘要翻译：本发明涉及一种透皮分析物监测系统，其包括适于与生物膜接合并接收来自生物膜的分析物的介质和包含多个电极的电极组件，其中所述介质适于与分析物连续反应，电信号由电极组件检测，电信号与分析物值相关。分析物值可以是通过生物膜的分析物的通量或受试者的体液中分析物的浓度。介质可以包括例如基于乙酸乙烯酯的水凝胶，基于琼脂糖的水凝胶或基于聚乙二醇二丙烯酸酯（PEG-DA）的水凝胶。电极的表面区域可以包括纯铂。该系统可以包括位于生物膜和电极组件之间的干涉滤波器，用于减少系统中的干扰。系统可以包括被编程为实现校正传感器漂移的纠错方法的处理器。

4. 发明申请

US20130035566A1 Method and Apparatus for Enhancement of Transdermal Transport 有权
标题翻译：用于增强透皮转运的方法和装置
公开(公告)号：US20130035566A1
公开(公告)日：2013-02-07
申请号：US13614032
申请日：2012-09-13
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
IPC分类号： A61M37/00 , A61B5/157
CPC分类号： A61K49/0004 , A61M37/0092
摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
摘要翻译：根据本发明，公开了一种增强透皮转运的方法。该方法包括通过透化装置增加膜的面积的渗透性的步骤。膜可以是生物皮肤或合成皮肤。渗透装置可以是超声产生装置。物质被运送进入膜并通过该区域。该物质可以是药物，疫苗或组织液的组分。

5. 发明申请

US20130204238A1 COMBINATION THERAPY 审中-公开
标题翻译：组合治疗
公开(公告)号：US20130204238A1
公开(公告)日：2013-08-08
申请号：US13637664
申请日：2011-03-07
申请人： Seth M. Lederman , Scott C. Kellogg , William Ju
发明人： Seth M. Lederman , Scott C. Kellogg , William Ju
IPC分类号： A61B18/20 , A61B17/3209
CPC分类号： A61B18/203 , A61B17/32093 , A61B2017/00747 , A61B2017/00761 , A61B2018/00452 , A61N5/0617
摘要： The present methods, systems, and kits permit the induction of multimodal injury to a subject's skin. This approach maximizes the responsiveness of the treated area to treatments for producing hair follicles; exciting, activating, and dispersing existing hair-producing structures; and bringing about other physiological changes that correspond to increased hair growth and/or the growth of more robust hairs. In contrast with conventional methodologies, the present methods and systems provide heretofore unattainable advantages through use of a multi-pronged approach of de novo hair follicle production, in combination with reorganization of existing structures to produce new follicular units, as well as pharmaceutical enhancement of both processes, and other gainful techniques.
摘要翻译：本方法，系统和试剂盒允许诱发受试者皮肤的多模式损伤。该方法使处理区域对生产毛囊的处理的响应性最大化; 刺激，激活和分散现有的发型结构; 并产生对应于增加的头发生长和/或更健壮的头发的生长的其它生理变化。与常规方法相比，本方法和系统通过使用从头毛囊生产的多管齐下的方法提供迄今无法获得的优点，结合现有结构的重新组合以产生新的滤泡单位，以及两者的药物增强流程和其他有益的技术。

6. 发明授权

US07066884B2 System, method, and device for non-invasive body fluid sampling and analysis 失效
公开(公告)号：US07066884B2
公开(公告)日：2006-06-27
申请号：US09979096
申请日：2001-03-16
申请人： Linda Custer , Tuan A. Elstrom , Scott C. Kellogg , Joseph Kost , Nicholas F. Warner
发明人： Linda Custer , Tuan A. Elstrom , Scott C. Kellogg , Joseph Kost , Nicholas F. Warner
IPC分类号： A61B5/00
CPC分类号： A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150083 , A61B5/150358 , A61B5/150755 , A61B5/15087 , A61B5/150969 , A61B5/15134 , A61B5/157 , A61B8/00 , A61B2010/008 , A61M25/02 , A61M37/0092 , A61M2025/0206
摘要： A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level; (2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte; and (8) providing the results of the step of analyzing the body fluid.

7. 发明申请

US20140079686A1 Methods For Treating Baldness And Promoting Hair Growth 审中-公开
标题翻译：治疗秃发和促进头发生长的方法
公开(公告)号：US20140079686A1
公开(公告)日：2014-03-20
申请号：US13991874
申请日：2011-12-06
申请人： Shikha P. Barman , William D. Ju , Scott C. Kellogg , Stephen M. Prouty , Eric Schweiger , Seth Lederman , Mary Osbakken , Alan D. Schinazi
发明人： Shikha P. Barman , William D. Ju , Scott C. Kellogg , Stephen M. Prouty , Eric Schweiger , Seth Lederman , Mary Osbakken , Alan D. Schinazi
IPC分类号： A61M37/00 , A61K38/48
CPC分类号： A61M37/00 , A45D2200/1054 , A61B17/00491 , A61B17/54 , A61B18/203 , A61B2017/00398 , A61B2017/00495 , A61B2017/00734 , A61B2017/00747 , A61B2017/00761 , A61B2017/320004 , A61B2018/00476 , A61B2018/00577 , A61H7/005 , A61H23/0245 , A61H2201/10 , A61H2201/105 , A61H2201/1215 , A61H2201/1604 , A61H2201/1671 , A61H2205/021 , A61K8/4953 , A61K8/63 , A61K8/69 , A61K38/4893 , A61K2800/884 , A61N5/0617 , A61N2005/0644 , A61N2005/067 , A61Q7/00
摘要： The invention relates to methods of treating baldness, treating alopecia, promoting hair growth, and/or promoting hair follicle development and/or activation or stimulation on an area of the skin of a subject (for example, a human) by subjecting said area of the skin to integumental perturbation. Integumental perturbation can be used in combination with other treatments for promoting hair growth. The invention provides devices for integumental perturbation for promoting hair growth, and provides pharmaceutical compositions for use in combination with integumental perturbation for promoting hair growth.
摘要翻译：本发明涉及治疗秃发，治疗脱发，促进毛发生长和/或促进毛囊发育和/或激活或刺激受试者（例如人）皮肤区域的方法，皮肤到皮肤扰动。视觉摄影可以与其他促进头发生长的治疗结合使用。本发明提供用于促进毛发生长的皮肤扰动装置，并提供用于促进头发生长的皮肤扰动组合使用的药物组合物。

8. 发明授权

US08870810B2 Method and apparatus for enhancement of transdermal transport 有权
标题翻译：用于增强透皮运输的方法和装置
公开(公告)号：US08870810B2
公开(公告)日：2014-10-28
申请号：US13614032
申请日：2012-09-13
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F Warner , Tuan A Elstrom
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F Warner , Tuan A Elstrom
IPC分类号： A61B17/20 , A61M31/00
CPC分类号： A61K49/0004 , A61M37/0092
摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
摘要翻译：根据本发明，公开了一种增强透皮转运的方法。该方法包括通过透化装置增加膜的面积的渗透性的步骤。膜可以是生物皮肤或合成皮肤。渗透装置可以是超声产生装置。物质被运送进入膜并通过该区域。该物质可以是药物，疫苗或组织液的组分。

9. 发明授权

US08287483B2 Method and apparatus for enhancement of transdermal transport 有权
标题翻译：用于增强透皮运输的方法和装置
公开(公告)号：US08287483B2
公开(公告)日：2012-10-16
申请号：US10792862
申请日：2004-03-05
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner , Tuan A. Elstrom
IPC分类号： A61B17/20 , A61M31/00
CPC分类号： A61B5/411 , A61B5/14532 , A61B5/415 , A61B5/418 , A61K49/0004 , A61M37/0092 , A61M2037/0007
摘要： According to the present invention, a method for enhancing transdermal transport is disclosed. The method includes the steps of increasing a permeability of an area of a membrane with a permeabilizing device. The membrane may be, inter alia, biologic skin or synthetic skin. The permeabilizing device may be an ultrasound-producing device. A substance is transported into and through the area of the membrane. The substance may be a drug, a vaccine, or a component of interstitial fluid.
摘要翻译：根据本发明，公开了一种增强透皮转运的方法。该方法包括通过透化装置增加膜的面积的渗透性的步骤。膜可以是生物皮肤或合成皮肤。渗透装置可以是超声产生装置。物质被运送进入并通过膜的区域。该物质可以是药物，疫苗或组织液的组分。

10. 发明授权

US06620123B1 Method and apparatus for producing homogenous cavitation to enhance transdermal transport 失效
标题翻译：用于产生均匀空化以增强透皮转运的方法和装置
公开(公告)号：US06620123B1
公开(公告)日：2003-09-16
申请号：US09868443
申请日：2001-07-26
申请人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner
发明人： Samir S. Mitragotri , Joseph Kost , Scott C. Kellogg , Nicholas F. Warner
IPC分类号： A61B1720
CPC分类号： A61M37/0092 , A61B2017/22008 , A61B2017/22027 , A61B2017/320072
摘要： The present invention is directed to apparatus and methods for producing homogenous cavitation. An ultrasound souce comprising an ultrasound transmitting element having an axis and a cross-section along the axis is disclosed The ultrasound transmitting element also has a first axial end and a second axial end operable to produce ultrasonic waves. The cross-section has an area having a maximum value at the first axial end and a minimum value at the second axial end. A method for producing homogenous cavitation at an area of skin comprises creating a volume of fluid having a uniformly dispersed concentration of cavitation nuclei adjacent the area of skin. Ultrasound is then applied to the volume of fluid and causes cavitation at the cavitation nuclei.
摘要翻译：本发明涉及用于产生均匀空化的装置和方法。公开了一种包括具有沿轴线的轴线和横截面的超声波发射元件的超声波囊。超声波发射元件还具有可操作以产生超声波的第一轴向端和第二轴向端。横截面具有在第一轴向端具有最大值的区域和在第二轴向端处的最小值。用于在皮肤区域产生均匀空化的方法包括产生具有与皮肤区域相邻的气蚀核的均匀分散浓度的流体体积。然后将超声波施加到体积的流体并在空化核处引起空化。

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