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1. 发明申请

US20230073902A1 SYRINGE AND SYRINGE BODY 有权
公开(公告)号：US20230073902A1
公开(公告)日：2023-03-09
申请号：US17759772
申请日：2021-04-22
申请人： Fresenius Kabi Deutschland GmbH
发明人： Torsten Brandenburger , Michael Schönhofen
IPC分类号： A61M5/34 , A61M5/31
摘要： The invention relates to a syringe body having a nozzle and a threaded connection. The syringe body consists of an inner part and an outer part, the inner part comprising, at least in regions, a cycloolefin, in particular a cycloolefin copolymer or a cycloolefin polymer, as a first material. The first material forms an inner wall of the syringe body. The threaded connection of the outer part comprises, at least in regions, a material different from the cycloolefin as a second material. The invention further relates to a syringe having the syringe body.

2. 发明申请

US20230049145A1 GLYCOSYLATED POLYPEPTIDES 有权
公开(公告)号：US20230049145A1
公开(公告)日：2023-02-16
申请号：US17781688
申请日：2020-12-11
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Markus O. IMHOF , Parul GUPTA , Adrian BLACKBURN , Hilary METCALFE
IPC分类号： C07K16/24 , C07D401/04 , C12P21/00
摘要： The present invention is directed to use of kifunensine for increasing sialylation of a glycosylated polypeptide, wherein a cell that produces the glycosylated polypeptide is contacted with kifunensine. Also provided are related methods for increasing sialylation of a glycosylated polypeptide and producing a glycosylated polypeptide, as well as glycosylated polypeptides and pharmaceutical compositions comprising the same, and their use in medicine.

3. 发明授权

US11498284B2 Contour-forming welding tool for pulse welding and contour-forming pulse welding method for a medical pack formed as a bag 有权
公开(公告)号：US11498284B2
公开(公告)日：2022-11-15
申请号：US17265317
申请日：2019-09-24
申请人： Fresenius Kabi Deutschland GmbH
发明人： Joern Wittorf , Gerald Wegner , Tobias Lenhardt
IPC分类号： B29C65/00 , B29C65/38 , A61J1/10 , B29C65/22
摘要： The invention relates to a welding tool and to a method for pulse welding of plastic films for medical packs formed as bags. In general, the invention provides that the film material which is plastified during welding and thus free-flowing is specifically displaced into a deepened, edge-side inner region of the sealing surface by increasing the sealing surface area. The film material accumulated in the recess leads to an increase in the film thickness in the inner region (25i) of the weld seam (6, 7, 8). As a result, the mechanical stability of the medical pack formed as a bag can be improved.

4. 发明授权

US11464902B1 Wearable medicament delivery device with compressible reservoir and method of use thereof 有权
公开(公告)号：US11464902B1
公开(公告)日：2022-10-11
申请号：US17178795
申请日：2021-02-18
申请人： Fresenius Kabi Deutschland GmbH
发明人： David R. Schiff , Sharon D. West , Jason Zerweck
IPC分类号： A61M5/142 , A61M5/168 , A61M5/148 , A61M5/145 , A61M5/152
摘要： A wearable drug delivery device and related methods are described. The wearable drug delivery device can include: a housing; a flexible bag disposed within the housing; a cannula in fluid communication with the flexible bag; and a pumping mechanism for forcing a drug from the flexible bag and into the cannula, wherein the pumping mechanism is proximate the flexible bag and includes a spring-loaded paddle or a driving bag.

5. 发明申请

US20220184638A1 System for Blood Cell Separation 有权
公开(公告)号：US20220184638A1
公开(公告)日：2022-06-16
申请号：US17542684
申请日：2021-12-06
申请人： Fresenius Kabi Deutschland GmbH
发明人： Heike Mitschulat , Anke Hannig , Michael Schwalm , Patrick Schwalm
IPC分类号： B04B5/04 , B04B11/02
摘要： A system for blood cell separation, comprising:
a separation chamber (10) comprising an inlet port for blood (12), an outlet port for plasma (14) and at least an outlet port for cellular blood components (16) for the separation of whole blood;
a blood pump (20) for pumping whole blood into the inlet port for blood (12);
a plasma pump (22) for pumping plasma and/or target cells from the outlet port for plasma (14) out of the separation chamber (10);
a red blood cell tube (30) comprising a first end (32) and a second end (34), wherein the first end (32) of the red blood cell tube (30) is connected to the outlet port for cellular blood components (16) for allowing red blood cells to leave the separation chamber (10); and
a drip chamber (40) comprising a reservoir (42) and an inlet (46), wherein the second end (34) of the red blood cell tube (30) is connected to the inlet (46), wherein the second end (34) of the red blood cell tube (30) extends into the volume of the reservoir (42) for pressure equalization during pumping from the outlet port for plasma (14).

6. 发明授权

US11344682B1 Drug supply cartridge with visual use indicator and delivery devices that use the same 有权
公开(公告)号：US11344682B1
公开(公告)日：2022-05-31
申请号：US17180647
申请日：2021-02-19
申请人： Fresenius Kabi Deutschland GmbH
发明人： Sharon D West , Jason Zerweck
IPC分类号： A61M5/50 , A61M5/315 , A61M5/19 , A61M5/28
摘要： A drug delivery device and cartridge wherein the cartridge includes a movable use indicator that indicates whether the cartridge has been opened and/or used.

7. 发明授权

US11311666B1 Modular wearable medicament delivery device and method of use thereof 有权
公开(公告)号：US11311666B1
公开(公告)日：2022-04-26
申请号：US17178782
申请日：2021-02-18
申请人： Fresenius Kabi Deutschland GmbH
发明人： Sharon D. West , Justin E. Bechstein
IPC分类号： A61M5/168 , A61M5/142
摘要： A medicament delivery device and method of use thereof. The device includes a sensor module and an injector module. The injector module is adapted to (i) be coupled to the sensor module during injection of a cannula and a needle into subcutaneous tissue and during delivery of the medicament and (ii) be removed from the sensor module after the delivery of the medicament.

8. 发明授权

US11254964B1 Cell culture methods for increased cell viability 有权
公开(公告)号：US11254964B1
公开(公告)日：2022-02-22
申请号：US15457579
申请日：2017-03-13
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Matthieu Stettler , Hervé Broly , Thomas Solacroup , Yolande Rouiller
IPC分类号： C07K16/14 , C12P21/02 , C07K16/24
摘要： The present invention relates to a method of maintaining cell viability at a level of at least 80% for up to 14 days in a fed-batch culture of cells producing a recombinant protein, the method comprising maintaining the cell culture medium at a pH of 6.5 to 7.0 and at a temperature of 31° C. to 35° C. for at least 5 consecutive days of the duration of the cell culture method.

9. 发明申请

US20210261673A1 Liquid Pharmaceutical Composition Comprising an Anti-IL-6 Receptor Antibody 有权
公开(公告)号：US20210261673A1
公开(公告)日：2021-08-26
申请号：US17181829
申请日：2021-02-22
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Alessandra DEL RIO , Carmela SABINA
IPC分类号： C07K16/28 , A61K9/00 , A61K47/26 , A61K47/18 , A61K9/08 , A61K39/395 , A61K47/02 , A61K47/20 , A61K47/22
摘要： The present invention relates to a novel protein formulation. In particular, the invention relates to a liquid pharmaceutical composition of an antibody directed to Interleukin-6 receptor, a method of manufacturing the composition, a kit including the composition, a package including the composition and to methods of treatment using the composition and/or package.

10. 发明申请

US20210213272A1 CONNECTOR FOR CONNECTING A FIRST MEDICAL LINE TO A SECOND MEDICAL LINE 有权
公开(公告)号：US20210213272A1
公开(公告)日：2021-07-15
申请号：US17056522
申请日：2019-06-05
申请人： Fresenius Kabi Deutschland GmbH
发明人： Steffen Baumgart
IPC分类号： A61M39/10
摘要： A connector for connecting a first medical line to a second medical line is disclosed. This connector comprises an insertion shaft (12) having a flow channel that is intended to be brought into fluid communication with a lumen of a first medical line (3); a collar (10) that circumferentially extends around the insertion shaft (12), wherein the collar (10) comprises a first thread (100) on an inner side that faces the insertion shaft (12); and an elastic member (14) that is placed between the insertion shaft (12) and the collar (10), wherein the elastic member (14) comprises an abutment portion (141) abutting a surface of the insertion shaft (12) and being displaceable relative to the surface of the insertion shaft (12). The collar (10) is radially movable around the insertion shaft (12) and the elastic member (14) comprises a thread portion (142) having a second thread that engages the first thread (100) of the collar (10) such that a rotational movement of the collar (10) around the insertion shaft (12) results in a lateral displacement of the elastic member (14) along the surface of the insertion shaft (12). Furthermore, a method for operating such a connector is disclosed. Additionally, a connector assembly comprising such a connector is disclosed.

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