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1. 发明授权

US11640847B2 Bioinformatic processes for determination of peptide binding 有权
公开(公告)号：US11640847B2
公开(公告)日：2023-05-02
申请号：US16921460
申请日：2020-07-06
申请人： IOGENETICS, LLC
发明人： Robert D. Bremel , Jane Homan
IPC分类号： G16B20/30 , G16B20/00 , G16B40/20 , G16B40/00 , G16B20/20 , G16B20/40
摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.

2. 发明授权

US10755801B2 Identifying peptides having T-cell-exposed motifs with known frequency of occurrence in a reference database 有权
公开(公告)号：US10755801B2
公开(公告)日：2020-08-25
申请号：US15325655
申请日：2015-07-10
申请人： IOGENETICS, LLC
发明人： Robert D. Bremel , Jane Homan , Michael Imboden
IPC分类号： G16B30/00 , G16B20/00 , G16B50/00 , G01N33/68
摘要： The present invention provides methods and systems for identifying and classifying epitopes and use of that information to analyze proteins and peptides within proteins, especially potential epitopes, and to use the information to design synthetic peptides and proteins, analyze biopharmaceutical proteins, and diagnose autoimmune conditions. Peptides which are bound in MHC grooves comprise two sets of amino acids: those that face inwards into the groove and determine the binding affinity to the MHC molecule (the groove exposed motifs or GEM) and those which do not interact with the groove but rather are on the obverse side exposed outwardly to the T-cells (the T-cell exposed Motifs or TCEM). The present invention utilizes information related to the identity and physiochemical characteristics of the GEM and TCEM.

3. 发明授权

US08703134B2 Targeted cryptosporidium biocides 有权
标题翻译：靶向隐孢子虫杀生物剂
公开(公告)号：US08703134B2
公开(公告)日：2014-04-22
申请号：US13760448
申请日：2013-02-06
申请人： ioGenetics, LLC
发明人： Michael Imboden , Michael Riggs , Deborah A. Schaefer , Jane Homan , Robert D. Bremel
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/20 , A61K2039/505 , C07K14/4703 , C07K2317/12 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/01 , C12N9/18
摘要： The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.
摘要翻译：本发明涉及包含微生物靶向分子（例如免疫球蛋白）和杀生物剂的融合蛋白。本发明还涉及在不同领域中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法。

4. 发明申请

US20130230516A1 TARGETED CRYPTOSPORIDIUM BIOCIDES 有权
标题翻译：有针对性的CRYPTOSPORIDIUM BIOCIDES
公开(公告)号：US20130230516A1
公开(公告)日：2013-09-05
申请号：US13760448
申请日：2013-02-06
申请人： Michael Imboden , Michael Riggs , Deborah A. Schaefer , Jane Homan , Robert D. Bremel
发明人： Michael Imboden , Michael Riggs , Deborah A. Schaefer , Jane Homan , Robert D. Bremel
IPC分类号： C07K16/20
CPC分类号： C07K16/20 , A61K2039/505 , C07K14/4703 , C07K2317/12 , C07K2317/56 , C07K2317/76 , C07K2319/00 , C07K2319/01 , C12N9/18
摘要： The present invention relates to fusion proteins comprising a microorganism targeting molecule (e.g., immunoglobulin) and a biocide. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in diverse fields.
摘要翻译：本发明涉及包含微生物靶向分子（例如免疫球蛋白）和杀生物剂的融合蛋白。本发明还涉及在不同领域中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法。

5. 发明申请

US20230019590A1 BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING 有权
公开(公告)号：US20230019590A1
公开(公告)日：2023-01-19
申请号：US17524123
申请日：2021-11-11
申请人： IOGENETICS, LLC
发明人： Robert D. Bremel , Jane Homan
IPC分类号： G16B15/20 , A61K39/085 , A61K39/00 , A61K39/145 , A61K39/02 , A61K39/095 , A61K39/09 , A61K39/04 , A61K39/21 , A61K39/285 , G16B15/00 , G16B20/00 , G16B15/30 , G16B40/20 , G16B20/20 , G16B20/30 , G16B20/50
摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.

6. 发明申请

US20210265008A1 IMMUNE REPERTOIRE PATTERNS 有权
公开(公告)号：US20210265008A1
公开(公告)日：2021-08-26
申请号：US17053955
申请日：2019-05-09
申请人： IOGENETICS, LLC
发明人： Robert D. BREMEL , Jane HOMAN
IPC分类号： G16B20/30 , G01N33/68 , G16B50/00
摘要： The present invention provides methods and systems for identifying and classifying patterns comprising the T cell exposed motifs and the frequencies of such motifs in collections of proteins that make up the human proteome, immunoglobulinome, T cell receptor repertoire or microbiome, and other proteomes of environmental of microbial origin, or subsets thereof. It further provides graphical representations that facilitate comparisons of T cell exposed motif patterns between samples or between time points. The present invention also provides methods and systems for identifying and classifying patterns in repertoires of cells including receptor bearing cells and cells of tissue samples and detecting patterns of utility in diagnosis and monitoring of health and disease.

7. 发明授权

US10706955B2 Bioinformatic processes for determination of peptide binding 有权
公开(公告)号：US10706955B2
公开(公告)日：2020-07-07
申请号：US13052733
申请日：2011-03-21
申请人： Robert D. Bremel , Jane Homan
发明人： Robert D. Bremel , Jane Homan
IPC分类号： G16B20/00 , G16B40/00
摘要： This invention relates to processes for identifying peptide and polypeptide ligands for a binding partner by using principal component analysis of amino acids to derive vectors describing amino acid subsets corresponding to peptides with known binding affinities and then using this information in a neural network modeling process to derive binding prediction equations. These binding prediction equations are then used in the analysis of subsets of amino acids from a target source to identify peptides or polypeptides ligands in the target source that have affinity for a binding partner.

8. 发明申请

US20130330335A1 BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING 审中-公开
标题翻译：用于确定肽结合的生物工艺
公开(公告)号：US20130330335A1
公开(公告)日：2013-12-12
申请号：US13052733
申请日：2011-03-21
申请人： Robert D. Bremel , Jane Homan
发明人： Robert D. Bremel , Jane Homan
IPC分类号： A61K39/395 , C07H21/04 , A61K39/00 , A61P37/04 , C07K16/00 , C07K19/00 , C12N9/96 , C12P21/00 , G01N33/53 , G01N33/569 , A61K38/02 , G06F17/10 , G06N3/08 , G06G7/58 , C07K14/00
摘要： This invention relates to the identification of peptide binding to ligands, and in particular to identification of epitopes expressed by microorganisms and by mammalian cells. The present invention provides polypeptides comprising the epitopes, and vaccines, antibodies and diagnostic products that utilize or are developed using the epitopes.
摘要翻译：本发明涉及肽结合配体的鉴定，特别涉及由微生物和哺乳动物细胞表达的表位的鉴定。本发明提供了包含表位的多肽，以及利用或使用表位开发的疫苗，抗体和诊断产物。

9. 发明申请

US20080269122A1 Antimicrobial Peptide Biocides 审中-公开
标题翻译：抗微生物肽杀菌剂
公开(公告)号：US20080269122A1
公开(公告)日：2008-10-30
申请号：US11875349
申请日：2007-10-19
申请人： Michael Imboden , Jane Homan , Robert D. Bremel
发明人： Michael Imboden , Jane Homan , Robert D. Bremel
IPC分类号： A61K38/00 , C12N15/00 , C12N5/06 , A61P31/00 , A23L3/3463
CPC分类号： A01N63/04 , A01N63/00 , A01N63/02 , A01N65/00 , C07K16/00 , C07K16/20 , C07K2317/52 , C07K2319/01 , C07K2319/035 , C07K2319/33 , C07K2319/55 , C07K2319/735
摘要： The present invention relates to retroviral constructs that encode novel monoclonal antibodies, novel fusion proteins, and chimeric monoclonal antibodies and to methods of using and producing the same. In particular, the present invention relates to methods of producing a fusion protein comprising a microorganism targeting molecule (e.g., immunoglobulin or innate immune system receptor molecule) and a biocide (e.g., bactericidal enzymes) in transgenic animals (e.g., bovines) and in cell cultures. The present invention also relates to therapeutic and prophylactic methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food processing (e.g., beef carcass processing). The present invention also relates to methods of using a fusion protein comprising a microorganism targeting molecule and a biocide in various diagnostic applications in number of diverse fields such as agriculture, medicine, and national defense.
摘要翻译：本发明涉及编码新单克隆抗体，新型融合蛋白和嵌合单克隆抗体的逆转录病毒构建体及其使用和生产方法。特别地，本发明涉及在转基因动物（例如牛）和细胞中产生包含微生物靶向分子（例如，免疫球蛋白或先天免疫系统受体分子）和杀生物剂（例如杀菌酶）的融合蛋白的方法。文化。本发明还涉及在医疗保健（例如人类和兽医），农业（例如动物和植物生产）和食品加工（例如，动物和植物生产）中使用包含微生物靶向分子和杀生物剂的融合蛋白的治疗和预防方法，牛肉屠体处理）。本发明还涉及在农业，医药，国防等不同领域的多种诊断应用中使用包含微生物靶向分子和杀生物剂的融合蛋白的方法。

10. 发明授权

US11069427B2 Mathematical processes for determination of peptidase cleavage 有权
公开(公告)号：US11069427B2
公开(公告)日：2021-07-20
申请号：US14895748
申请日：2014-06-09
申请人： IOGENETICS, LLC
发明人： Robert D. Bremel
IPC分类号： G16B20/00 , G16B5/00 , G16B40/00 , G06N3/04 , G06N3/08
摘要： This invention relates to the identification of peptidase cleavage sites in proteins and in particular to identification protease cleavage by the endopeptidases. The present invention utilizes a bioinformatic methodology for prediction of peptidase cleavage sites based on principal component analysis and based on training sets obtained by experimental protein cleavage. This invention is not limited to training sets derived from CSL approaches, nor to any other experimental determination of cleavage site.

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