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1. 发明授权

US10105101B2 Methods, systems, and devices for optimal positioning of sensors 有权
公开(公告)号：US10105101B2
公开(公告)日：2018-10-23
申请号：US15108588
申请日：2014-12-23
申请人： LifeScan, Inc.
发明人： Richard Fougere , Curtis Lee , Ryan Walsh
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/06 , A61B5/024 , A61B5/0478 , A61B5/0488 , A61B5/053 , A61B5/021 , A61B5/145
摘要： A biomedical sensor has conducting elements disposed at least partly over a skin-facing surface. A sensing element detects a signal representative of a physiological parameter of a body using the conducting elements. A storage device stores a physiological model. A processor determines sensor placement quality by comparing the signal to the model and operates an indicator to indicate the determined quality. A method of measuring using the sensor includes computing a measurement acceptance criterion using numerous measurements, determining whether a subsequent test measurement corresponds to the measurement acceptance criterion obtained from the computing step, and indicating the results via the indicator. A system for measuring a physiological property of the body includes the sensor, a user interface device to receive measurements from the sensor, and a processor associated with the user interface device and configured to provide feedback if the measurement does not meet a selected acceptance criterion.

2. 发明授权

US09969982B2 Differentiation of human embryonic stem cells 有权
公开(公告)号：US09969982B2
公开(公告)日：2018-05-15
申请号：US14719124
申请日：2015-05-21
申请人： LifeScan, Inc.
发明人： Alireza Rezania
IPC分类号： C12N5/071
CPC分类号： C12N5/0678 , C12N5/0676 , C12N2501/105 , C12N2501/117 , C12N2501/12 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/335 , C12N2501/385 , C12N2501/40 , C12N2501/41 , C12N2501/415 , C12N2501/42 , C12N2501/70 , C12N2501/727 , C12N2501/998 , C12N2501/999 , C12N2506/02 , C12N2533/90
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer and the products related to or resulting from such methods. The present invention also provides methods to promote glucose-stimulated insulin secretion in insulin-producing cells derived from pluripotent stem cells.

3. 发明授权

US09927388B2 Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity 有权
公开(公告)号：US09927388B2
公开(公告)日：2018-03-27
申请号：US14511235
申请日：2014-10-10
申请人： LifeScan, Inc.
发明人： Ronald C. Chatelier , Dennis Rylatt , Linda Raineri , Alastair M. Hodges
IPC分类号： G01N27/327 , G01N27/48 , G01N33/49 , G01N33/80
CPC分类号： G01N27/3272 , G01N27/3273 , G01N27/3274 , G01N27/48 , G01N33/49 , G01N33/80 , G01N2333/4737
摘要： Methods for determining the hematocrit of a blood sample, and devices and systems used in conjunction with the same. The hematocrit value can be determined on its own, and further, it can be further used to determine a concentration of an analyte in a sample. In one exemplary embodiment of a method for determining the hematocrit value in a blood sample, a volume of blood is provided in a sample analyzing device having a working and a counter electrode. An electric potential is applied between the electrodes and an initial fill velocity of the sample into the device is calculated. The hematocrit of the blood, as well as a concentration of an analyte in view of the initial fill velocity can then be determined. Systems and devices that take advantage of the use of an initial fill velocity to determine hematocrit levels and make analyte concentration determinations are also provided.

4. 发明授权

US09861747B2 Method and system for management of diabetes with a glucose monitor and infusion pump to provide feedback on bolus dosing 有权
公开(公告)号：US09861747B2
公开(公告)日：2018-01-09
申请号：US14098353
申请日：2013-12-05
申请人： LifeScan, Inc.
发明人： Sweta Chovanda , Carlos Omar Morales
IPC分类号： A61M31/00 , A61M5/172 , G06F19/00
CPC分类号： A61M5/1723 , A61M2205/3569 , A61M2205/502 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/67 , G16H50/20 , G16H80/00
摘要： Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The system provides the user with the ability to understand the effects of bolus insulin dosing upon their glucose levels. Specifically, the system provides a message that must include: (a) the trend of the user's glucose; (b) the recommended bolus; and (c) the actual bolus.

5. 发明授权

US09744195B2 Differentiation of human embryonic stem cells 有权
公开(公告)号：US09744195B2
公开(公告)日：2017-08-29
申请号：US14751416
申请日：2015-06-26
申请人： LifeScan, Inc.
发明人： Jean Xu
IPC分类号： C12N5/00 , A61K35/39 , C12N5/071
CPC分类号： A61K35/39 , C12N5/0676 , C12N2500/34 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/21 , C12N2501/23 , C12N2501/335 , C12N2501/385 , C12N2501/40 , C12N2501/415 , C12N2501/42 , C12N2501/70 , C12N2501/999 , C12N2506/02 , C12N2533/90
摘要： The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.

6. 发明授权

US09504412B2 Method and system to derive glycemic patterns from clustering of glucose data 有权
标题翻译：从葡萄糖数据聚类中得出血糖模式的方法和系统
公开(公告)号：US09504412B2
公开(公告)日：2016-11-29
申请号：US13621499
申请日：2012-09-17
申请人： Thomas Schaible
发明人： Thomas Schaible
IPC分类号： A61B5/1486 , A61B5/155 , A61B5/157 , A61B5/145 , A61B5/15 , A61B5/00
CPC分类号： G01N27/3273 , A61B5/0022 , A61B5/0031 , A61B5/14532 , A61B5/1477 , A61B5/1486 , A61B5/14865 , A61B5/150022 , A61B5/150358 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7455 , A61M5/1723 , C12Q1/006 , G01N27/3272 , G06F19/00 , G16H50/20
摘要： Described are methods and systems for determining clusters of glucose data that can be utilized to provide insights to the person with diabetes, such as, for example, when a certain number of measurements during a predetermined time period is less than a predetermined threshold so that the subject is notified that the number of glucose measurements is less than optimum for management of diabetes.
摘要翻译：描述了用于确定可用于向糖尿病患者提供见解的葡萄糖数据簇的方法和系统，例如当在预定时间段期间的一定数量的测量值小于预定阈值时，通知受试者葡萄糖测量的数量少于管理糖尿病的最佳值。

7. 发明授权

US09075004B2 Electrochemical cell 有权
标题翻译：电化学电池
公开(公告)号：US09075004B2
公开(公告)日：2015-07-07
申请号：US14094288
申请日：2013-12-02
申请人： LifeScan, Inc.
发明人： Alastair McIndoe Hodges , Thomas William Beck , Oddvar Johansen
IPC分类号： G01N27/403 , C12Q1/00 , G01N27/327
CPC分类号： G01N27/403 , C12Q1/004 , G01N27/3272 , G01N27/3273 , Y10T29/49117
摘要： Devices and methods are provided for determining the concentration of a reduced form of a redox species. For example, a device can include a working electrode and a counter electrode spaced by a predetermined distance so that reaction produces from the counter electrode arrive at the working electrode. An electric potential difference can be applied between the electrodes, and the potential of the working electrode can be selected such that the rate of electro-oxidation of the reduced form of the species is diffusion controlled. Current as a function of time can be determined, the magnitude of the steady state current can be estimated, and a value indicative of the diffusion coefficient and/or of the concentration of the reduced form of the species can be obtained from the change in current with time and the magnitude of the steady state current. Other embodiments of apparatuses, devices, and methods are also provided.
摘要翻译：提供了用于确定还原形式的氧化还原物质的浓度的装置和方法。例如，器件可以包括隔开预定距离的工作电极和对电极，使得从反电极产生的反应到达工作电极。可以在电极之间施加电位差，并且可以选择工作电极的电位，使得物种的还原形式的电氧化速率被扩散控制。可以确定作为时间的函数的电流，可以估计稳态电流的大小，并且可以从电流的变化获得指示物种的还原形式的扩散系数和/或浓度的值随着时间和稳态电流的大小。还提供了装置，装置和方法的其他实施例。

8. 外观设计

USD732058S1 Display screen with computer icon for blood glucose monitoring 有权
标题翻译：显示屏带有电脑图标进行血糖监测
公开(公告)号：USD732058S1
公开(公告)日：2015-06-16
申请号：US29496566
申请日：2014-07-15
申请人： LifeScan, Inc.
设计人： Jeremy Landis , Salve Retuta Pascual

9. 发明申请

US20140148668A1 ANALYTE METER WITH BASIC AND ADVANCED METER PRESET MODE SELECTION BASED ON STRUCTURED QUERIES 有权
标题翻译：基于结构化查询的基本和高级计预选模式选择分析仪
公开(公告)号：US20140148668A1
公开(公告)日：2014-05-29
申请号：US13689446
申请日：2012-11-29
申请人： LIFESCAN, INC.
发明人： Sweta CHOVANDA , Shawn Berven
IPC分类号： G06T11/20 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/743
摘要： Described are methods and systems to allow users to select a basic mode or an advanced mode in which additional features can be customized for the user based on structured queries presented to the user.
摘要翻译：描述了允许用户选择基本模式或高级模式的方法和系统，其中可以基于呈现给用户的结构化查询为用户定制附加特征。

10. 发明申请

US20140081103A1 METHOD AND SYSTEM TO DERIVE GLYCEMIC PATTERNS FROM CLUSTERING OF GLUCOSE DATA 有权
标题翻译：用于从凝胶数据聚集中提取糖化图案的方法和系统
公开(公告)号：US20140081103A1
公开(公告)日：2014-03-20
申请号：US13621499
申请日：2012-09-17
申请人： Thomas SCHAIBLE
发明人： Thomas SCHAIBLE
IPC分类号： A61B5/1486
CPC分类号： G01N27/3273 , A61B5/0022 , A61B5/0031 , A61B5/14532 , A61B5/1477 , A61B5/1486 , A61B5/14865 , A61B5/150022 , A61B5/150358 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7455 , A61M5/1723 , C12Q1/006 , G01N27/3272 , G06F19/00 , G16H50/20
摘要： Described are methods and systems for determining clusters of glucose data that can be utilized to provide insights to the person with diabetes, such as, for example, when a certain number of measurements during a predetermined time period is less than a predetermined threshold so that the subject is notified that the number of glucose measurements is less than optimum for management of diabetes.
摘要翻译：描述了用于确定可用于向糖尿病患者提供见解的葡萄糖数据簇的方法和系统，例如当在预定时间段期间的一定数量的测量值小于预定阈值时，通知受试者葡萄糖测量的数量少于管理糖尿病的最佳值。

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