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1. 发明授权

US10829516B2 Peptidomimetics for imaging the ghrelin receptor 有权
公开(公告)号：US10829516B2
公开(公告)日：2020-11-10
申请号：US15578105
申请日：2016-05-27
申请人： London Health Sciences Centre Research Inc.
发明人： Leonard G. Luyt , Milan Mrazek Fowkes
IPC分类号： A61K38/00 , A61K51/08 , C07K7/06 , C07K14/60 , C07K5/00 , C07K5/10 , G01N33/574 , C07K5/107 , G01N33/74 , C07K19/00
摘要： The present invention concerns compositions comprising and methods of identification and use of imaging agents. The imaging agents comprise a growth hormone secretagogues having a conjugated fluoride. The imaging agents of the present invention may be used for detection, diagnosis and/or staging of prostate or other forms of cancer, and may also be used for cardiac disease.

2. 发明授权

US09890197B2 RHAMM binding peptides 有权
公开(公告)号：US09890197B2
公开(公告)日：2018-02-13
申请号：US14806814
申请日：2015-07-23
申请人： The London Health Sciences Centre Research Inc.
发明人： Leonard G. Luyt , Eva A. Turley , Kenneth Virgel Esguerra
IPC分类号： C12Q1/00 , G01N33/53 , C12N5/00 , A61K49/00 , C07K7/08 , G01T1/24 , G01N33/50 , C07K14/47 , A61K51/08 , C07K7/06 , C07K14/705 , G01N33/574 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/0043 , A61K49/0056 , A61K51/088 , C07K7/06 , C07K14/47 , C07K14/705 , G01N33/5011 , G01N33/57492 , G01N2333/70596 , G01T1/249
摘要： The present invention provides for peptides that bind to Receptor for Hyaluronic Acid Mediated Motility (RHAMM) molecules. More specifically, provided are peptides capable of specifically binding RHAMM molecules and capable of binding RHAMM with substantially high affinity. These novel RHAMM-binding peptides provide the basis for new imaging probes that can be used to identify cells expressing RHAMM, and for methods of imaging, prognosis, diagnosis and treatment of conditions associated with RHAMM expression.

3. 发明授权

US09215999B2 EEG monitor of fetal health 有权
标题翻译：脑电监护仪胎儿健康
公开(公告)号：US09215999B2
公开(公告)日：2015-12-22
申请号：US12532874
申请日：2008-03-28
申请人： Bryan S. Richardson , Martin G. Frasch
发明人： Bryan S. Richardson , Martin G. Frasch
IPC分类号： A61B5/048 , A61B5/00 , A61B5/024 , B63B29/06 , B63C11/02 , F16M11/24 , F16M13/02 , A61B5/0448
CPC分类号： A61B5/7246 , A61B5/02411 , A61B5/0448 , A61B5/048 , A61B5/4362 , A61B5/7257 , B63B29/06 , B63C11/02 , B63C2011/024 , F16M11/24 , F16M13/02
摘要： A method for predicting health compromise in a fetus comprises acquiring one or more EEG signals and a fetal heart rate (FHR) signal from the surface of the head of a fetus; and determining the spectral edge frequency (SEF) of the one or more EEG signals. A repetitive temporal correlation between the FHR signal and the SEF of the one or more EEG signals is indicative of fetal health compromise. A system for detecting the correlation between FHR signal and the SEF of the one or more EEG signals and predicting fetal health compromise is also described.
摘要翻译：一种用于预测胎儿健康危害的方法包括从胎儿头部的表面获取一个或多个EEG信号和胎儿心率（FHR）信号; 以及确定所述一个或多个EEG信号的频谱边缘频率（SEF）。一个或多个EEG信号的FHR信号和SEF之间的重复时间相关性表示胎儿健康危害。还描述了用于检测FHR信号和一个或多个EEG信号的SEF之间的相关性并预测胎儿健康危害的系统。

4. 发明申请

US20140314879A1 TREATMENT OF COMPARTMENT SYNDROME 有权
标题翻译：治疗室内综合征
公开(公告)号：US20140314879A1
公开(公告)日：2014-10-23
申请号：US14253750
申请日：2014-04-15
申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
发明人： Abdel-Rahman LAWENDY , David W. SANDERS , Gediminas CEPlNSKAS
IPC分类号： A61K33/00 , A61K31/28
CPC分类号： A61K33/00 , A61K31/28
摘要： The present invention relates to a method of treating or preventing compartment syndrome in a patient. According to the invention, the method includes: (a) identifying a patient suffering from compartment syndrome; and (b) administering to the patient a therapeutically effective amount of a carbon monoxide (CO).
摘要翻译：本发明涉及一种治疗或预防病人室间综合征的方法。根据本发明，该方法包括：（a）识别患有隔室综合征的患者; 和（b）向患者施用治疗有效量的一氧化碳（CO）。

5. 发明授权

US08151593B2 Embedding method and apparatus for the preparation of frozen section tissue 有权
标题翻译：用于制备冷冻切片组织的嵌入方法和装置
公开(公告)号：US08151593B2
公开(公告)日：2012-04-10
申请号：US12065842
申请日：2006-09-07
申请人： Colin Henderson , Claire Temple-Oberle
发明人： Colin Henderson , Claire Temple-Oberle
IPC分类号： F25C5/14
CPC分类号： G01N1/42 , A01N1/00 , G01N1/36 , Y10T436/25
摘要： Various embodiments for an apparatus and method for preparing frozen tissue specimens are described. In an exemplary embodiment, the apparatus includes a sample container for receiving an excised tissue sample and embedding material. The sample container includes a flat base along which the tissue sample is flattened. The apparatus further includes a freezing box with a freezing platform and a freezing agent. The sample container is placed on the freezing platform to begin the freezing process. A chuck with a generally planar surface can be placed on the sample container during the freezing process joining the chuck, tissue specimen, and sample container base in generally parallel planes. In some cases, the sample container can be made from a suitable material, such as plastic, that is at least semi-transparent to allow visual confirmation of tissue flatness and freezing.
摘要翻译：描述了用于制备冷冻组织标本的装置和方法的各种实施例。在示例性实施例中，该装置包括用于接收切除的组织样本和嵌入材料的样本容器。样品容器包括平坦的基底，组织样本沿着平坦的基底平坦化。该装置还包括具有冷冻平台和冷冻剂的冷冻箱。将样品容器放置在冷冻平台上以开始冷冻处理。具有大致平坦表面的卡盘可以在冷冻过程中放置在样品容器上，该冷冻过程在大致平行的平面中连接卡盘，组织样本和样本容器底座。在一些情况下，样品容器可以由诸如塑料的合适材料制成，其至少是半透明的，以允许组织平整度和冷冻的视觉确认。

6. 发明申请

US20120032882A1 HANDS-FREE POINTER SYSTEM 有权
标题翻译：无手指系统
公开(公告)号：US20120032882A1
公开(公告)日：2012-02-09
申请号：US13141065
申请日：2009-11-20
申请人： Christopher M. Schlachta , Rajnikant V. Patel , Ana Luisa Trejos , Michael David Naish
发明人： Christopher M. Schlachta , Rajnikant V. Patel , Ana Luisa Trejos , Michael David Naish
IPC分类号： G06F3/033
CPC分类号： G06F3/012 , A61B1/00039 , G06F3/011 , G06F3/0346
摘要： The present invention describes a hands-free system for controlling the movement of a cursor on one or more display devices. A tracking device including a traceable marker and one or more accelerometers and gyroscopes are used to track position and acceleration of the marker relative to a target of interest. A processing means processes the motion signals from the tracking device to determine the location of the cursor on the operator's monitor, which may also be displayed on more monitors. The tracking device is worn by the operator, optimally on the operator's head. The operator's head movements determine movement of the cursor.
摘要翻译：本发明描述了一种用于控制光标在一个或多个显示设备上的移动的免提系统。使用包括可跟踪标记和一个或多个加速度计和陀螺仪的跟踪装置跟踪相对于感兴趣的目标的标记的位置和加速度。处理装置处理来自跟踪装置的运动信号以确定光标在操作员监视器上的位置，其也可以显示在更多的监视器上。跟踪装置由操作者佩戴，最佳地在操作人员的头上。操作者的头部移动确定光标的移动。

7. 发明申请

US20100028350A1 PREVENTING IL-2 MEDIATED INFLAMMATION IN EPITHELIAL CELLS 审中-公开
标题翻译：预防上皮细胞中IL-2介导的炎症反应
公开(公告)号：US20100028350A1
公开(公告)日：2010-02-04
申请号：US12281474
申请日：2007-03-05
申请人： Anthony M. Jevnikar , Caigan Du
发明人： Anthony M. Jevnikar , Caigan Du
IPC分类号： A61K39/395 , A61K31/713 , A61P37/00 , A61P29/00 , A61P37/06 , A61P1/00
CPC分类号： A61K38/2013 , A61K31/7105
摘要： The present invention provides new methods for treating, minimizing and/or preventing inflammatory injury involving IL-2 activity on epithelial cells expressing IL-2 receptors. Methods for reducing or preventing inflammatory injury in a tissue/organ comprise inhibiting IL-2 receptor activity in cells of the tissue/organ.
摘要翻译：本发明提供了治疗，最小化和/或预防涉及IL-2活性的IL-2活性的新型方法，所述炎症性损伤涉及表达IL-2受体的上皮细胞。减少或预防组织/器官炎症损伤的方法包括抑制组织/器官细胞中的IL-2受体活性。

8. 发明申请

US20230135443A1 DETERMINING CENTRAL NERVOUS SYSTEM INJURY AND RECOVERY 有权
公开(公告)号：US20230135443A1
公开(公告)日：2023-05-04
申请号：US17910700
申请日：2021-03-11
申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
发明人： Douglas FRASER
IPC分类号： G01N33/92 , G16H50/20 , G16H10/40
摘要： A method of diagnosing acquired CNS injury (ACNSI) in a subject comprising: (a) obtaining a test sample from the subject (b) comparing levels of a lipid species or a cohort of multiple lipid species in the test sample with the levels of the single lipid species or the cohort of multiple lipid species in a control sample, or comparing to a normal reference range, (i.e. non-ACNSI (referred to as “normal”) subjects) using quantitative measurements, wherein a change (i.e. a drop or an increase) in the level of the lipid species or the cohort of multiple lipid species in the test sample relative to the control sample is indicative of ACNSI in the subject.

9. 发明申请

US20230113275A1 EXPANDABLE CELL POPULATIONS FROM BRAIN BIOPSIES OF LIVING SUBJECTS 有权
公开(公告)号：US20230113275A1
公开(公告)日：2023-04-13
申请号：US18080811
申请日：2022-12-14
申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
发明人： Matthew Olding HEBB
IPC分类号： C12N5/079 , A61K35/30 , G01N33/50
摘要： The present invention relates to a method of producing expandable cultured brain cells. The brain cells are neurotrophic factor (NTF) positive. The expandable cultured brain cells are obtained by culturing a biopsy obtained from the cortical and/or subcortical brain region of a living subject. The biopsies can be obtained during neurosurgical procedures such as deep brain stimulation. The expandable cultured brain cells of the present invention are useful for the treatment of neurological diseases and other medical conditions.

10. 发明授权

US10943350B2 Automated segmentation of histological sections for vasculature quantification 有权
公开(公告)号：US10943350B2
公开(公告)日：2021-03-09
申请号：US15553842
申请日：2016-02-25
申请人： LONDON HEALTH SCIENCES CENTRE RESEARCH INC.
发明人： Aaron Devin Ward , Yi Wen Xu , John Geoffrey Pickering
IPC分类号： G06T7/11 , G06T7/12 , G06T7/181 , G06T7/136
摘要： A fully automated method for detecting and measuring a target of interest such as vasculature, capable of processing whole slide images and extracting large number of targets of interest per slide. The method includes the steps of: (a) obtaining a digital image of a tissue specimen; (b) using a first set of mathematical algorithms based on objectively-defined criteria to isolate the one or more targets of interest from the slide, thereby detecting the one or more targets of interest; and (c) using a second set of mathematical algorithms based on objectively-defined criteria to construct boundaries around the detected targets of interest and obtain quantitative attributes of these one or more targets throughout the slide, thereby measuring the one or more targets.

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