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1. 发明授权

US08352025B2 Leadless cardiac pacemaker triggered by conductive communication 有权
标题翻译：无引导心脏起搏器由导电通讯触发
公开(公告)号：US08352025B2
公开(公告)日：2013-01-08
申请号：US11549596
申请日：2006-10-13
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A leadless cardiac pacemaker configured for implantation in electrical contact with a left ventricular cardiac chamber and configured for leadless triggered left-ventricular pacing for cardiac resynchronization therapy (CRT) in response to conducted signals from a pulse generator.
摘要翻译：一种无引线心脏起搏器，其被配置用于植入与左心室心室的电接触，并且被配置用于响应于来自脉冲发生器的传导信号用于心脏再同步治疗（CRT）的无引导式左心室起搏。

2. 发明授权

US07945333B2 Programmer for biostimulator system 有权
标题翻译：生物刺激仪系统程序员
公开(公告)号：US07945333B2
公开(公告)日：2011-05-17
申请号：US11549605
申请日：2006-10-13
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A biostimulator system comprises one or more implantable devices and an external programmer configured for communicating with the implantable device or devices via bidirectional communication pathways comprising a receiving pathway that decodes information encoded on stimulation pulses generated by ones of the implantable device or devices and conducted through body tissue to the external programmer.
摘要翻译：生物刺激器系统包括一个或多个可植入装置和外部编程器，该外部编程器经配置以经由双向通信路径与可植入装置进行通信，所述双向通信路径包括接收途径，该接收途径解码由所述可植入装置或装置中的一个产生的刺激脉冲编码的信息，组织到外部程序员。

3. 发明申请

US20110071586A1 Leadless Cardiac Pacemaker Triggered by Conductive Communication 有权
标题翻译：无引导心脏起搏器由导电通讯触发
公开(公告)号：US20110071586A1
公开(公告)日：2011-03-24
申请号：US12953282
申请日：2010-11-23
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/08 , A61N1/362
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A leadless cardiac pacemaker configured for implantation in electrical contact with a left ventricular cardiac chamber and configured for leadless triggered left-ventricular pacing for cardiac resynchronization therapy (CRT) in response to conducted signals from a pulse generator.
摘要翻译：一种无引线心脏起搏器，其被配置用于植入与左心室心室的电接触，并且被配置用于响应于来自脉冲发生器的传导信号用于心脏再同步治疗（CRT）的无引导式左心室起搏。

4. 发明申请

US20140058494A1 X-Ray Identification for Active Implantable Medical Device 有权
标题翻译：有源植入式医疗器械的X射线识别
公开(公告)号：US20140058494A1
公开(公告)日：2014-02-27
申请号：US13972828
申请日：2013-08-21
申请人： Nanostim, Inc.
发明人： Alan Ostroff , Paul Paspa , Peter M. Jacobson , Wade A. Keller , Christopher Alan Hubbard
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61B2090/3966 , A61N1/0573 , A61N1/37205 , A61N1/3756
摘要： An active implantable medical device is disclosed herein having a radio-opaque marker. The radio-opaque marker can be formed within an exterior wall of the device or within recesses on the outside of the exterior wall. The implantable medical device can be a leadless pacemaker. The shape of the radio-opaque marker can be designed to facilitate visualization and identification of the location, orientation, and rotation of the implanted medical device by conventional fluoroscopy. Methods of use are also disclosed.
摘要翻译：本文公开了一种具有无线电不透明标记的主动植入式医疗装置。不透射线的标记可以形成在装置的外壁内或在外壁外侧的凹槽内。可植入医疗装置可以是无引线起搏器。不透射线标记的形状可以被设计成便于通过常规荧光透视来观察和识别植入的医疗装置的位置，取向和旋转。还公开了使用方法。

5. 发明申请

US20110218587A1 Programmer for Biostimulator System 有权
标题翻译：生物刺激仪系统程序员
公开(公告)号：US20110218587A1
公开(公告)日：2011-09-08
申请号：US13109728
申请日：2011-05-17
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A biostimulator system comprises one or more implantable devices and an external programmer configured for communicating with the implantable device or devices via bidirectional communication pathways comprising a receiving pathway that decodes information encoded on stimulation pulses generated by ones of the implantable device or devices and conducted through body tissue to the external programmer.
摘要翻译：生物刺激器系统包括一个或多个可植入装置和外部编程器，该外部编程器经配置以经由双向通信路径与可植入装置进行通信，所述双向通信路径包括接收途径，该接收途径解码由所述可植入装置或装置中的一个产生的刺激脉冲编码的信息，组织到外部程序员。

6. 发明申请

US20110208260A1 Rate Responsive Leadless Cardiac Pacemaker 有权
标题翻译：价格反应无引导心脏起搏器
公开(公告)号：US20110208260A1
公开(公告)日：2011-08-25
申请号：US13098266
申请日：2011-04-29
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A leadless cardiac pacemaker comprises a housing, a plurality of electrodes coupled to an outer surface of the housing, and a pulse delivery system hermetically contained within the housing and electrically coupled to the electrode plurality, the pulse delivery system configured for sourcing energy internal to the housing, generating and delivering electrical pulses to the electrode plurality. The pacemaker further comprises an activity sensor hermetically contained within the housing and adapted to sense activity and a processor hermetically contained within the housing and communicatively coupled to the pulse delivery system, the activity sensor, and the electrode plurality, the processor configured to control electrical pulse delivery at least partly based on the sensed activity.
摘要翻译：无引线心脏起搏器包括壳体，耦合到壳体的外表面的多个电极和密封地容纳在壳体内并电耦合到电极多个的脉冲传送系统，该脉冲传送系统被配置用于将内部的能量壳体，产生和传递电脉冲到电极多个。起搏器还包括气密地容纳在壳体内并且适于感测活动的活动传感器和密封地容纳在壳体内并且通信地耦合到脉冲传送系统，活动传感器和电极多个的处理器，处理器被配置为控制电脉冲至少部分地基于感测到的活动来递送。

7. 发明申请

US20140074114A1 DELIVERY CATHETER SYSTEMS AND METHODS 有权
标题翻译：交付导管系统和方法
公开(公告)号：US20140074114A1
公开(公告)日：2014-03-13
申请号：US14084034
申请日：2013-11-19
申请人： Nanostim, Inc.
发明人： Alexander Khairkhahan , Alan Klenk
IPC分类号： A61N1/05
CPC分类号： A61M25/0074 , A61N1/057 , A61N1/0573 , A61N1/362 , A61N1/3756 , A61N2001/058
摘要： A delivery system for implanting a leadless cardiac pacemaker into a patient is provided. The cardiac pacemaker can include a docking or delivery feature having a through-hole disposed on or near a proximal end of the pacemaker for attachment to the delivery system. In some embodiments, the delivery catheter can include first and second tethers configured to engage the delivery feature of the pacemaker. The tethers, when partially aligned, can have a cross-sectional diameter larger than the through-hole of the delivery feature, and when un-aligned, can have a cross-sectional diameter smaller than the through-hole of the delivery feature. Methods of delivering the leadless cardiac pacemaker with the delivery system are also provided.
摘要翻译：提供了一种用于将无引线心脏起搏器植入患者体内的输送系统。心脏起搏器可以包括具有设置在起搏器的近端上或附近的通孔的对接或递送特征，用于附接到递送系统。在一些实施例中，输送导管可以包括构造成接合起搏器的输送特征的第一和第二系绳。当部分对准时，系绳的横截面直径可以大于输送特征的通孔，并且当不对准时，其横截面直径可以小于输送特征的通孔。还提供了使用输送系统递送无引线心脏起搏器的方法。

8. 发明申请

US20140039570A1 BIOSTIMULATOR CIRCUIT WITH FLYING CELL 有权
标题翻译：生物调节器电路与飞行器
公开(公告)号：US20140039570A1
公开(公告)日：2014-02-06
申请号：US13956946
申请日：2013-08-01
申请人： Nanostim, Inc.
发明人： Kenneth J. Carroll , Alan Ostroff , Peter M. Jacobson
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61N1/362 , A61N1/37205 , A61N1/3758
摘要： A leadless cardiac pacemaker is provided which can include any number of features. In one embodiment, the pacemaker can include a tip electrode, pacing electronics disposed on a p-type substrate in an electronics housing, the pacing electronics being electrically connected to the tip electrode, an energy source disposed in a cell housing, the energy source comprising a negative terminal electrically connected to the cell housing and a positive terminal electrically connected to the pacing electronics, wherein the pacing electronics are configured to drive the tip electrode negative with respect to the cell housing during a stimulation pulse. The pacemaker advantageously allows p-type pacing electronics to drive a tip electrode negative with respect to the can electrode when the can electrode is directly connected to a negative terminal of the cell. Methods of use are also provided.
摘要翻译：提供无引线心脏起搏器，其可以包括任何数量的特征。在一个实施例中，起搏器可以包括尖端电极，起搏电子器件设置在电子器件壳体中的p型衬底上，起搏电子器件电连接到尖端电极，设置在电池壳体中的能量源包括电连接到电池壳体的负极端子和电连接到起搏电子器件的正极端子，其中起搏电子器件构造成在刺激脉冲期间相对于电池壳体驱动尖端电极为负极。当罐电极直接连接到电池的负极端子时，起搏器有利地允许p型起搏电子器件驱动相对于罐电极为负的尖端电极。还提供了使用方法。

9. 发明授权

US08543205B2 Temperature sensor for a leadless cardiac pacemaker 有权
标题翻译：无引线心脏起搏器的温度传感器
公开(公告)号：US08543205B2
公开(公告)日：2013-09-24
申请号：US13272092
申请日：2011-10-12
申请人： Alan Ostroff
发明人： Alan Ostroff
IPC分类号： A61N1/372
CPC分类号： A61N1/3655 , A61B5/01 , A61B5/686 , A61N1/36514 , A61N1/37205 , A61N1/3756
摘要： A leadless cardiac pacemaker comprises a housing, a plurality of electrodes coupled to an outer surface of the housing, and a pulse delivery system hermetically contained within the housing and electrically coupled to the electrode plurality, the pulse delivery system configured for sourcing energy internal to the housing, generating and delivering electrical pulses to the electrode plurality. The pacemaker further comprises a temperature sensor hermetically contained within the housing and adapted to sense temperature information, wherein the pacemaker can control electrical pulse delivery at least partly based on the temperature information.
摘要翻译：无引线心脏起搏器包括壳体，耦合到壳体的外表面的多个电极和密封地容纳在壳体内并电耦合到电极多个的脉冲传送系统，该脉冲传送系统被配置用于将内部的能量壳体，产生和传递电脉冲到电极多个。起搏器还包括气密地容纳在壳体内并适于感测温度信息的温度传感器，其中起搏器可以至少部分地基于温度信息来控制电脉冲输送。

10. 发明授权

US08295939B2 Programmer for biostimulator system 有权
标题翻译：生物刺激仪系统程序员
公开(公告)号：US08295939B2
公开(公告)日：2012-10-23
申请号：US13109728
申请日：2011-05-17
申请人： Peter M. Jacobson
发明人： Peter M. Jacobson
IPC分类号： A61N1/372
CPC分类号： A61N1/3962 , A61M25/0662 , A61N1/056 , A61N1/0573 , A61N1/0587 , A61N1/059 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36542 , A61N1/368 , A61N1/3684 , A61N1/3704 , A61N1/3706 , A61N1/3708 , A61N1/372 , A61N1/37205 , A61N1/37217 , A61N1/37252 , A61N1/3727 , A61N1/37288 , A61N1/375 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N2001/058 , H04B13/005
摘要： A biostimulator system comprises one or more implantable devices and an external programmer configured for communicating with the implantable device or devices via bidirectional communication pathways comprising a receiving pathway that decodes information encoded on stimulation pulses generated by ones of the implantable device or devices and conducted through body tissue to the external programmer.
摘要翻译：生物刺激器系统包括一个或多个可植入装置和外部编程器，该外部编程器经配置以经由双向通信路径与可植入装置进行通信，所述双向通信路径包括接收途径，该接收途径解码由所述可植入装置或装置中的一个产生的刺激脉冲编码的信息，组织到外部程序员。

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