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1. 发明授权

US11008319B2 4H-pyrido[1,2-a]pyrimidin-4-one compounds 有权
公开(公告)号：US11008319B2
公开(公告)日：2021-05-18
申请号：US16910896
申请日：2020-06-24
申请人： Prana Biotechnology Limited
发明人： Penelope Jane Huggins , Jack Gordon Parsons , Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Antony Vincent Robinson
IPC分类号： C07D239/00 , C07D471/04 , A61K31/519 , C07D498/14 , C07F1/08 , C07F3/06
摘要： The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or compositions in the treatment, of neurological disorders.

2. 发明申请

US20150094334A1 8-HYDROXY QUINOLINE DERIVATIVES 审中-公开
标题翻译： 8-羟基喹啉衍生物
公开(公告)号：US20150094334A1
公开(公告)日：2015-04-02
申请号：US14510652
申请日：2014-10-09
申请人： PRANA BIOTECHNOLOGY LIMITED
发明人： Kevin Jeffrey BARNHAM , Elisabeth Colette Louise GAUTIER , Gaik Beng KOK , Guy KRIPPNER
IPC分类号： C07D215/48 , C07D215/26 , A61K45/06 , C07D401/04 , C07D401/12 , A61K31/47 , A61K31/4709
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译：本发明描述了治疗受试者神经学病症的方法，其包括向有需要的受试者施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或溶剂化物。

3. 发明授权

US07618634B2 Neurotoxic oligomers 有权
标题翻译：神经毒性低聚物
公开(公告)号：US07618634B2
公开(公告)日：2009-11-17
申请号：US10312437
申请日：2001-06-28
申请人： Ashley Bush , Robert Cherny , Rudolph Emile Tanzi
发明人： Ashley Bush , Robert Cherny , Rudolph Emile Tanzi
IPC分类号： A61K39/00 , A61K38/00 , A61K38/04
CPC分类号： A61K38/1709 , A61K39/0007 , A61K47/64 , A61K2039/6081 , C07K16/18 , G01N33/6896
摘要： This invention relates to methods and compositions for the treatment or alleviation of Alzheimer's disease and of other conditions related to abnormal protein aggregation. In particular, the invention relates to methods and compositions for the immunotherapy of Alzheimer's disease, Parkinson's disease, and cataract. In one aspect the invention provides a method of prophylaxis, treatment or alleviation of a condition characterized by pathological aggregation and accumulation of a specific protein associated with an immunizing-effective dose of one or more tyrosine cross-linked compounds, and optionally also comprising copper ions complexed to the compound. Alternatively passive immunization against a tyrosine cross-linked compound may be used. Prophylactic or therapeutic compositions and diagnostic methods are also disclosed and claimed.
摘要翻译：本发明涉及用于治疗或缓解阿尔茨海默病和与异常蛋白质聚集相关的其它病症的方法和组合物。特别地，本发明涉及用于阿尔茨海默氏病，帕金森病和白内障的免疫治疗的方法和组合物。一方面，本发明提供了一种预防，治疗或缓解特征在于与免疫有效剂量的一种或多种酪氨酸交联化合物相关的特异性蛋白质的病理性聚集和积累的病症的方法，以及任选还包含铜离子复合化合物。或者可以使用针对酪氨酸交联化合物的被动免疫。还公开并要求保护的预防或治疗组合物和诊断方法。

4. 发明申请

US20200317670A1 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE COMPOUNDS 审中-公开
公开(公告)号：US20200317670A1
公开(公告)日：2020-10-08
申请号：US16910896
申请日：2020-06-24
申请人： Prana Biotechnology Limited
发明人： Penelope Jane Huggins , Jack Gordon Parsons , Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Antony Vincent Robinson
IPC分类号： C07D471/04 , A61K31/519 , C07D498/14 , C07F1/08 , C07F3/06
摘要： The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or compositions in the treatment, of neurological disorders.

5. 发明授权

US10738050B2 4H-pyrido[1,2-A]pyrimidin-4-one compounds 有权
公开(公告)号：US10738050B2
公开(公告)日：2020-08-11
申请号：US16409296
申请日：2019-05-10
申请人： Prana Biotechnology Limited
发明人： Penelope Jane Huggins , Jack Gordon Parsons , Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Antony Vincent Robinson
IPC分类号： C07D239/00 , C07D471/04 , A61K31/519 , C07D498/14 , C07F1/08 , C07F3/06
摘要： The present invention relates to compounds of the formula I or II: (I) (II) processes for their preparation and their use as pharmaceutical agents or compositions in the treatment, of neurological disorders.

6. 发明授权

US09169211B2 8-hydroxy quinoline derivatives 有权
标题翻译： 8-羟基喹啉衍生物
公开(公告)号：US09169211B2
公开(公告)日：2015-10-27
申请号：US14510652
申请日：2014-10-09
申请人： PRANA BIOTECHNOLOGY LIMITED
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Guy Krippner
IPC分类号： A61K31/47 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D215/48 , A61K31/4709 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , A61K31/4725
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译：本发明描述了治疗受试者神经学病症的方法，其包括向有需要的受试者施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或溶剂化物。

7. 发明授权

US09145375B2 Quinazolinone compounds 有权
标题翻译：喹唑啉酮化合物
公开(公告)号：US09145375B2
公开(公告)日：2015-09-29
申请号：US14508646
申请日：2014-10-07
申请人： PRANA BIOTECHNOLOGY LIMITED
发明人： Penelope Jane Huggins , Jack Gordon Parsons
IPC分类号： C07D239/72 , C07D239/88 , C07D239/90 , C07D239/91 , A61K31/517 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/88 , C07D239/90 , C07D239/91 , Y02P20/582
摘要： The present invention relates to quinazolinone compounds, processes for their preparation and their use as pharmaceutical agents for the treatment of Parkinson's disease (PD). The quinazolinone compounds are of general formula (I).
摘要翻译：本发明涉及喹唑啉酮化合物，其制备方法及其作为药物治疗帕金森病（PD）的用途。喹唑啉酮化合物具有通式（I）。

8. 发明授权

US08163760B2 Use of pyridopyrimidine compounds in the treatment of gliomas 有权
标题翻译：吡啶并嘧啶化合物在治疗神经胶质瘤中的应用
公开(公告)号：US08163760B2
公开(公告)日：2012-04-24
申请号：US12306202
申请日：2007-06-22
申请人： Ashley Bush , Penelope Jane Huggins , Jack Gordon Parsons , Gaik Beng Kok , Vijaya Kenche
发明人： Ashley Bush , Penelope Jane Huggins , Jack Gordon Parsons , Gaik Beng Kok , Vijaya Kenche
IPC分类号： A01N43/54 , A01N43/90 , A01N43/42 , A61K31/517 , A61K31/519 , A61K31/44
CPC分类号： A61K31/47 , A61K31/517
摘要： The present invention relates generally to therapeutic agents, formulations comprising them and their use in the treatment, amelioration and/or prophylaxis of glioma brain tumors and related conditions. The therapeutic agent comprises two fused 6-membered rings with at least a nitrogen at position 1 and a hydroxyl at position 8.
摘要翻译：本发明一般涉及治疗剂，包含它们的制剂及其在治疗，改善和/或预防胶质瘤脑肿瘤和相关病症中的用途。治疗剂包含两个稠合的6元环，其中位于第1位的至少有氮和位置8处的羟基。

9. 发明申请

US20120040980A1 QUINAZOLINONE COMPOUNDS 有权
标题翻译：喹唑啉酮化合物
公开(公告)号：US20120040980A1
公开(公告)日：2012-02-16
申请号：US13142162
申请日：2009-12-23
申请人： Penelope Jane Huggins , Jack Gordon Parsons
发明人： Penelope Jane Huggins , Jack Gordon Parsons
IPC分类号： A61K31/517 , C07D403/06 , A61P25/16 , C07D401/06 , A61K31/5377 , C07D239/90 , C07D413/06
CPC分类号： A61K31/517 , A61K31/5377 , A61K45/06 , C07D239/88 , C07D239/90 , C07D239/91 , Y02P20/582
摘要： The present invention relates to quinazolinone compounds, processes for their preparation and their use as pharmaceutical agents for the treatment of Parkinson's disease (PD). The quinazolinone compounds are of general formula (I).
摘要翻译：本发明涉及喹唑啉酮化合物，其制备方法及其作为药物治疗帕金森病（PD）的用途。喹唑啉酮化合物具有通式（I）。

10. 发明申请

US20100160346A1 NEUROLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：神经活性化合物
公开(公告)号：US20100160346A1
公开(公告)日：2010-06-24
申请号：US12717631
申请日：2010-03-04
申请人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Brenda Kwan Yi Leung
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： A61K31/4375 , A61K31/435 , A61K31/436 , A61K31/47 , A61K31/473 , A61K31/4745 , A61K31/495 , A61K31/498 , A61K31/50 , A61K31/5025 , A61K31/517 , A61K31/519 , C07C233/54 , C07D239/88 , C07D241/42 , C07D471/04
摘要： The present invention relates to neurologically-active compounds, processes for their preparation and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, more specifically neurodegenerative conditions such as Alzheimer's disease.
摘要翻译：本发明涉及神经活性化合物，其制备方法及其作为药物或兽药的用途，特别是用于治疗神经病症，更具体地说是神经变性疾病如阿尔茨海默病。

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