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1. 发明授权

US11905250B2 Methods for preparation of jasmonate compounds 有权
公开(公告)号：US11905250B2
公开(公告)日：2024-02-20
申请号：US16960089
申请日：2019-01-06
申请人： Vidac Pharma Ltd.
发明人： Paul Salama , Oren Menahem Becker
IPC分类号： C07D215/24 , C07C57/03 , C07D215/32 , C07C17/357 , C07C51/09 , C07C51/41 , C07C67/10 , C07C67/303 , C07C67/317 , C07C67/32 , C07C67/343 , C07C67/475
CPC分类号： C07D215/32 , C07C17/357 , C07C51/09 , C07C51/412 , C07C67/10 , C07C67/303 , C07C67/317 , C07C67/32 , C07C67/343 , C07C67/475
摘要： This invention relates to methods for preparation of jasmonate compounds via a salt of jasmonic acid.

2. 发明授权

US11332455B2 α,β-unsaturated amide compound 有权
公开(公告)号：US11332455B2
公开(公告)日：2022-05-17
申请号：US17034604
申请日：2020-09-28
申请人： KYOWA KIRIN CO., LTD.
发明人： Tomohiro Danjo , Katsuaki Fujiwara , Tomoyuki Nishikawa , Takahiro Nakajima , Nobumasa Otsubo , Toshihiro Seike
IPC分类号： C07D311/68 , C07D401/04 , C07D405/12 , C07D311/74 , A61K31/5377 , A61K31/353 , C07D215/38 , A61K31/4433 , A61K31/4709 , A61K31/47 , C07D213/74 , C07D213/75 , C07D215/24 , C07D401/12
摘要： The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I): [wherein, “A” represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents —O—, —S—, —SO2—, —NRX1— (wherein, RX1 represents hydrogen atom or lower alkyl), —CHRX2— (wherein, RX2 represents hydrogen atom or hydroxy), —CH═CH—, —CO— or —NH—CO—, and n1 and n2 are the same or different, and each represents 0 or 1].

3. 发明授权

US10139406B2 Alkyl quinolones as biomarkers of pseudomonas aeruginosa infection and uses thereof 有权
公开(公告)号：US10139406B2
公开(公告)日：2018-11-27
申请号：US14891242
申请日：2014-05-13
申请人： The University of Nottingham
发明人： Miguel Camara , Paul Williams , David Barrett , Nigel Halliday , Alan Knox , Alan Smyth , Andrew Fogarty , Helen Barr , Doug Forrester
IPC分类号： G01N33/569 , C07D215/22 , C07D215/24 , C07D215/26 , C07H17/02 , C07K16/12 , C12Q1/04 , G01N33/84
摘要： A method of determining the P. aeruginosa or related species infection status of a subject comprising: (i) providing a sample of material obtained from the subject; (ii) determining the level of one or more alkyl quinolones or metabolites thereof produced by P. aeruginosa or a related species in the sample

4. 发明授权

US09169211B2 8-hydroxy quinoline derivatives 有权
标题翻译： 8-羟基喹啉衍生物
公开(公告)号：US09169211B2
公开(公告)日：2015-10-27
申请号：US14510652
申请日：2014-10-09
申请人： PRANA BIOTECHNOLOGY LIMITED
发明人： Kevin Jeffrey Barnham , Elisabeth Colette Louise Gautier , Gaik Beng Kok , Guy Krippner
IPC分类号： A61K31/47 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D215/48 , A61K31/4709 , A61K45/06 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , A61K31/4725
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D215/00 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/38 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/04 , C07D417/12 , C07D417/14 , Y02A50/411 , A61K2300/00
摘要： The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.
摘要翻译：本发明描述了治疗受试者神经学病症的方法，其包括向有需要的受试者施用治疗有效量的下式化合物或其药学上可接受的盐，水合物或溶剂化物。

5. 发明申请

US20140323520A1 Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells 审中-公开
标题翻译：增加成人唾液干细胞增殖的组成和方法
公开(公告)号：US20140323520A1
公开(公告)日：2014-10-30
申请号：US14110390
申请日：2012-04-26
申请人： Che-Hong Chen , Daria Mochly-Rosen , Quynh-Thu Le
发明人： Che-Hong Chen , Daria Mochly-Rosen , Quynh-Thu Le
IPC分类号： C07D317/58 , C07C233/11 , C07D215/24 , C07D317/50 , C07D235/16
摘要： The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer.
摘要翻译：本公开提供了增加成人唾液干细胞增殖的方法。所述方法包括使体内，体外或体外与醛脱氢酶（ALDH）激动剂接触成人唾液干细胞。可以进行增加成人唾液干细胞的增殖，以提供在头颈部癌症接受放射治疗的个体中增加成人唾液干细胞的数量。

6. 发明授权

US5569669A Alkylaminoindane compounds 失效
标题翻译：烷基氨基茚满化合物
公开(公告)号：US5569669A
公开(公告)日：1996-10-29
申请号：US401768
申请日：1995-03-10
申请人： G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
发明人： G erald Guillaumet , Marie-Claude Viaud , Pierre Renard , G erard Adam , Daniel-Henri Caignard , B eatrice Guardiola-Lemaitre , Marie-Claire Rettori
IPC分类号： A61K31/335 , A61K31/357 , A61K31/36 , A61K31/38 , A61K31/382 , A61K31/39 , A61K31/47 , A61K31/472 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C217/14 , C07C217/60 , C07C217/62 , C07D215/24 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D307/79 , C07D311/04 , C07D311/58 , C07D317/64 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08
CPC分类号： C07D307/79 , C07C217/60 , C07C217/62 , C07D215/26 , C07D217/02 , C07D237/28 , C07D239/74 , C07D241/42 , C07D311/58 , C07D317/66 , C07D319/08 , C07D319/18 , C07D327/06 , C07D335/06 , C07D339/08 , C07C2102/08
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.2', R.sub.2", R.sub.2'", R.sub.3 and n are as defined in the description, an optical isomer, and an addition salt thereof with a pharmaceutically-acceptable acid or base,and medicinal product containing the same useful for treating a mammal afflicted with a disorder associated to 5-HT.sub.1A or 5-HT.sub.2C receptors.
摘要翻译：本发明涉及一种选自式（I）的化合物：其中R1，R2，R2'，R2“，R2”'，R3和n如说明书中所定义，光学异构体及其与药学上可接受的酸或碱的加成盐，以及含有可用于治疗患有与5-HT1A或5-HT2C受体相关的病症的哺乳动物的药物。

7. 发明授权

US5006534A Substituted ethers, thioethers and amines for use as lipoxygenase inhibitors 失效
标题翻译：用作脂氧合酶抑制剂的取代醚，硫醚和胺
公开(公告)号：US5006534A
公开(公告)日：1991-04-09
申请号：US304895
申请日：1989-01-30
申请人： Klaus-Helmut Mohrs , Romanis Fruchtmann , Christian Kohlsdorfer
发明人： Klaus-Helmut Mohrs , Romanis Fruchtmann , Christian Kohlsdorfer
IPC分类号： A61K31/425 , A61K31/47 , C07D215/18 , C07D215/22 , C07D215/24 , C07D215/26 , C07D215/28 , C07D215/36 , C07D215/38 , C07D215/40 , C07D215/60 , C07D217/02 , C07D277/64 , C07D277/76
CPC分类号： C07D277/76 , C07D215/26 , C07D215/28 , C07D215/36 , C07D215/40 , C07D215/60 , C07D217/02 , C07D277/64
摘要： Substituted benzyl ethers, benzyl thioethers, and benzylamines of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, sulphonylalkyl, halogenoalkoxy, halogenoalkylthio, aralkoxy, aralkylthio, halogen, nitro, cyano or hydroxyl, or represent a group of the formula ##STR2## wherein R.sup.4 and R.sup.5 are identical or different and represent hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl or acyl,R.sup.3 represents a group of the formula ##STR3## in which R.sup.6 represents hydrogen, alkyl or acyl,R.sup.7 represents hydrogen or alkyl andn represents a number from 3 to 10,B represents --CH.sub.2 --X-- or --X--CH.sub.2 --,wherein X represents O, S or NR.sup.7,and wherein R.sup.7 has the abovementioned meaning and the group ##STR4## represents a benzo-fused heterocyclic system, A in the heterocyclic radical being 3-, 4- or 5-membered and containing nitrogen, oxygen and/or sulphur as hetero-atoms. These compounds are lipoxygenase inhibitors.
摘要翻译：取代的苄基醚，苄基硫醚和式（I）的苄胺，其中R 1和R 2相同或不同并且代表氢，烷基，烯基，环烷基，烷氧基，烷硫基，卤代烷基，磺酰基烷基，卤代烷氧基，卤代烷硫基，芳烷氧基，芳烷硫基，卤素，硝基，氰基或羟基，或代表下式的基团，其中R4和R5相同或不同，代表氢，烷基，烯基，环烷基，芳烷基，芳基或酰基，R3代表其中R 6表示氢，烷基或酰基，R 7表示氢或烷基，n表示3至10的数，B表示-CH 2 -X-或-X-CH 2 - ，其中X表示 O，S或NR7，并且其中R7具有上述含义，并且基团“IMAGE”表示苯并稠合杂环体系，杂环基中的A为3-，4-或5-元并且含有氮，氧和/或硫作为杂原子。这些化合物是脂氧合酶抑制剂。

8. 发明授权

US4608372A Process for preparing .beta.' form of copper 8-hydroxyquinoline 失效
标题翻译：制备β'形式的8-羟基喹啉铜的方法
公开(公告)号：US4608372A
公开(公告)日：1986-08-26
申请号：US700855
申请日：1985-02-12
申请人： Bernard Muller , Rene Piat , Cornelis Rensing , Jean-Paul Trajin
发明人： Bernard Muller , Rene Piat , Cornelis Rensing , Jean-Paul Trajin
IPC分类号： A01N25/22 , A01N43/42 , C07D215/24 , C07D215/30 , A01N55/02
CPC分类号： A01N43/42 , C07D215/30 , Y10S514/949
摘要： A process for the preparation of the .beta.' form of the copper chelate of 8-hydroxyquinoline (copper oxinate), stabilized compositions containing said chelate, fungicidal compositions containing said chelate, and the methods for using said .beta.' form chelate or compositions for combatting fungi are disclosed.
摘要翻译：制备8-羟基喹啉（硫酸铜）的铜螯合物的β-型形式，含有所述螯合物的稳定化组合物，含有所述螯合物的杀真菌组合物的方法以及使用所述β'形式的螯合物或组合物来对抗真菌的方法被披露。

9. 发明授权

US4480099A Decahydroquinolyl benzamides 失效
标题翻译：十氢醌基苯甲酰胺
公开(公告)号：US4480099A
公开(公告)日：1984-10-30
申请号：US390353
申请日：1982-06-21
申请人： Michael S. Hadley
发明人： Michael S. Hadley
IPC分类号： C07D215/14 , C07D215/12 , C07D215/20 , C07D215/24 , C07D215/38 , C07D215/48 , C07D215/16
CPC分类号： C07D215/24 , C07D215/12 , C07D215/20 , C07D215/38 , C07D215/48
摘要： A compound of formula (I), and salts thereof: ##STR1## wherein: R.sub.1 is a C.sub.1-6 alkoxy group;R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, CF.sub.3, C.sub.1-7 acyl, amino, C.sub.1-7 acyl amino, aminocarbonyl or aminosulphone optionally substituted by one or two C.sub.1-6 alkyl groups; C.sub.1-6 alkyl-SO.sub.n wherein n is 1 or 2; or nitro;R.sub.4 is hydrogen or C.sub.1-6 alkyl;R.sub.5 is C.sub.1-6 alkyl or a group --(CH.sub.2).sub.s R.sub.6 wherein s is 1 or 2 and R.sub.6 is C.sub.3-8 cycloalkyl or phenyl, which phenyl may optionally be substituted by one or two substituents selected from C.sub.1-6 alkyl, C.sub.1-4 alkoxy, CF.sub.3 and halogen;n is 0 to 3;p is 3 to 6; andr plus s is 2 to 5; may be used for the treatment of disorders of the gastro-intestinal function.
摘要翻译：式（I）化合物及其盐：其中：R 1是C 1-6烷氧基; R2和R3相同或不同，为氢，卤素，CF3，C1-7酰基，氨基，C1-7酰基氨基，氨基羰基或氨基砜，任选被一个或两个C 1-6烷基取代; 其中n为1或2的C 1-6烷基-SO 2; 或硝基; R4是氢或C1-6烷基; R 5是C 1-6烷基或基团 - （CH 2）s R 6，其中s是1或2，R 6是C 3-8环烷基或苯基，该苯基可以任选地被一个或两个选自C 1-6烷基， 4烷氧基，CF 3和卤素; n为0〜3; p为3〜6; r加s为2〜5; 可用于治疗胃肠功能障碍。

10. 发明授权

US4302588A Carbostyril compounds 失效
标题翻译：碳青霉烯化合物
公开(公告)号：US4302588A
公开(公告)日：1981-11-24
申请号：US965469
申请日：1978-11-30
申请人： Michiaki Tominaga , Hitoshi Tone , Kazuyuki Nakagawa
发明人： Michiaki Tominaga , Hitoshi Tone , Kazuyuki Nakagawa
IPC分类号： C07D215/24 , C07D215/26 , C07D215/32 , C07D401/12 , C07D405/12 , C07D413/12 , C07D215/22 , A61K31/47
CPC分类号： C07D215/32 , C07D215/26 , Y10S514/821 , Y10S514/826
摘要： Carbostyril compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkyl group; R.sub.2 represents a hydrogen atom, an alkyl group or a phenylalkyl group; R.sub.3 represents a hydrogen atom and R.sub.4 represents a phenylalkyl group or a phenoxyalkyl group; the 3,4-bond of the carbostyril nucleus represents a single or double bond, pharmaceutically acceptable acid addition salts thereof, and process for preparing the same.
摘要翻译：由式（I）表示的卡博司坦化合物：其中R 1表示氢原子或烷基; R2表示氢原子，烷基或苯基烷基; R3表示氢原子，R4表示苯基烷基或苯氧基烷基; 喹诺酮环的3,4键代表单键或双键，其药学上可接受的酸加成盐及其制备方法。

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