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1. 发明申请

US20140113263A1 Clinical Training and Advice Based on Cognitive Agent with Psychological Profile 审中-公开
标题翻译：基于认知代理心理学的临床训练与咨询
公开(公告)号：US20140113263A1
公开(公告)日：2014-04-24
申请号：US13656688
申请日：2012-10-20
申请人： Bruce Jarrell , Sergei Nirenburg , Marjorie Joan McShane , Stephen Beale , George Fantry
发明人： Bruce Jarrell , Sergei Nirenburg , Marjorie Joan McShane , Stephen Beale , George Fantry
IPC分类号： G09B19/00
CPC分类号： G09B19/00 , G09B23/28
摘要： A method and apparatus for a clinical simulation system targets psychological phenomena that can negatively impact the decision making of both a clinician and a patient. Techniques include identifying an independently reasoning agent in a medical clinical information processing system configured to simulate interactions between a clinician and a patient. The method also includes determining, on the system, psychological profile data that indicates one or more personality traits for the agent. The method further includes storing psychological profile data on the system in a hierarchical data structure for a natural language processing system. The method still further includes determining simulation output from the system based at least in part on the psychological profile data.
摘要翻译：用于临床模拟系统的方法和装置针对可能对临床医师和患者的决策产生不利影响的心理现象。技术包括在被配置为模拟临床医生和患者之间的相互作用的医疗临床信息处理系统中识别独立推理剂。该方法还包括在系统上确定指示代理人的一个或多个人格特征的心理简档数据。该方法还包括在自然语言处理系统的分层数据结构中在系统上存储心理简档数据。该方法还包括至少部分地基于心理简档数据来确定来自系统的模拟输出。

2. 发明授权

US07288532B1 Modified chitosan polymers and enzymatic methods for the production thereof 失效
标题翻译：改性壳聚糖聚合物及其制备方法
公开(公告)号：US07288532B1
公开(公告)日：2007-10-30
申请号：US09763324
申请日：1999-08-20
申请人： Gregory F. Payne , Guneet Kumar
发明人： Gregory F. Payne , Guneet Kumar
IPC分类号： C08G8/00 , C12P19/04
CPC分类号： C12P19/26 , C08B37/003
摘要： The present invention is directed to homogeneous phase enzyme-catalyzed processes for producing modified chitosan polymers or oligomers. An enzyme is reacted with a phenolic substrate in the presence of a chitosan polymer or oligomer to produce a modified chitosan polymer or oligomer. The invention also includes modified chitosan polymers or oligomers produced by the novel processes, in particular modified chitosan polymers or oligomers having useful functional properties, such as base solubility and/or high viscosity.
摘要翻译：本发明涉及用于制备改性壳聚糖聚合物或低聚物的均相酶催化方法。在壳聚糖聚合物或低聚物的存在下，使酶与酚底物反应以制备改性的壳聚糖聚合物或低聚物。本发明还包括通过新方法生产的改性壳聚糖聚合物或低聚物，特别是具有有用功能性质的改性壳聚糖聚合物或低聚物，例如碱溶解度和/或高粘度。

3. 发明申请

US20230022767A1 SALTS OF (2R, 6R)-HYDROXYNORKETAMINE, THEIR CRYSTAL FORMS, AND METHODS OF MAKING THE SAME 有权
公开(公告)号：US20230022767A1
公开(公告)日：2023-01-26
申请号：US17777654
申请日：2020-11-17
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC , THE UNIVERSITY OF MARYLAND, BALTIMORE
发明人： Patrick Joseph Morris , Craig Joseph Thomas , Stephen J. Byard , Martin P. Wilmshurst , Todd Gould , Carlos Zarate , Ruin Moaddel
IPC分类号： C07C225/20
摘要： The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.

4. 发明授权

US11285293B2 Ultraviolet sterilizing drainage catheter 有权
公开(公告)号：US11285293B2
公开(公告)日：2022-03-29
申请号：US16216076
申请日：2018-12-11
申请人： The University of Maryland, Baltimore , The United States of America as represented by the Department of Veterans Affairs
发明人： Cha-Min Tang , Paul E. Bigeleisen , Samuel M. Galvagno, Jr. , Mark E. Shirtliff
IPC分类号： A61M25/00 , A61M25/04 , A61L29/06 , A61M27/00
摘要： A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

5. 发明授权

US10920194B2 Functional myelination of neurons 有权
公开(公告)号：US10920194B2
公开(公告)日：2021-02-16
申请号：US15802845
申请日：2017-11-03
申请人： The University of Maryland, Baltimore , The United States of America as represented by the Department of Veterans Affairs
发明人： Thomas Hornyak , Sandeep Joshi
IPC分类号： C12N5/0797 , A61K35/36 , C12N5/079 , C12N5/071
摘要： Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker Gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. These cells of neural crest lineage can be used to produce a dense myelin sheath on neurons which lack myelin due to genetic defect, trauma, toxin, infection, or disease process. Therefore, embodiments of the invention provide methods for preparing such cells, the cells themselves and compositions containing the cells, as well as methods for using the cells.

6. 发明授权

US10571465B2 Plasmonic substrates for metal-enhanced fluorescence based sensing, imaging and assays for cells 有权
公开(公告)号：US10571465B2
公开(公告)日：2020-02-25
申请号：US14965560
申请日：2015-12-10
申请人： The University of Maryland, Baltimore
发明人： Henryk Szmacinski , Joseph R. Lakowicz
IPC分类号： G01N33/543 , G01N33/553 , G01N21/64 , G01N21/27
摘要： Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.

7. 发明授权

US10183144B2 Ultraviolet Sterilizing Drainage Catheter 有权
公开(公告)号：US10183144B2
公开(公告)日：2019-01-22
申请号：US14535296
申请日：2014-11-06
申请人： The University of Maryland, Baltimore , The United States of America as represented by the Department of Veterans Affairs
发明人： Cha-Min Tang , Paul E. Bigeleisen , Samuel M. Galvagno, Jr. , Mark E. Shirtliff
IPC分类号： A61M1/00 , A61M25/00 , A61L29/06
摘要： A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

8. 发明申请

US20180193666A1 SYSTEM AND METHOD FOR IRRADIATION THERAPY USING VOXEL BASED FUNCTIONAL MEASUREMENTS OF ORGANS AT RISK 审中-公开
公开(公告)号：US20180193666A1
公开(公告)日：2018-07-12
申请号：US15915420
申请日：2018-03-08
申请人： Hao H. Zhang , Warren D. D'Souza , Nilesh N. Mistry , Hamid R. Ghaffari
发明人： Hao H. Zhang , Warren D. D'Souza , Nilesh N. Mistry , Hamid R. Ghaffari
IPC分类号： A61N5/10 , A61B6/03 , A61B5/055 , A61B6/00 , G16H30/40 , A61B5/00 , A61B5/08
CPC分类号： A61N5/1039 , A61B5/055 , A61B5/08 , A61B5/7278 , A61B5/743 , A61B6/032 , A61B6/037 , A61B6/486 , A61B6/5211 , A61B6/5235 , A61N5/1081 , G06F19/321 , G16H30/20 , G16H30/40
摘要： A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure fj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure fj for that voxel summed over all voxels.

9. 发明授权

US09476033B2 Recombinant newcastle disease viruses useful as vaccines or vaccine vectors 有权
标题翻译：用作疫苗或疫苗载体的重组新城疫病毒
公开(公告)号：US09476033B2
公开(公告)日：2016-10-25
申请号：US13188392
申请日：2011-07-21
申请人： Siba K. Samal , Zhuhui Huang
发明人： Siba K. Samal , Zhuhui Huang
IPC分类号： A61K39/295 , C12N15/63 , A61P31/12 , C12N7/00 , C12N15/86 , A61K39/00
CPC分类号： C12N7/00 , A61K2039/525 , C12N15/86 , C12N2760/18143 , C12N2840/203
摘要： The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M genes, and/or between HN and L genes. The invention is also directed toward a cDNA encoding a recombinant antigenomic RNA having one or more foreign genes inserted according to the invention, a cell containing the cDNA, a plasmid comprising the cDNA, a cell containing the plasmid, a cell containing the recombinant antigenomic RNA, and a recombinant NDV containing the recombinant antigenomic RNA of the invention, such as a recombinant NDV carrying one or more foreign genes recovered from transcription of the cDNA or the plasmid in a competent cell. The recombinant NDV carrying the one or more foreign genes can be used as a vaccine or vaccine vector.
摘要翻译：本发明涉及携带在NP基因之前，P和M基因之间和/或HN和L基因之间插入的一个或多个外来基因的新城疫病毒（NDV）的基因组RNA。本发明还涉及编码具有根据本发明插入的一个或多个外源基因的重组基因组RNA的cDNA，含有cDNA的细胞，包含cDNA的质粒，含有该质粒的细胞，含有重组基因组RNA的细胞，以及含有本发明的重组基因组RNA的重组NDV，例如携带从感受态细胞中的cDNA或质粒转录回收的一个或多个外来基因的重组NDV。携带一个或多个外来基因的重组NDV可以用作疫苗或疫苗载体。

10. 发明授权

US09222558B2 Geared infinitely variable transmission 有权
标题翻译：齿轮无级变速器
公开(公告)号：US09222558B2
公开(公告)日：2015-12-29
申请号：US14071989
申请日：2013-11-05
申请人： University of Maryland, Baltimore County
发明人： Weidong Zhu , Xuefeng Wang
IPC分类号： F16H29/00 , F16H29/20 , F16H29/04 , F16H21/14 , F16H21/20 , F16H19/04
CPC分类号： F16H29/20 , F16H19/043 , F16H21/14 , F16H21/20 , F16H29/04 , Y10T74/18408
摘要： A geared infinitely variable transmission (GIVT) to provide a continuous output-to-input speed ratio from zero to a certain value is designed, and its working principle is illustrated. Crank-slider systems are used in the GIVT; the output-to-input speed ratio is changed with the crank length. Racks and pinions, controlled by planetary gear sets, are used to change the crank length when the cranks are rotating. One-way bearings rectify the output speeds from different crank-slider systems to obtain the output speed of the GIVT. Noncircular gears are used to minimize variations since the crank-slider systems can introduce variations of the instantaneous speed ratio. A direction control system is provided using planetary gear sets.
摘要翻译：设计了一种从零到一定值提供连续输出到输入速度比的齿轮无级变速器（GIVT），并说明了其工作原理。 GIVT中使用曲柄滑块系统; 输出转速比随曲柄长度变化。由行星齿轮组控制的齿条和小齿轮用于在曲柄旋转时改变曲柄长度。单向轴承整流不同曲柄滑块系统的输出速度，以获得GIVT的输出速度。使用非圆形齿轮来最小化变化，因为曲柄滑块系统可以引入瞬时速度比的变化。使用行星齿轮组提供方向控制系统。

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