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1. 发明申请

US20220315922A1 Methods and Compositions for Selecting siRNA of Improved Functionality 有权
公开(公告)号：US20220315922A1
公开(公告)日：2022-10-06
申请号：US17520530
申请日：2021-11-05
申请人： Thermo Fisher Scientific Inc.
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11 , A61K48/00
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.

2. 发明授权

US10288555B2 Tamper seal detection system and method of use 有权
公开(公告)号：US10288555B2
公开(公告)日：2019-05-14
申请号：US15786238
申请日：2017-10-17
申请人： THERMO FISHER SCIENTIFIC, INC.
发明人： Cody T. Kerschner , Christian S. Heaps , Justin J. Tomel , Shawn M. Regits
IPC分类号： G01N21/00 , G01N21/29 , B65D55/02 , G01N21/01 , G01N21/63 , G09F3/00 , G09F3/03 , B07C5/00 , B65B51/00 , B65B57/00 , G01N21/90 , G01N21/956
摘要： A tamper seal detection system for detecting a sealing sticker on a packaging box includes a housing at least partially bounding an inspection zone, the inspection zone being configured to receive the packaging box. A first sensor is configured to detect the presence of the first sealing sticker located on the packaging box when the packaging box is received within the inspection zone. A push guide is movable relative to the inspection floor between a first position and a spaced apart second position and can be used to push the packaging box out of the inspection zone.

3. 发明授权

US10035617B1 Tamper seal detection system with conveyor belt and method of use 有权
公开(公告)号：US10035617B1
公开(公告)日：2018-07-31
申请号：US15421721
申请日：2017-02-01
申请人： THERMO FISHER SCIENTIFIC, INC.
发明人： Martin Shipp
IPC分类号： B61L1/16 , B65B57/18 , B65B7/20 , G01V8/10
摘要： A method for detecting sealing stickers on a packaging box includes placing a first packaging box onto a conveyor belt of a conveyor belt system at an inspection zone, the first packaging box having a first sealing sticker thereon that at least partially seals the first packaging box closed; and activating a first optical sensor to detect whether the first sealing sticker is located on a first side of the first packaging box while the packaging box is in the inspection zone.

4. 发明授权

US09719094B2 RNAi targeting SEC61G 有权
公开(公告)号：US09719094B2
公开(公告)日：2017-08-01
申请号：US15255973
申请日：2016-09-02
申请人： Thermo Fisher Scientific Inc.
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C07H21/04 , C12N15/113 , A61K31/713
CPC分类号： C12N15/1138 , A61K31/713 , C12N2310/14
摘要： Efficient sequence specific gene silencing is possible through the use of RNAi technology. By selecting particular RNAi molecules by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of RNAi molecules are disclosed including those directed to nucleotide sequences for SEC61G.

5. 发明授权

US09360406B2 Method and apparatus for self-calibration of density profiler 有权
标题翻译：密度分析仪自校准的方法和装置
公开(公告)号：US09360406B2
公开(公告)日：2016-06-07
申请号：US13864459
申请日：2013-04-17
申请人： Thermo Fisher Scientific Inc.
发明人： Alex Kulik , Michael George Brosseau , Hai Wang
IPC分类号： G01F1/12 , G01F25/00 , G01N9/00 , G01N9/24
CPC分类号： G01N9/00 , G01N9/24
摘要： A process and system for self-calibration of a density profiler is disclosed. The process may include measuring a density profile of a fluid in a vessel using a plurality of sensors or a single sensor, and measuring a density profile of the fluid in the vessel using a plurality of sample ports. A density of the fluid proximate a location of at least one of the plurality of sample ports based on the sensor measured density profile may then be interpolated. A density of the fluid proximate a location of at least one of the plurality of sensors based on the sample port measured density profile may also be interpolated. Adjustment of a calibration of at least one of the plurality of sensors may then be made based on both the interpolated sample port density and the interpolated sensor density.
摘要翻译：公开了用于密度分析器的自校准的过程和系统。该过程可以包括使用多个传感器或单个传感器来测量容器中的流体的密度分布，并且使用多个样品端口测量容器中的流体的密度分布。然后可以内插基于传感器测量密度分布的多个采样端口中至少一个的位置附近的流体的密度。基于样本端口测量的密度分布，接近于多个传感器中的至少一个的位置的流体的密度也可被内插。然后可以基于插值的采样端口密度和内插的传感器密度来对多个传感器中的至少一个的校准进行调整。

6. 发明授权

US09228186B2 Methods and compositions for selecting siRNA of improved functionality 有权
标题翻译：用于选择改进功能的siRNA的方法和组合物
公开(公告)号：US09228186B2
公开(公告)日：2016-01-05
申请号：US14097551
申请日：2013-12-05
申请人： Thermo Fisher Scientific Inc.
发明人： Anastasia Khvorova , Angela Reynolds , Devin Leake , William Marshall , Steven Read , Stephen Scaringe
IPC分类号： C07H21/02 , C12N15/113 , A61K31/713 , C12N15/10 , C12N15/11
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1048 , C12N15/111 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12Y113/12007 , C12Y502/01008
摘要： Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
摘要翻译：通过使用siRNA技术，有效的序列特异性基因沉默是可能的。通过合理设计选择特定的siRNA，可以最大限度地产生有效的基因沉默试剂，以及沉默基因的方法。公开了通过合理设计siRNA产生的方法，组合物和试剂盒，包括针对TTR的核苷酸序列的那些。

7. 发明授权

US08937275B2 Method and apparatus to monitor gain of a proportional counter including correcting the counting threshold of a pulse height spectrum 有权
标题翻译：监视比例计数器的增益的方法和装置，包括校正脉冲高度谱的计数阈值
公开(公告)号：US08937275B2
公开(公告)日：2015-01-20
申请号：US13650771
申请日：2012-10-12
申请人： Alex Kulik , Alexander Joseph Esin
发明人： Alex Kulik , Alexander Joseph Esin
IPC分类号： H01J40/14 , H03K21/02
CPC分类号： H03K21/02
摘要： A method and apparatus in accordance with the present disclosure relate to monitoring gain of a proportional counter. The method includes generating a pulse height spectrum of the proportional counter, defining a first window and a second window within the pulse height spectrum, counting electrical pulses outputted by the proportional counter within the first window of the pulse height spectrum, thereby defining a first window count, counting electrical pulses outputted by the proportional counter within the second window of the pulse height spectrum, thereby defining a second window count, and determining a difference between the first window count and the second window count.
摘要翻译：根据本公开的方法和装置涉及监视比例计数器的增益。该方法包括生成比例计数器的脉冲高度谱，定义脉冲高度谱内的第一窗口和第二窗口，对脉冲高度频谱的第一窗口内的比例计数器输出的电脉冲进行计数，从而定义第一窗口计数，计数由脉冲高度频谱的第二窗口内的比例计数器输出的电脉冲，从而定义第二窗口计数，以及确定第一窗口计数和第二窗口计数之间的差。

8. 发明授权

US08840767B2 Low maintenance reference electrode for electrochemical measurements 有权
标题翻译：用于电化学测量的低维护参比电极
公开(公告)号：US08840767B2
公开(公告)日：2014-09-23
申请号：US13455727
申请日：2012-04-25
申请人： Xiaowen Wen , Hyoungsik Yim , Lori Hrdy , Dawood Bhaijee
发明人： Xiaowen Wen , Hyoungsik Yim , Lori Hrdy , Dawood Bhaijee
IPC分类号： G01N27/30 , G01N27/36 , G01N27/403 , G01N33/49 , G01N33/18
CPC分类号： G01N27/4035 , G01N27/301 , G01N33/18 , G01N33/49
摘要： A low maintenance reference electrode has a liquid junction body with a multiplicity of micron-sized capillary channels extending through the body for transporting electrolyte to a test solution. A viscosity-increasing agent thickens the electrolyte to limit its flow to a rate on the order of microliters/day so that a few milliliters of electrolyte suffice to provide an extended electrode life.
摘要翻译：低维护参考电极具有液体接合体，其具有延伸穿过主体的多个微米级毛细通道，用于将电解质输送到测试溶液。粘度增加剂使电解液增稠以将其流动限制在微升/天的数量级，使得几毫升的电解液足以提供延长的电极寿命。

9. 发明授权

US08758698B2 Combustion tube and method for combusting a sample for combustion analysis 失效
标题翻译：燃烧管和用于燃烧样品进行燃烧分析的方法
公开(公告)号：US08758698B2
公开(公告)日：2014-06-24
申请号：US12054006
申请日：2008-03-24
申请人： Louis Marie Smeets , Fransiscus Maria Folst , Peter Joannes Coenders
发明人： Louis Marie Smeets , Fransiscus Maria Folst , Peter Joannes Coenders
IPC分类号： G01N25/24 , G01N31/12
CPC分类号： G01N33/0004 , F23C3/00 , F23C6/04 , G01N31/12
摘要： Combustion tube (100,130,150) and method for combusting a sample to form combustion products for analysis. A primary combustion chamber (102) receives and combusts a sample to form first combustion products. A secondary combustion chamber (110) receives and combusts the first combustion products to form second combustion products. The secondary chamber is disposed around the primary chamber and comprises a plurality of—preferably, three—combustion compartments (112-116). Each successive compartment is disposed around the preceding compartment and defines a respective gas flow channel having an inlet opening (108,118,120) and an outlet opening (118,120,122) at opposite ends. Each successive gas flow channel shares its inlet opening with the outlet opening of the preceding channel. The plurality of combustion compartments define a substantially continuous gas flow conduit from the inlet opening of the innermost compartment to the outlet opening of the outermost compartment. Static gas mixers (132,134) may be employed to enhance mixing of the combustion products.
摘要翻译：燃烧管（100,130,150）和燃烧样品以形成燃烧产物进行分析的方法。主燃烧室（102）接收并燃烧样品以形成第一燃烧产物。二次燃烧室（110）接收并燃烧第一燃烧产物以形成第二燃烧产物。辅助室设置在主室周围，并且包括多个优选的三燃烧室（112-116）。每个连续的隔室设置在前一隔室周围，并且限定相应的气体流动通道，其具有在相对端的入口开口（108,118,120）和出口开口（118,120,122）。每个连续的气体流动通道与前一通道的出口开口共用其入口开口。多个燃烧室限定从最内隔室的入口到最外隔室的出口的基本上连续的气流导管。静态气体混合器（132,134）可用于增强燃烧产物的混合。

10. 发明授权

US08496995B2 Method of manufacture of encapsulated gallium alloy containing switch 有权
标题翻译：封装含镓合金开关的制造方法
公开(公告)号：US08496995B2
公开(公告)日：2013-07-30
申请号：US13180409
申请日：2011-07-11
申请人： Marcos Hernandez , Carl Rosenblatt
发明人： Marcos Hernandez , Carl Rosenblatt
IPC分类号： B05D5/00 , B05D3/00 , B05D7/22 , B05D3/10
CPC分类号： B05D3/002 , B05D3/104 , B05D5/00 , B05D7/22 , B05D2203/35 , B05D2254/04 , H01H29/06 , H01H29/22 , Y10T29/49105 , Y10T156/10
摘要： Encapsulated switches are disclosed which substitute non-toxic gallium alloy for mercury. In one embodiment, wetting of the interior surfaces of the housing is prevented by coating the surfaces with an electrically insulative inorganic non-metallic material, such as alumina or boron nitrate. According to another embodiment, a perfluorocarbon liquid is employed as the anti-wetting agent.
摘要翻译：公开了用无毒镓合金代替汞的封装开关。在一个实施例中，通过用电绝缘的无机非金属材料（例如氧化铝或硝酸硼）涂覆表面来防止外壳的内表面的润湿。根据另一个实施方案，使用全氟化碳液体作为抗湿润剂。

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