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1. 发明授权

US09329278B2 Dosimeter with RFID tag 有权
标题翻译：带有RFID标签的剂量计
公开(公告)号：US09329278B2
公开(公告)日：2016-05-03
申请号：US14715935
申请日：2015-05-19
申请人： LANDAUER, INC.
发明人： R. Craig Yoder
IPC分类号： G01T1/105 , G01T3/00
CPC分类号： G01T1/105 , G01T3/00
摘要： Described is device comprising dosimeter for measuring one or more doses of radiation; and an RFID tag comprising an antenna for communicating with an RFID tag reader and non-volatile memory for storing data therein.
摘要翻译：描述了包括用于测量一个或多个剂量的辐射的剂量计的装置; 以及包括用于与RFID标签读取器通信的天线和用于在其中存储数据的非易失性存储器的RFID标签。

2. 发明授权

US09328145B2 Designing a soluble full-length HIV-1 gp41 trimer 有权
标题翻译：设计可溶性全长HIV-1 gp41三聚体
公开(公告)号：US09328145B2
公开(公告)日：2016-05-03
申请号：US14091401
申请日：2013-11-27
申请人： The Catholic University of America
发明人： Venigalla B. Rao , Guofen Gao
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , C07K2319/35 , C07K2319/70 , C07K2319/735 , C12N7/00 , C12N7/02 , C12N2740/16122 , C12N2740/16222 , C12N2795/10122 , C12N2795/10123
摘要： Described herein is a soluble HIV-1 retrovirus transmembrane glycoprotein gp41 trimer (Soc-gp41M-Fd) containing a partial ectodomain and the cytoplasmic domain, that is fused to the small outer capsid (Soc) protein of bacteriophage T4 and the Foldon domain of the bacteriophage T4 fibritin (Fd). The gp41 trimer that has a prehairpin structure could be utilized to understand the mechanism of viral entry and as a candidate for development of HIV-1 vaccines, diagnostics and therapeutics. Other secondary embodiments of the gp41 proteins containing different modifications are also disclosed. According to one embodiment, the gp41 trimer is further attached to a cell penetration peptide (CPP). Methods of producing gp41 trimers are also disclosed.
摘要翻译：本文描述的是含有部分胞外域和细胞质结构域的可溶性HIV-1逆转录病毒跨膜糖蛋白gp41三聚体（Soc-gp41M-Fd），其与噬菌体T4的小外壳（Soc）蛋白和噬菌体T4纤维蛋白（Fd）。具有前贴片结构的gp41三聚体可用于了解病毒进入的机制，并且作为HIV-1疫苗，诊断和治疗学的发展的候选者。还公开了含有不同修饰物的gp41蛋白质的其它次要实施方案。根据一个实施方案，gp41三聚体进一步连接于细胞穿透肽（CPP）。还公开了生产gp41三聚体的方法。

3. 发明授权

US09252555B2 Frequency-stabilized random distributed feedback fiber ring laser with low intensity noise 有权
标题翻译：频率稳定的随机分布反馈光纤环形激光器具有低强度噪声
公开(公告)号：US09252555B2
公开(公告)日：2016-02-02
申请号：US14636432
申请日：2015-03-03
申请人： University of Ottawa
发明人： Yang Li , Ping Lu , Xiaoyi Bao , Zhonghua Ou
IPC分类号： H01S3/067 , H01S3/13 , H01S3/094 , H01S3/0941
CPC分类号： H01S3/0675 , H01S3/06712 , H01S3/06716 , H01S3/06791 , H01S3/094003 , H01S3/094042 , H01S3/0941 , H01S3/10023 , H01S3/1305 , H01S2301/02
摘要： A method and apparatus for producing single mode random fiber ring laser by inducing random distributed feedback in a short section of the fiber ring to thereby enable single mode lasing while reducing frequency jitter and relative intensity noise. The random distributed feedback maybe achieved through deep refractive index modulation at a series of randomly distributed laser-irradiated points inscribed along the length of the induced random distributed feedback fiber. The laser-processed random distributed feedback fiber maybe incorporated into the fiber ring in conjunction with a variable optical attenuator and band pass optical filter for enhancing the single mode operation.
摘要翻译：一种用于通过在纤维环的短截面中诱导随机分布反馈来产生单模随机光纤环形激光的方法和装置，从而使单模激光同时降低频率抖动和相对强度噪声。随机分布反馈可以通过在沿着感应随机分布反馈光纤的长度内接的一系列随机分布的激光照射点上的深折射率调制来实现。激光处理的随机分布反馈光纤可以结合可变光衰减器和带通光滤波器并入到光纤环中，以增强单模操作。

4. 发明授权

US08975269B2 Six-membered N-heterocyclic carbene-based catalysts for asymmetric reactions 有权
标题翻译：用于不对称反应的六元N-杂环卡宾型催化剂
公开(公告)号：US08975269B2
公开(公告)日：2015-03-10
申请号：US14445121
申请日：2014-07-29
申请人： Florida State University Research Foundation
发明人： D. Tyler McQuade , Jin Kyoon Park , Matthew D. Rexford , Hershel H. Lackey
IPC分类号： C07D487/04 , C07F5/04 , C09K3/00 , C07F1/08 , B01J31/12 , C07F5/02 , B01J31/22
CPC分类号： C07F5/025 , B01J31/2269 , B01J31/2273 , B01J2231/323 , B01J2531/16 , C07D487/04 , C07F1/08
摘要： The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided.
摘要翻译：本发明提供催化剂配合物及其组合物，用于具有高反应性和对映选择性的多种有机反应中。催化剂是具有三个稠环的N-杂环卡宾，其中第一和第二个环是六元环，第三个是五元环。第一个环与第二个环融合并具有四个取代基。第二个环具有两个碳原子侧面的氮，一个氮与一个取代基结合。卡宾原子可以任选地与金属键合。第三个环与第二个环融合并含有两个氮。催化剂的第三环具有双键和相邻非稠合碳上的两个取代基。第三环的非稠合氮部分键合到另一个取代基。还提供了合成和使用本发明的催化剂实施方案的方法。

5. 发明授权

US08822924B2 Wireless, motion and position-sensing, integrating radiation occupational and environmental dosimetry 有权
标题翻译：无线，运动和位置感应，用于职业和环境剂量测定的辐射传感器
公开(公告)号：US08822924B2
公开(公告)日：2014-09-02
申请号：US13906553
申请日：2013-05-31
申请人： Daniel J. Valentino , James R. Thistlethwaite, III , R. Craig Yoder
发明人： Daniel J. Valentino , James R. Thistlethwaite, III , R. Craig Yoder
IPC分类号： G01J1/00 , G01J1/04 , G01T1/16
CPC分类号： G01T1/02 , G01J1/0219 , G01J1/0488 , G01J1/4204 , G01P15/00 , G01T1/026 , G01T1/16 , G01T1/167 , G01T1/17 , G01T1/244 , G01T3/08 , G01T7/00 , G01V5/0083 , G01V5/025 , H04W4/02 , H04W84/18
摘要： Described is a radiation dosimeter including multiple sensor devices (including one or more passive integrating electronic radiation sensor, a MEMS accelerometers, a wireless transmitters and, optionally, a GPS, a thermistor, or other chemical, biological or EMF sensors) and a computer program for the simultaneous detection and wireless transmission of ionizing radiation, motion and global position for use in occupational and environmental dosimetry. The described dosimeter utilizes new processes and algorithms to create a self-contained, passive, integrating dosimeter. Furthermore, disclosed embodiments provide the use of MEMS and nanotechnology manufacturing techniques to encapsulate individual ionizing radiation sensor elements within a radiation attenuating material that provides a “filtration bubble” around the sensor element, the use of multiple attenuating materials (filters) around multiple sensor elements, and the use of a software algorithm to discriminate between different types of ionizing radiation and different radiation energy.
摘要翻译：描述了包括多个传感器装置（包括一个或多个无源积分电子辐射传感器，MEMS加速度计，无线发射器，以及可选地，GPS，热敏电阻或其它化学，生物或EMF传感器）和计算机程序用于电离辐射的同时检测和无线传输，用于职业和环境剂量测定的运动和全局位置。所描述的剂量计利用新的过程和算法来创建一个独立的，被动的，积分的剂量计。此外，所公开的实施例提供了MEMS和纳米技术制造技术的用途，以将单独的电离辐射传感器元件封装在辐射衰减材料内，辐射衰减材料围绕传感器元件提供“过滤气泡”，在多个传感器元件周围使用多个衰减材料，以及使用软件算法来区分不同类型的电离辐射和不同的辐射能量。

6. 发明授权

US08802418B2 Protein and nucleic acid delivery vehicles, components and mechanisms thereof 有权
标题翻译：蛋白质和核酸递送载体，其组分和机理
公开(公告)号：US08802418B2
公开(公告)日：2014-08-12
申请号：US13082466
申请日：2011-04-08
申请人： Venigalla B. Rao
发明人： Venigalla B. Rao
IPC分类号： C12Q1/70 , C12N7/00
CPC分类号： C12N15/86 , A61K31/7088 , A61K31/711 , A61K47/48776 , A61K47/6901 , A61K48/00 , C07K14/005 , C12N7/00 , C12N15/87 , C12N15/88 , C12N2795/10042 , C12N2795/10122 , C12N2795/10142 , C12N2795/10152
摘要： Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.
摘要翻译：复杂病毒通过顺序和不可逆组装由简单蛋白质亚基组装。在噬菌体的基因组包装过程中，一个强大的分子马达组装在一个空头颅的特殊门户顶点，开始包装。本发明的一个方面涉及高度混杂的噬菌体T4包装机，将DNA转运到成品噬菌体头以及pro头中。单个电机可以将外源DNA以与头孢子相同的速率强制进入噬菌体头，并且噬菌体头经历反复引发，将多个DNA分子包装在相同的头中。这表明噬菌体DNA包装机具有不寻常的构象可塑性，将DNA提供到明显被动的衣壳容器中，包括高度稳定的病毒壳，直至其充满。这些特征允许设计一种新型的纳米框输送车辆。

7. 发明授权

US08766887B2 Allocating registers on a spatial light modulator 有权
标题翻译：在空间光调制器上分配寄存器
公开(公告)号：US08766887B2
公开(公告)日：2014-07-01
申请号：US14012292
申请日：2013-08-28
申请人： Karl M. Guttag
发明人： Karl M. Guttag
IPC分类号： G09G3/34 , G09G5/10 , G09G3/20
CPC分类号： G09G5/10 , G06F3/147 , G09G3/2014 , G09G3/2022 , G09G3/34 , G09G3/346 , G09G2300/0809 , G09G2300/0857 , G09G2310/0221 , G09G2310/0275
摘要： Described is a device comprising: an array of light modulating elements; and one or more processing elements for controlling each of the light modulating elements, wherein the light modulating elements are arranged in a two-dimensional array, and wherein the one or more processing elements are adapted to skip some bit locations and use other bit locations of bit values when performing multiple bit logical and/or arithmetic operations.
摘要翻译：描述了一种装置，包括：光调制元件阵列; 以及用于控制每个光调制元件的一个或多个处理元件，其中所述光调制元件被布置成二维阵列，并且其中所述一个或多个处理元件适于跳过某些位位置并使用其它位位置执行多位逻辑和/或算术运算时的位值。

8. 发明授权

US08725423B2 Replication timing profiles for leukemia and other cancers 有权
标题翻译：白血病和其他癌症的复制时机
公开(公告)号：US08725423B2
公开(公告)日：2014-05-13
申请号：US13726803
申请日：2012-12-26
申请人： David M. Gilbert , Tyrone Ryba
发明人： David M. Gilbert , Tyrone Ryba
IPC分类号： G06F19/26
CPC分类号： G06F19/26 , G06F19/18 , G06F19/24
摘要： Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells.
摘要翻译：描述了基于细胞群体的复制时间指纹来确定细胞群体是特定类型的白血病细胞的方法。

9. 发明授权

US08668344B2 Marker sphere including edged opening to aid in molding 有权
标题翻译：标记球包括边缘开口以帮助成型
公开(公告)号：US08668344B2
公开(公告)日：2014-03-11
申请号：US13408070
申请日：2012-02-29
申请人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
发明人： Helen Zinreich Shafer , David Alan Zinreich , Douglas Crumb
IPC分类号： G02B5/134
CPC分类号： G01T1/105 , B65D75/327 , B65D75/36 , B65D85/58 , B65D2575/3281 , B65D2575/329 , G01T1/2014 , G02B5/134
摘要： Described is a device comprising a retro-reflective marker sphere comprising: a core ball comprising: a generally spherical body portion, a mounting base extending from one end of the body portion of the core ball, and a mounting recess having a recess opening in the mounting base and extending into the body portion of the core ball, and a retro-reflective covering on the core ball, the retro-reflective covering comprising an opening through which the mounting base of the core ball extends, wherein a flat lower surface of the mounting base is spaced proximally from a lower edge of the opening of the retro-reflective covering, and wherein the mounting recess includes an interior screw thread for engaging an exterior screw thread of a mounting post when the retro-reflective marker sphere is mounted on the mounting post.
摘要翻译：描述了一种包括回射标记球的装置，包括：芯球，包括：大体上球形的主体部分，从芯球的主体部分的一端延伸的安装基座和在其中具有凹部开口的安装凹部安装基座并延伸到芯球的主体部分中，以及在芯球上的后向反射覆盖物，所述回射覆盖物包括开口，芯球的安装基座穿过该开口延伸，其中，安装基座从后向反射覆盖物的开口的下边缘向近侧间隔开，并且其中安装凹部包括用于当将反射式标记球安装在安装座上时与安装柱的外螺纹接合的内螺纹安装柱

10. 发明授权

US08575572B2 Power system for dosimeter reader 有权
标题翻译：电量读数器用电量系统
公开(公告)号：US08575572B2
公开(公告)日：2013-11-05
申请号：US13798427
申请日：2013-03-13
申请人： R. Craig Yoder , Mark S. Akselrod , Kent J. Dillin , Vasiliy V. Fomenko , David F. Johnson , Yoshikazu Tatsumi , Tse-Min Lo
发明人： R. Craig Yoder , Mark S. Akselrod , Kent J. Dillin , Vasiliy V. Fomenko , David F. Johnson , Yoshikazu Tatsumi , Tse-Min Lo
IPC分类号： H05B33/00
CPC分类号： G01T1/105 , G01T1/10 , G01T1/115
摘要： A portable dosimeter reader device includes an optically stimulated luminescence (OSL) reader for reading one or more OSL sensors of a dosimeter sled; a sled slider that is driven by a sled slider motor to position in turn each of the one or more OSL sensors of the dosimeter sled at a reading position where the OSL reader reads each respective OSL sensor; a display for displaying information relating to reading the one or more OSL sensors; and a battery compartment for one or more batteries, wherein the OSL reader includes an LED light source, wherein the battery compartment is electrically connected to the OSL reader, the sled slider motor and the display, and wherein the one or more batteries provide all of the power required for operating the OSL reader, the sled slider motor and the display.
摘要翻译：便携式剂量计读取器装置包括用于读取剂量计滑板的一个或多个OSL传感器的光学刺激发光（OSL）读取器; 滑动滑块，其由滑动滑块电机驱动以依次将剂量计的一个或多个OSL传感器中的每一个安置在OSL读取器读取每个相应OSL传感器的读取位置; 用于显示与读取所述一个或多个OSL传感器有关的信息的显示器; 以及用于一个或多个电池的电池室，其中所述OSL读取器包括LED光源，其中所述电池室电连接到所述OSL读取器，所述滑动滑块电机和所述显示器，并且其中所述一个或多个电池提供全部操作OSL读卡器，滑轨滑块电机和显示器所需的电源。

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