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1. 发明授权

US11638911B2 Mesoporous metal titanates as multifunctional catalysts 有权
公开(公告)号：US11638911B2
公开(公告)日：2023-05-02
申请号：US16793669
申请日：2020-02-18
申请人： University of Connecticut
发明人： Steven L. Suib , Wimalika Rasangi Kumari Thalgaspitiya , Tharindu M. P. K. Kapuge
IPC分类号： B01J23/755 , B01J37/08 , B01J23/10 , B01J23/75 , B01J23/72 , B01J23/745 , B01J23/02 , B01J23/34 , B01J23/28 , B01J23/22 , B01J23/30 , B01J23/06 , B01J35/10 , B01J37/04 , B01J37/00 , B01J37/06 , B01J23/18
摘要： The present disclosure relates to mesoporous metal titanate materials composition. Specifically, the present disclosure relates to a mesoporous metal titanate material composition that is active for multiple reactions, including aromatic alkylation, alkene coupling, alkene cyclization, alkyne oxidation, alcohol dehydrogenation reactions.

2. 发明授权

US11634329B2 Liquid-exfoliated nanomaterials 有权
公开(公告)号：US11634329B2
公开(公告)日：2023-04-25
申请号：US17283052
申请日：2019-10-11
申请人： Advanced Material Development Limited
发明人： Alan Dalton , Matthew Large , Sean Ogilvie
IPC分类号： C01B32/19 , C01G39/06 , B82Y40/00
摘要： Nanoplatelets are prepared from a 3D layered material by: providing a dispersion of the 3D layered material, pressurising the dispersion, rapidly depressurising the dispersion to create shear forces that exfoliate the 3D layered material into nanoplatelets; and/or providing a dispersion of the 3D layered material, forming a first flow of the dispersion along a first flowpath in a first direction, forming a second flow of the dispersion along a second flowpath in a second direction by reversing the first flow or by forming the second flow in a second flowpath, wherein the second flowpath is substantially reverse and non-coaxial with the first flowpath, whereby shear forces between material in the first flowpath and material in the second flowpath exfoliate the 3D layered material into nanoplatelets. Also provided are apparatuses for carrying out the invention and nanoplatelets obtained by the invention.

3. 发明授权

US11618023B2 Microfluidic device and a method for provision of emulsion droplets 有权
公开(公告)号：US11618023B2
公开(公告)日：2023-04-04
申请号：US16770138
申请日：2018-12-04
申请人： SAMPLIX APS
发明人： Thomas Kvist , Solène Cherre , Marie Just Mikkelsen
IPC分类号： B01L3/00 , B01F23/41 , B01F33/3011
摘要： The present invention relates to a microfluidic device and method for providing emulsion droplets. The device comprising: a microfluidic section comprising one or more microfluidic units; and a well section comprising one or more groups of wells comprising one group of wells for each microfluidic unit; the well section and the microfluidic section forming a fixedly connected unit such that each group of wells forms a fixedly connected unit with a respective corresponding microfluidic unit, each microfluidic unit comprising a fluid conduit network comprising: a plurality of supply conduits comprising a secondary supply conduit and a primary supply conduit comprising a capillary structure having a volume of at least 2 μL; a transfer conduit; and a first fluid junction providing fluid communication between the primary supply conduit, the secondary supply conduit, and the transfer conduit; each group of wells comprising a plurality of wells comprising a collection well and one or more supply wells comprising a primary supply well, the collection well being in fluid communication with the transfer conduit of the corresponding microfluidic unit, the primary supply well being in fluid communication with the primary supply conduit and the secondary supply conduit of the corresponding microfluidic unit.

4. 发明授权

US11612665B2 Pyrrolobenzodiazepine-antibody conjugates 有权
公开(公告)号：US11612665B2
公开(公告)日：2023-03-28
申请号：US16484342
申请日：2018-02-08
申请人： MEDIMMUNE LIMITED
发明人： Patricius Hendrikus Cornelis Van Berkel
IPC分类号： A61K47/68 , A61P35/00 , A61K31/5517 , A61K45/06
摘要： A conjugate of formula (I): Ab-(DL)p wherein: Ab is an antibody, or an active fragment of an antibody; DL is (II).

5. 发明授权

US11598780B2 Engineering lymphocytes with specific alpha and beta chains on their t-cell receptor 有权
公开(公告)号：US11598780B2
公开(公告)日：2023-03-07
申请号：US16753684
申请日：2018-10-05
申请人： The University of Chicago , OncoTherapy Science, Inc.
发明人： Yusuke Nakamura , Jae-Hyun Park , Sachiko Yoshimura , Tetsuro Hikichi
IPC分类号： G01N33/68 , A61K35/17 , C07K14/725 , C12N5/0783 , C12N15/85 , G01N33/50 , G01N33/569
摘要： Provided herein are methods to identify TCR-recognizing cancer-specific antigens, and TCR-engineered T cells having antigen-specific cytotoxic activity. Provided herein are engineered T lymphocytes produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the engineered T lymphocytes described herein. Provided herein are antibodies, or fragments thereof, produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the antibodies described herein to a subject. In some embodiments, the therapeutic compositions (e.g., engineered lymphocytes, antibodies, etc.) and methods herein are provided as part of a kit or system.

6. 发明授权

US11524969B2 Pyrrolobenzodiazepines and conjugates thereof as antitumour agents 有权
公开(公告)号：US11524969B2
公开(公告)日：2022-12-13
申请号：US17046498
申请日：2019-04-12
申请人： MEDIMMUNE LIMITED
发明人： Philip Wilson Howard , Niall John Dickinson
IPC分类号： C07D487/04 , C07D519/00 , A61P35/00 , A61K31/551 , A61K47/68 , A61K45/06
摘要： A compound with the formula I: (I) and salts and solvates thereof, wherein: R″ is a group of formula II: (II) where each of n and m are independently selected from 1, 2 and 3.

7. 发明授权

US11524011B2 H3K27 demethylase inhibitors in pediatric and juvenile osteoporosis 有权
公开(公告)号：US11524011B2
公开(公告)日：2022-12-13
申请号：US16643672
申请日：2018-08-29
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： Mei Wan , Xu Cao
IPC分类号： A61K31/55 , A61P19/10
摘要： The present invention provides methods for manipulating epigenetic factors to treat pediatric or juvenile osteoporosis. Specifically, the present invention provides methods for the application of H3K27 demethylase inhibitors in pediatric or juvenile subjects with osteoporosis. Thus, the present invention provides methods of administration of the H3K27 demethylase inhibitor, GSK-J4, to pediatric or juvenile subjects to effectively inhibit primary and secondary pediatric osteoporosis, especially for long-term glucocorticoid treated patients (juvenile rheumatoid disorders, Crohn's disease, nephrotic syndrome, and Duchenne muscular dystrophy) and patients who have compromised mobility (cerebral palsy, Rett syndrome, Duchenne muscular dystrophy, spina bifida, and spinal muscular atrophy).

8. 发明授权

US11517648B2 Nanofiber paste for growth factor delivery and bone regeneration 有权
公开(公告)号：US11517648B2
公开(公告)日：2022-12-06
申请号：US15293666
申请日：2016-10-14
申请人： Northwestern University
发明人： Mark Trosper McClendon , Samuel I. Stupp , Sungsoo Lee , Erin L. Hsu
IPC分类号： A61K38/18 , A61L27/54 , A61L27/48 , A61L27/52
摘要： Provided herein are compositions comprising a composite of peptide amphiphiles and biocompatible particles and methods of use thereof for treatment of bone and/or tissue defects. In particular, compositions comprise a slurry paste of a peptide amphiphile nanofiber solution mixed with solid biocompatible particles, and find use in tissue/bone regeneration, growth factor delivery, and/or cell delivery.

9. 发明授权

US11458178B2 Method for alleviating fatigue 有权
公开(公告)号：US11458178B2
公开(公告)日：2022-10-04
申请号：US16765070
申请日：2018-11-26
申请人： RIKEN , OZEKI CORPORATION
发明人： Masanori Yamato , Yosky Kataoka , Yasuhisa Tamura , Satoshi Kume , Toshitaka Minetoki , Kazuhisa Hizume , Satoshi Okazaki , Miyo Hirata , Shinya Okuda , Takayuki Bogaki
IPC分类号： A61K36/06 , A23L33/10 , A61P25/00 , A23L2/52
摘要： The present invention provides a novel IL-1β and/or IL-6 expression inhibitor and use thereof. The IL-1β and/or IL-6 expression inhibitor in accordance with an aspect of the present invention contains a component derived from alcoholic fermentation lees.

10. 发明授权

US11452724B2 Methods for treating amyotrophic lateral sclerosis 有权
公开(公告)号：US11452724B2
公开(公告)日：2022-09-27
申请号：US16855623
申请日：2020-04-22
申请人： The Regents of the University of Michigan
发明人： Eva L. Feldman , Ben Murdock , Stephen Goutman , Stacey Jacoby
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61K9/00 , A61K31/428 , A61K31/53 , A61K31/7105 , A61K31/4439 , A61K31/444 , A61K31/51 , A61K31/4152 , A61K31/133
摘要： Provided herein are methods for treating, delaying progression of, or reducing the severity of amyotrophic lateral sclerosis (ALS) in a subject through administration of therapeutically effective amounts of agents (e.g., JAK kinase inhibitors (e.g., tofacitinib)) capable of interfering with central nervous system related natural killer cell (NK) levels and function.

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