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1. 发明授权

US11324869B2 Dialysis systems and methods for modulating flow of a dialysate during dialysis using Raman spectroscopy 有权
公开(公告)号：US11324869B2
公开(公告)日：2022-05-10
申请号：US17434294
申请日：2020-02-26
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： John L. Robertson , Ryan Senger
IPC分类号： A61M1/16 , G01N21/65
摘要： The present invention is a system to continuously monitor, in real-time, the small molecules being dialyzed during hemodialysis treatment using Raman spectroscopy and press control algorithms. By monitoring the treatment, the amount of water needed per dialysis treatment is drastically reduced by optimizing analyte saturation and removal of wastes. This will significantly conserve water and reduce the cost of dialysis treatments, possibly reducing the amount of time necessary for dialysis treatment, improving quality of life for patients during and after treatment, and reducing the costs of building new treatment centers as well as operating costs.

2. 发明授权

US11116773B2 Method of treating dementia 有权
公开(公告)号：US11116773B2
公开(公告)日：2021-09-14
申请号：US16831330
申请日：2020-03-26
申请人： LA PharmaTech Inc.
发明人： Jianmin Wang , Geping Cui
IPC分类号： A61K31/55 , A61P25/28 , A61K9/00
摘要： Methods of treating patients suffering from or exhibiting symptoms of mental, behavioral, and/or cognitive disorders with azelastine or a pharmaceutically acceptable salt of azelastine are disclosed.

3. 发明授权

US11086516B2 Mobile, versatile, transparent, double-sided data input or control device 有权
公开(公告)号：US11086516B2
公开(公告)日：2021-08-10
申请号：US16658605
申请日：2019-10-21
申请人： Christie Scott Wall
发明人： Christie Scott Wall
IPC分类号： G06F3/0488 , G06F3/02 , G06F3/023 , G06F3/0481
摘要： A mobile, versatile, transparent, double-sided data input device is described. The data input device includes a programmable, virtual keyboard with ergonomic benefits. The data input device includes a double-sided transparent touchscreen which provides keyed input and/or trackpad input to a separate computing device such as a mainframe computer, desktop computer, laptop, tablet, netbook, notebook, personal digital assistant (PDA), gaming console, e-reader, smartphone, or smartwatch by way of a wired or wireless connection, and includes control devices, such as a remote controller for gaming and/or control of one or more vehicles.

4. 发明授权

US10133245B2 Method for predicting and mitigating power fluctuations at a photovoltaic power plant due to cloud cover 有权
公开(公告)号：US10133245B2
公开(公告)日：2018-11-20
申请号：US14537104
申请日：2014-11-10
申请人： TMEIC Corporation
发明人： Paul S. Bixel
IPC分类号： G01W1/10 , G05B13/04 , G01W1/12
摘要： A method for forecasting reduction in sunlight intensity due to cloud cover at a photovoltaic power plant is described. The method comprises determining characteristics of one or more clouds from sensors surrounding the photovoltaic power plant. The cloud characteristics are used to create a 3D map of the clouds. The 3D map in combination with information on the angle of the sun is used to create a 3D projection on the surface of the earth, resulting in a 2D surface irradiance map. The 2D surface irradiance map may be taken in successive projections or used in combination with wind speed data to forecast fluctuation in irradiance at the photovoltaic power plant. The forecasted reductions in power may be used to enact measures at the plant such as reducing the power output of inverters to prevent sudden fluctuations in the power output of the photovoltaic plant feeding the utility.

5. 发明授权

US09867652B2 Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds 有权
公开(公告)号：US09867652B2
公开(公告)日：2018-01-16
申请号：US13989175
申请日：2011-11-23
申请人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal, II
发明人： Michael B. Sano , Rafael V. Davalos , John L. Robertson , Paulo A. Garcia , Robert E. Neal, II
IPC分类号： A61B18/14 , A61K48/00 , A61M5/00 , A61B18/00 , A61N1/32
CPC分类号： A61B18/14 , A61B18/1492 , A61B2018/00613 , A61B2018/1472 , A61B2218/002 , A61K48/0075 , A61M5/00 , A61N1/327
摘要： The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

6. 发明授权

US09303861B2 Light emitting diode light source modules 有权
标题翻译：发光二极管光源模块
公开(公告)号：US09303861B2
公开(公告)日：2016-04-05
申请号：US12975445
申请日：2010-12-22
申请人： Qing (Charles) Li , Yangcheng Huang , Haijun Wang , Guowen Lei , Cuie Wei , Menghua Long , GuiLin Wang
发明人： Qing (Charles) Li , Yangcheng Huang , Haijun Wang , Guowen Lei , Cuie Wei , Menghua Long , GuiLin Wang
IPC分类号： F21V7/20 , F21V31/04 , F21S4/00 , F21Y101/02
CPC分类号： F21V31/04 , F21S4/10 , F21Y2115/10
摘要： The present invention provides a highly-protective, heat dissipating LED light source module that may be waterproof or non-waterproof. In an embodiment, the present invention provides an LED light source module comprising: a waterproof housing comprising a metal substrate and a plastic cover integrally disposed on one or more surfaces of the metal substrate; and at least one light emitting diode, electronic component, and power line disposed on and operably connected with the metal substrate and encapsulated thereon by the plastic cover. In other embodiments are provided LED light source modules comprising: a circuit board with at least two through holes disposed at selected positions; at least one light emitting diode, electronic component, and power line disposed on the circuit board and operably connected therewith; and a plastic cover comprising at least two pins disposed and shaped for interconnection with corresponding through holes of the circuit board. The simple LED light source models disclosed may be efficiently and inexpensively produced and are capable of withstanding the harsh environments in which they are sometimes used.
摘要翻译：本发明提供一种可防水或不防水的高保护性散热LED光源模块。在一个实施例中，本发明提供了一种LED光源模块，包括：防水壳体，包括金属基板和整体设置在所述金属基板的一个或多个表面上的塑料盖; 以及至少一个发光二极管，电子元件和电力线，其设置在金属基板上并与金属基板可操作地连接，并由塑料盖封装在其上。在其它实施例中，提供了LED光源模块，包括：具有设置在选定位置处的至少两个通孔的电路板; 至少一个发光二极管，电子部件和设置在电路板上并与其可操作地连接的电力线; 以及塑料盖，其包括设置和成形为用于与电路板的相应通孔相互连接的至少两个销。所公开的简单的LED光源模型可以有效且廉价地产生，并且能够承受有时使用它们的恶劣环境。

7. 发明授权

US09283051B2 System and method for estimating a treatment volume for administering electrical-energy based therapies 有权
标题翻译：用于估计用于施用基于电能的治疗的治疗体积的系统和方法
公开(公告)号：US09283051B2
公开(公告)日：2016-03-15
申请号：US14012832
申请日：2013-08-28
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Paulo A. Garcia , Rafael V. Davalos
IPC分类号： A61B18/12 , A61B19/00 , A61B18/18 , C12N13/00 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B34/10 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00767 , A61B2018/00875 , A61B2018/1425 , A61B2034/104 , C12N13/00
摘要： The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
摘要翻译：本发明提供一种用于估计通过定义治疗区域的多个电极施加治疗能量的装置的三维治疗体积的系统，所述系统包括存储器，显示装置，耦合到存储器和显示器的处理器设备和存储在存储器中并由处理器执行的治疗计划模块。在一个实施例中，治疗计划模块适于基于治疗区域的最大电导率与治疗区域的基线电导率的比率来生成用于在显示装置中显示的估计的第一3维治疗体积。本发明还提供了一种用于估计三维处理量的方法，该方法的步骤可通过处理器执行。在实施例中，系统和方法基于可以在可通过处理器执行的计算机可读代码中实现的数值模型。

8. 发明授权

US09272196B2 Double-sided home plate 有权
标题翻译：双面家用板
公开(公告)号：US09272196B2
公开(公告)日：2016-03-01
申请号：US14150225
申请日：2014-01-08
申请人： Chad Kropff , Catherine Kropff
发明人： Chad Kropff , Catherine Kropff
IPC分类号： A63B71/00 , A63B69/00
CPC分类号： A63B69/0013 , A63B69/0002 , A63B2102/18 , A63B2209/10 , A63B2243/0004
摘要： The present invention relates to home plates for ball fields, such as softball and baseball fields. Embodiments of the invention provide a double-sided home plate. Double-sided home plates according to embodiments can comprise a support base with two opposing recesses each shaped to receive a home plate insert, with a home plate insert fixed in each recess. Also provided is an improved home plate comprising two identical sides so when one side is worn due to use all that is required is to invert the home plate to expose a new surface.
摘要翻译：本发明涉及球场的垒板，如垒球和棒球场。本发明的实施例提供一种双面家用板。根据实施例的双面家用板可以包括支撑基座，其具有两个相对的凹部，每个凹部成形为接收本机插入件，固定在每个凹部中的本体插入件。还提供了一种改进的家用板，其包括两个相同的侧面，因此当一侧被佩戴时，由于所需要的一切是反转家用板以露出新的表面。

9. 发明授权

US09270164B2 Methods, systems, computer program products, and devices for renewable energy site power limit control 有权
标题翻译：方法，系统，计算机程序产品和可再生能源现场电力限制控制装置
公开(公告)号：US09270164B2
公开(公告)日：2016-02-23
申请号：US13921788
申请日：2013-06-19
申请人： TMEIC Corporation
发明人： Paul S. Bixel , Benjamin D. Rudolph
IPC分类号： H02M1/42 , H02J3/38 , H02M7/493
CPC分类号： H02M1/42 , H02J3/382 , H02M7/493 , Y02B70/126 , Y02E10/763
摘要： The present invention provides methods, systems, computer program products, and devices for renewable energy site power limit control that address conditions of plant saturation and loop delay. In an exemplary embodiment, power limit control of the present invention is broken into two levels of control: a site-wide real power limit control that produces a single site-wide command, SitePlimCom, for all inverters, and inverter-level power limit control that outputs a command, Inv[x].PlimCom[k], for individual inverters. In some embodiments, the invention has one or more of the following features: an integrator with nonlinear gains, limit based anti-windup, a power limit control term based on the sum of both integrator and feed-forward terms, and an inverter-level controller designed to meet slew rate and site power overshoot constraints. The invention can be used at any renewable energy site employing inverters wherein improved dynamic control performance is needed, including solar, wind, and tidal energy sites.
摘要翻译：本发明提供了用于可再生能源位置功率限制控制的方法，系统，计算机程序产品和设备，其针对工厂饱和和环路延迟的条件。在示例性实施例中，本发明的功率限制控制被分为两个级别的控制：针对所有逆变器产生单个站点范围命令，SitePlimCom的现场范围有功功率限制控制和逆变器级功率限制控制它为各个逆变器输出一个命令Inv [x] .PlimCom [k]。在一些实施例中，本发明具有以下特征中的一个或多个：具有非线性增益的积分器，基于限制的抗融合，基于积分器和前馈项之和的功率限制控制项，以及逆变器级控制器设计用于满足压摆率和现场功率过冲约束。本发明可以用于需要改进的动态控制性能的逆变器的任何可再生能源地点，包括太阳能，风能和潮汐能场所。

10. 发明授权

US09205578B2 Fabrication tools for exerting normal forces on feedstock 有权
标题翻译：在原料上施加正常力的制作工具
公开(公告)号：US09205578B2
公开(公告)日：2015-12-08
申请号：US14159105
申请日：2014-01-20
申请人： Aeroprobe Corporation
发明人： Jeffrey Patrick Schultz , Kevin D. Creehan
IPC分类号： B23K20/12 , B29C41/36 , C23C24/04 , C23C24/06 , C23C26/00
CPC分类号： B23K20/1215 , B22F2998/00 , B23K20/1205 , B23K20/1245 , B23K20/1255 , B23K20/1275 , B23K20/128 , B29C41/36 , C23C24/045 , C23C24/06 , C23C26/00 , C22C32/00 , C22C29/00
摘要： The present invention relates to tooling and methods for disposing, coating, building up, repairing, or otherwise modifying the surface of a metal substrate using frictional heating and compressive loading of a consumable metal material against the substrate. Embodiments of the invention include friction-based fabrication tooling comprising a non-consumable member with a throat and a consumable member disposed in the throat, wherein the throat is operably configured such that during rotation of the non-consumable member at a selected speed, the throat exerts normal forces on and rotates the consumable member at the selected speed; and comprising means for dispensing the consumable member through the throat and onto a substrate using frictional heating and compressive loading. Embodiments of the invention also include fabrication methods using the tools described herein.
摘要翻译：本发明涉及使用消耗性金属材料相对于基底的摩擦加热和压缩载荷来设置，涂覆，建立，修复或以其它方式改变金属基底的表面的工具和方法。本发明的实施例包括基于摩擦的制造工具，其包括具有喉部的非消耗性构件和设置在喉部中的可消耗构件，其中喉部可操作地构造成使得在以非选择的速度旋转非消耗性构件期间，喉部以选定的速度施加正常的力并使消耗部件旋转; 并且包括用于通过摩擦加热和压缩载荷将消耗部件分配通过喉部并且移动到基底上的装置。本发明的实施例还包括使用本文所述的工具的制造方法。

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