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1. 发明授权

US07670627B2 pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients 失效
标题翻译： pH触发用于递送药物活性成分的靶向控制释放系统
公开(公告)号：US07670627B2
公开(公告)日：2010-03-02
申请号：US10315801
申请日：2002-12-09
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K9/14
CPC分类号： A61K9/5138 , A61K9/1635 , A61K9/2077 , A61K9/5084 , A61K49/0404 , A61K49/0485 , B82Y5/00
摘要： The present invention relates to a novel pH triggered, targeted controlled release system. The controlled delivery system of the present invention is substantially a free-flowing powder formed of solid hydrophobic nano-spheres comprising pharmaceutical active ingredients that are encapsulated in a pH sensitive micro-spheres. The invention also relates to the processes for preparing the compositions and processes for using same. The controlled release system can be used to target and control the release of pharmaceutical active ingredients onto certain regions of the gastrointestinal tract including the stomach and the small intestine. The invention further pertains to pharmaceutical products comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种新的pH触发的靶向控制释放系统。本发明的受控递送系统基本上是由固体疏水性纳米球形成的自由流动的粉末，其包含被包封在pH敏感的微球中的药物活性成分。本发明还涉及制备组合物的方法及其使用方法。控制释放系统可用于靶向和控制药物活性成分在包括胃和小肠的胃肠道的某些区域的释放。本发明还涉及包含本发明的控制释放系统的药物产品。

2. 发明授权

US07338928B2 System for releasing encapsulated active ingredients 有权
标题翻译：用于释放封装的活性成分的系统
公开(公告)号：US07338928B2
公开(公告)日：2008-03-04
申请号：US11003869
申请日：2004-12-03
申请人： Willie Lau , Curtis Schwartz , Adi Shefer
发明人： Willie Lau , Curtis Schwartz , Adi Shefer
IPC分类号： C11D17/06 , C11D3/50 , C11D3/37 , A61K8/11 , A61K9/51
CPC分类号： A61Q19/00 , A61K8/0241 , A61K8/11 , A61K8/8129 , A61K8/8147 , A61K8/8152 , A61K2800/412 , A61K2800/413 , A61K2800/624 , A61Q5/02 , A61Q5/06 , A61Q5/065 , A61Q5/12 , A61Q13/00 , A61Q15/00 , A61Q19/10
摘要： The present invention relates to a controlled release system that can be incorporated in cosmetic, personal care, and household products to effectively encapsulate wide range of active ingredients and sensory markers and release them in response to moisture or over an extended period of time. The controlled release system of the present invention consists of oil absorbing polymer nanospheres coated with water sensitive surface active polymers.
摘要翻译：本发明涉及可以并入化妆品，个人护理和家用产品中的控制释放系统，以有效地包封大范围的活性成分和感官标记物，并且响应于水分或延长的时间段释放它们。本发明的控制释放系统由涂覆有水敏表面活性聚合物的吸油聚合物纳米球组成。

3. 发明授权

US07115282B2 Multi component controlled release system for anhydrous cosmetic compositions 失效
标题翻译：用于无水化妆品组合物的多组分控释系统
公开(公告)号：US07115282B2
公开(公告)日：2006-10-03
申请号：US10124207
申请日：2002-04-17
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K9/16 , A61K9/14 , A61K6/00
CPC分类号： B82Y5/00 , A61K8/0287 , A61K2800/31 , A61K2800/413 , A61K2800/56 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/001
摘要： The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or different from those encapsulated in the micro-sphere. The encapsulation of one or more fragrances, flavors or active agents in the various components of the system, such as nano-spheres and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor character) during the use of the product, in response to moisture, such as wetting the lips, perspiration, and the like. The incorporation of the controlled release system of the present invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in the solid hydrophobic nano-spheres over an extended period of time.
摘要翻译：本发明涉及可以并入无水化妆品制剂中并可以包封不同类型的香料，香料，活性成分或香料，香料和各种活性成分的组合的改进的控释系统。本发明的受控递送系统是固体疏水性纳米球形成的基本自由流动的粉末，其被包封在湿气敏感的微球体中。包封在纳米球体中的香料，香料和活性成分可以与包封在微球体中的那些相同或不同。将一种或多种香料，香料或活性剂包封在系统的各种组分如纳米球体和微球体中，在使用期间提供气味或风味转变（气味特征的变化或风味特征的变化）该产品响应于湿气，例如润湿嘴唇，出汗等。发现将本发明的控制释放系统并入无水化妆品制剂中提供了水分触发释放，以及将包封在固体疏水性纳米球体中的香料，香料和活性成分的延长释放延长一段的时间。

4. 发明授权

US06979440B2 Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric 失效
标题翻译：将有效成分和感官标记物靶向控制递送到毛发，皮肤和织物上的组合物和方法
公开(公告)号：US06979440B2
公开(公告)日：2005-12-27
申请号：US10222054
申请日：2002-08-16
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K8/00 , A61K8/04 , A61K8/11 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/67 , A61K8/81 , A61K8/84 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/97 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/00 , C11D3/37 , C11D17/00 , A61K31/74
CPC分类号： B82Y5/00 , A61K8/0204 , A61K8/11 , A61K8/34 , A61K8/416 , A61K8/671 , A61K8/8111 , A61K8/84 , A61K2800/244 , A61K2800/413 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/001 , C11D3/3719 , C11D3/3723 , C11D17/0039
摘要： The present invention is a controlled delivery system that can be incorporated in hair, skin, and fabric care products such as shampoos, conditioners, hair styling products, lotions, creams, liquid laundry detergents, fabric softener, and other hair, skin, and fabric care products to effectively deliver a broad range of active agents and sensory markers onto the hair, skin, and fabric. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon blow drying the hair, ironing the fabric, or other types of heat treatment. The controlled delivery system of the present invention is a nano-sphere, having an average sphere diameter of from about 0.01 microns to about 10 microns. The nano-sphere comprises hydrophobic materials, cationic conditioning agent or, cationic conditioning agent in conjunction with a cationic charge booster to assist in adhering the spheres onto hair, skin, and fabric. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.
摘要翻译：本发明是可以并入头发，皮肤和织物护理产品如洗发剂，调理剂，发型产品，洗剂，霜剂，液体衣物洗涤剂，织物柔软剂和其它头发，皮肤和织物中的受控递送系统。护理产品以有效地将广泛的活性剂和感官标记物递送到头发，皮肤和织物上。该系统还可延长活性剂或感官标记物在延长的时间段内的释放速率，或者提供活性剂的热触发释放，并且在吹干头发，熨烫织物时产生高冲击性香味“爆裂” 其他类型的热处理。本发明的受控递送系统是纳米球体，平均球体直径为约0.01微米至约10微米。纳米球包括疏水性材料，阳离子调理剂或阳离子调理剂，与阳离子电荷增强剂结合以帮助将球体粘附到毛发，皮肤和织物上。本发明还涉及一种受控递送系统，其中活性成分的释放速率与感官标记物的释放速率同步，以向消费者传达产品性能。

5. 发明申请

US20050112235A1 Multi component controlled release system for oral care, food products, nutraceutical, and beverages 审中-公开
公开(公告)号：US20050112235A1
公开(公告)日：2005-05-26
申请号：US11025256
申请日：2004-12-29
申请人： Adi Shefer , Samuel Shefer
发明人： Adi Shefer , Samuel Shefer
IPC分类号： A23G1/00 , A23G1/54 , A23L1/22 , A23L2/39 , A61F2/00 , A61F13/00 , A61K8/02 , A61K8/04 , A61K8/11 , A61K8/34 , A61K8/49 , A61K8/92 , A61K9/00 , A61K9/127 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/51 , A61Q11/00 , A23G3/30
CPC分类号： A23G1/54 , A23L2/39 , A23L27/72 , A23V2002/00 , A61K8/0241 , A61K8/11 , A61K8/347 , A61K8/4926 , A61K8/92 , A61K8/922 , A61K9/006 , A61K9/0063 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/5123 , A61K2800/412 , A61K2800/413 , A61K2800/56 , A61Q11/00 , A23V2200/25
摘要： The present invention relates to an improved controlled release system that can encapsulate different flavors, sensory markers, and active ingredients, or combinations of flavors, sensory markers and various active ingredients and release multiple active ingredients in a consecutive manner, one after the other. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nanospheres that are encapsulated in a moisture sensitive microspheres. The flavors, and active ingredients encapsulated in the hydrophobic nanospheres, in the water sensitive microsphere, or in both the nano and the microsphere. The flavors and active ingredients encapsulated in the nanospheres can be the same or different from those encapsulated in the microspheres. The encapsulation of different flavors or active agents in the various components of the system, such as nanospheres and microspheres, provides flavor transition (change in flavor character) during the use of the products. The controlled release system of the present invention enhances the stability and bioavailability of wide range of flavors, sensory markers, and other active ingredients, prolong their residence time in the oral cavity, control their release characteristics, and prolong the sensation of flavors and other sensory markers in the mouth to provide long lasting organoleptic perception or long lasting mouthfeel. The invention further relates oral care, food products, and beverages comprising the controlled release system of the present invention.

6. 发明授权

US06491902B2 Controlled delivery system for hair care products 有权
标题翻译：护发产品的控制送货系统
公开(公告)号：US06491902B2
公开(公告)日：2002-12-10
申请号：US09771752
申请日：2001-01-29
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K706
CPC分类号： B82Y5/00 , A61K8/0283 , A61K8/11 , A61K8/34 , A61K8/416 , A61K8/671 , A61K8/8111 , A61K8/84 , A61K2800/244 , A61K2800/413 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/001 , C11D3/3719 , C11D3/3723 , C11D17/0039
摘要： The present invention is a controlled delivery system that can be incorporated in hair care products such as shampoos, conditioners, hair styling products, and other hair care products to effectively deliver a broad range of active agents and sensory markers, such as fragrances or cooling agents onto the hair. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon blow drying the hair or other types of heat treatment. The controlled delivery system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns. The nano-particle comprises hydrophobic polymers and co-polymers, cationic charge boosters in conjunction with cationic surface-active conditioning agents that assist in adhering the particles onto hair. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.
摘要翻译：本发明是可以并入头发护理产品如洗发剂，护发素，头发定型产品和其它护发产品中的受控递送系统，以有效地递送广泛范围的活性剂和感官标记物，例如香料或冷却剂到头发上该系统还可延长活性剂或感官标记物在延长的时间内的释放速率，或提供活性剂的热触发释放，并在吹干头发或其它类型的热处理时产生高冲击性香味“爆裂” 。本发明的受控递送系统是平均粒径为约0.01微米至约10微米的纳米颗粒。纳米颗粒包括疏水性聚合物和共聚物，阳离子电荷增效剂与阳离子表面活性调节剂有助于将颗粒粘附到毛发上。本发明还涉及一种受控递送系统，其中活性成分的释放速率与感官标记物的释放速率同步，以向消费者传达产品性能。

7. 发明授权

US6051540A Method employing drum chilling and apparatus therefor for producing fragrance-containing long lasting solid particle 有权
标题翻译：使用鼓式冷藏的方法及其装置，用于生产含香料的持久固体颗粒
公开(公告)号：US6051540A
公开(公告)日：2000-04-18
申请号：US186487
申请日：1998-11-05
申请人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
发明人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
IPC分类号： C11D1/66 , C11D3/50 , C11D11/00 , C11D17/04
CPC分类号： C11D17/047 , C11D1/667 , C11D11/0082 , C11D3/505
摘要： A method and apparatus is disclosed for producing a fragrance-containing solid particle, capable of controllably releasing the fragrance to the environment in which the particle is contained for incorporation into laundry detergents, fabric softener compositions and drier-added fabric softener articles.
摘要翻译：公开了用于生产含香料的固体颗粒的方法和装置，其能够可控地将香料释放到其中包含颗粒的环境中以便结合到衣物洗涤剂中，织物柔软剂组合物和加入干燥剂的织物柔软剂制品中。

8. 发明授权

US6042792A Apparatus for preparing a solid phase microparticulate composition 失效
标题翻译：用于制备固相微粒组合物的装置
公开(公告)号：US6042792A
公开(公告)日：2000-03-28
申请号：US933599
申请日：1997-09-18
申请人： Adi Shefer , Keith J. McDermott , Shmuel David Shefer , Chee-Teck Tan
发明人： Adi Shefer , Keith J. McDermott , Shmuel David Shefer , Chee-Teck Tan
IPC分类号： A61K8/11 , A61Q13/00 , B01F3/08 , G01N30/00 , B01F7/16
CPC分类号： A61Q13/00 , A61K8/11 , G01N30/00
摘要： Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to services such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log.sub.10 P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity.
摘要翻译：描述了用于靶向递送到诸如皮肤，毛发和织物以及邻近的环境的受控的时间释放微粒活性和生物活性组合物（包括加香组合物），其中活性和生物活性材料具有计算的log 10P值在1和 8（P为正辛醇 - 水分配系数）。这样的组合物包括在单相中的活性或生物活性物质，也在其上涂覆有和/或含有相容表面活性剂的蜡或聚合物基质中的固体溶液。还描述了制备这种组合物的方法和装置以及使用它们的方法。此外，上述组合物的某些组分彼此组合是新颖的，并且其它组分在增加香味直接性方面具有新颖的用途。

9. 发明授权

US06825161B2 Multi component controlled delivery system for soap bars 有权
标题翻译：肥皂条的多部件控制输送系统
公开(公告)号：US06825161B2
公开(公告)日：2004-11-30
申请号：US10286143
申请日：2002-11-01
申请人： Adi Shefer , Samuel Shefer
发明人： Adi Shefer , Samuel Shefer
IPC分类号： C11D1708
CPC分类号： A61K8/11 , A61K8/0287 , A61K2800/413 , A61K2800/56 , A61Q13/00 , A61Q19/00 , C11D1/62 , C11D3/505 , C11D9/00 , C11D9/26 , C11D9/36 , C11D17/0039
摘要： The present invention relates to an improved controlled delivery system that can be incorporated in soap bars to enhance deposition of active ingredients and sensory markers onto skin. The carrier system also provides controlled release or prolonged release of these actives from the skin over an extended period of time. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nanospheres of encapsulated active ingredients, that are encapsulated in moisture sensitive microspheres. The high cationic charge density of the nanosphere improves deposition of active ingredients onto skin. The high cationic charge density on the nanosphere surface is created by incorporating a cationic conditioning agent into the solid hydrophobic matrix of the nanospheres, by incorporating a cationic charge “booster” in the moisture sensitive microsphere matrix, or by using a cationic conditioning agent in the nanosphere matrix in conjunction with a cationic charge “booster” in the microsphere matrix. The invention also pertains to soap products comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种改进的受控递送系统，其可并入皂条中以增强活性成分和感官标记物在皮肤上的沉积。载体系统还在延长的时间内提供这些活性物质从皮肤的控制释放或延长释放。本发明的受控递送系统包括基本上自由流动的由包封的活性成分的固体疏水性，带正电荷的纳米球形成的粉末，其被包封在湿敏性微球体中。纳米球的高阳离子电荷密度改善了活性成分在皮肤上的沉积。纳米球表面上的高阳离子电荷密度是通过将阳离子调理剂掺入到纳米球的固体疏水基质中，通过在水分敏感性微球体基质中引入阳离子电荷“促进剂”，或者通过使用阳离子调理剂纳米球基体与微球体中的阳离子电荷“助剂”相结合。本发明还涉及包含本发明的控制释放系统的肥皂产品。

10. 发明授权

US06740631B2 Multi component controlled delivery system for fabric care products 失效
标题翻译：用于织物护理产品的多组分控制递送系统
公开(公告)号：US06740631B2
公开(公告)日：2004-05-25
申请号：US10133833
申请日：2002-04-26
申请人： Adi Shefer , Samuel David Shefer
发明人： Adi Shefer , Samuel David Shefer
IPC分类号： A61K951
CPC分类号： C11D17/0039 , C11D1/62 , C11D3/505 , C11D9/00 , C11D9/26 , C11D9/36
摘要： The present invention relates to an improved controlled delivery system that can be incorporated in dry granular, or powder, fabric care products, such as laundry detergents, tumble dryer sheets, rinse added products, and other fabric care products, to enhance fragrance performance. The controlled delivery system of the present invention comprises substantially free-flowing, powder formed of solid hydrophobic, positively charged, nano-spheres of encapsulated active ingredients, such as a fragrance, that are encapsulated in a moisture sensitive micro-spheres, solid spheres. The high cationic charge density of the nano-sphere improves fragrance deposition onto the laundered fabric. The high cationic charge density on the nano-sphere surface is created by incorporating a cationic fabric conditioning agent into the solid hydrophobic matrix of the nano-spheres, by incorporating a cationic charge “booster” in the water sensitive micro-sphere matrix, or by using a cationic fabric conditioning agent in the nano-sphere matrix in conjunction with a cationic charge “booster” in the micro-sphere matrix. The fragrance carrier system also provides controlled release or prolonged fragrance release from the dry laundered fabric over an extended period of time, or yields a high impact fragrance “burst” upon ironing the fabric. The invention also pertains to fabric care products comprising the controlled release system of the present invention.
摘要翻译：本发明涉及一种改进的受控递送系统，其可并入干燥颗粒状或粉末状织物护理产品，例如衣物洗涤剂，滚筒干燥片，漂洗添加产品和其它织物护理产品中，以增强香味性能。本发明的受控递送系统包括基本上自由流动的粉末，其由包封的活性成分（例如香料）的固体疏水性，带正电荷的纳米球形成，其被包封在湿气敏感的微球体，固体球体中。纳米球的高阳离子电荷密度改善了洗涤织物上的香味沉积。纳米球表面上的高阳离子电荷密度是通过将阳离子织物调理剂掺入到纳米球的固体疏水性基质中，通过在水敏微孔基质中掺入阳离子电荷“助剂”或通过在纳米球基质中使用阳离子织物调理剂与微球基质中的阳离子电荷“增强剂”相结合。香料载体系统还在延长的时间内提供受控释放或长时间从干洗织物释放的香料，或在熨烫织物时产生高冲击性的香料“爆裂”。本发明还涉及包含本发明的控制释放系统的织物护理产品。

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