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1. 发明授权

US11055851B2 Multi-class image segmentation method 有权
公开(公告)号：US11055851B2
公开(公告)日：2021-07-06
申请号：US16479626
申请日：2018-01-24
申请人： Agfa Healthcare NV , VRVIS ZENTRUM FÜR VIRTUAL REALITY UND VISUALISIERUNG
发明人： Alexey Novikov , David Major , Dimitrios Lenis , Maria Wimmer , Katja Buehler
IPC分类号： G06T7/11 , G06K9/62 , G06N3/04 , G06N3/08 , G06T7/00 , A61B5/055 , A61B6/00 , A61B8/08
摘要： A pipe-line method for multi-label segmentation of anatomic structures in a medical image using a convolutional neural network trained with a weighted loss function takes into account under—representation of at least one anatomical structure in a ground-truth mask relative to other anatomical structures. Different architectures for the convolutional neural network are described.

2. 发明授权

US10945682B2 Geometric misalignment correction method for chest tomosynthesis reconstruction 有权
公开(公告)号：US10945682B2
公开(公告)日：2021-03-16
申请号：US16308303
申请日：2017-06-08
申请人： Agfa Healthcare NV
发明人： Jeroen Cant , Jan Sijbers
IPC分类号： A61B6/02 , A61B6/00 , G06T11/00 , G16H30/40
摘要： A method and system to correct for alignment errors between assumed and actual geometric parameters of an acquisition geometry during image reconstruction in a chest tomosynthesis application includes receiving at least 2 raw projection images acquired on at least 2 different positions in a known acquisition geometry, determining an actual geometric parameter value by determining the minimum of a redundant planes cost function which is calculated for a varying range of the geometric parameter values, and which is determined by: a) at least one plane which intersects an X-ray source trajectory with at least two points, b) an intersection between the planes and a detector surface for which points the source positions are determined, and c) for which the parameters determining the intersection (λ, μ, l) are used for the construction of the cost function, applying the calculated actual geometric parameter value of the acquisition geometry for the image reconstruction of the plurality of images, characterized in that, a weighting function is applied to the plurality of acquired images prior to calculating the cost function.

3. 发明申请

US20210073996A1 AVOIDING CATASTROPHIC INTERFERENCE WHILE TRAINING AN ARTIFICIAL NEURAL NETWORK ON AN ADDITIONAL TASK 有权
公开(公告)号：US20210073996A1
公开(公告)日：2021-03-11
申请号：US16757438
申请日：2018-10-10
申请人： Agfa HealthCare NV , VRVIS ZENTRUM FÜR VIRTUAL REALITY UND VISUALISIERUNG
发明人： Alexey NOVIKOV , Katja BUEHLER , David MAJOR , Maria WIMMER
IPC分类号： G06T7/10 , G06T7/00
摘要： A method for training an artificial neural network on an additional untrained segmentation task prevents the loss of previously acquired segmentation skills on originally trained segmentation tasks.

4. 发明授权

US10127683B2 Method for determining the short axis in a lesion region in a three dimensional medical image 有权
公开(公告)号：US10127683B2
公开(公告)日：2018-11-13
申请号：US15541027
申请日：2015-12-16
申请人： Agfa HealthCare NV
发明人： Asma Ouji , Yoni De Witte
IPC分类号： G06T7/62 , G06T7/00
摘要： A short axis in a 3 dimensional image of a lesion is determined starting from voxels defining the long axis and voxels in the plane of the long axis. Voxels within the plane of the long axis are projected perpendicularly onto the long axis and receive an identifier indicative of the region on the long axis onto which they are projected. Distances between points (projected sub-voxels) in pairs of points within the same range and within adjacent ranges are evaluated in order to determine the longest distance.

5. 发明申请

US20180299565A1 A METHOD FOR RESHAPING THE CHARACTERISTIC EXPOSURE RESPONSE AND DOSIMETRY OF A DIRECT RADIOGRAPHY SYSTEM 审中-公开
公开(公告)号：US20180299565A1
公开(公告)日：2018-10-18
申请号：US15769075
申请日：2016-10-18
申请人： Agfa HealthCare NV
发明人： Marc CRESENS , Stefan STOMMELS
IPC分类号： G01T1/164 , A61B6/00 , H05G1/26 , G01T1/02
CPC分类号： G01T1/1645 , A61B6/582 , G01T1/02 , G01T1/24 , H05G1/265
摘要： A method for reshaping the characteristic exposure response and dosimetry of a direct radiography system into a specified exposure response profile includes pixel-wise converting image data according to a response transfer model which is derived from an x-ray generator's post exposure parameters data associated with image signals obtained at various exposure levels during system calibration and from a few extra dose measurements and their corresponding post exposure data also gathered during system calibration under reference exposure conditions.

6. 发明授权

US09763635B2 Method, apparatus and system for identifying a specific part of a spine in an image 有权
公开(公告)号：US09763635B2
公开(公告)日：2017-09-19
申请号：US14761317
申请日：2014-01-20
申请人： Agfa Healthcare NV , VRVIS ZENTRUM FUER VIRTUAL REALITY UND VISUALISIERUNG FORSCHUNGS-GMBH , IMP FORSCHUNGSINSTITUT FUER MOLEKULARE PATHOLOGIE GMBH
发明人： Jiri Hladuvka , David Major , Katja Buehler
IPC分类号： G06T7/00 , A61B6/00 , A61B6/03 , G06K9/00 , G06K9/46 , G06T5/00 , A61B5/107
CPC分类号： A61B6/505 , A61B5/107 , A61B5/1075 , A61B6/032 , A61B6/468 , A61B6/5217 , G06K9/00536 , G06K9/4609 , G06K2209/055 , G06T5/002 , G06T7/0012 , G06T2207/10081 , G06T2207/30012
摘要： A method, apparatus, and system for reliably identifying a specific part of a spine in an image of a human or animal body, includes the steps of determining one or more parts of the spine in the image, determining one or more discriminative parameters for each of the one or more parts of the spine in the image, the discriminative parameters relating to at least one anatomical property of each of the one or more parts of the spine, classifying the discriminative parameters of the one or more parts of the spine in the image, and identifying a specific part of the spine based on the classification of the discriminative parameters of the one or more parts of the spine in the image. An identified vertebra, in particular the T12 vertebra and/or its associated intervertebral discs, can be used advantageously as a starting point of powerful automatic spine labeling algorithms.

7. 发明授权

US09597048B2 Method for selecting a direct radiographic panel as active DR panel 有权
公开(公告)号：US09597048B2
公开(公告)日：2017-03-21
申请号：US14409030
申请日：2013-06-28
申请人： Agfa HealthCare NV
发明人： Walter Exelmans
IPC分类号： H05G1/56 , A61B6/00 , G01T1/17 , G06F17/50
CPC分类号： A61B6/4494 , A61B6/4216 , A61B6/4233 , A61B6/4452 , A61B6/467 , A61B6/542 , A61B6/563 , A61B6/587 , G01T1/17 , G06F17/50
摘要： A method includes selecting, in a radiographic exposure unit, a direct radiographic panel as an active panel for a forthcoming radiographic exposure, activating a gravity sensor installed on the direct radiographic panel, and activating by the activated gravity sensor a processor installed on the direct radiographic panel. As a result of a communication from the processor with a radiographic work station over a network, the activated direct radiographic panel is retained as the active direct radiographic panel for the forthcoming radiographic exposure.

8. 发明申请

US20170007726A1 PROCESS FOR PURIFYING 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAACETIC ACID 审中-公开
标题翻译：净化1,4,7,10-四氮杂环十二烷基-1,4,7,10-四氢酸的方法
公开(公告)号：US20170007726A1
公开(公告)日：2017-01-12
申请号：US15116263
申请日：2015-02-02
申请人： Agfa HealthCare NV
发明人： Diederik BUFFEL , Xavier BOI , Judith PYPE
IPC分类号： A61K49/10 , B01D61/02 , A61K47/18 , C07D295/15 , C07F5/00
CPC分类号： A61K49/108 , A61K47/18 , B01D61/027 , B01D2311/2649 , B01D2311/2673 , B01D2315/16 , C07D257/02 , C07D295/15 , C07F5/003
摘要： A process for purifying a compound of formula 1, includes the following steps: a) adding an acid to an aqueous solution of the compound of formula 1, including salts and hydrates thereof so as to obtain a slurry having a pH≦3; and b) filtering the slurry and at least one time washing the obtained precipitate with a liquid comprising water; and c) dissolving the precipitate obtained in step b) in water to obtain an aqueous solution; and d) filtering of the solution obtained in step c) over a nanofiltration membrane having a Molecular Weight Cut Off in the range from 150 to 500 and wherein optionally, between step c) and step d) the pH of the aqueous solution is adjusted to a pH value in the pH range as specified by the manufacturer of the nanofiltration membrane. A process for preparing a gadolinium complex of the purified compound of formula 1 is also disclosed. This gadolinium complex can be used for making a pharmaceutical composition as a contrast agent for magnetic resonance imaging.
摘要翻译：包括以下步骤：a）向式1化合物的水溶液中加入酸，包括其盐和水合物，以获得pH≤3的浆料; 和b）过滤浆料，并至少一次用包含水的液体洗涤所获得的沉淀物; 和c）将步骤b）中获得的沉淀溶解在水中以获得水溶液; 以及d）将步骤c）中获得的溶液过滤到分子量截留在150-500范围内的纳滤膜中，并且其中任选地在步骤c）和步骤d）之间，将水溶液的pH调节至在纳米过滤膜制造商规定的pH范围内的pH值。还公开了制备纯化的式1化合物的钆络合物的方法。该钆络合物可用于制备用作磁共振成像的造影剂的药物组合物。

9. 发明申请

US20150356729A1 METHOD, APPARATUS AND SYSTEM FOR IDENTIFYING A SPECIFIC PART OF A SPINE IN AN IMAGE 有权
标题翻译：用于识别图像中的脊柱的特定部分的方法，装置和系统
公开(公告)号：US20150356729A1
公开(公告)日：2015-12-10
申请号：US14761317
申请日：2014-01-20
申请人： AGFA HEALTHCARE NV , VRVIS ZENTRUM FÜR VIRTUAL REALITY UND VISUAL- ISIERUNG FORSCHUNGS-GMBH , IMP FORSCHUNGSINSTITUT FÜR MOLEKULARE PATHOLOGIE GMBH
发明人： Jiri HLADUVKA , David MAJOR , Katja BÜHLER
IPC分类号： G06T7/00 , A61B6/00 , G06T5/00 , A61B6/03 , G06K9/46 , G06K9/00
CPC分类号： A61B6/505 , A61B5/107 , A61B5/1075 , A61B6/032 , A61B6/468 , A61B6/5217 , G06K9/00536 , G06K9/4609 , G06K2209/055 , G06T5/002 , G06T7/0012 , G06T2207/10081 , G06T2207/30012
摘要： A method, apparatus, and system for reliably identifying a specific part of a spine in an image of a human or animal body, includes the steps of determining one or more parts of the spine in the image, determining one or more discriminative parameters for each of the one or more parts of the spine in the image, the discriminative parameters relating to at least one anatomical property of each of the one or more parts of the spine, classifying the discriminative parameters of the one or more parts of the spine in the image, and identifying a specific part of the spine based on the classification of the discriminative parameters of the one or more parts of the spine in the image. An identified vertebra, in particular the T12 vertebra and/or its associated intervertebral discs, can be used advantageously as a starting point of powerful automatic spine labeling algorithms.
摘要翻译：一种用于可靠地识别人体或动物身体的图像中的脊柱的特定部分的方法，装置和系统，包括以下步骤：确定图像中的脊柱的一个或多个部分，为每一个确定一个或多个鉴别参数在图像中的脊柱的一个或多个部分中，与脊柱的一个或多个部分中的每一个的至少一个解剖特性相关的鉴别参数，将脊柱的一个或多个部分的鉴别参数分类为图像，以及基于图像中脊柱的一个或多个部分的辨别参数的分类来识别脊柱的特定部分。识别的椎骨，特别是T12椎骨和/或其相关的椎间盘，可以有利地用作强大的自动脊柱标记算法的起点。

10. 发明申请

US20150173701A1 METHOD, APPARATUS AND SYSTEM FOR AUTOMATED SPINE LABELING 有权
标题翻译：方法，装置和系统的自动脊柱标签
公开(公告)号：US20150173701A1
公开(公告)日：2015-06-25
申请号：US14416711
申请日：2013-07-23
申请人： AGFA HEALTHCARE NV , VRVis Forschungs GmbH , AVL LIST GMBH , IMP FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GMBH
发明人： David Major , Jiri Hladuvka , Katja Bühler , Florian Schulze
IPC分类号： A61B6/00 , A61B6/03 , A61B5/00 , G06T7/00 , G06K9/62
CPC分类号： A61B6/468 , A61B5/4566 , A61B6/032 , A61B6/505 , A61B6/5217 , A61B2560/0295 , G06K9/6297 , G06T7/11 , G06T7/143 , G06T7/174 , G06T2207/10081 , G06T2207/30012
摘要： A method, an apparatus, and a system label one or more parts of a spine in an image, in particular a computed tomography (CT) image, of a human or animal body, and in order to achieve a reliable spine labeling and a high throughput of images, match a model of a spine segment with segments of the spine in the image by starting matching the model of a spine segment with an initial segment of the spine in the image, wherein the initial segment of the spine in the image is located at an initial position along the spine in the image, and continue to match the model of a spine segment with one or more further segments of the spine in the image, wherein the further segments of the spine in the image are located at positions farther along the spine in the image.
摘要翻译：一种方法，装置和系统标记人或动物身体的图像中的脊柱的一个或多个部分，特别是计算机断层摄影（CT）图像，并且为了实现可靠的脊柱标记和高的图像的吞吐量通过开始将脊柱段的模型与图像中的脊柱的初始段匹配起来，将脊柱段的模型与图像中的脊柱的部分匹配，其中图像中的脊柱的初始段是位于沿图像中的脊柱的初始位置，并且继续将脊柱段的模型与图像中的脊柱的一个或多个另外的段匹配，其中图像中的脊柱的另外的部分位于更远的位置沿着图像中的脊柱。

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