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1. 发明授权

US07736312B2 Acoustic monitoring system 有权
标题翻译：声学监控系统
公开(公告)号：US07736312B2
公开(公告)日：2010-06-15
申请号：US10762963
申请日：2004-01-22
申请人： Terri K. Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Ferrer Wilson , Pierre S. Ostiguy , Bertil Romner , Alan J. Dextradeur
发明人： Terri K. Taylor , Meir Rosenberg , Rainuka Gupta , Stephen Ferrer Wilson , Pierre S. Ostiguy , Bertil Romner , Alan J. Dextradeur
IPC分类号： A61B8/00
CPC分类号： A61B7/005 , A61B2562/0204
摘要： An acoustic monitoring system that is able to verify the success or failure of the positional adjustment of a valve without the need for additional energy during non-invasive reprogramming is provided. The acoustic monitoring system includes a programmer for generating a sequence of commands to adjust the valve mechanism, and for receiving acoustic signals for analysis, a transmitter to implement the command and adjust the valve, and a sensor for detecting an acoustic signal generated from the valve during execution of the commands. A method for using the acoustic monitoring system is also provided.
摘要翻译：提供一种声学监测系统，其能够在非侵入式重新编程期间验证阀的位置调整的成功或失败，而不需要额外的能量。声学监测系统包括一个编程器，用于产生一系列命令以调节阀门机构，并且用于接收用于分析的声学信号，发射器来实现该指令并调整阀门;以及传感器，用于检测从阀门产生的声学信号在执行命令期间。还提供了一种使用声学监测系统的方法。

2. 发明申请

US20130253266A1 FLUID MANAGEMENT CATHETER AND METHODS OF USING SAME 审中-公开
公开(公告)号：US20130253266A1
公开(公告)日：2013-09-26
申请号：US13427232
申请日：2012-03-22
申请人： ALAN J. DEXTRADEUR , DANIEL McCUSKER
发明人： ALAN J. DEXTRADEUR , DANIEL McCUSKER
IPC分类号： A61M27/00 , A61B1/00 , A61M3/02
CPC分类号： A61B1/313 , A61B1/00165 , A61B1/015 , A61B18/24 , A61B2018/00446 , A61B2018/00982 , A61B2018/1807 , A61B2018/2005 , A61B2018/2261 , A61B2218/002 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M27/00 , A61M27/006 , A61M2027/004 , A61M2210/0693 , A61N5/0601 , A61N5/0603 , A61N2005/0612
摘要： A catheter and method for managing fluid in a patient, the catheter having an elongated shaft with a distal end and a proximal end. The shaft defines at least one lumen extending substantially therethrough, the shaft further defining a plurality of drainage holes along a distal portion of the shaft, with the drainage holes in fluid communication with the lumen. The catheter further has a substantially transparent tip portion attached to the distal end of the shaft with an outer distal leading surface that is substantially rounded to assist insertion through tissue.

3. 发明授权

US07585280B2 System and method for measuring the pressure of a fluid system within a patient 有权
标题翻译：用于测量患者内的流体系统的压力的系统和方法
公开(公告)号：US07585280B2
公开(公告)日：2009-09-08
申请号：US11025683
申请日：2004-12-29
申请人： Stephen F. Wilson , Alan J. Dextradeur
发明人： Stephen F. Wilson , Alan J. Dextradeur
IPC分类号： A61B5/00 , A61M5/00
CPC分类号： A61B5/032 , A61B5/031 , A61B5/742 , A61B2090/064 , A61B2562/0247 , A61M2202/0464
摘要： A pressure sensing apparatus has a pressure sensor component that includes a pressure sensing port, a pressure sensor for sensing a pressure of a fluid in the pressure sensing port, and a digital processor communicating with the pressure sensor for performing calculations involving fluid pressures sensed. The pressure sensing apparatus further includes a first chamber in fluid contact with the pressure sensing port, a second chamber fluidically connectable with a patient's cerebrospinal fluid system, and a membrane located between the first and second chambers so as to transmit fluid pressure from the second chamber to the first chamber.
摘要翻译：压力传感装置具有压力传感器部件，该压力传感器部件包括压力检测端口，用于感测压力感测端口中的流体的压力的压力传感器，以及与压力传感器通信的数字处理器，用于执行涉及所感测的流体压力的计算。压力感测装置还包括与压力感测端口流体接触的第一腔室，与患者的脑脊液系统可流体连接的第二腔室，以及位于第一腔室和第二腔室之间的膜，以便从第二腔室到第一个房间。

4. 发明授权

US07510533B2 Pressure sensing valve 有权
标题翻译：压力传感阀
公开(公告)号：US07510533B2
公开(公告)日：2009-03-31
申请号：US10907665
申请日：2005-04-11
申请人： Christophe Mauge , Alan J. Dextradeur , Daniel J. McCusker , Stefan Meyer , Volker Boedecker , Robert G. Kraus , Max G. Ostermeier
发明人： Christophe Mauge , Alan J. Dextradeur , Daniel J. McCusker , Stefan Meyer , Volker Boedecker , Robert G. Kraus , Max G. Ostermeier
IPC分类号： A61B5/00 , F16K1/48 , A61B5/02
CPC分类号： A61B5/031 , A61F2/24 , A61M27/006
摘要： A pressure sensing catheter having a pressure sensor and an antenna that is coupled to the pressure sensor, e.g., by a connector, are provided. The pressure sensor can be adapted to measure a pressure surrounding the catheter, and the antenna can be adapted to telemetrically communicate the measured pressure to an external device. In an exemplary embodiment, the antenna, pressure sensor, and/or connector are hermetically sealed, e.g., by the catheter and/or a coating, to prevent the antenna, pressure sensor, and connector from coming into contact with fluid, thereby allowing the catheter to be permanently implanted or otherwise used for long term use. Exemplary methods for manufacturing and using pressure sensing catheters are also provided.
摘要翻译：具有压力传感器的压力传感导管，其具有例如通过连接器耦合到压力传感器的压力传感器和天线。压力传感器可以适于测量导管周围的压力，并且天线可以适于将所测量的压力遥测地传递到外部设备。在示例性实施例中，天线，压力传感器和/或连接器例如通过导管和/或涂层被密封，以防止天线，压力传感器和连接器与流体接触，从而允许导管永久植入或以其他方式长期使用。还提供了用于制造和使用压力传感导管的示例性方法。

5. 发明申请

US20080125759A1 CONVECTION-ENHANCED DRUG DELIVERY DEVICE AND METHOD OF USE 审中-公开
标题翻译：对流增强药物递送装置及其使用方法
公开(公告)号：US20080125759A1
公开(公告)日：2008-05-29
申请号：US12024402
申请日：2008-02-01
申请人： David D. Konieczynski , Alan J. Dextradeur , William L. Rohr
发明人： David D. Konieczynski , Alan J. Dextradeur , William L. Rohr
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M25/0075 , A61M2202/0464
摘要： An implantable drug delivery system includes an infusion pump assembly with a fluid outlet, a fluid delivery pathway extending from the pump outlet to a target tissue site; and a controlled release material unit positioned in the fluid delivery pathway to release a drug or bioactive material into the delivery pathway. The pump assembly delivers fluid as a high flow infusion flow in said pathway, entraining drug material released by the release unit and establishing a pressure gradient at the distal end of the pathway that results in convection-enhanced transport such that the released drug(s) or treatment material enter the target tissue site with enhanced penetration depth and/or concentration. The pump delivers a carrier fluid that may reside in an external or in an implanted reservoir, or that may be an endogenous fluid, such as plasma or CSF.
摘要翻译：可植入药物递送系统包括具有流体出口的输液泵组件，从泵出口延伸到目标组织部位的流体递送通道; 以及定位在流体输送路径中以将药物或生物活性物质释放到输送路径中的控释材料单元。泵组件在所述通路中输送作为高流量输注流的流体，夹带由释放单元释放的药物材料，并在通路的远端建立压力梯度，导致对流增强的运输，使得释放的药物或治疗材料进入目标组织部位，具有增强的穿透深度和/或浓度。泵输送载体流体，其可以驻留在外部或植入的储存器中，或者可以是内源性流体，例如血浆或CSF。

6. 发明授权

US07192413B2 Needle guard having inherent probe directing features 有权
标题翻译：针头具有固有的探针导向功能
公开(公告)号：US07192413B2
公开(公告)日：2007-03-20
申请号：US10459406
申请日：2003-06-11
申请人： Robert G. Kraus , Alan J. Dextradeur
发明人： Robert G. Kraus , Alan J. Dextradeur
IPC分类号： A61M5/00 , A31M31/00 , A61M37/00
CPC分类号： A61M27/006
摘要： A needle or puncture guard that has inherent probe directing features for use in an in-line configured shunt valve is provided. The guard comprises a base member configured for mounting within the domed reservoir of the shunt valve, and a guide wall seated on the base member. The guide wall is defined by a top wall, an inner side wall, and an opposed outer side wall. The inner side wall has an indented section with an aperture extending through the indented section. The inner side wall can be concavely curved, while the indented section has a curvature that directs instruments that are pressed against the guide wall towards the aperture. A method for performing catheter revisions on a shunt system having a guard within the shunt valve is provided as well. Also provided is a method for placement of an intracranial pressure sensor percutaneously into a ventricular catheter for determining intracranial pressure.
摘要翻译：提供具有固有探针引导特征的针或穿刺保护装置，用于在线配置的分流阀中。护罩包括构造成用于安装在分流阀的圆顶形容器内的基座构件和安置在基座构件上的引导壁。引导壁由顶壁，内侧壁和相对的外侧壁限定。内侧壁具有凹口部分，其具有延伸穿过凹入部分的孔。内侧壁可以是凹形弯曲的，而凹进部分具有将朝向孔径压靠在引导壁上的工具引导的曲率。还提供了在具有分流阀内的防护件的分流系统上执行导管修正的方法。还提供了用于将颅内压力传感器经皮放置到心室导管中用于确定颅内压的方法。

7. 发明授权

US07108680B2 Closed-loop drug delivery system 有权
公开(公告)号：US07108680B2
公开(公告)日：2006-09-19
申请号：US10092955
申请日：2002-03-06
申请人： William L. Rohr , Alan J. Dextradeur , David D. Konieczynski
发明人： William L. Rohr , Alan J. Dextradeur , David D. Konieczynski
IPC分类号： A61M1/00 , A61M31/00
CPC分类号： A61B5/14546 , A61B5/04001 , A61B5/14503 , A61B5/1455 , A61B5/14553 , A61B5/1486 , A61B5/4082 , A61B5/4088 , A61B5/4839 , A61M5/14276 , A61M5/16804 , A61M5/16836 , A61M5/1723 , A61M2005/1726 , A61M2205/3306 , A61M2205/50
摘要： A delivery system for a drug or bioactive agent includes an implantable pump and a delivery conduit that may be implanted in an organ or other tissue (e.g., the central or the peripheral nervous system) of a subject. A sensor is also implanted, and a controller unit receives the sensor output and directs drug delivery from within the patient pump accordingly. The sensor directly measures a primary biochemical material or state in the tissue or organ system, and the monitoring unit effects closed loop feedback control of the pump to achieve a desired end. The end may be the regulation of metabolism or maintenance of a stable metabolic or other state, or may be treatment regimen, e.g., by delivery of a dosage level or distribution of a drug in specific brain or nervous an system tissue. The sensed material may be the agent itself, a metabolite, or a related native material, tissue state or condition.

8. 发明授权

US07040485B2 Method and apparatus for packaging a drug-device combination product 有权
标题翻译：用于包装药物装置组合产品的方法和装置
公开(公告)号：US07040485B2
公开(公告)日：2006-05-09
申请号：US11174115
申请日：2005-07-01
申请人： Rainuka Gupta , Alan J. Dextradeur
发明人： Rainuka Gupta , Alan J. Dextradeur
IPC分类号： B65D73/00
CPC分类号： A61L2/206 , A61L2/07 , A61L2/14 , A61L2/18 , A61L2/20 , B65D33/01
摘要： A package for a drug-device combination product includes an outer package including a first gas impermeable sheet and a second gas impermeable sheet hermetically sealed there to on three sides. A gas permeable header is attached to an unsealed side of the first sheet and sealed to the second sheet on two sides. The first and second gas impermeable sheets and the header form an interior and an opening communicating with the interior. A gas permeable inner package is disposed within the outer package. A product is sealed within the inner package. The inner package is placed within the outer package and a top end of the header is sealed to the second sheet. The outer package is then sealed by sealing the first gas impermeable sheet to the second gas impermeable sheet at a seal point below the point where the header attaches to the first sheet.
摘要翻译：用于药物装置组合产品的包装包括外包装，其包括第一不透气片和在三面上气密密封的第二不透气片。气体可渗透的头部附接到第一片的未密封侧并且在两侧密封到第二片。第一和第二气体不可渗透片材和头部形成与内部连通的内部和开口。气体可渗透的内包装设置在外包装内。产品密封在内包装内。内包装被放置在外包装内，并且头部的顶端被密封到第二片。然后通过在头部附接到第一片材的点下方的密封点处将第一不透气片材密封到第二不透气片材上来密封外包装。

9. 发明授权

US07038449B1 Biased magnetic field strength indication tool 有权
标题翻译：偏磁场强度指示工具
公开(公告)号：US07038449B1
公开(公告)日：2006-05-02
申请号：US11097498
申请日：2005-04-01
申请人： Stephen F. Wilson , Alan J. Dextradeur
发明人： Stephen F. Wilson , Alan J. Dextradeur
IPC分类号： G01R33/02
CPC分类号： G01R33/038
摘要： A detection device, for detecting a strength of a magnetic field of an object, includes a housing having a center, a first end and a detection end. A permanent magnetic element is suspended above the center of the housing having a first magnetic field strength and an indicator. A biasing permanent magnetic element is disposed at the first end of the housing and has a second magnetic field strength for biasing the indicator toward the first end. A first distance is between the permanent magnetic element and the biasing permanent magnetic element so that a threshold magnetic field strength can be determined from the first magnetic field strength, the second magnetic field strength and the first distance. Thus, when the object is placed approximate to the detection end and the object magnetic field strength is greater than the threshold magnetic field strength, the indicator rotates toward the detection end.
摘要翻译：用于检测物体的磁场强度的检测装置包括具有中心，第一端和检测端的壳体。永磁元件悬挂在具有第一磁场强度的壳体的中心上方和指示器上。偏置永磁元件设置在壳体的第一端，并且具有用于朝向第一端偏压指示器的第二磁场强度。永磁元件和偏置永磁元件之间的第一距离可以从第一磁场强度，第二磁场强度和第一距离确定阈值磁场强度。因此，当物体近似于检测端放置并且物体磁场强度大于阈值磁场强度时，指示器朝检测端转动。

10. 发明申请

US20100210992A1 MULTI-BRANCHED ANTI-REFLUX VALVE 有权
标题翻译：多分支防反应阀
公开(公告)号：US20100210992A1
公开(公告)日：2010-08-19
申请号：US12772847
申请日：2010-05-03
申请人： Alan J. Dextradeur , Robert Kraus
发明人： Alan J. Dextradeur , Robert Kraus
IPC分类号： A61M1/00
CPC分类号： A61M27/006
摘要： A shunt system includes a first catheter and a second catheter, each having a proximal end and a distal end, and at least one opening adjacent to its distal end. A proximal end of a drainage catheter is in fluid communication with the proximal end of the first catheter and the proximal end of the second catheter. A first one-way valve is disposed in fluid communication with the first catheter between its proximal end and its at least one opening. The first one-way valve effectively blocks fluid flow from the proximal end to the at least one opening. A second one-way valve is disposed in fluid communication with the second catheter between its proximal end and its at least one opening. The second one-way valve effectively blocks fluid flow from the proximal end to the at least one opening.
摘要翻译：分流系统包括第一导管和第二导管，每个具有近端和远端，以及与其远端相邻的至少一个开口。排水导管的近端与第一导管的近端和第二导管的近端流体连通。第一单向阀设置成在其近端和其至少一个开口之间与第一导管流体连通。第一单向阀有效地阻止从近端到至少一个开口的流体流动。第二单向阀设置成在其近端与其至少一个开口之间与第二导管流体连通。第二单向阀有效地阻止从近端到至少一个开口的流体流动。

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