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1. 发明申请

US20220184255A1 Personal Sanitation Sprayer 有权
公开(公告)号：US20220184255A1
公开(公告)日：2022-06-16
申请号：US17524822
申请日：2021-11-12
申请人： Alexander Kim
发明人： Alexander Kim
IPC分类号： A61L2/18 , B05B11/00 , G01F23/02 , G04B47/00 , A61L2/10
摘要： The present invention relates generally to the field of sanitizing devices. More specifically, the present invention relates to a wrist-worn sanitation sprayer having hollow body with a side surface with an opening sized and configured to fit around a wrist of a wearer. The top surface has a pump-action spray nozzle and an internal tubing. A disinfectant spray is stored within a reservoir within the body and reaches the nozzle via the internal tubing.

2. 发明授权

US08344009B2 Substituted phenoxy thiazolidinediones as estrogen related receptor-á modulators 有权
标题翻译：取代苯氧基噻唑烷二酮作为雌激素相关受体α调节剂
公开(公告)号：US08344009B2
公开(公告)日：2013-01-01
申请号：US12899812
申请日：2010-10-07
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/426 , C07D277/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

3. 发明申请

US20060148792A1 Substituted 1,4-benzodiazepines and uses thereof 审中-公开
标题翻译：取代的1,4-苯并二氮杂及其用途
公开(公告)号：US20060148792A1
公开(公告)日：2006-07-06
申请号：US11371964
申请日：2006-03-09
申请人： Tianbao Lu , Louis LaFrance , Daniel Parks , Karen Milkiewicz , Raul Calvo , Maxwell Cummings , Alexander Kim , Bruce Grasberger , Theodore Carver
发明人： Tianbao Lu , Louis LaFrance , Daniel Parks , Karen Milkiewicz , Raul Calvo , Maxwell Cummings , Alexander Kim , Bruce Grasberger , Theodore Carver
IPC分类号： A61K31/551 , C07D243/12 , C07D243/18
CPC分类号： C07D401/04 , C07D243/14 , C07D403/10 , C07D405/04 , C07D409/04
摘要： The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein: X and Y are independently —C(O)—, —CH2— or —C(S)—; R1, R2, R3, R4, R7, R8, Rb, Rc, Rd and M arm defined herein; R5 is hydrogen, alkyl, cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroaralkyl, carboxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, aminocarbonyl, aminocarbonylalkyl, alkylaminocarbonyl or alkylaminocarbonylalkyl; R6 is cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, aralkyl, heteroarylalkyl, or a saturated or partially unsaturated heterocycle, each of which is optionally substituted; R9 is cycloalkyl: aryl, heteroaryl, a saturated or partially unsaturated heterocycle, cycloalkyl(alkyl), aralkyl or heteroarylalkyl, each of which is optionally substituted; and R10 is —(CH2)n—CO2Rb, —(CH2)m—CO2M, —(CH2)i—OH or —(CH2)j—CONRcRd n is 0-8, m is 0-8, i is 1-8 and j is 0-8.
摘要翻译：本发明涉及新的1,4-苯二氮卓类药物，其药物组合物及其作为HDM2-p53相互作用抑制剂的用途。化合物具有式I：或其溶剂合物，水合物或其药学上可接受的盐; 其中：X和Y独立地为-C（O） - ， - CH 2 - 或-C（S） - ; R 1，R 2，R 3，R 4，R 7， R 8，R b，R c，R d，R d和M臂; R 5是氢，烷基，环烷基，任选取代的芳基，任选取代的杂芳基，任选取代的芳烷基，任选取代的杂芳烷基，羧基烷基，烷氧基羰基，烷氧基羰基烷基，氨基羰基，氨基羰基烷基，烷基氨基羰基或烷基氨基羰基烷基; R 6是环烷基，芳基，杂芳基，环烷基烷基，芳烷基，杂芳基烷基或饱和或部分不饱和的杂环，其各自任选被取代; R 9是环烷基：芳基，杂芳基，饱和或部分不饱和的杂环，环烷基（烷基），芳烷基或杂芳基烷基，其各自任选被取代; 和R 10是 - （CH 2）n - - - - - - （CH 2）n - ， - （CH 2）2 - ， - M 2 - ， - （CH 2） -OH或 - （CH 2 CH 2）n -CONR C n R n为0-8 ，m为0-8，i为1-8，j为0-8。

4. 发明授权

US08580832B2 Substituted phenoxy aminothiazolones as estrogen related receptor-α modulators 有权
标题翻译：取代的苯氧基氨基噻唑酮作为雌激素相关受体α调节剂
公开(公告)号：US08580832B2
公开(公告)日：2013-11-12
申请号：US12043311
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Dionisios Rentzeperis , Gilles C. Bignan
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Dionisios Rentzeperis , Gilles C. Bignan
IPC分类号： A61K31/425 , C07D277/08 , C07D277/12
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

5. 发明申请

US20080221179A1 SUBSTITUTED PHENOXY AMINOTHIAZOLONES as estrogen related receptor-alpha modulators 有权
标题翻译：作为雌激素相关受体α调节剂的替代苯氧基丙酮酸
公开(公告)号：US20080221179A1
公开(公告)日：2008-09-11
申请号：US12043311
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Dionisios Rentzeperis , Gilles C. Bignan
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Dionisios Rentzeperis , Gilles C. Bignan
IPC分类号： A61K31/426 , C07D277/56 , A61P19/00 , A61P11/00 , A61P35/04 , A61P3/00
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

6. 发明申请

US20060281772A1 ALKYLQUINOLINE AND ALKYLQUINAZOLINE KINASE MODULATORS 有权
标题翻译：烷基胆碱和碱性氨基酸激酶调节剂
公开(公告)号：US20060281772A1
公开(公告)日：2006-12-14
申请号：US11422349
申请日：2006-06-06
申请人： Nand Baindur , Michael Gaul , Kevin Kreutter , Christian Baumann , Alexander Kim , Guozhang Xu , Robert Tuman , Dana Johnson
发明人： Nand Baindur , Michael Gaul , Kevin Kreutter , Christian Baumann , Alexander Kim , Guozhang Xu , Robert Tuman , Dana Johnson
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/04 , C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
摘要翻译：本发明涉及式I的烷基喹啉和烷基喹唑啉化合物：其中R 1，R 2，R 3，B，Z，G， Q和X如本文所定义，使用这些化合物如蛋白酪氨酸激酶调节剂，特别是FLT3和/或c-kit和/或TrkB的抑制剂，使用这些化合物来降低或抑制FLT3和/或 c-kit和/或TrkB，以及这些化合物在受试者中用于预防或治疗细胞增殖性疾病和/或与FLT3和/或c-kit和/或TrkB相关的疾病的用途。本发明进一步涉及包含本发明化合物的药物组合物和治疗诸如癌症和其它细胞增殖性疾病的病症的方法。

7. 发明授权

US5564129A Safety helmet with attached cable and lock 失效
标题翻译：安全头盔附带电缆和锁
公开(公告)号：US5564129A
公开(公告)日：1996-10-15
申请号：US545222
申请日：1995-10-19
申请人： Larry Ball , Alexander Kim , Peter Christensen
发明人： Larry Ball , Alexander Kim , Peter Christensen
IPC分类号： A42B3/04 , B62J11/00 , E05B69/00
CPC分类号： B62J11/005 , A42B3/0413 , Y10T70/5013
摘要： An improved safety helmet with an embedded lock, and a cable, the cable having a fixed end attached to the helmet and a retractable end which may be secured by the lock. When not in use, the cable is locked and stored in the groove in the brim of the helmet. The helmet also has pegs which function to retain the cable within the groove while it is being stored.
摘要翻译：具有嵌入式锁的改进的安全头盔和电缆，所述电缆具有附接到头盔的固定端和可由锁固定的可伸缩端。当不使用时，电缆被锁定并存放在头盔边缘的凹槽中。头盔还具有钉子，其具有在被存储时将电缆保持在凹槽内的功能。

8. 发明申请

US20110237625A1 SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-á MODULATORS 有权
标题翻译：作为雌激素相关受体 - 阿尔法调节剂的取代的苯氧基噻唑烷二酮
公开(公告)号：US20110237625A1
公开(公告)日：2011-09-29
申请号：US12899812
申请日：2010-10-07
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/454 , C07D277/34 , A61K31/426 , C07D263/44 , A61K31/421 , A61P19/00 , A61P11/00 , A61P35/00 , A61P3/00 , A61P9/12
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

9. 发明授权

US07846953B2 Substituted phenoxy thiazolidinediones as estrogen related receptor-α modulators 有权
标题翻译：取代苯氧基噻唑烷二酮类作为雌激素相关受体α调节剂
公开(公告)号：US07846953B2
公开(公告)日：2010-12-07
申请号：US12043269
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond Patch , Dionisois Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/426 , C07D277/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖症，升高的血糖水平和胰岛素抵抗。

10. 发明申请

US20090111855A1 SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-alpha MODULATORS 有权
标题翻译：作为雌激素相关受体-α调节剂的取代的苯氧基噻唑烷
公开(公告)号：US20090111855A1
公开(公告)日：2009-04-30
申请号：US12043269
申请日：2008-03-06
申请人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
发明人： Michael Gaul , Alexander Kim , Lily Lee Searle , Raymond J. Patch , Dionisios Rentzeperis , Guozhang Xu , Xizhen Zhu
IPC分类号： A61K31/454 , C07D277/34 , A61K31/426 , A61K31/421 , C07D263/44 , A61P3/04
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
摘要翻译：本发明涉及式（I）化合物，制备这些化合物的方法，组合物，中间体及其衍生物，用于治疗包括但不限于强直性脊柱炎，动脉粥样硬化，关节炎（如类风湿性关节炎，感染性关节炎，儿童期关节炎，牛皮癣关节炎，反应性关节炎），骨相关疾病（包括与骨形成相关的疾病），乳腺癌（包括对抗雌激素治疗无反应的那些），心血管疾病，软骨相关疾病（如软骨损伤/损失，软骨变性和与软骨形成相关的软骨变性，软骨发育不全，软骨肉瘤，慢性背部损伤，慢性支气管炎，慢性炎症性气道疾病，慢性阻塞性肺病，糖尿病，能量稳态障碍，痛风，假性血糖，脂质障碍，代谢综合征，多发性骨髓瘤，肥胖症，骨关节炎，成骨不全，骨质溶解骨骨质疏松症，骨质疏松症，佩吉特氏病，牙周病，风湿性多肌痛，莱特综合征，重复性应激损伤，高血糖，升高的血糖水平和胰岛素抵抗。

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