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1. 发明授权

US07994783B2 Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI 有权
标题翻译：集成微芯片结合原子磁强计和微流体通道用于NMR和MRI
公开(公告)号：US07994783B2
公开(公告)日：2011-08-09
申请号：US12367292
申请日：2009-02-06
申请人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
发明人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
IPC分类号： G01V3/00
CPC分类号： G01R33/26 , G01R33/282
摘要： An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
摘要翻译：一体化的微流体装置包括碱蒸汽池和微流体通道，其可用于检测核磁共振（NMR）和磁共振成像（MRI）的磁性。可以通过光学偏振和探测小磁场中的自旋进动来测量蒸气室附近的小磁场。这可以用于检测相邻微流体通道中的编码分析物中的磁场。通过在微流体芯片（远程检测模式）上游应用适当的无线电或音频脉冲序列来调节微流体通道中的磁性，以产生检测NMR和MRI的敏感手段。

2. 发明申请

US20100102811A1 NMR, MRI, and Spectroscopic MRI in Inhomogeneous Fields 有权
标题翻译：核磁共振，MRI和光谱MRI在不均匀场
公开(公告)号：US20100102811A1
公开(公告)日：2010-04-29
申请号：US11917639
申请日：2006-06-16
申请人： Vasiliki Demas , Alexander Pines , Rachel W. Martin , John Franck , Jeffrey A. Reimer
发明人： Vasiliki Demas , Alexander Pines , Rachel W. Martin , John Franck , Jeffrey A. Reimer
IPC分类号： G01R33/48 , G01R23/00
CPC分类号： G01R33/4833 , G01N24/084 , G01R33/3808 , G01R33/445 , G01R33/485 , G01R33/56563
摘要： A method for locally creating effectively homogeneous or “clean” magnetic field gradients (of high uniformity) for imaging (with NMR, MRI, or spectroscopic MRI) both in in-situ and ex-situ systems with high degrees of inhomogeneous field strength. The method of imaging comprises: a) providing a functional approximation of an inhomogeneous static magnetic field strength B0 (r) at a spatial position r; b) providing a temporal functional approximation of Gshim(t) with i basis functions and j variables for each basis function, resulting in vij variables; c) providing a measured value Ω, which is an temporally accumulated dephasing due to the inhomogeneities of B0 (r); and d) minimizing a difference in the local dephasing angle (I) by varying the vij variables to form a set of minimized vij variables. The method requires calibration of the static fields prior to minimization, but may thereafter he implemented without such calibration, may he used in open or closed systems, and potentially portable systems.
摘要翻译：在具有高度不均匀场强的原位和非原位系统中，用于局部创建有效均匀或“清洁”磁场梯度（高均匀度））用于成像（使用NMR，MRI或光谱MRI）的方法。成像方法包括：a）在空间位置r处提供非均匀静态磁场强度B0（r）的函数近似值; b）提供Gshim（t）的时间函数近似与i基函数和每个基函数的j变量，导致vij变量; c）提供由于B0（r）的不均匀性而导致的时间累积去相位的测量值＆amp; 以及d）通过改变vij变量来最小化局部相移角（I）的差异以形成一组最小化的vij变量。该方法需要在最小化之前对静态场进行校准，然后可以在不进行这种校准的情况下进行实施，可以在开放或封闭的系统以及潜在的便携式系统中使用。

3. 发明授权

US07187169B2 NMR and MRI apparatus and method 失效
标题翻译： NMR和MRI装置及方法
公开(公告)号：US07187169B2
公开(公告)日：2007-03-06
申请号：US10980984
申请日：2004-11-03
申请人： John Clarke , Nathan Kelso , SeungKyun Lee , Michael Moessle , Whittier Myers , Robert McDermott , Bernard ten Haken , Alexander Pines , Andreas Trabesinger
发明人： John Clarke , Nathan Kelso , SeungKyun Lee , Michael Moessle , Whittier Myers , Robert McDermott , Bernard ten Haken , Alexander Pines , Andreas Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. Additional signal to noise benefits are obtained by use of a low noise polarization coil, comprising litz wire or superconducting materials. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。通过使用包含绞合线或超导材料的低噪声极化线圈可以获得额外的噪声有益效果。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

4. 发明申请

US20060176054A1 SQUID Detected NRM and MRI at Ultralow Fields 有权
标题翻译： SQUID检测到超声场的NRM和MRI
公开(公告)号：US20060176054A1
公开(公告)日：2006-08-10
申请号：US11277550
申请日：2006-03-27
申请人： John Clarke , Robert McDermott , Alexander Pines , Andreas Trabesinger
发明人： John Clarke , Robert McDermott , Alexander Pines , Andreas Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/445
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

5. 发明申请

US20140167759A1 NMR BOREHOLE LOGGING DEVICE AND METHOD OF USE 审中-公开
标题翻译： NMR井筒记录装置及其使用方法
公开(公告)号：US20140167759A1
公开(公告)日：2014-06-19
申请号：US14033037
申请日：2013-09-20
申请人： Alexander Pines , Vikram Bajaj , Scott J. Seltzer
发明人： Alexander Pines , Vikram Bajaj , Scott J. Seltzer
IPC分类号： G01R33/36
CPC分类号： G01N24/081
摘要： This disclosure provides systems, methods, and apparatus related to depth well logging. In one aspect, an apparatus includes a radio frequency (RF) coil and a magnetic field sensing device. The apparatus is configured to be positioned in a first magnetic field. The first magnetic field polarizes nuclear spins of species in a detection region proximate the apparatus. The apparatus generates a second magnetic field for a time period with the RF coil to excite the nuclear spins of the species in the detection region. Then, the apparatus measures electromagnetic radiation, using the magnetic field sensing device, generated by the species as a result of the excitation of the nuclear spins.
摘要翻译：本公开提供了与深度测井相关的系统，方法和装置。一方面，一种装置包括射频（RF）线圈和磁场感测装置。该装置被配置为定位在第一磁场中。第一磁场使靠近设备的检测区域中的物质核自旋极化。该装置在RF线圈产生一段时间的第二磁场，以激发检测区域中物种的核自旋。然后，该装置利用由该核自旋的激发而由物种产生的磁场感测装置来测量电磁辐射。

6. 发明授权

US08633693B2 Rotating-frame gradient fields for magnetic resonance imaging and nuclear magnetic resonance in low fields 有权
标题翻译：用于低场磁共振成像和核磁共振的旋转帧梯度场
公开(公告)号：US08633693B2
公开(公告)日：2014-01-21
申请号：US12594341
申请日：2008-04-02
申请人： Louis-Serge Bouchard , Alexander Pines , Vasiliki Demas
发明人： Louis-Serge Bouchard , Alexander Pines , Vasiliki Demas
IPC分类号： G01V3/00
CPC分类号： G01R33/48 , G01R33/445 , G01R33/483 , G01R33/4833 , G01R33/56341 , G01R33/56581
摘要： A system and method for Fourier encoding a nuclear magnetic resonance (NMR) signal is disclosed. A static magnetic field B0 is provided along a first direction. An NMR signal from the sample is Fourier encoded by applying a rotating-frame gradient field BG superimposed on the B0, where the BG comprises a vector component rotating in a plane perpendicular to the first direction at an angular frequency ω in a laboratory frame. The Fourier-encoded NMR signal is detected.
摘要翻译：公开了一种用于傅里叶编码核磁共振（NMR）信号的系统和方法。沿着第一方向设置静磁场B0。来自样本的NMR信号通过施加叠加在B0上的旋转帧梯度场BG进行傅里叶编码，其中BG包括在实验室框架中以角频率ω在垂直于第一方向的平面中旋转的矢量分量。检测傅里叶编码的NMR信号。

7. 发明授权

US08570042B2 Adjustable permanent magnet assembly for NMR and MRI 有权
标题翻译：用于NMR和MRI的可调式永磁体组件
公开(公告)号：US08570042B2
公开(公告)日：2013-10-29
申请号：US12675604
申请日：2008-08-29
申请人： Alexander Pines , Jeffrey Paulsen , Louis S. Bouchard , Bernhard Blumich
发明人： Alexander Pines , Jeffrey Paulsen , Louis S. Bouchard , Bernhard Blumich
IPC分类号： G01V3/00 , G01V3/14
CPC分类号： G01R33/3808 , G01R33/383
摘要： System and methods for designing and using single-sided magnet assemblies for magnetic resonance imaging (MRI) are disclosed. The single-sided magnet assemblies can include an array of permanent magnets disposed at selected positions. At least one of the permanent magnets can be configured to rotate about an axis of rotation in the range of at least +/−10 degrees and can include a magnetization having a vector component perpendicular to the axis of rotation. The single-sided magnet assemblies can further include a magnet frame that is configured to hold the permanent magnets in place while allowing the at least one of the permanent magnets to rotate about the axis of rotation.
摘要翻译：公开了用于设计和使用用于磁共振成像（MRI）的单面磁体组件的系统和方法。单面磁体组件可以包括设置在选定位置的永磁体阵列。永磁体中的至少一个可以被配置为围绕至少+/- 10度的范围内的旋转轴线旋转，并且可以包括具有垂直于旋转轴线的矢量分量的磁化。单面磁体组件还可以包括磁体框架，该磁体框架构造成将永磁体保持在适当位置，同时允许永磁体中的至少一个围绕旋转轴线旋转。

8. 发明申请

US20090256561A1 INTEGRATED MICROCHIP INCORPORATING ATOMIC MAGNETOMETER AND MICROFLUIDIC CHANNEL FOR NMR AND MRI 有权
标题翻译：集成微型计算机核磁共振和核磁共振成像原理磁光计和微流通道
公开(公告)号：US20090256561A1
公开(公告)日：2009-10-15
申请号：US12367292
申请日：2009-02-06
申请人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
发明人： Micah P. Ledbetter , Igor M. Savukov , Dmitry Budker , Vishal K. Shah , Svenja Knappe , John Kitching , David J. Michalak , Shoujun Xu , Alexander Pines
IPC分类号： G01R33/26
CPC分类号： G01R33/26 , G01R33/282
摘要： An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
摘要翻译：一体化的微流体装置包括碱蒸汽池和微流体通道，其可用于检测核磁共振（NMR）和磁共振成像（MRI）的磁性。可以通过光学偏振和探测小磁场中的自旋进动来测量蒸气室附近的小磁场。这可以用于检测相邻微流体通道中的编码分析物中的磁场。通过在微流体芯片（远程检测模式）上游应用适当的无线电或音频脉冲序列来调节微流体通道中的磁性，以产生检测NMR和MRI的敏感手段。

9. 发明申请

US20080074113A1 SQUID DETECTED NMR AND MRI AT ULTRALOW FIELDS 失效
标题翻译：超声检测核磁共振和核磁共振检测
公开(公告)号：US20080074113A1
公开(公告)日：2008-03-27
申请号：US11740339
申请日：2007-04-26
申请人： John Clarke , Alexander Pines , Robert McDermott , Andreas Trabesinger
发明人： John Clarke , Alexander Pines , Robert McDermott , Andreas Trabesinger
IPC分类号： G01V3/00
CPC分类号： G01R33/326 , G01R33/0356 , G01R33/445
摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.
摘要翻译：核磁共振（NMR）信号在微量场中检测。随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。超低磁场中的MRI是基于超低场的NMR。应用梯度磁场，并根据检测到的NMR信号构建图像。

10. 发明申请

US20070194788A1 NUCLEAR MAGNETIC RESONANCE DETECTION IN INHOMOGENEOUS MAGNETIC FIELDS 有权
标题翻译：非均质磁场中的核磁共振检测
公开(公告)号：US20070194788A1
公开(公告)日：2007-08-23
申请号：US11625209
申请日：2007-01-19
申请人： Alexander Pines , Daniel Topgaard , Dimitrios Sakellariou , Rachel Martin , Carlos Meriles
发明人： Alexander Pines , Daniel Topgaard , Dimitrios Sakellariou , Rachel Martin , Carlos Meriles
IPC分类号： G01V3/00
CPC分类号： G01R33/36 , G01R33/3808 , G01R33/385 , G01R33/445 , G01R33/4616 , G01R33/56563
摘要： Methods and systems for compensating for static magnetic field inhomogeneities during nuclear magnetic resonance detection are disclosed. Application of radio frequency pulses and/or magnetic field gradients may be used to correct for spin dephasing caused by the inhomogeneities. The methods and system may be used to improve signal-to-noise ratios in NMR and MRI systems where magnetic field inhomogeneity may have an effect.
摘要翻译：公开了用于在核磁共振检测期间补偿静态磁场不均匀性的方法和系统。可以使用射频脉冲和/或磁场梯度来校正由不均匀性引起的自旋去相位。该方法和系统可用于提高NMR和MRI系统中的磁场不均匀性可能具有影响的信噪比。

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