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1. 发明授权

US09681925B2 Method for augmented reality instrument placement using an image based navigation system 有权
公开(公告)号：US09681925B2
公开(公告)日：2017-06-20
申请号：US11107640
申请日：2005-04-15
申请人： Fred S. Azar , Ali Khamene , Frank Sauer , Sebastian Vogt
发明人： Fred S. Azar , Ali Khamene , Frank Sauer , Sebastian Vogt
IPC分类号： A61B5/05 , A61B90/00 , A61B34/20 , A61B90/11 , A61B34/10
CPC分类号： A61B90/36 , A61B34/10 , A61B34/20 , A61B90/11 , A61B90/361 , A61B2034/107 , A61B2090/365
摘要： A system and method for instrument placement using an image based navigation system is disclosed. A target of interest is identified in a medical image of a patient. An image plane is displayed that goes through a center of the target. The image plane has a configurable orientation. The image plane is used to select a path for an instrument from a position on the patient's skin to the center of the target. A trajectory plane is viewed from a tip of the instrument to the center of the target. The trajectory plane reflects an orientation of the instrument. A particular trajectory plane is selected that is representative of a desired orientation of the instrument. An image of the particular trajectory plane is frozen. The instrument can then be inserted using a virtual guide and is navigated toward the target.

2. 发明授权

US08244332B2 Three-dimensional breast anatomy imaging system 有权
标题翻译：三维乳房解剖成像系统
公开(公告)号：US08244332B2
公开(公告)日：2012-08-14
申请号：US11292338
申请日：2005-12-01
申请人： Fred S. Azar , Ali Khamene , Frank Sauer , Bruce Tromberg , Albert Cerussi
发明人： Fred S. Azar , Ali Khamene , Frank Sauer , Bruce Tromberg , Albert Cerussi
IPC分类号： A61B6/00
CPC分类号： A61B5/4312 , A61B5/0091 , A61B34/20 , A61B2034/105 , A61B2034/2051 , A61B2034/2055 , A61B2090/373 , G01N21/359 , G01N21/474 , G01N21/4795 , G01N2021/1787 , G01N2021/4745 , G01N2201/0221 , G01N2201/0612 , G01N2201/0691 , G01N2201/08
摘要： A diffuse optical spectroscopy system comprises a laser breast scanner, a handheld probe connected to the laser breast scanner for scanning a breast, and a tracking device coupled to the handheld probe, wherein the tracking device determines locations of the handheld probe relative to the breast. The tracking device comprises a magnetic tracking device, an optical tracking device or a laser tracking device.
摘要翻译：扩散光谱系统包括激光乳房扫描器，连接到用于扫描乳房的激光乳房扫描器的手持式探头以及耦合到手持探针的跟踪装置，其中跟踪装置确定手持式探针相对于乳房的位置。跟踪装置包括磁跟踪装置，光学跟踪装置或激光跟踪装置。

3. 发明授权

US07711405B2 Method of registering pre-operative high field closed magnetic resonance images with intra-operative low field open interventional magnetic resonance images 失效
标题翻译：用术中低场开放介入磁共振图像记录术前高磁场闭合磁共振图像的方法
公开(公告)号：US07711405B2
公开(公告)日：2010-05-04
申请号：US10833742
申请日：2004-04-28
申请人： Ali Khamene , Frank Sauer
发明人： Ali Khamene , Frank Sauer
IPC分类号： A61B5/05
CPC分类号： G01R33/56 , G01R33/5608
摘要： A system and method for registering pre-operative magnetic resonance (MR) images with intra-operative MR images is disclosed. A pre-operative MR image of an object is received. A set of intra-operative MR images of the object is received. The pre-operative MR image is rigidly registered with the initial intra-operative MR image. The subsequent set of intra-operative images is deformably registered. The pre-operative MR image undergoes both rigid and deformation transformation to match specification of each image with in intra-operative MR image set.
摘要翻译：公开了一种用于将术前磁共振（MR）图像与术中MR图像对准的系统和方法。接收对象的术前MR图像。接收对象的一组手术中MR图像。手术前MR图像与初始手术中MR图像刚性对齐。随后的一组术中图像可变形地记录。手术前MR图像经历刚性和变形变换，以在手术中的MR图像组中匹配每个图像的规格。

4. 发明申请

US20050249398A1 Rapid and robust 3D/3D registration technique 有权
标题翻译：快速和健壮的3D / 3D注册技术
公开(公告)号：US20050249398A1
公开(公告)日：2005-11-10
申请号：US11109119
申请日：2005-04-19
申请人： Ali Khamene , Frank Sauer , Chenyang Xu
发明人： Ali Khamene , Frank Sauer , Chenyang Xu
IPC分类号： A61K31/4439 , A61P9/00 , C07D401/14 , G06K9/00 , G06K9/32 , G06T7/00
CPC分类号： G06T7/38 , G06T2207/30004
摘要： Exemplary methods are provided. In one exemplary method, a lower-dimension signature is generated for each of a plurality of data sets of a given dimension. Registration is performed on the lower-dimension signatures. In another exemplary method, a two-dimensional signature is generated for each of a plurality of three-dimensional volumes. Registration is performed on the two-dimensional signatures.
摘要翻译：提供了示例性方法。在一个示例性方法中，为给定维度的多个数据集中的每一个产生较低维度签名。对较低维的签名执行注册。在另一示例性方法中，为多个三维体积中的每一个生成二维签名。对二维签名执行注册。

5. 发明申请

US20050203380A1 System and method for augmented reality navigation in a medical intervention procedure 有权
标题翻译：医疗干预程序中增强现实导航的系统和方法
公开(公告)号：US20050203380A1
公开(公告)日：2005-09-15
申请号：US11056317
申请日：2005-02-11
申请人： Frank Sauer , Ali Khamene , Sebastian Vogt
发明人： Frank Sauer , Ali Khamene , Sebastian Vogt
IPC分类号： A61B5/05
CPC分类号： G02B7/002 , A61B34/10 , A61B34/20 , A61B90/20 , A61B90/36 , A61B90/361 , A61B2034/107 , A61B2034/2055 , A61B2034/2072 , A61B2090/371 , G02B27/017 , G02B2027/0138 , G02B2027/0187 , G06F3/012
摘要： A method for augmented reality navigation of a medical intervention includes providing a stereoscopic head mounted display, the display including a pair of stereo viewing cameras, at least one tracking camera, and a stereoscopic guidance display. During a medical intervention on a patient, the patient's body pose is determined from a rigid body transformation between the tracking camera and frame markers on the scanning table, and the pose of an intervention instrument with respect to the table is determined. A visual representation of the patient overlaid with an image of the intervention target, the instrument, and a path for guiding the instrument to perform said medical intervention is displayed in the stereoscopic guidance display.
摘要翻译：用于医疗干预的增强现实导航的方法包括提供立体头戴式显示器，所述显示器包括一对立体观看照相机，至少一个跟踪相机和立体指导显示器。在患者的医疗干预中，患者的身体姿势由跟踪摄像机和扫描台上的帧标记之间的刚性身体变换确定，并且确定干预仪器相对于桌子的姿势。在立体指导显示中显示覆盖有介入目标图像，仪器和用于引导仪器执行所述医疗干预的路径的患者的视觉表示。

6. 发明授权

US08073220B2 Methods and systems for fully automatic segmentation of medical images 有权
标题翻译：医学图像全自动分割的方法和系统
公开(公告)号：US08073220B2
公开(公告)日：2011-12-06
申请号：US12426320
申请日：2009-04-20
申请人： Ali Khamene , Leo Grady , Eike Rietzel , Thomas Boettger
发明人： Ali Khamene , Leo Grady , Eike Rietzel , Thomas Boettger
IPC分类号： G06K9/34 , G06K9/00
CPC分类号： G06K9/469 , G06K2209/051 , G06T7/12 , G06T7/149 , G06T2207/20124 , G06T2207/20128 , G06T2207/20156
摘要： Methods and systems dedicated to automatic object segmentation from image data are provided. In a first step a fuzzy seed set is generated that is learned from training data. The fuzzy seed set is registered to image data containing an object that needs to be segmented from a background. In a second step a random walker segmentation is applied to the image data by using the fuzzy seed set as an automatic seeding for segmentation. Liver segmentation, lung segmentation and kidney segmentation examples are provided.
摘要翻译：提供专用于图像数据自动对象分割的方法和系统。在第一步中，生成从训练数据中学习的模糊种子集。将模糊种子集登记到包含需要从背景分割的对象的图像数据。在第二步中，通过使用模糊种子集作为用于分割的自动播种，将随机游侠分割应用于图像数据。提供肝分割，肺分割和肾分割实例。

7. 发明授权

US07949385B2 System and method for reconstruction of the human ear canal from optical coherence tomography scans 有权
标题翻译：用于从光学相干断层扫描重建人耳道的系统和方法
公开(公告)号：US07949385B2
公开(公告)日：2011-05-24
申请号：US11405304
申请日：2006-04-17
申请人： Ali Khamene , Martin W. Masters , Frank Sauer , Therese Velde
发明人： Ali Khamene , Martin W. Masters , Frank Sauer , Therese Velde
IPC分类号： A61B5/05
CPC分类号： A61B5/1077 , A61B5/0066 , H04R25/652 , H04R25/658 , H04R2225/77
摘要： A method for reconstructing an ear canal from optical coherence tomography (OCT) scan data of an ear comprises extracting frame numbers and line numbers of interference intensities corresponding to one or more markers on an OCT scan guide, receiving reference frame numbers and lines numbers for one or more markers, determining a starting position and direction for the OCT ear scan from the ear scan marker frame and line numbers and the reference marker frame and line numbers, for each scan line, finding a pixel number of a maximum interference intensity value, and determining an offset distance of said pixel from said scan guide, and reconstructing a surface of the ear canal from the distance offset data.
摘要翻译：用于从耳朵的光学相干断层扫描（OCT）扫描数据重建耳道的方法包括在OCT扫描引导件上提取对应于一个或多个标记的干扰强度的帧号和干扰强度的行号，接收参考帧编号和一个或更多的标记，为每个扫描线确定来自耳朵扫描标记帧和线号以及参考标记帧和线号的OCT耳朵扫描的起始位置和方向，找到最大干扰强度值的像素数，以及确定所述像素与所述扫描引导件的偏移距离，以及从所述距离偏移数据重建所述耳道的表面。

8. 发明授权

US07940999B2 System and method for learning-based 2D/3D rigid registration for image-guided surgery using Jensen-Shannon divergence 有权
标题翻译：使用Jensen-Shannon分歧的图像引导手术的基于学习的2D / 3D刚性注册的系统和方法
公开(公告)号：US07940999B2
公开(公告)日：2011-05-10
申请号：US11686533
申请日：2007-03-15
申请人： Rui Liao , Christoph Guetter , Chenyang Xu , Yiyong Sun , Ali Khamene , Frank Sauer
发明人： Rui Liao , Christoph Guetter , Chenyang Xu , Yiyong Sun , Ali Khamene , Frank Sauer
IPC分类号： G06K9/00 , G06K9/32 , G06K9/62
CPC分类号： G06K9/00208 , G06K9/6212 , G06T7/33 , G06T7/35 , G06T2207/30101
摘要： A method of registering 3-dimensional digitized images to 2-dimensional digitized images during a medical procedure includes providing a pair of correctly-registered training images L={lr, lf} and their joint intensity distribution pl(ir, if), wherein ir and if are reference and floating images, respectively, providing a pair of observed images O={or, of} and their joint intensity distribution po(ir, if), mapping a marginal intensity distribution of the observed pair O={or, of} to a marginal intensity distribution of the training pair L={lr, lf}, and estimating a set of parameters T that registers image of to image or by maximizing a weighted sum of a Jensen-Shannon divergence (JSD) of a joint intensity distribution of the observed pair and a joint intensity distribution of the training pair and a similarity measure between the observed images.
摘要翻译：在医疗过程中将三维数字化图像注册到二维数字化图像的方法包括提供一对正确注册的训练图像L = {lr，lf}及其联合强度分布pl（ir，if），其中ir 并且如果分别是参考和浮动图像，则提供一对观察图像O = {或，}和它们的联合强度分布po（ir，if），映射观察到的对的边缘强度分布O = {或， }到训练对的边缘强度分布L = {lr，lf}，并且估计登记到图像的图像的一组参数T或者通过最大化联合强度的Jensen-Shannon散度（JSD）的加权和观察对的分布和训练对的联合强度分布以及观察图像之间的相似性度量。

9. 发明授权

US07869562B2 Automatic patient positioning system 有权
标题翻译：患者自动定位系统
公开(公告)号：US07869562B2
公开(公告)日：2011-01-11
申请号：US12406233
申请日：2009-03-18
申请人： Ali Khamene , Stefan Käpplinger , Gabriel Haras , Eike Rietzel
发明人： Ali Khamene , Stefan Käpplinger , Gabriel Haras , Eike Rietzel
IPC分类号： H05G1/60 , A61B6/04 , G01D18/00
CPC分类号： A61B6/08 , A61B5/0064 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B6/583 , A61N5/1037 , A61N5/1049 , A61N2005/1059
摘要： A patient positioning system for positioning a patient relative to radiographic equipment. The system includes: a 3D optical imaging system for optically scanning the patient, such 3D optical imaging system having a focal plane and providing, for each position on the object, data representative of the intensity of reflected energy received by the system from such position and data representative of distance from such position on the object to the focal plane; a table apparatus for supporting the patient and for moving the table relative to the radiographic equipment in response to positioning signals; and a processor responsive to data from the radiographic equipment and the data from the a 3D optical imaging system for producing the positioning signals. The system enables a method for displaying temporal changes in a patient positioned with a bore of radiographic equipment.
摘要翻译：一种用于相对于射线照相设备定位患者的患者定位系统。该系统包括：用于光学扫描患者的3D光学成像系统，具有焦平面的3D光学成像系统，并且为对象上的每个位置提供表示系统从该位置接收的反射能量的强度的数据，以及表示从物体上的这种位置到焦平面的距离的数据; 用于响应于定位信号而支撑患者并相对于射线照相设备移动台的桌子装置; 以及响应于来自放射线照相设备的数据和来自3D光学成像系统的数据的处理器，用于产生定位信号。该系统实现了一种用于在放射照相设备的孔定位的患者中显示时间变化的方法。

10. 发明授权

US07853308B2 System and method for patient positioning for radiotherapy in the presence of respiratory motion 有权
标题翻译：在有呼吸运动的情况下进行放射治疗的患者定位的系统和方法
公开(公告)号：US07853308B2
公开(公告)日：2010-12-14
申请号：US11056318
申请日：2005-02-11
申请人： Frank Sauer , Ali Khamene
发明人： Frank Sauer , Ali Khamene
IPC分类号： A61B5/05
CPC分类号： A61N5/1049 , A61B5/1135 , A61B5/7289 , A61B6/12 , A61N5/1037 , A61N2005/1061 , A61N2005/1062
摘要： A system and method for positioning a patient for radiotherapy is provided. The method comprises: acquiring a first x-ray image sequence of a target inside the patient at a first angle; acquiring first respiratory signals of the patient while acquiring the first x-ray image sequence; acquiring a second x-ray image sequence of the target at a second angle; acquiring second respiratory signals of the patient while acquiring the second x-ray image sequence; synchronizing the first and second x-ray image sequences with the first and second respiratory signals to form synchronized first and second x-ray image sequences; identifying the target in the synchronized first and second x-ray image sequences; and determining three-dimensional (3D) positions of the target through time in the synchronized first and second x-ray image sequences.
摘要翻译：提供了一种放射治疗患者定位系统和方法。该方法包括：以第一角度获取患者内的目标的第一x射线图像序列; 在获取第一x射线图像序列的同时获取患者的第一呼吸信号; 以第二角度获取目标的第二x射线图像序列; 在获取第二X射线图像序列的同时获取患者的第二呼吸信号; 使第一和第二X射线图像序列与第一和第二呼吸信号同步以形成同步的第一和第二X射线图像序列; 识别同步的第一和第二X射线图像序列中的目标; 以及在所述同步的第一和第二X射线图像序列中确定所述目标通过时间的三维（3D）位置。

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