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1. 发明申请

US20110258527A1 SYSTEM AND METHOD FOR ANNOTATING AN ELECTRONIC DOCUMENT INDEPENDENTLY OF ITS CONTENT 有权
标题翻译：用于提取电子文档的系统和方法，不包括其内容
公开(公告)号：US20110258527A1
公开(公告)日：2011-10-20
申请号：US13175109
申请日：2011-07-01
申请人： Susan D. Woolf , Andrew Baird , Sheng Jiang , John L. Beezer , Darryl E. Rubin
发明人： Susan D. Woolf , Andrew Baird , Sheng Jiang , John L. Beezer , Darryl E. Rubin
IPC分类号： G06F17/20
CPC分类号： G06F17/241 , Y10S707/99943
摘要： A system, method, and apparatus for annotating an electronic document independently of its content is provided. According to one variation, a tablet and stylus-based computer is programmed with a document browser that permits a user to annotate documents viewed through the browser. The annotations are stored separately from the viewed document pages but are correlated with the pages such that when a previously annotated page is revisited, annotations relating to that page are retrieved and displayed on top of the page as an “ink” layer. Three different annotation modes are possible: ink, highlight, and erase. Each mode can be selected through a user interface supplied through the browser or through controls embedded in a document.
摘要翻译：提供了一种独立于其内容来注释电子文档的系统，方法和装置。根据一个变体，使用文档浏览器对基于平板电脑和基于笔的计算机进行编程，该文档浏览器允许用户注释通过浏览器查看的文档。注释与所查看的文档页面分开存储，但与页面相关联，使得当重新访问先前注释的页面时，与页面相关的注释被检索并显示在页面顶部作为“墨水”层。可以使用三种不同的注释模式：墨水，高光和擦除。每个模式都可以通过浏览器提供的用户界面或嵌入在文档中的控件进行选择。

2. 发明授权

US07602347B2 Squint-beam corrugated horn 有权
标题翻译：斜梁波纹喇叭
公开(公告)号：US07602347B2
公开(公告)日：2009-10-13
申请号：US11423256
申请日：2006-06-09
申请人： Stephen John Flynn , Neil Wolfenden , Andrew Baird , Craig Mitchelson
发明人： Stephen John Flynn , Neil Wolfenden , Andrew Baird , Craig Mitchelson
IPC分类号： H01Q13/00
CPC分类号： H01Q13/0208
摘要： A feed having a waveguide with a longitudinal axis. A plurality of corrugations extending from an end of the waveguide. The corrugations coaxial with the longitudinal axis, forming an extension of the waveguide. The corrugations having an end face angle less than 90 degrees with respect to the longitudinal axis to squint the feed beam.
摘要翻译：具有纵轴的波导的进料。从波导的端部延伸的多个波纹。波纹与纵向轴线同轴，形成波导的延伸。波纹具有相对于纵向轴线小于90度的端面角度以使进给光束偏斜。

3. 发明申请

US20060235023A1 Inhibitors of macrophage migration inhibitory factor and methods for indentifying the same 失效
标题翻译：抑制巨噬细胞迁移抑制因子及其鉴定方法
公开(公告)号：US20060235023A1
公开(公告)日：2006-10-19
申请号：US11415628
申请日：2006-05-02
申请人： Federice Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
发明人： Federice Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
IPC分类号： A61K31/496 , A61K31/497
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译：提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。

4. 发明申请

US20060205734A1 Inhibitors of macrophage migration inhibitory factor and methods for identifying the same 失效
公开(公告)号：US20060205734A1
公开(公告)日：2006-09-14
申请号：US11344938
申请日：2006-01-31
申请人： Federico Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
发明人： Federico Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
IPC分类号： A61K31/496
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

5. 发明申请

US20060199827A1 Inhibitors of macrophage migration inhibitory factor and methods for identifying the same 失效
公开(公告)号：US20060199827A1
公开(公告)日：2006-09-07
申请号：US11415842
申请日：2006-05-02
申请人： Federico Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
发明人： Federico Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil K.C.
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.

6. 发明申请

US20060181472A1 Multiple Beam Feed Assembly 有权
标题翻译：多光束馈送组件
公开(公告)号：US20060181472A1
公开(公告)日：2006-08-17
申请号：US10906273
申请日：2005-02-11
申请人： Andrew Baird , Neil Wolfenden
发明人： Andrew Baird , Neil Wolfenden
IPC分类号： H01Q13/00
CPC分类号： H01Q19/17 , H01Q5/45 , H01Q13/06
摘要： A multi-beam feed assembly having a feed assembly housing with a plurality of input waveguide(s) formed in a front face. The housing may be adapted for manufacture via die casting. The housing also having at least two PCB mounting surface(s), a plurality of probe aperture(s) through the housing between the input waveguide(s) and at least one of the PCB mounting surface(s) and at least one interconnect waveguide through the housing between two of the PCB mounting surface(s). A plurality of PCB may be coupled to the housing at the PCB mounting surfaces. A plurality of transition probe(s) located in the probe aperture(s) coupling each input waveguide to one of the plurality of the PCB and the at least one interconnect waveguide between the at least two PCB mounting surfaces coupling signals between the PCB.
摘要翻译：一种多光束进给组件，其具有在前表面形成的多个输入波导的进给组件壳体。壳体可以适于通过压铸制造。壳体还具有至少两个PCB安装表面，在输入波导和至少一个PCB安装表面之间的壳体中的多个探针孔，以及至少一个互连波导通过两个PCB安装面之间的外壳。多个PCB可以在PCB安装表面处联接到壳体。位于所述探针孔中的多个过渡探针将每个输入波导耦合到所述多个PCB中的一个，并且所述至少两个PCB安装表面之间的所述至少一个互连波导耦合所述PCB之间的信号。

7. 发明申请

US20060181365A1 WAVEGUIDE TO MICROSTRIP TRANSITION 失效
标题翻译：波导到微波转换
公开(公告)号：US20060181365A1
公开(公告)日：2006-08-17
申请号：US10907329
申请日：2005-03-29
申请人： Andrew Baird
发明人： Andrew Baird
IPC分类号： H01P5/107
CPC分类号： H01P5/107
摘要： A first waveguide to microstrip transition, the waveguide having a top, a bottom, a first sidewall, a second sidewall and a closed end. A transition slot normal to a longitudinal axis of the waveguide intersects the top and the first sidewall. A probe having a 90 degree bend is arranged in the transition slot, a distal end of the probe projecting into the waveguide normal to the top. A proximal end of the probe is coupled to a microstrip on a dielectric substrate. An impedance matching feature may be included projecting from the bottom, proximate the distal end of the probe. A hole may be formed in the dielectric substrate proximate the proximal end of the probe. A second waveguide and transition arrangement may be aligned bottom to bottom with the first waveguide and similarly arranged with a probe coupled to a second microstrip on the dielectric substrate.
摘要翻译：第一波导到微带过渡，波导具有顶部，底部，第一侧壁，第二侧壁和封闭端。与波导的纵向轴垂直的过渡槽与顶部和第一侧壁相交。具有90度弯曲的探针设置在过渡槽中，探针的远端突出到垂直于顶部的波导中。探针的近端与电介质基底上的微带耦合。可以包括从底部突出的阻抗匹配特征，邻近探针的远端。可以在接近探针的近端处的电介质基板中形成孔。第二波导和转换装置可以从底部到底部与第一波导对准，并且类似地布置有耦合到电介质基板上的第二微带的探针。

8. 发明申请

US20050140461A1 Waveguide polarization rotator 有权
标题翻译：波导偏振旋转器
公开(公告)号：US20050140461A1
公开(公告)日：2005-06-30
申请号：US11061582
申请日：2005-02-18
申请人： Andrew Baird , Jamie Stokes
发明人： Andrew Baird , Jamie Stokes
IPC分类号： H01P1/161 , H01P1/165
CPC分类号： H01P1/161 , H01P1/165
摘要： There is disclosed herein a waveguide rotator for use with a dual polarization waveguide probe system. The waveguide has an internal structure that protrudes into the waveguide such that a first orthogonal component of the incident polarized signal propagates to the end of the waveguide and is reflected therefrom and the second orthogonally polarized component is cut-off by the protruding structure which narrows the waveguide, at a distance from a short circuit at the end of the waveguide, and is reflected substantially at the cut-off point, the cut-off point being frequency dependant. At some predetermined distance from the reflecting means and the cut-off point, the first component and the second component are recombined such that the polarization of the recombined structure is rotated 90° from the incident polarization. The protruding interior surface creates a pocket or cavity behind the waveguide into which components from a circuit board can be inserted.
摘要翻译：这里公开了一种用于双极化波导探针系统的波导旋转器。波导具有突出到波导中的内部结构，使得入射偏振信号的第一正交分量传播到波导的端部并被反射，并且第二正交极化分量被突出结构截断，该突出结构使波导，在与波导端部的短路相距一定距离处，并且基本上在截止点处反射，截止点是频率依赖的。在与反射装置和截止点相距预定的距离处，第一分量和第二分量被复合，使得重组结构的偏振从入射偏振旋转90°。突出的内表面在波导后面形成了可以插入来自电路板的部件的袋或腔。

9. 发明授权

US5916772A Recombinant production of saporin-containing proteins 失效
标题翻译：重组生成含有saporin的蛋白质
公开(公告)号：US5916772A
公开(公告)日：1999-06-29
申请号：US356161
申请日：1995-04-13
申请人： Douglas A. Lappi , Isabel Barthelemy , J. Andrew Baird , Barbara A. Sosnowski
发明人： Douglas A. Lappi , Isabel Barthelemy , J. Andrew Baird , Barbara A. Sosnowski
IPC分类号： C12N15/09 , A61K39/00 , C07K1/20 , C07K1/22 , C07K14/415 , C07K14/50 , C07K14/575 , C07K16/00 , C07K19/00 , C12N1/21 , C12N15/29 , C12P21/02 , C12P21/04 , C12R1/19 , C12N15/62
CPC分类号： C07K14/503 , C07K14/415 , A61K39/00 , C07K2319/035 , C07K2319/55 , C07K2319/75
摘要： Methods for the recombinant production of saporin-containing proteins, including cell surface binding protein-saporin fusion proteins, are provided. The resulting fusion proteins are cytotoxic to targeted cells. In preferred embodiments, methods are provided for the production of basic fibroblast factor (bFGF)-saporin fusion proteins by culturing Escherichia coli that has been transformed with a vector containing DNA encoding bFGF linked via a spacer peptide to the amino terminus of a cytotoxic portion of a saporin polypeptide to obtain expression of the DNA, and isolating the resulting FGF-saporin fusion protein. FGF-saporin fusion proteins and saporin proteins containing from about 5 to 12 amino acid N-terminal extensions are also provided.
摘要翻译： PCT No.PCT / US93 / 05702 Sec。 371日期1995年04月13日 102（e）日期1995年4月13日PCT Filed 1993年6月14日PCT公布。公开号WO93 / 25688 PCT 日期：1993年12月23日提供重组生成含有saporin的蛋白质，包括细胞表面结合蛋白 - 通丝蛋白融合蛋白的方法。所得融合蛋白对靶细胞具有细胞毒性。在优选的实施方案中，提供了通过培养已经用含有经由间隔肽连接的编码bFGF的DNA的载体转化到大肠杆菌的细胞毒性部分的氨基末端的大肠杆菌来生产碱性成纤维细胞因子（bFGF） - 通道蛋白融合蛋白的方法皂质蛋白多肽以获得DNA的表达，并分离得到的FGF-通丝蛋白融合蛋白。还提供了含有约5至12个氨基酸的N-末端延伸的FGF-通丝蛋白融合蛋白和通丝蛋白。

10. 发明授权

US5191067A Fibroblast growth factor conjugates 失效
标题翻译： FIBROBLAST生长因子结合
公开(公告)号：US5191067A
公开(公告)日：1993-03-02
申请号：US344109
申请日：1989-04-27
申请人： Douglas A. Lappi , Andrew Baird
发明人： Douglas A. Lappi , Andrew Baird
IPC分类号： A61K38/22 , A61K38/00 , A61K45/00 , A61K47/48 , A61P3/08 , A61P9/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07K14/50 , G01N33/50
CPC分类号： A61K47/48269
摘要： The invention provides a conjugate comprising FGF or other polypeptide reactive with an FGF receptor, and a cytotoxic agent. The cytotoxic agent can be a ribosome-inactivating protein (RIP), such as saporin, although other cytotoxic agents can also be advantageously used. The cytotoxic agent can be attached to FGF through a chemical bond or the composition can be prepared as a chimera, using techniques of recombinant DNA. The conjugate can be used to treat FGF-mediated pathophysiological conditions by specifically targeting cells having FGF receptors and inhibiting proliferation of or causing death of the cells. Additionally, the conjugate can be used to target cytotoxic agents into cells having FGF receptors, and to inhibit the proliferation of such cells. A method of purifying the conjugate on an immobilized heparin column is also provided.
摘要翻译：本发明提供了包含FGF或与FGF受体反应的其它多肽的缀合物和细胞毒性剂。细胞毒性剂可以是核糖体失活蛋白（RIP），例如皂素蛋白，尽管也可以有利地使用其它细胞毒性剂。细胞毒性剂可以通过化学键连接到FGF上，或者使用重组DNA的技术将组合物制备成嵌合体。缀合物可用于通过特异性靶向具有FGF受体的细胞并抑制细胞的增殖或引起细胞死亡来治疗FGF介导的病理生理条件。另外，缀合物可用于将细胞毒剂靶向具有FGF受体的细胞中，并抑制这些细胞的增殖。还提供了在固定化肝素柱上纯化缀合物的方法。

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