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1. 发明申请

US20110116606A1 MEDICAL IMAGING SYSTEM FOR ACCURATE MEASUREMENT EVALUATION OF CHANGES 审中-公开
标题翻译：精确测量医学成像系统的变化评估
公开(公告)号：US20110116606A1
公开(公告)日：2011-05-19
申请号：US13012113
申请日：2011-01-24
申请人： David F. Yankelevitz , Anthony P. Reeves , Claudia Ingrid Henschke
发明人： David F. Yankelevitz , Anthony P. Reeves , Claudia Ingrid Henschke
IPC分类号： G01D18/00
CPC分类号： A61B6/583 , A61B5/1075 , A61B6/03 , A61B6/032 , A61B6/12 , G06T7/0012 , G06T7/12 , G06T11/60 , G06T2207/30004 , G06T2207/30096
摘要： A system and method for nodule boundary visualization superimposed on a scan image, including generating phantom image measurements of at least one synthetic calibration object in relation to a body to calibrate a scanner; acquiring a first image of a nodule on the calibrated scanner; computing and marking a boundary on the image; displaying the first image with the boundary superimposed over the first image; presenting the initial boundary to a user for modification where the user can add one or more modification points to the image to create a modified boundary that is encompassed by the one or more modification points; once the user has marked the one or more modification points on the image, computing an updated boundary that adapts to include the new points.
摘要翻译：一种叠加在扫描图像上的结节边界可视化的系统和方法，包括相对于身体产生至少一个合成校准物体的幻影图像测量以校准扫描仪; 在校准的扫描器上获取结节的第一图像; 计算和标记图像上的边界; 以叠加在第一图像上的边界显示第一图像; 向用户呈现初始边界以进行修改，其中用户可以向图像添加一个或多个修改点以创建被一个或多个修改点包围的修改的边界; 一旦用户已经标记了图像上的一个或多个修改点，则计算适应于包括新点的更新的边界。

2. 发明申请

US20100272341A1 Method and Apparatus for Small Pulmonary Nodule Computer Aided Diagnosis from Computed Tomography Scans 有权
标题翻译：用于计算机断层扫描的小型肺结节计算机辅助诊断的方法和装置
公开(公告)号：US20100272341A1
公开(公告)日：2010-10-28
申请号：US12829717
申请日：2010-07-02
申请人： Anthony P. Reeves , David Yankelevitz , Claudia Henschke , Antoni Chan
发明人： Anthony P. Reeves , David Yankelevitz , Claudia Henschke , Antoni Chan
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T3/0075 , G06T7/44 , G06T2207/10081 , G06T2207/30061
摘要： The present invention is a multi-stage detection algorithm using a successive nodule candidate refinement approach. The detection algorithm involves four major steps. First, a lung region is segmented from a whole lung CT scan. This is followed by a hypothesis generation stage in which nodule candidate locations are identified from the lung region. In the third stage, nodule candidate sub-images or the lung region of the CT scan pass through a streaking artifact removal process. The nodule candidates are then successively refined using a sequence of filters of increasing complexity. A first filter uses attachment area information to remove vessels and large vessel bifurcation points from the nodule candidate list. A second filter removes small bifurcation points.
摘要翻译：本发明是使用连续结节候选细化方法的多级检测算法。检测算法涉及四个主要步骤。首先，从整个肺CT扫描分割肺部区域。随后是从肺区识别结节候选位置的假设生成阶段。在第三阶段，CT扫描的结节候选子图像或肺区域通过条纹伪影去除过程。然后使用逐渐增加的复杂度的一系列滤波器连续地细化结节候选物。第一个过滤器使用附件区域信息从结节候选列表中移除血管和大血管分叉点。第二个过滤器移除小分叉点。

3. 发明授权

US07660451B2 System, method and apparatus for small pulmonary nodule computer aided diagnosis from computed tomography scans 有权
标题翻译：用于计算机断层扫描的小型肺结节计算机辅助诊断系统，方法和装置
公开(公告)号：US07660451B2
公开(公告)日：2010-02-09
申请号：US12074211
申请日：2008-02-29
申请人： Anthony P. Reeves , David Yankelevitz , Claudia Henshke , Antoni Chan
发明人： Anthony P. Reeves , David Yankelevitz , Claudia Henshke , Antoni Chan
IPC分类号： G06K9/62
CPC分类号： A61B6/5258 , G06T5/20 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T2207/10081 , G06T2207/30064
摘要： The present invention is directed to diagnostic imaging of small pulmonary nodules. There are two main stages in the evaluation of pulmonary nodules from Computed Tomography (CT) scans: detection, in which the locations of possible nodules are identified, and characterization, in which a nodule is represented by measured features that may be used to evaluate the probability that the nodule is cancer. Currently, the most useful prediction feature is growth rate, which requires the comparison of size estimates from two CT scans recorded at different times. The present invention includes methods for detection and feature extraction for size characterization. The invention focuses the analysis of small pulmonary nodules that are less than 1 centimeter in size, but is also suitable for larger nodules as well.
摘要翻译：本发明涉及小型肺结节的诊断成像。计算机断层扫描（CT）扫描对肺结节进行评估有两个主要阶段：其中确定可能结节位置的检测和表征，其中结节由可用于评估结节的测量特征表示结节是癌症的概率。目前，最有用的预测特征是增长率，这需要比较不同时间记录的两个CT扫描的大小估计。本发明包括用于尺寸表征的检测和特征提取的方法。本发明重点分析小小于1厘米的小肺结节，但也适用于较大的结节。

4. 发明申请

US20080205717A1 System and method for three-dimensional image rendering and analysis 有权
公开(公告)号：US20080205717A1
公开(公告)日：2008-08-28
申请号：US11827994
申请日：2007-07-13
申请人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
发明人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
IPC分类号： G06K9/00
CPC分类号： G06T5/005 , G06T5/002 , G06T5/30 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T7/62 , G06T11/008 , G06T15/08 , G06T17/10 , G06T2200/04 , G06T2207/10081 , G06T2207/30061 , G06T2207/30096
摘要： The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.

5. 发明申请

US20080187204A1 System, method and apparatus for small pulmonary nodule computer aided diagnosis from computed tomography scans 有权
标题翻译：用于计算机断层扫描的小型肺结节计算机辅助诊断系统，方法和装置
公开(公告)号：US20080187204A1
公开(公告)日：2008-08-07
申请号：US12074211
申请日：2008-02-29
申请人： Anthony P. Reeves , David Yankelevitz , Claudia Henshke , Antoni Chan
发明人： Anthony P. Reeves , David Yankelevitz , Claudia Henshke , Antoni Chan
IPC分类号： G06K9/00
CPC分类号： A61B6/5258 , G06T5/20 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T2207/10081 , G06T2207/30064
摘要： The present invention is directed to diagnostic imaging of small pulmonary nodules. There are two main stages in the evaluation of pulmonary nodules from Computed Tomography (CT) scans: detection, in which the locations of possible nodules are identified, and characterization, in which a nodule is represented by measured features that may be used to evaluate the probability that the nodule is cancer. Currently, the most useful prediction feature is growth rate, which requires the comparison of size estimates from two CT scans recorded at different times. The present invention includes methods for detection and feature extraction for size characterization. The invention focuses the analysis of small pulmonary nodules that are less than 1 centimeter in size, but is also suitable for larger nodules as well.
摘要翻译：本发明涉及小型肺结节的诊断成像。计算机断层扫描（CT）扫描的肺结节评估有两个主要阶段：其中确定可能结节的位置的检测和表征，其中结节由可用于评估结节的测量特征表示结节是癌症的概率。目前，最有用的预测特征是增长率，这需要比较不同时间记录的两个CT扫描的大小估计。本发明包括用于尺寸表征的检测和特征提取的方法。本发明重点分析小小于1厘米的小肺结节，但也适用于较大的结节。

6. 发明授权

US08577129B2 System and method for three-dimensional image rendering and analysis 有权
标题翻译：用于三维图像渲染和分析的系统和方法
公开(公告)号：US08577129B2
公开(公告)日：2013-11-05
申请号：US13453293
申请日：2012-04-23
申请人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
发明人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
IPC分类号： G06K9/00
CPC分类号： G06T5/005 , G06T5/002 , G06T5/30 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T7/155 , G06T7/62 , G06T11/008 , G06T15/08 , G06T17/10 , G06T2200/04 , G06T2207/10081 , G06T2207/30064 , G06T2207/30096
摘要： The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.
摘要翻译：本发明涉及用于进行三维图像分析和诊断的方法和系统以及与之有关的可能的处理。本发明包括处理包含与由扫描介质扫描的物体的三维表示相关的信息（数据）的信号的方法。本发明还包括制造和分析体积测量和体积测量变化的方法，其可用于诊断和治疗的目的。

7. 发明申请

US20120219200A1 System and Method for Three-Dimensional Image Rendering and Analysis 有权
标题翻译：三维图像渲染与分析的系统与方法
公开(公告)号：US20120219200A1
公开(公告)日：2012-08-30
申请号：US13453293
申请日：2012-04-23
申请人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
发明人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
IPC分类号： G06K9/00
CPC分类号： G06T5/005 , G06T5/002 , G06T5/30 , G06T7/0012 , G06T7/11 , G06T7/136 , G06T7/155 , G06T7/62 , G06T11/008 , G06T15/08 , G06T17/10 , G06T2200/04 , G06T2207/10081 , G06T2207/30064 , G06T2207/30096
摘要： The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.
摘要翻译：本发明涉及用于进行三维图像分析和诊断的方法和系统以及与之有关的可能的处理。本发明包括处理包含与由扫描介质扫描的物体的三维表示相关的信息（数据）的信号的方法。本发明还包括制造和分析体积测量和体积测量变化的方法，其可用于诊断和治疗的目的。

8. 发明授权

US08045770B2 System and method for three-dimensional image rendering and analysis 有权
标题翻译：用于三维图像渲染和分析的系统和方法
公开(公告)号：US08045770B2
公开(公告)日：2011-10-25
申请号：US11827994
申请日：2007-07-13
申请人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
发明人： Anthony P. Reeves , William J. Kostis , Claudia Henschke , David Yankelevitz
IPC分类号： G06K9/00
CPC分类号： G06T5/005 , G06T5/002 , G06T5/30 , G06T7/0012 , G06T7/11 , G06T7/155 , G06T7/62 , G06T11/008 , G06T15/08 , G06T17/10 , G06T2200/04 , G06T2207/10081 , G06T2207/30061 , G06T2207/30096
摘要： The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.
摘要翻译：本发明涉及用于进行三维图像分析和诊断的方法和系统以及与之有关的可能的处理。本发明包括处理包含与由扫描介质扫描的物体的三维表示有关的信息（数据）的信号的方法。本发明还包括制造和分析体积测量和体积测量变化的方法，其可用于诊断和治疗的目的。

9. 发明授权

US07596401B2 Method for expanding the domain of imaging software in a diagnostic work-up 有权
标题翻译：在诊断处理中扩展成像软件领域的方法
公开(公告)号：US07596401B2
公开(公告)日：2009-09-29
申请号：US11377031
申请日：2006-03-16
申请人： David F. Yankelevitz , Anthony P. Reeves , Claudia Ingrid Henschke
发明人： David F. Yankelevitz , Anthony P. Reeves , Claudia Ingrid Henschke
IPC分类号： A61B5/00
CPC分类号： G06T7/0012 , A61B6/12 , G06F19/00 , G06F19/321 , G06T2207/30004 , G16H50/20
摘要： A method for expanding the domain of imaging software in a diagnostic work-up includes the steps of: imaging a patient's body parts for a first condition using a first imaging technique directed to a first condition; acquiring known patient risk factors indicating a second condition; compensating for differences in accuracy between a first imaging technique directed to a first condition, and a second imaging technique directed to testing for the second condition to generate a set of measures; placing a range and confidence interval around the set of measures; and evaluating for a second condition using the set of measures and known patient risk factors.
摘要翻译：一种用于在诊断处理中扩展成像软件的领域的方法包括以下步骤：使用针对第一状态的第一成像技术对患者的身体部位进行第一状态成像; 获取指示第二个状况的已知患者危险因素; 补偿针对第一条件的第一成像技术之间的精度差异，以及针对第二条件的测试以产生一组措施的第二成像技术; 在一组措施周围放置范围和置信区间; 并使用所述测量集和已知的患者危险因素来评估第二条件。

10. 发明申请

US20090083075A1 System and method for analyzing medical data to determine diagnosis and treatment 审中-公开
标题翻译：用于分析医疗数据以确定诊断和治疗的系统和方法
公开(公告)号：US20090083075A1
公开(公告)日：2009-03-26
申请号：US12245888
申请日：2008-10-06
申请人： Claudia Ingrid Henschke , Anthony P. Reeves , David F. Yankelevitz
发明人： Claudia Ingrid Henschke , Anthony P. Reeves , David F. Yankelevitz
IPC分类号： G06Q50/00
CPC分类号： G06F19/3481 , G06Q50/24 , G16H10/60 , G16H50/20
摘要： A system and method for generating an action plan for diagnosis and treatment of a patient. In particular, a historical database is complied which includes a plurality of records. Each record includes a personal profile and diagnosis data for a person. A plurality of characterizations and corresponding weighting coefficients are derived based on the records in the historical database. Pre-diagnostic patient profile data for a selected patient is obtained for the selected patient. One or more computing modules generate output data for the selected patient as a function of (i) the pre-diagnostic patient profile data, along with the physician's modifications, if any and (ii) the plurality of characterizations and corresponding weighting coefficients. The output data includes at least one of a diagnostic action plan, a confirmation action plan, a confirmation patient profile data and a therapeutic action plan. is
摘要翻译：一种用于产生用于诊断和治疗患者的动作计划的系统和方法。特别地，遵循包括多个记录的历史数据库。每个记录包括一个人的个人资料和诊断数据。基于历史数据库中的记录导出多个表征和对应的加权系数。获得所选患者的预诊断患者资料数据。一个或多个计算模块根据（i）预诊断患者简档数据以及医师的修改（如果有的话）和（ii）多个表征和对应的加权系数，生成所选择的患者的输出数据。输出数据包括诊断动作计划，确认动作计划，确认患者简档数据和治疗动作计划中的至少一个。是的

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