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1. 发明申请

US20070008528A1 Device and method for simultaneous optical trapping, stretching, and real-time detection and measurement for morphological deformation of micro-particles 审中-公开
标题翻译：用于同时光学捕获，拉伸和实时检测和测量微粒形态变形的装置和方法
公开(公告)号：US20070008528A1
公开(公告)日：2007-01-11
申请号：US11175140
申请日：2005-07-07
申请人： Arthur Chiou , Chi-Hung Lin , Artashes Karmenyan , I Hsiao
发明人： Arthur Chiou , Chi-Hung Lin , Artashes Karmenyan , I Hsiao
IPC分类号： G01N21/00 , G01B11/24
CPC分类号： G01N15/1475 , G01N2015/1493 , G01N2015/1495
摘要： The present invention provides a method and device for simultaneous optical trapping, stretching, and measurement of morphological deformation of a micro-particle in real-time. Using the setup of the present invention, the deformability of a living cell can be obtained in real-time by measuring the variation in coupling efficiency with optical power of light coupled from one single-mode fiber to the other through the lensing effect of the trapped-and-stretched micro-particle.
摘要翻译：本发明提供了一种用于同时光学捕获，拉伸和测量微粒形态变形的方法和装置。利用本发明的设置，可以通过测量由一个单模光纤耦合到另一个单模光纤的光的光功率的耦合效率的变化，通过被捕获的透镜效应来实时获得活细胞的变形能力并拉伸微粒。

2. 发明申请

US20050214931A1 SYSTEM AND METHOD FOR ANALYZING BIOCHIP 审中-公开
标题翻译：用于分析生物化学的系统和方法
公开(公告)号：US20050214931A1
公开(公告)日：2005-09-29
申请号：US10906889
申请日：2005-03-11
申请人： Terry B.J. Kuo , Arthur Chiou , Cheng-Yu Wei , Chun-Nan Teng , Kun-Shan Lu
发明人： Terry B.J. Kuo , Arthur Chiou , Cheng-Yu Wei , Chun-Nan Teng , Kun-Shan Lu
IPC分类号： B01L3/00 , C12Q1/68 , G01N21/64
CPC分类号： G01N21/6452 , B01L3/50851
摘要： A system and method for analyzing a biochip are provided. Wherein, a first modulator circuit outputs a first modulated signal with a first frequency. A first light source module output a first light beam based on the first modulated signal. A first optical signal is generated after the first light beam being emitted onto the biochip. An optical sensing module sense the first optical signal and outputting a first sensing signal. A first filter circuit filters the first sensing signal and outputting a first portion sensing signal. A first demodulator circuit demodulates the first portion sensing signal and outputting a first demodulated signal. An analog to digital converter convert the first demodulated signal to a first digital signal. A signal display module receives and display the first digital signal.
摘要翻译：提供了一种用于分析生物芯片的系统和方法。其中，第一调制器电路输出具有第一频率的第一调制信号。第一光源模块基于第一调制信号输出第一光束。在第一光束被发射到生物芯片上之后产生第一光信号。光学感测模块感测第一光学信号并输出第一感测信号。第一滤波器电路对第一感测信号进行滤波并输出第一部分感测信号。第一解调器电路解调第一部分感测信号并输出第一解调信号。模数转换器将第一解调信号转换为第一数字信号。信号显示模块接收并显示第一数字信号。

3. 发明授权

US07961369B2 Large-angle agile laser beam steering apparatus and method 有权
标题翻译：大角度敏捷激光束转向装置及方法
公开(公告)号：US07961369B2
公开(公告)日：2011-06-14
申请号：US11238590
申请日：2005-09-28
申请人： Mohsen Khoshnevisan , Ray C. Delcher , Mark D. Ewbank , Arthur Chiou , William R. Christian , Randolph L. Hall
发明人： Mohsen Khoshnevisan , Ray C. Delcher , Mark D. Ewbank , Arthur Chiou , William R. Christian , Randolph L. Hall
IPC分类号： G02B26/12
CPC分类号： G02B26/0816 , G02B5/284
摘要： A laser beam steering apparatus includes a beam steering cell with an adjustable shape, with the cell having opposing Fabry-Perot filters, and a steering mechanism coupled to the cell to adjust its shape so that the direction of a laser beam emitted from the cell is changed in response to a change in the cell shape.
摘要翻译：激光束转向装置包括具有可调节形状的光束转向单元，该单元具有相对的法布里 - 珀罗滤光器，以及耦合到单元以调节其形状的转向机构，使得从单元发射的激光束的方向为响应于细胞形状的变化而改变。

4. 发明授权

US07843635B2 Device for trapping or stretching microscopic substance and method thereof 失效
标题翻译：用于捕获或拉伸微观物质的装置及其方法
公开(公告)号：US07843635B2
公开(公告)日：2010-11-30
申请号：US11764433
申请日：2007-06-18
申请人： Guan-Bo Liao , Chi-Hung Lin , Arthur Chiou
发明人： Guan-Bo Liao , Chi-Hung Lin , Arthur Chiou
IPC分类号： G02B13/10 , G02F1/33
CPC分类号： G01N15/1475 , B01L3/502761 , G01N2015/1006 , G01N2015/1495 , G01N2203/0075 , G01N2203/0089 , G01N2203/0094
摘要： The present invention provides a device for trapping or stretching a microscopic substance comprising (a) a light source; (b) an acousto-optic modulator (AOM); (c)a beam-expander; (d) an object lens; and (e) an incoherent light source. The present invention further provides a method for trapping or stretching a microscopic substance comprising (a) providing a focused laser beam to form a focal spot and (b) scanning a plurality of points on said microscopic substance by said focal spot by way of the AOM.
摘要翻译：本发明提供一种捕获或拉伸微观物质的装置，包括（a）光源; （b）声光调制器（AOM）; （c）射束扩张器; （d）物镜; 和（e）非相干光源。本发明还提供了一种用于捕获或拉伸微观物质的方法，包括（a）提供聚焦的激光束以形成焦点，以及（b）通过所述焦点通过所述AOM扫描所述微观物质上的多个点。

5. 发明申请

US20080310009A1 Device for trapping or stretching microscopic substance and method thereof 失效
标题翻译：用于捕获或拉伸微观物质的装置及其方法
公开(公告)号：US20080310009A1
公开(公告)日：2008-12-18
申请号：US11764433
申请日：2007-06-18
申请人： Guan-Bo Liao , Chi-Hung Lin , Arthur Chiou
发明人： Guan-Bo Liao , Chi-Hung Lin , Arthur Chiou
IPC分类号： G02F1/33
CPC分类号： G01N15/1475 , B01L3/502761 , G01N2015/1006 , G01N2015/1495 , G01N2203/0075 , G01N2203/0089 , G01N2203/0094
摘要： The present invention provides a device for trapping or stretching a microscopic substance comprising (a) a light source for irradiating laser beam; (b) an acousto-optic modulator (AOM) for regulating the direction of said laser beam irradiating from said light source; (c) a beam-expander for expanding and collimating the light beam emitting from said AOM; (d) an object lens for focusing the laser beam passing through said beam-expander; and (e) an incoherent light source for imaging said microscopic substance.The present invention further provides a method for trapping or stretching a microscopic substance comprising (a) providing a focused laser beam to form a focal spot and (b) scanning a plurality of points on said microscopic substance by said focal spot by way of the AOM.
摘要翻译：本发明提供一种用于捕获或拉伸微观物质的装置，包括（a）用于照射激光束的光源; （b）用于调节从所述光源照射的所述激光束的方向的声光调制器（AOM）; （c）用于扩展和准直从所述AOM发射的光束的光束扩展器; （d）用于聚焦通过所述光束扩展器的激光束的物镜; 和（e）用于对所述微观物质进行成像的非相干光源。本发明还提供了一种用于捕获或拉伸微观物质的方法，包括（a）提供聚焦激光束以形成焦点，和（b）通过所述焦点通过所述AOM扫描所述微观物质上的多个点。

6. 发明申请

US20070070482A1 Large-angle agile laser beam steering apparatus and method 有权
标题翻译：大角度敏捷激光束转向装置及方法
公开(公告)号：US20070070482A1
公开(公告)日：2007-03-29
申请号：US11238590
申请日：2005-09-28
申请人： Mohsen Khoshnevisan , Ray Delcher , Mark Ewbank , Arthur Chiou , William Christian , Randolph Hall
发明人： Mohsen Khoshnevisan , Ray Delcher , Mark Ewbank , Arthur Chiou , William Christian , Randolph Hall
IPC分类号： G02B26/08
CPC分类号： G02B26/0816 , G02B5/284
摘要： A laser beam steering apparatus includes a beam steering cell with an adjustable shape, with the cell having opposing Fabry-Perot filters, and a steering mechanism coupled to the cell to adjust its shape so that the direction of a laser beam emitted from the cell is changed in response to a change in the cell shape.
摘要翻译：激光束转向装置包括具有可调节形状的光束转向单元，该单元具有相对的法布里 - 珀罗滤光器，以及耦合到单元以调节其形状的转向机构，使得从单元发射的激光束的方向为响应于细胞形状的变化而改变。

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